HIGH PERFORMANCE POLYMERS
·
2016
·
IF 1.045
Yang Su,Tao Wang,Guodong Dang,Hongwei Zhou,Chunhai Chen
Polyether ether ketone (PEEK) mixed with manganese (Mn) of different valences was prepared to simulate conditions of impurity. The melt flow rate (MFR) and rheological behaviour were systematically studied to characterize the mobility from different angles. MFR test was used for the preliminary exploration of mixtures of Mn ions. The results showed that Mn, Mn(II), and Mn(IV) had little impact on the mobility of PEEK contrary to Mn(VII) and that long chain branching or cross-linking was suspected. Mn(VII) was determined to be the main object of this research. Capillary rheometer test demonstrated that the apparent shear viscosity constantly reduced with the increase of apparent shear rate, and that the addition of Mn(VII) could worsen the mobility of PEEK. Similarly, parallel plate rheometer studies proved that the complex viscosity increased along with the content of Mn(VII) and LCB was confirmed. Thermal analysis revealed that LCB occurred internally and that thermal stability was worse.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Feng Wang,Kewei Lin,Qiaomei Shen,Dongjie Liu,Gengsheng Xiao,Lukai Ma
In this study, the ultrasonic-microwave pretreatment was defined as a processing technology in the production of tribute citrus powder, and it could increase the flavonoid compounds in the processing fruit powder. A total of 183 upregulated metabolites and 280 downregulated metabolites were obtained by non-targeted metabolomics , and the differential metabolites was mainly involved in the pathways of flavonoid biosynthesis , flavone and flavonol biosynthesis. A total of 8 flavonoid differential metabolites were obtained including 5 upregulated metabolites (6”- O -acetylglycitin, scutellarin , isosakuranin, rutin , and robinin), and 3 downregulated metabolites (astragalin, luteolin , and (−)-catechin gallate) by flavonoids-targeted metabolomics. The 8 flavonoid differential metabolites participated in the flavonoid biosynthesis pathways, flavone and flavonol biosynthesis pathways, and isoflavonoid biosynthesis pathways. The results provide a reference for further understanding the relationship between food processing and food components, and also lay a basis for the development of food targeted-processing technologies.
研究领域:
食品科学
·
植物化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2021
·
IF 6.165
Ruihong Wang,Botian Ding,Guizhao Liang
Cyclodextrins (CDs) can improve the solubility and stability of flavonoids by forming supramolecular complexes. However, the detailed inclusion mechanism has not been fully elucidated. In this study, the binding ability of eight flavonoids with four common CDs (α-, β-, methyl-β-, γ-CD) was investigated. Then, the interaction characteristics of two flavonoids (Dihydromyricetin (DMY) and Naringenin) with M-β-CD were further explored by using phase solubility, ultraviolet, infrared, X-ray diffraction, differential scanning calorimetry, molecular docking and ONIOM calculations. The results indicated that the molecular volume of flavonoids and the cavity size of CDs have distinct effects on the host-guest interaction. DMY and Naringenin form stable supramolecular complexes with M-β-CD mainly through hydrophobic interactions and Van der Waals forces. In addition, the stability of the Naringenin/m-β-CD is higher than that of DMY/M-β-CD, which is consistent with the experimental stability constant. Both of the above flavonoids entered the large hole of the hydrophobic cavity of M-β-CD through one end of the B-ring, which has a significant contribution to the formation of the host-guest hydrogen bonds . Taken together, this study is helpful to further understand the interaction mechanism between CDs and guest molecules, expand the application of CDs, and promote the utilization of natural active compounds.
研究领域:
药剂学
·
分子生物学
·
化学
✓ 已验证
DOI
高影响因子
HIGH PERFORMANCE POLYMERS
·
2021
·
IF 2.161
Huifa Meng,Qian Zhang,Maoping Lu,Zhencai Qu,Bing Chen,Chang-an Xu,Mangeng Lu
Benzene-1,3,5-triyl tribenzoate (TBB), both 3,5-bis(benzoyloxy)benzoate-terminated poly (aryl ether ketone) oligomers (BPAPK and TMPK), containing active ester (Ph−O−(C=O)− structure), were prepared and served as curing agents for dicyclopentadiene novoalc epoxy (DCPD). The curing kinetics and properties of three epoxy thermosets were systematically investigated. The model reaction of TBB and glycidyl phenyl ether was designed to understand the curing mechanism of oxirane ring with active ester. TMPK/DCPD displays the lowest reaction activation energy, which is the result of the combined influence of free volume and diffusion. In addition, TMPK/DCPD has the highest Tg value (218°C), which enhances 34.6% and 42.5% compared with BPAPK/DCPD and TBB/DCPD, respectively. Meanwhile, TMPK/DCPD also shows superior dielectric and water resistance properties due to no secondary alcohol generated after curing and hydrophobic tetramethyl-substituted biphenyl structure. Herein, TMPK/DCPD as high-performance epoxy thermosets has potential applications in electronic packaging fields.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
CELLULOSE
·
2019
·Vol. 26
·期 12
·7195-7206
·
IF 3.917
Fu Gen-Que,Su Li-Yuan,Yue Pan-Pan,Huang Yan-Hui,Bian Jing,Li Ming-Fei,Peng Feng,Sun Run-Cang
A functional biopolymer was synthesized by introducing stearic acid (SA) to the backbone of xylan (X) obtained from viscose fiber mills. The SA–X derivatives were characterized by various tests for analysis of the functional properties. Effects on the esterification conditions including molar ratio, time and temperature were discussed, and the degree of substitution (DS) was in the range of 0.34–1.54. SA–X nanoparticles (SA–X NPs) were synthesized by dialysis, and the average particle size of the NPs was about 194 nm. Ketoprofen (KPF) was chosen as a hydrophobic model drug for the loading function evaluation, and the final encapsulation efficiency was about 64%. The KPF release profile in buffer standard solution with pH 11.0 and 2.0 were tested, and the final released amount were 43.6% and 53.8%, respectively. Thus, the fabrication of functional SA–X NPs provided a new way to improve the unreasonable application of factory biopolymer by-products.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF CULTURAL HERITAGE
·
2014
·
IF 1.111
Mingyuan Sun,Jiahe Wang,Hui Zhang,Bingjian Zhang,Zaixuan Fan,Bomin Su
The study of how to remove the ineffective conservation materials without damaging the mural's surface has been one of the hot issues of modern conservation science, and the reversibility problem of mural protective materials needs to be resolved instantly. In this article, we measured the reversible rates of 4 typical protective agents both on glazed tiles and model samples of Dunhuang murals, and used 3D microscopic system to observe the removal effect. The experimental results show that the cleaning agents should not contain water considering the water-soluble binding material of Dunhuang murals. All conservation materials are reversible, but their reversibilities are different. We obtained the best pairs of “conservation material-cleaning agent”, which are “silicone-acrylic emulsion-p-xylene + propylene carbonate”, “acrylic emulsion-p-xylene”, “polyvinyl acetate emulsion-p-xylene + ethyl acetate” and “Paraloid B72-p-xylene + propylene carbonate”. It is also found that the reversible rate of conservation materials declines after aging.
研究领域:
文物保护
·
材料科学
✓ 已验证
DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2022
·
IF 6.064
Yu Han,Xiao Qiaohong,Qi Guilin,Chen Feixiang,Tu Biyue,Zhang Suo,Li Yinping,Chen Yun,Yu Hui,Duan Peng
Hydrogels with adhesive properties have the potential for rapid haemostasis and wound healing in uncontrolled non-pressurized surface bleeding. Herein, a typical hydrogen bond-crosslinked hydrogel with the above functions was constructed by directly mixing solutions of humic acid (HA) and polyvinylpyrrolidone (PVP), in which the HA worked as a crosslinking agent to form hydrogen bonds with the PVP. By altering the concentration of HA, a cluster of stable and uniform hydrogels were prepared within 10 s. The dynamic and reversible nature of the hydrogen bonds gave the HA/PVP complex (HPC) hydrogels injectability and good flexibility, as well as a self-healing ability. Moreover, the numerous functional groups in the hydrogels enhanced the cohesion strength and interaction on the interface between the hydrogel and the substrate, endowing them with good adhesion properties. The unique chemical composition and cross-linking mechanism gave the HPC hydrogel good biocompatibility. Taking advantage of all these features, the HPC hydrogels obtained in this work were broadly applied as haemostatic agents and showed a good therapeutic effect. This work might lead to an improvement in the development of multifunctional non-covalent hydrogels for application to biomaterials.
研究领域:
生物材料学
·
医学工程
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2018
·
IF 3.862
Qilong Wang,Qiuxuan Yang,Xia Cao,Qiuyu Wei,Caleb K. Firempong,Min Guo,Feng Shi,Ximing Xu,Wenwen Deng,Jiangnan Yu
[6]-Shogaol, an alkylphenol compound purified from the root and stem of ginger ( Zingiber officinale ), has attracted considerable interest due to its potential anticancer, antioxidative and antirheumatic properties. However, the oral bioavailability of [6]-shogaol has been severely limited because of its poor solubility. In this study, a significant quantity of high-purity [6]-shogaol (yield: 3.6%; purity: 98.65%) was extracted and encapsulated in solid lipid nanoparticles (SLNs) via high-pressure homogenization (encapsulation efficiency: 87.67%) to improve its solubility and oral bioavailability. The resulting [6]-shogaol-loaded solid lipid nanoparticles (SSLNs) were stable, homogeneous and well-dispersed. Its mean particle size and zeta potential were 73.56 ± 5.62 nm and −15.2 ± 1.3 mV, respectively. Importantly, the in vitro release profile and in vivo oral bioavailability of SSLNs were significantly improved compared with the free drug. Furthermore, the SSLNs could remarkably lower the uric acid level via inhibiting the activity of xanthine oxidase and reduce the production of interleukin-1β (IL-1β) and tumor necrosis factor (TNF-α) in the hyperuricemia/gouty arthritis rat model, when compared to the free [6]-shogaol. Collectively, SLNs could serve as a promising drug delivery system to improve the oral bioavailability of [6]-shogaol for effective treatment of gouty arthritis.
研究领域:
药剂学
·
生物化学
·
纳米医学
✓ 已验证
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Hetong Qi,Yuxi Tong,Mengyue Zhang,Xuemei Wu,Ling Yue
We demonstrate the preparation of a dual-site carbon nanozyme, boron-doped and ketonic carbonyl (−C=O) group-enriched graphdiyne (B-GDY), with an enhanced peroxidase-like activity. Taking advantage of acidic oxidation treatment, GDY oxide (GDYO) with abundant surface oxygen-containing groups is obtained from pristine bulk GDY. Upon further thermal annealing of GDYO with H3BO3 under an inert atmosphere, B is introduced into GDY, while the loading of −C=O groups is increased onto B-GDY. We discover that boron-doped and ketonic carbonyl group-enriched graphdiyne as a dual-site carbon nanozyme endows it with an enhanced peroxidase-like activity, which is nearly 4.2-fold higher than that of GDY without B atoms and 6.6-fold higher than that of GDYO without B atoms and with low loading of −C=O groups. The high peroxidase-like activity of B-GDY is ascribed to the dual active sites (−C=O group and B atom) within it, which facilitates the adsorption and decomposition of H2O2 into hydroxyl radicals revealed by experimental and theoretical studies. Moreover, B-GDY is successfully employed to develop a colorimetric method for the detection of glucose with good sensitivity and selectivity. This work probes into the intrinsic peroxidase activity and structure–reactivity correlation, creating effective strategies for the preparation of GDY-based nanozymes.
研究领域:
材料科学
·
生物化学
·
纳米医学
✓ 已验证
DOI
高影响因子
DRUG DELIVERY
·
2021
·
IF 6.419
Luting Wang,Lin Xu,Junfeng Du,Xiao Zhao,Mei Liu,Jianfang Feng,Kaili Hu
Targeted treatment of cerebral ischemia/reperfusion injury (CIRI) remains a problem due to the difficulty in drug delivery across the blood–brain barrier (BBB). In this study, we developed Bo-TSA-NP, a novel tanshinone IIA (TSA) loaded nanoparticles modified by borneol, which has long been proved with the ability to enhance other drugs’ transport across the BBB. The Bo-TSA-NP, with a particle size of about 160 nm, drug loading of 3.6%, showed sustained release and P-glycoprotein (P-gp) inhibition property. It demonstrated a significantly higher uptake by 16HBE cells in vitro through the clathrin/caveolae-mediated endocytosis and micropinocytosis. Following intranasal (IN) administration, Bo-TSA-NP significantly improved the preventive effect on a rat model of CIRI with improved neurological scores, decreased cerebral infarction areas and a reduced content of malondialdehyde (MDA) and increased activity of superoxide dismutase (SOD) in rat brain. In conclusion, these results indicate that Bo-TSA-NP is a promising nose-to-brain delivery system that can enhance the prevention effect of TSA on CIRI.
研究领域:
药剂学
·
神经科学
·
药物递送系统
✓ 已验证
DOI
高影响因子
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
·
2020
·
IF 4.966
Wei Wang,Junmei Tian,Zhijia Zhu,Chenmiao Zhu,Baojiang Liu,Chunyan Hu
A facile, efficient, precise and reliable method based on liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was established to separate and determine two typical quinolone antibiotics (ofloxacin and lomefloxacin) and two typical sulfonamide antibiotics (sulfadimeisoxazole and sulfadimidine). The photocatalytic degradation effects, identification of intermediate products and decomposition pathways of these four antibiotics degraded by Bi 2 MoO 6 /Bi 2 WO 6 /MWCNTs composite catalyst were analyzed using the developed HPLC-MS/MS method. It was found that all four antibiotics can be synchronously decomposed with the ultrahigh removal rates of above 95 %. Three main degradation reactions of quinolones were detected: the decarboxylation of quinolones, the ring opening reaction of piperazine and the defluorination of C–F. The main decomposition reactions of sulfonamides included the sulfonamide bond (S N) breaking at the active sites, the oxidation of the amino acids on the benzene rings , and the substitution and oxidation ring opening reaction of pyrimidine. This study not only developed a detailed isolation and identification method for the degradation pathways and mechanisms of mixed pharmaceutical pollutants, but also provides a superb photocatalyst for the removal of multiplex pharmaceutical pollutants.
研究领域:
环境科学
·
分析化学
·
药理学
✓ 已验证
DOI
高影响因子
Metabolites
·
2022
·Vol. 12
·期 9
·790
·
IF 5.581
Chengcai Zhang,Yang Jiang,Changzheng Liu,Linyuan Shi,Jintong Li,Yan Zeng,Lanping Guo,Sheng Wang
Fagopyrum dibotrys, being native to southwest China, is widely distributed in Yunnan, Guizhou Provinces and Chongqing City. However, the quality of medicinal materials growing in different origins varies greatly, and cannot meet the market demand for high-qualityF. dibotrys. In this study, 648 metabolites were identified, and phenolic compounds ofF. dibotrysfrom different origins were clearly separated by principal component analysis (PCA). Our results suggested that the medicinal differences ofF. dibotrysfrom different origins can be elucidated via the variations in the abundance of the phenolic and flavonoid compounds. We found that the epicatechin, total flavonoids and total tannin content in Yunnan Qujing (YQ) and Yunnan Kunming (YK) were higher than those in Chongqing Shizhu (CS), Chongqing Fuling (CF) and Guizhou Bijie (GB), suggesting that Yunnan Province can be considered as one of the areas that produce high-quality medicinal materials. Additionally, 1,6-di-O-galloyl-β-D-glucose, 2,3-di-O-galloyl-D-glucose and gallic acid could be used as ideal marker compounds for the quality control ofF. dibotrysfrom different origins caused by metabolites, and theF. dibotrysplanted in Yunnan Province is well worth exploiting.
研究领域:
植物学
·
药理学
·
分析化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）