ORGANOMETALLICS
·
2022
·
IF 3.837
Tongshun An,Chenwei Liu,Yanzhao Yin,Xiao-Feng Wu,Zhiping Yin
A general palladium and silver co-catalyzed denitrogenative carbonylation of benzotriazoles for the synthesis of benzoxazin-4-ones has been developed. Employing benzotriazoles as easily accessible substrates and Cr(CO)6 as bench-stable solid carbonyl sources, various benzoxazin-4-ones were synthesized through a ring-opening/denitrogenative/carbonylation cascade processes in moderate to good yields. Notably, this protocol avoids the use of toxic CO gas and special equipment and can also be applied to the late-stage functionalization of substrates derived from the uricosuric agent probenecid.
研究领域:
有机化学
·
药物化学
✓ 已验证
DOI
高影响因子
APPLIED BIOCHEMISTRY AND MICROBIOLOGY
·
2023
·Vol. 59
·期 6
·946-958
·
IF 0.8
Zhong T.,Li J.,Zhang S.,Pan H.
Abstract Interleukin-6 (IL-6) is essential for regulating the immune system and initiating acute inflammatory responses. While normal levels of IL-6 are very low in healthy individuals, current detection methods rely primarily on sophisticated instrumentation in central laboratories. Here, we developed a novel fluorescent immunochromatographic test strip method based on CdSe@ZnS quantum dots for point-of-care testing of IL-6. The test strip takes only 20 min to test the sample. Four analysis methods were developed: a self-developed smartphone application, smartphone photographs analyzed with ImageJ, a self-constructed portable immunoanalyzer, and a commercial immunoanalyzer. The performance of these four methods was evaluated and compared. The commercial immunoanalyzer achieved the best limit of detection (LOD) at 2.65 pg/mL, followed by the portable immunoanalyzer (5.74 pg/mL) and ImageJ (8.25 pg/mL). These LODs were sensitive enough to quantify IL-6 in healthy human serum around the clinically relevant cut-off of 10 pg/mL. Despite a higher LOD of 50 pg/mL, customized smartphone application enabled rapid IL-6 quantification and screening, which is useful in resource-scarce areas and well suited for measuring IL-6 levels. The developed method provides a simple, rapid, and portable tool for diagnosing and monitoring IL-6-related diseases.
研究领域:
医学诊断
·
生物化学
·
纳米技术
✓ 已验证
DOI
高影响因子
SOLID STATE SCIENCES
·
2019
·
IF 2.155
Yunfei Li,Fei Liang,Huimin Song,Wang Liu,Zheshuai Lin,Guochun Zhang,Yicheng Wu
A new pyrophosphate crystal, CsLiMgP 2 O 7 , was successfully synthesized using the high-temperature solution method. It crystallizes in the orthorhombic system with space group Pnma (No. 62). CsLiMgP 2 O 7 features a [LiMgP 4 O 18 ] 6-membered ring fundamental building block composed of four PO 4 and two Li/MgO 4 tetrahedrons, which connected with each other to form an interesting 6-membered ring chain. The DSC analysis proves that CsLiMgP 2 O 7 melts congruently. The spectral analyses were performed on the title compound, and the relationship between the electronic structures and optical properties has also been investigated by theoretical calculations.
研究领域:
材料科学
·
晶体化学
·
光学材料
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2014
·
IF 2.129
Zhengjuan Sun,Yali Liu,Yuanfang Li
A novel and rapid spectrofluorometry method for the recognition of 6-mercaptopurine (6-MP) has been developed based on luminescent metal–organic frameworks Fe-MIL-88NH 2 as fluorescent probe. The strong fluorescence of Fe-MIL-88NH 2 at 430 nm could be quenched by 6-MP directly, and the Fe-MIL-88NH 2 shows high selectivity for 6-MP compared to other thiol-containing amino acids such as homocysteine (Hcy), cysteine (Cys), glutathione (GSH), etc. Under optimal conditions, the relative fluorescence intensity was linearly proportional to the concentration of 6-MP in the range of 5–600 μM with the detection limit at 1.17 μM (S/N = 3). Furthermore, the present approach has been successfully applied to the determination of 6-MP in human serum samples. The possible fluorescence quenching mechanism has also been investigated, where it is revealed that the quenching was attributed to competition of absorption of the light source energy as well as electron transfer between Fe-MIL-88NH 2 and 6-MP.
研究领域:
分析化学
·
药物分析
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ChemistrySelect
·
2023
·Vol. 8
·期 26
·e202204971
·
IF 2.1
Taiwen Zhang,Jun Guo,Yiju Zhang,Dan Zhang,Lin Lu,Shuangyan Qiu,Jiangqin Zhong
Graphical The two modified rare heterogeneous Keggin-type crystalline heteropolyacid Calix[6]arene-like catalysts were synthesized by one-pot method with PMo 12 or PW 12 , and these were characterized using single-crystal X-ray diffraction, Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TG), X-ray diffraction (XRD), and elemental analysis, finally, the catalytic performance and reaction kinetics for the two compounds’ effects were compared during the oxidation process. Two modified Calix[6]arene-like polyoxometalates of the Keggin type with similar structures were synthesized under hydrothermal conditions by H 3 PMo 12 O 40 . H 3 PW 12 O 40 , 4H-1,2,4-triazol-3-amine (3-atrz) and copper ions were used as precursors, respectively, bridging organic ligand and transition metals. The result of single-crystal X-ray diffraction and elemental analysis showed that the structural formulas of the two crystalline compounds were: [2(C 6 H 12 N 12 Cu 3 PW 12 O 40 )] (3-atrz-Cu-PW 12 ), and [2(C 6 H 12 N 12 Cu 3 PMo 12 O 40 )] ⋅ 0.5H 2 O (3-atrz-Cu-PMo 12 ). They were composed of two classic Keggin-type polyoxometalate anions and six [Cu(C 2 H 4 N 4 )] + coordination polymers similar to Calix[6]arene. The catalytic studies represented that the two heterogeneous catalysts catalyzed the oxidation of iodide ions in hydrogen peroxide. The catalytic reaction of 3-atrz-Cu-PW 12 only took 30 min and 15 s to complete the reaction. The rate of iodine generation was 6.86×10 −7 mol L −1 s −1 . The 3-atrz-Cu-PMo 12 catalytic reaction needed only 1 min and 51 s, in which the rate of iodine generation was 1.126×10 −5 mol L −1 s −1 . The catalytic reaction rate of 3-atrz-Cu-PMo 12 was 16.35 times higher than 3-atrz-Cu-PW 12 . Both catalysts were reused nine times, and the conversion rate was still 99.96 %, showing excellent catalytic activity and repeatability.
研究领域:
无机化学
·
催化材料科学
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2025
·Vol. 17
·期 4
·475
·
IF 4.9
Ke Liu,Bohan Liang,Shujuan Zhang,Ruyi Li,Junming Dai,Wangyang Lu
In this study, a novel macromolecular flame retardant (MFR) with a phosphine oxide structure is successfully synthesized to improve the flame retardancy of polyamide 6 (PA6). Following this, the flame-retardant polyamide 6 (FR–PA6) is prepared via melt blending the MFR with PA6. Results indicate that the introduction of MFR has little effect on the melting and crystallization temperature of FR–PA6. While it slightly reduces the thermal stability of PA6, MFR significantly enhances its flame retardancy. The limiting oxygen index of FR–PA6 increases from 21.8% to 28.2%, and it successfully passes the UL-94 V-0 rating when it contains 0.5 wt% of phosphorus. Compared with pure PA6, the av-EHC of FR–PA6 is reduced by 32.2% and the SEA is increased by 66.7%. The MFR showed a flame-retardant mechanism in both the gas phase and the condensed phase. In the gas phase, the decomposition of MFR releases phosphorus-containing free radicals to interrupt the combustion chain reaction and reduces the concentration of the combustible caprolactam. In the condensed phase, the MFR promotes faster formation of melt droplets during combustion, taking heat away from the burning PA6 timely.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER COMPOSITES
·
2024
·
IF 4.8
Guang-Zhao Li,Shuai Zhang,Hao Yu,Gen Liu,Wenyan Wang,Gang Chen,Jie Wang,Weicai Wan,Qian Lu,Honglin Chen,Rui Han
Inspired by the strong adhesion of mussels, basalt fibers (BFs) were modified with polydopamine and then composited with nylon 6. The effect of polydopamine content on the interfacial interactions and mechanical properties of the composites was investigated. In addition, silica nanoparticles were grown on the surface of polydopamine-modified BFs to investigate the synergistic effect. The study revealed that the mechanical properties of the composites based on polydopamine-modified BF were gradually enhanced with the increase of the dopamine coverage concentration, and gradually decreased after reaching the peak. 0.5 g/L concentration of dopamine solution modified BFs showed the best enhancement effect on nylon 6, and its tensile strength could reach 133.1 MPa, which was 28.5% higher than that of the unmodified composites. The tensile strength of the composites modified with both dopamine and silica nanoparticles reached 157 MPa, which was 51.7% higher than that of the unmodified composites. In addition, scanning electron microscope images of fracture sections confirmed the strong interfacial interaction between BF and PA6. Highlights The surface roughness of BF was increased by nano-SiO 2 . Hydrogen bonding was formed between PDA and PA6. Physical interlock was formed between nano-SiO 2 and PA6. Tensile strength increased by 51.7% with both nano-SiO 2 and PDA. Stronger interfacial interaction leads to higher thermal stability.
研究领域:
材料科学
·
复合材料
·
界面化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MICROENCAPSULATION
·
2019
·
IF 2.04
Ran Li,Rui Bao,Qiu-Xuan Yang,Qi-Long Wang,Michael Adu-Frimpong,Qiu-Yu Wei,Toreniyazov Elmurat,Hao Ji,Jiang-Nan Yu,Xi-Ming Xu
Aims: The aim was to improve the absorption and bioavailability of [6]-shogaol with β-cyclodextrin (β-CD) prior to in vitro and in vivo evaluation.Methods: [6]-Shogaol/β-CDs inclusion complexes (6-S-β-CDs) were developed using saturated aqueous solution method and characterised with appropriate techniques. The absorption and bioavailability potential of [6]-shogaol was evaluated via in vivo pharmacokinetics and in situ intestinal perfusion.Results: The results of characterisation showed that 6-S-β-CDs (drug loading, 7.15%) were successfully formulated. In vitro release study indicated significantly improved [6]-shogaol release. Pharmacokinetic parameters such as Cmax, AUC0–36 h, and oral relative bioavailability (about 685.36%) were substantially enhanced. The in situ intestinal perfusion study revealed that [6]-shogaol was markedly absorbed via passive diffusion in the intestinal segments, and duodenum followed by ileum and jejunum.Conclusions: Cyclodextrin inclusion technology could enhance the intestinal absorption and oral bioavailability of hydrophobic drugs like [6]-shogaol.
研究领域:
药剂学
·
药物代谢动力学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2019
·Vol. 137
·期 24
·48804
·
IF 2.188
Yan Feng,Runjun Sun,Chengkun Liu,Meiyu Chen,Qiushi Wang
The electrospun polyamide 6 (PA6) membranes are treated with different methods. The rough surfaces with different protuberances size and the fiber diameter are prepared by wet, dry heat, wet heat, and ethanol treatments under relaxation, and the formation mechanisms are analyzed. A relative stable structure of PA6 membrane is also prepared by ethanol treatment under tension, and its structure is as same as the untreated membrane. The dynamic water contact angles (WCAs) of the treated membranes are measured. The starting WCA of the membrane with wet heat treatment under relaxation is 90.95°, which is larger than those of wet, dry heat, and ethanol treatments under relaxation. The effects of surface morphologies with different treatments on wettability are analyzed. For obtaining hydrophobicity, the membrane with wet heat treatment under relaxation was coated by polyvinylidene fluoride (PVDF). The WCA of the membrane increases to 127.1° after coating. From another point of view, the WCA of the PVDF/treated PA6 membrane is much larger than that of the pure casting PVDF membrane, which means the rough surface of the treated PA6 membrane can improve the hydrophobicity of the PVDF membrane. Furthermore, the membrane is endowed with superhydrophobicity (WCA of 153.5°) after being coated by SiO 2 /PVDF due to the multilevel structured surface roughness. It is a relative low cost and convenient operation method to prepare the superhydrophobic material. The results provide a novel preparation method of the superhydrophobic material and a treatment method of the electrospun PA6 membrane to obtain a stable structure. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137 , 48804.
研究领域:
材料科学
·
表面工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2016
·
IF 2.196
Tao Li,Renlun Deng,Gang Wu,Pengfei Gu,Yonghong Hu,Wenge Yang,Yemin Yu,Yuhao Zhang,Chen Yang
Data on corresponding solid–liquid equilibrium of 6-benzyladenine in different solvents are essential for a preliminary study of industrial applications. In this paper, the solid–liquid equilibrium of 6-benzyladenine in methanol, ethanol, 1-butanol, acetone, acetonitrile, ethyl acetate, dimethyl formamide and tetrahydrofuran pure solvents and (dimethyl formamide + actone) mixture solvents was explored within the temperature range from (278.15 to 333.15) K under 0.1 MPa. For the temperature range investigated, the solubility of 6-benzyladenine in the solvents increased with increasing temperature. The solubility of 6-benzyladenine in dimethyl formamide is superior to other selected pure solvents. The modified Apelblat model, the Buchowski-Ksiazaczak λh model, and the ideal model were adopted to describe and predict the change tendency of solubility. Computational results showed that the modified Apelblat model has more advantages than the other two models. The solubility results were fitted using a modified Apelblat equation, a variant of the combined nearly ideal binary solvent/Redich-Kister (CNIBS/R-K) model, Jouyban-Acree model and Ma model in (dimethyl formamide + acetone) binary solvent mixture. Computational results showed that the modified Apelblat model is superior to the other equations.
研究领域:
化学工程
·
药物化学
✓ 已验证
DOI
高影响因子
TRIBOLOGY INTERNATIONAL
·
2020
·
IF 4.271
Lei Sun,Ming Cao,Fan Xiao,Jiaopeng Xu,Yingbo Chen
Frictional and wear properties of polyamide 6 (PA6) are very important for its use as anengineering plastic. In this study, octaamino-polyhedral oligomeric silsesquioxane (POSS) functionalized graphene oxide (GO) was used to fabricate a PA6/reduced GO-POSS (rGO-POSS) nanocomposites. Compared with PA6, the PA6/rGO-POSS nanocomposites with 0.3 wt% GO-POSS has a decrease of friction coefficient by 86.36% from 0.44 to 0.06. The depth and width of the wear scar were reduced by 79.64% and 70.69%, respectively. Meanwhile, the wear rate reached the lowest and dropped by about 65.72%. The research found that GO-POSS is self-fixed in the matrix and effectively increases the interface bonding strength .
研究领域:
材料科学
·
工程学
✓ 已验证
DOI
高影响因子
INFLAMMOPHARMACOLOGY
·
2018
·Vol. 27
·期 5
·969-974
·
IF 3.304
Zhao Mingyi,Zhou Peng,Yu Jun,James Asenso,Xiao Feng,Wang Chun,Wei Wei
Paeoniflorin-6′-O-benzene sulfonate (code: CP-25) is a novel ester derivative of paeoniflorin (Pae). Compared to Pae, CP-25 has higher lipid solubility, bioavailability and better bioactivity. However, the tissue distribution and excretion of CP-25 still remain unknown. The LC–MS method was applied to investigate the tissue distribution and excretion of CP-25 in rats. As such, 50 mg/kg of CP-25 and Pae were administered to rats in multiple doses via an oral route. CP-25 and Pae were distributed widely and rapidly in all the tested tissues. Compared with Pae, the concentrations of CP-25 were almost increased evidently in most tissues. The highest CP-25 level was found in the liver (1476.33 ± 535.20 ng/g, male; 1970.38 ± 177.21 ng/g, female) at 3 h, and a high concentration of CP-25 was detected in male and female intestine, synovium, muscle, lung, and brain. Following a single oral dose of 50 mg/kg of CP-25 in rats, the total excretion of CP-25 was merely 21.8% (18.40, 3.19 and 0.22% for feces, bile and urine, respectively) in males; and was approximately 21.3% (14.04, 7.16 and 0.14% for feces, bile and urine, respectively) in females. The results indicated that the CP-25 concentration was higher in major tissues than Pae; CP-25 was primarily excreted through the feces; and there were gender-related differences in the tissue distribution and excretion.
研究领域:
药理学
·
中药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）