Chemistry-An Asian Journal
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2020
·Vol. 15
·期 8
·1272-1276
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IF 4.056
Yueming Cao,Peipei Li,Tengteng Wu,Meiling Liu,Youyu Zhang
Graphical HKUST-1 (Cu−BTC, BTC=benzene-1,3,5 tricarboxylate) was selected as an electrocatalyst for the reaction of conversion N 2 to NH 3 under ambient conditions. At −0.75 V vs. reversible hydrogen electrode, it achieves excellent performance with high NH 3 yield (46.63 μg h −1 mg −1 cat. or 4.66 μg h −1 cm −2 ) and Faraday efficiency (2.45%). Electrolytic ammonia synthesis from nitrogen at ambient conditions is appearing as a promising alternative to the Haber-Bosch process which is consuming high energy and emitting CO 2 . Here, a typical MOF material, HKUST-1 (Cu−BTC, BTC=benzene-1,3,5-tricarboxylate), was selected as an electrocatalyst for the reaction of converting N 2 to NH 3 under ambient conditions. At −0.75 V vs. reversible hydrogen electrode, it achieves excellent catalytic performance in the electrochemical synthesis of ammonia with high NH 3 yield (46.63 μg h −1 mg −1 cat. or 4.66 μg h −1 cm −2 ) and good Faraday efficiency (2.45%). It is indicated that the good performance of the HKUST-1 catalyst may originate from the formation of Cu(I). In addition, the catalyst also has good selectivity for N 2 to NH 3 .
研究领域:
材料科学
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电化学
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催化反应
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DOI
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2015
·Vol. 31
·期 2
·224-227
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IF 0.875
Zhang Ran,Xu Lihua,Chen Hui,Qin Zhihong,Zhao Yu,Ni Zhonghai
1-Thiohydroxypyrene( 1 ) and its two intermediates, 1-pyrenyl- O -thiocarbamate( 2 ) and 1-pyrenyl- S -thiocarbamate( 3 ), were synthesized using 1-hydroxypyrene as the starting material. The key synthetic step is Newman-Kwart rearrangement. The results indicate that the Newman-Kwart rearrangement is more effective in suitable solvent than conventional method based on pure organic compound. The structures of compounds 1 – 3 were characterized by FTIR, NMR, GC-MS and elementary analysis. The crystal structures of two new compounds( 2 and 3 ) were determined by single crystal X-ray diffraction analysis. The whole synthetic process is simple, mild and with high yield.
研究领域:
有机化学
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材料科学
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DOI
高影响因子
MedComm
·
2024
·Vol. 5
·期 5
·e555
·
IF 10.7
Heng Liang,Jiani Zhan,Yunqiu Chen,Zikang Xing,Zhen Ning Tony He,Yuying Liu,Xuewen Li,Yijia Chen,Zhiyao Li,Chunxiang Kuang,Dan Yang,Qing Yang
Indoleamine 2,3-dioxygenase 1 (IDO1), the key enzyme in the catabolism of the essential amino acid tryptophan (Trp) through kynurenine pathway, induces immune tolerance and is considered as a critical immune checkpoint, but its impacts as a metabolism enzyme on glucose and lipid metabolism are overlooked. We aim to clarify the potential role of IDO1 in aerobic glycolysis in pancreatic cancer (PC). Analysis of database revealed the positive correlation in PC between the expressions of IDO1 and genes encoding important glycolytic enzyme hexokinase 2 (HK2) , pyruvate kinase (PK) , lactate dehydrogenase A (LDHA) and glucose transporter 1 (GLUT1) . It was found that IDO1 could modulate glycolysis and glucose uptake in PC cells, Trp deficiency caused by IDO1 overexpression enhanced glucose uptake by stimulating GLUT1 translocation to the plasma membrane of PC cells. Besides, Trp deficiency caused by IDO1 overexpression suppressed the apoptosis of PC cells via promoting glycolysis, which reveals the presence of IDO1–glycolysis–apoptosis axis in PC. IDO1 inhibitors could inhibit glycolysis, promote apoptosis, and exhibit robust therapeutic efficacy when combined with GLUT1 inhibitor in PC mice. Our study reveals the function of IDO1 in the glucose metabolism of PC and provides new insights into the therapeutic strategy for PC.
研究领域:
癌症生物学
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代谢途径
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免疫学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2025
·Vol. 30
·期 10
·2122
·
IF 4.6
Zhinan Wang,Xiaowei Li,Liang Zhao,Saiwa Liu,Jingjing Du,Xi Jia,Lirui Ge,Jian Xu,Kexin Cui,Yu Ga,Jinxiu Wang,Xi Xia
The emergence ofmcr-1-mediated colistin resistance has become a critical global health concern, highlighting the urgent need for innovative approaches to restore colistin’s therapeutic potential. In this study, we evaluated the antibacterial activity of four matrine-type alkaloids—namely, matrine, oxymatrine, sophocarpine, and sophoramine—againstmcr-1-positiveEscherichia coli. While these alkaloids showed limited efficacy when used alone, the combination of matrine with colistin exhibited remarkable synergistic effects, as demonstrated by checkerboard assays and time-kill curve analyses. The matrine–colistin combination caused minimal erythrocyte damage while effectively attenuating resistance development in vitro. This synergy was further corroborated in a murine infection model, where the combination significantly reduced bacterial loads in target tissues. Mechanistic studies revealed that the matrine–colistin combination enhances antimicrobial activity by disrupting bacterial membrane integrity, increasing intracellular colistin accumulation, and triggering reactive oxygen species-mediated oxidative damage. Collectively, these findings highlight the potential of matrine as a promising adjuvant to overcome colistin resistance, providing a novel therapeutic approach to address the challenge of infections cause by multidrug-resistant Gram-negative bacteria.
研究领域:
微生物学
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药理学
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感染病学
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DOI
PubMed
高影响因子
Plants-Basel
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2024
·Vol. 13
·期 11
·1494
·
IF 4
Kaiming Mao,Chengzhe Li,Huacai Zhai,Yuying Wang,Yonggen Lou,Wenhua Xue,Guoxin Zhou
Green leaf volatiles (GLVs) play pivotal roles in plant anti-herbivore defense. This study investigated whether the rice 13-lipoxygense geneOsRCI-1is involved in GLV production and plant defense in rice. The overexpression ofOsRCI-1(oeRCIlines) in rice resulted in increased wound-induced levels of two prominent GLVs,cis-3-hexen-1-ol andcis-3-hexenal. In a previous study, we found that the overexpression ofOsRCI-1reduced the colonization by the rice brown planthopper (BPH,Nilaparvata lugens) but increased the attractiveness to the egg parasitoidAnagrus nilaparvataecompared to wild-type (WT) plants. This study found that whencis-3-hexen-1-ol, but notcis-3-hexenal, was added to WT plants, it could change the BPH’s colonization preference, i.e., more BPHs preferred to colonize theoeRCIlines. The exogenous application ofcis-3-hexen-1-ol orcis-3-hexenal to BPH-infested WT plants could weaken or overturn the preference ofA. nilaparvataeforoeRCIlines. However, field experiments revealed that onlycis-3-hexenal was attractive to the parasitoid and increased the parasitism rates of BPH eggs. These results indicate thatOsRCI-1is involved in rice GLV production and therefore modulates both direct and indirect defense in rice.
研究领域:
植物学
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昆虫学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
Polymers
·
2018
·Vol. 10
·期 8
·872
·
IF 2.935
Yongxian Zhao,Chen Ma,Shijie Cheng,Wei Xu,Yuejuan Du,Yansong Bao,Zuojie Xiao
Maleic anhydride (MAH)–divinyl benzene (DVB) multi-monomer melt-grafting onto isotactic polybutene-1 (iPB-1) was carried out in a torque rheometer. The effects of dicumyl peroxide (DCP), MAH, and DVB concentrations, and temperature, on the reaction, were investigated. The optimized conditions were 170 °C, DVB/MAH = 4:6 (mass ratio). DVB as a comonomer enhanced the grafting degree (Gd) and grafting efficiency (Ge) of iPB-g-MAH better than styrene. The initiator DCP had little effect on Gd as its concentration over 0.2 phr, but the grafts’ melt flow rate (MFR) increased significantly, and relative molecular weight decreased remarkably with increased DCP concentration. With increasing Gd, the contact angle of grafts with water decreased, and there was a larger crystallization rate. The study of iPB-1 and iPB-g-MAH (Gd = 1.5%)-modified polyamide 6 (PA6) showed that iPB-g-MAH had an obviously toughening effect on PA6. With increasing iPB-g-MAH concentration, the blends of impact strength and elongation at break increased obviously, tensile strength decreased slightly, and MFR decreased prominently, which greatly slowed the processing degradation of PA6. The properties of iPB-1/PA6 blends deteriorated. Both DSC curves and SEM micrographs confirmed that PA6/iPB-g-MAH blends had much better compatibility than PA6/iPB. The reason was that the anhydride group in iPB-g-MAH reacted with amide group in PA6 to improve the compatibility between two phases, and iPB-g-MAH is an excellent modifier for PA6.Keywords:isotactic polybutene-1;maleic anhydride;divinyl benzene;polyamide 6;modification
研究领域:
材料科学
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高分子化学
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产品关联
DOI
PubMed
高影响因子
POSTHARVEST BIOLOGY AND TECHNOLOGY
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2018
·
IF 3.112
Yurong Ma,Qingfeng Ban,Jingying Shi,Tiantian Dong,Cai-Zhong Jiang,Qingguo Wang
The effects of 1-methylcyclopropene (1-MCP) treatment, storage time, and shelf life and temperature on phenolic concentrations and antioxidant activity in apple peel and flesh of ‘Jonagold’ apple ( Malus domestica Borkh) have been investigated. Hyperoside and chlorogenic acid were the most abundant phenolic compounds in the peel and flesh, respectively. The flesh had lower concentrations of individual phenolics, total phenolics, flavonoids and lower antioxidant activity (determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay) than the peel. In addition, the profiles of phenolics as well as the changing patterns of individual phenolics also differed between the peel and the flesh. After long-time storage (180 d), the greatest decrease of concentrations was the concentrations of hyperoside (27 %) in the peel and total phenolics (35 %) in the flesh. Also, during the 90–180 d storage period, hyperoside and rutin in the peel, chlorogenic acid in the flesh, and flavonoids and antioxidant activity decreased in both peel and flesh tissues. Individual phenolics exhibited different stabilities during the early stages after harvest. 1-MCP reduced the reduction in the concentrations of hyperoside in the peel, chlorogenic acid in the flesh, and total phenolics, flavonoids and antioxidant activity in both the peel and flesh tissues during storage and shelf life. However, for quercetin and rutin, the protective effect of 1-MCP was only observed during the shelf life period. Overall, phenolic compounds responded variously to storage, shelf life, shelf temperature and 1-MCP treatment.
研究领域:
食品科学
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植物生理学
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产品关联
DOI
高影响因子
MOLECULES
·
2021
·Vol. 26
·期 5
·1462
·
IF 4.412
Hao Xu,Jie Zhu,Xiong Wang,Chao Shen,Shengshen Meng,Kai Zheng,Chao Lei,Longfeng Zhu
Developing sustainable routes for the synthesis of zeolites is still a vital and challenging task in zeolite scientific community. One of the typical examples is sustainable synthesis of aluminosilicate EU-1 zeolite, which is not very efficient and environmental-unfriendly under hydrothermal condition due to the use of a large amount of water as solvent. Herein, we report a sustainable synthesis route for aluminosilicate EU-1 zeolite without the use of solvent for the first time. The physicochemical properties of the obtained EU-1 zeolite are characterized by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetry-differential thermal analysis (TG-DTA), N2sorption, inductively coupled plasma (ICP) analysis, and solid nuclear magnetic resonance (NMR), which show the product has high crystallinity, uniform morphology, large BET surface area, and four-coordinated aluminum species. Moreover, the impact of synthesis conditions is investigated in detail. The sustainable synthesis of aluminosilicate EU-1 zeolite under solvent-freeKeywords:zeolite;aluminosilicate EU-1;sustainable route;solvent-free
研究领域:
材料科学
·
化学工程
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产品关联
DOI
PubMed
高影响因子
Frontiers in Chemistry
·
2022
·
IF 5.545
Zhang Changsheng,Chu Shaoqi,Jiang Jie,Zhao Jinchong,Wen Song,Sun Bing,Xu Wei
Synthesis of zeolites in more efficient and greener methods is of great significance in both industrial and academic fields. However, the relative long time for zeolite crystallization and much consumption of water solvent make the target challengeable. Herein, a route for ultrafast synthesis of nano Silicalite-1 zeolites in 10 min with much less water consumption has been developed. Comprehensive characterizations, i.e., X-ray powder diffraction, N2 sorption, scanning electron microscope, and NMR, confirm the high quality of such obtained Silicalite-1 zeolites. In the catalytic deoxygenation of O2-containing ethylene (mixture of O2 and ethylene), these reported Silicalite-1 zeolite samples show the comparable performance with the conventional Silicalite-1 zeolites synthesized under hydrothermal conditions. This research therefore provides a new trial toward the ultrafast synthesis of zeolite materials in an environment-friendly route.
研究领域:
材料科学
·
催化化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2017
·
IF 2.323
Huanxin Li,Junwei Zhang,Yonghui Dou,Li Xu,Guoji Liu
Data of liquid–liquid equilibria (LLE) for water + 1,6-hexanediamine + 1-butanol and water + 1,6-hexanediamine + 1-pentanol ternary systems were determined at T = 298.2, 308.2, and 318.2 K under atmospheric pressure. The distribution coefficients and selectivity factors calculated from LLE data were applied to evaluate the feasibility and effectiveness of extracting 1,6-hexanediamine from the aqueous solution. The results showed that the selectivity factors decrease with the amount of 1,6-hexanediamine increasing in the aqueous phase, and the effect of temperature is insignificant in this study. The nonrandom two-liquid and universal quasichemical activity coefficient models were also applied to regress the experimental equilibrium data of the two ternary systems and the root mean square deviation values between the correlated and experimental results were lower than 0.7%. It turned out that these phase equilibrium behaviors can be described by the two models. Meanwhile, the binary model parameters were acquired from the relevant process simulations.
研究领域:
化学工程
·
物理化学
✓ 已验证
DOI
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2022
·
IF 4.198
Yueyue Zhu,Rupeng Dai,Chaoqun Huang,Wang Zhou,Xiaoyuan Zhang,Kundi Yang,Hongmei Wen,Wei Li,Jian Liu
In this study, we report a novel and efficient synthetic method to construct isoquinolone scaffold via the Rh(III)-catalyzed (4 + 2) annulation of benzamide with an unreported coupling reagent methyl 2-chloroacrylate. Accordingly, other valuable 1,2-benzothiazine and naphtho[1′,2′:4,5]imidazo[1,2-a]pyridine derivatives are also obtained through a similar synthetic protocol. Thus, our developed method is highlighted by high yield and reaction versatility.
研究领域:
有机化学
·
药物化学
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DOI
高影响因子
FREE RADICAL BIOLOGY AND MEDICINE
·
2024
·
IF 7.1
Yiming Zhou,Mengting Zhang,Siyu Lu,Li Liu,Zhigui Duan,Fang Wei,Guolin Li
Purpose While reactive oxygen species (ROS) have been identified as key redox signaling agents contributing to aging process, which and how specific oxidants trigger healthy longevity remain unclear. This paper aimed to explore the precise role and signaling mechanism of superoxide (O 2 •− ) in health and longevity. Methods A tool for precise regulation of O 2 •− levels in vivo was developed based on the inhibition of superoxide dismutase 1 (SOD1) by tetrathiomolybdate (TM) in Caenorhabditis elegans ( C. elegans ). Then, we examined the effects of TM on lifespan, reproduction, lipofuscin accumulation, mobility, and stress resistance. Finally, the signaling mechanism for longevity induced by TM-O 2 •− was screened by transcriptome analysis and tested in sod-1 and argk-1 RNAi strains, sod-2 , sod-3 , and daf-16 mutants. Results TM promoted longevity in C. elegans with a concomitant extension of healthy lifespan as indicated by increasing fertility and mobility and reducing lipofuscin accumulation, as well as enhanced resistance to different abiotic stresses. Mechanically, TM could precisely regulate O 2 •− levels in nematodes via modulating SOD1 activity. An O 2 •− scavenger Mn(III)TBAP abolished TM-induced lifespan extension, while an O 2 •− generator paraquat at low concentration mimicked the life prolongation effects. The longevity in TM-treated worms was abolished by sod-1 RNAi but was not affected in sod-2 or sod-3 mutants. Further transcriptome analysis revealed arginine kinase ARGK-1 and its downstream insulin/insulin-like growth factor 1 signaling (IIS) as potential effectors for TM-O 2 •‾ -induced longevity, and argk-1 RNAi or daf-16 mutant nullified the longevity. Conclusions These findings indicate that it is feasible to precisely control specific oxidant in vivo and O 2 •− orchestrates TM-induced health and longevity in C. elegans via ARGK-1-IIS axis.
研究领域:
衰老
·
分子生物学
·
遗传学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）