EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 5.9
Gongmeiyue Su,Yangkun Liu,Wenxin Chou,Yilei Xiao,Zhao Li,Rongji Dai,Yulin Deng,Hongyou Zhao
The development of wound dressings with high antibacterial efficacy is critical for the treatment of bacterial infections. Antimicrobial photodynamic therapy (aPDT) is a promising approach, and aggregation-induced emission photosensitizers (AIE-PSs) have garnered significant attention for their enhanced performance in the aggregated state, where the restriction of intramolecular motion serves as the underlying mechanism. However, conventional aggregation often leads to loosely packed PSs, leaving space for intramolecular motion. Crystallization provides a powerful strategy for forming tightly packed molecular aggregates. In this study, an AIE-PS (MeTS 2 IC) was designed by attaching a propeller-like moiety to rigid planar groups. The former enables intramolecular motion and maintains a twisted conformation, while the latter facilitates crystallization. A bactericidal function alone is insufficient for optimal wound healing; thus, a hydrogel matrix was introduced for biocompatibility. The AIE-PS can easily form microcrystals (MCs) when its concentrated solution is added to the pre-gel solution. Subsequent photo-crosslinking in situ forms the light-activated antibacterial AIE-PS-MCs@hydrogel dressing on the wound. Under white light irradiation, the dressing effectively eliminates bacteria, reduces inflammation, promotes vascular network recovery, and accelerates wound healing. The combination of AIE-PS MCs with hydrogel offers a simple, effective strategy for managing infected wounds, with promising potential for future clinical applications.
研究领域:
生物医学工程
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材料科学
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光动力疗法
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伤口愈合
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抗菌剂
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高分子化学
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产品关联
DOI
PubMed
高影响因子
Science China-Chemistry
·
2024
·
IF 10.4
Zhu Yilin,Zhang Liping,Zhang Rongyuan,He Chenghan,Yang Han,Liu Yong,Kwok Ryan T. K.,Lam Jacky W. Y.,Sun Jianwei,Feng Jing,Zhao Zheng,Yao Cuiping,Tang Ben Zhong
Photodynamic therapy (PDT) is a promising cancer treatment that uses photosensitizers (PSs) to generate cytotoxic reactive oxygen species (ROS) under light, but improving its efficacy is crucial for clinical applications. To address this, we propose a smart nanoplatform (P@BAO-DOX) for synergistic chemo-photodynamic therapy, featuring efficient PDT, controllable drug release, and fluorescence imaging guidance. We designed an aggregation-induced emission (AIE)-based PS (BAO) with effective ROS generation and NIR-II fluorescence. Additionally, BAO as a PS and doxorubicin (DOX) as a chemo drug were encapsulated in pH-responsive nanogels (PNA) to obtain P@BAO-DOX nanogels. Upon uptake by tumor cells, the nanogel releases drugs in acidic conditions, leading to cell death. White light irradiation further triggers BAO to produce substantial ROS, enhancing phototoxicity and synergistic chemo-PDT cancer therapy. Thus, P@BAO-DOX nanogels, as a smart nanoplatform, offer precise drug release and efficient ROS generation for imaging-guided chemo-PDT synergistic therapy, showing promise in advancing cancer treatment.
研究领域:
肿瘤学
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纳米医学
·
生物材料
✓ 已验证
DOI
高影响因子
MOLECULES
·
2016
·Vol. 22
·期 1
·54
·
IF 2.465
Shan Jiang,Tian Ya Huang,Ke Min Wang,Ben Zhong Tang,Qiang Yu
An accurate method of the fluorescence probe approach based on an aggregation-induced emission (AIE) molecule (tetraphenylethylene) for measuring the solubility parameter of the polymer is reported. This method is distinctive in that the approach can make the polymer chain conformation in solution be related to the fluorescence intensity. Since the solubility parameter of the polymer is also closely linked to its chain conformation in solution, the solubility parameter can be determined by the fluorescence intensity. The range of the solubility parameter of polymethyl methacrylate (PMMA) tested by this method was from 9.00 cal1/2cm−3/2to 10.00 cal1/2cm−3/2. The results are more accurate than those obtained from the traditional turbidimetric titration method, ranging from 8.60 cal1/2cm−3/2to 12.15 cal1/2cm−3/2. According to the photoluminescence (PL) intensities spectra, the solubility parameters of PMMA and polyvinyl acetate (PVAc) are 9.19 cal1/2cm−3/2and 9.85 cal1/2cm−3/2, respectively.
研究领域:
高分子科学
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材料化学
·
荧光光谱学
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DOI
高影响因子
RSC Advances
·
2013
·Vol. 3
·期 21
·7996-8002
·
IF 2.562
Qingkai Qi,Yifei Liu,Xiaofeng Fang,Yumo Zhang,Peng Chen,Yi Wang,Bing Yang,Bin Xu,Wenjing Tian,Sean Xiao-An Zhang
Two methoxy-substituted tetraphenylethylene (TPE) derivatives, tetra(4-methoxyphenyl)ethylene (TMOE) and tetra(3,4-dimethoxyphenyl)ethylene (TDMOE), were synthesized by McMurry reaction in high yields. The nearly centrosymmetric and natural propeller shape of TMOE and TDMOE excluded intermolecular effects, such as H or J-aggregation and π–π stacking, on their AIE (AIEE) and mechanofluorochromic performance. The crystal structures of TMOE and TDMOE, and theoretical calculations proved that their emission colours are determined by single molecular conjugation. These molecules were used to investigate pure conformational effects on molecular emissions. The spectral properties of these molecules in five environments of crystal(s), THF solution, THF–water binary solution, solidified THF and amorphous states, were investigated. The crystalline to amorphous phase transition by grinding resulted in good mechanofluorochromic performances with high quantum yields and distinguishable emission change, which was further explored as anti-counterfeiting inks on banknotes.
研究领域:
有机化学
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材料科学
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2018
·
IF 5.667
Yongxiang Hong,Peisheng Zhang,Hong Wang,Maolin Yu,Yong Gao,Jian Chen
Current lysosomal H 2 S-responsive fluorescent probes usually possess notorious aggregation caused quenching (ACQ) phenomenon and suffer from the inevitable background fluorescence signals. To circumvent this problem, we here combined H 2 S recognizing aggregation-induced emission (AIE) group with photochromic spiropyran moiety to rational design novel photoswitchable AIE nanoprobe (DNBS-DCM-SP) for lysosomal H 2 S detection with high spatiotemporal resolution. In the presence of H 2 S, the electron-withdrawing DNBS moiety will deviate from DNBS-DCM-SP via a H 2 S-induced O S bond cleavage, induced a sensitive turn-on fluorescence response at about 592 nm. The prepared nanoprobe displays good sensitivity (∼5.0 nM), and high specificity (especial against other thiols). In additon, the fluorescence of the H 2 S-activated AIE nanoprobe (DCM-SP) can be reversibly switched by selective fluorescence resonance energy transfer (FRET) from the AIE fluorophore (DCM) to ring-opened state of spiropyran via alternating UV/visible light irradiation. Moreover, the feasibility of the prepared photoswitchable AIE nanoprobe is also demonstrated by mapping the production of endogenous H 2 S in living cells as well as reversible dual-color fluorescence imaging.
研究领域:
生物化学
·
医学影像
·
分子生物学
✓ 已验证
DOI
高影响因子
BIOMATERIALS
·
2026
·
IF 13.6
Wen-Jin Wang,Ying-Xin Hao,Yu-Meng Wang,Zhuo-Yang Xin,Man Zhang,Hao-Tian Xin,Jing Feng,Kang Li,Zheng Zhao,Ben Zhong Tang,Kang-Nan Wang
Mitochondrial damage in tumor cells has recently emerged as a mechanism of immunogenic cell death, with precise triggers acting as potent antitumor immunostimulants. Here, we developed PyTPAMa, an asymmetric AIE-active photosensitizer that selectively accumulates in mitochondria and binds mitochondrial DNA (mtDNA) and induces mitochondrial fragmentation to trigger strong immunostimulation. Upon light activation, PyTPAMa generates a spatially confined, hybrid Type I/II ROS burst that disrupts the mitochondrial network, causing mitochondrial fragmentation, opening the mitochondrial permeability transition pore, and releasing mtDNA into the cytosol. This activates the NLRP3-GSDMD inflammasome, initiating pyroptosis and orchestrating systemic antitumor immunity. RNA sequencing reveals widespread silencing of mitochondrial genes and reprogramming of the NLRP3 inflammasome and antigen-presentation pathways. As a programmable immune ignition switch, PyTPAMa induces immunogenic cell death in vitro, transforms distant “cold” tumors into immune-infiltrated lesions in vivo, and achieves 96% suppression of bilateral 4T1 tumors without systemic toxicity. This work establishes mitochondrial fragmentation as a programmable immune switch and validates PyTPAMa for fragmentation-driven cancer immunotherapy.
✓ 已验证
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2016
·
IF 3.42
Zi Long,Meiying Liu,Ke Wang,Fengjie Deng,Dazhuang Xu,Liangji Liu,Yiqun Wan,Xiaoyong Zhang,Yen Wei
In this work, we reported a rather facile method for fabrication of ultrabright, well dispersible and biocompatible fluorescent organic nanoparticles (FONs) with aggregation-induced emission (AIE) properties through combination of esterification and ring-opening reaction. The hydroxyl groups of Pluronic F127 was first reacted with the chloride of trimellitic anhydride chloride (TMAC), and its anhydride groups were further reacted with the amino groups of amino-terminated AIE dye (PhNH 2 ) through ring-opening reaction. The optical properties , biocompatibility as well as cell uptake behavior of these obtained AIE-active nanoparticles (F127-TMAC-PhNH 2 FONs) were examined by a series of characterization techniques and assays. We demonstrated that uniform organic nanoparticles with high water dispersibility, strong luminescence and desirable biocompatibility can be facilely obtained, which are promising for biological imaging applications. More importantly, a number of carboxyl groups were introduced into these AIE-active nanoparticles, which can be further utilized for further conjugation reaction and carrying anticancer drugs such as cisplatin. Therefore, the strategy of described in this work should be a simple and useful route for fabrication of multifunctional AIE-active luminescent nanotheranostic systems.
研究领域:
材料科学
·
生物学
·
医学
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产品关联
DOI
PubMed
高影响因子
Materials Chemistry Frontiers
·
2018
·Vol. 2
·期 8
·1554-1562
·
IF 0
Ya-Long Wang,Cheng Fan,Bo Xin,Jian-Ping Zhang,Ting Luo,Ze-Qiang Chen,Qi-Yuan Zhou,Qi Yu,Xiang-Ning Li,Zhen-Li Huang,Chong Li,Ming-Qiang Zhu,Ben Zhong Tang
Fluorescence microscopy is an intuitive detection method of β-amyloid (Aβ) fibrillation, which usually occurs in early-stage Alzheimer's disease. With the aid of single-molecular localization of reversibly-activated fluorogens, the limit of optical diffraction in fluorescence microscopy can be overcome and the imaging resolution can be promoted to the sub-100 nm boundary. Aggregation-induced emission (AIE) is the fluorogenic emission behavior in which fluorescence is significantly enhanced due to the restriction of intramolecular motion when the fluorogens aggregate together or bind with specific targets. Reversible binding events of AIE-active fluorogens cause fluorescence switching enabling single-molecular localization and super-resolution imaging. Here, we report a series of super-resolution fluorescent probes with AIE activity, which are used for the detection and super-resolution imaging of fibrillar amyloids. The AIE-active fluorogens show superior in vitro sensitivity to fibrillar amyloids of hen egg white lysozyme (HEWL), which is usually used as a model protein for amyloid studies, with the limit of detection down to 63.71 nM. The fluorescence colocalization imaging indicates the excellent ex vivo targeting capability of Aβ plaques in mouse brain slices, with the colocalization degrees more than 90%. Based on the reversible binding between AIE-fluorogens and Aβ fibrils, the AIE-based super-resolution imaging of in vitro Aβ fibrillation in tubes and ex vivo Aβ plaques in mouse brain slices is accomplished. The detailed structure information reveals that Aβ plaques in the mouse brain are composed of numerous radiant nanofibrils with an optical imaging resolution of about 30 nm.
研究领域:
生物化学
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神经科学
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医学影像学
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产品关联
DOI
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Chunjing Guo,Yanguo Su,Ziting Cheng,Qiang Chen,Huimin Guo,Ming Kong,Daquan Chen
Chemodynamic therapy (CDT) has been widely used in the treatment of many kinds of tumors, which can effectively induce tumor cell apoptosis by using produced reactive oxygen species (ROS). In this paper, ROS-sensitive multifunctional marine biomaterial natural polysaccharide nanoparticles were designed. Aggregation-induced emission (AIE) molecules tetraphenylethylene (TPE) labeled and caffeic acid (CA) modified fucoidan (FUC) amphiphilic carrier material (CA-FUC-TK-TPE, CFTT) was fabricated, in which the thioketal bond(TK) was used as the linkage arm between TPE and fucoidan chain, giving the CFTT material ROS sensitivity. In addition, amphiphilic carrier material (FUC-TK-VE, FTVE) composed of thioketal-linked vitamin E and fucoidan was synthesized. The mixed carrier material CFTT and FTVE self-assembled in water to form nanoparticles (CFTT – FTVE@PTX-Fe 3+ ) loaded with PTX and Fe 3+ . The CDT effect was combined with the chemotherapeutic drug PTX to achieve tumor inhibition. In vitro cell studies have proved that CT/PTX nanoparticles have excellent cell permeability and tumor cytotoxicity. In vivo antitumor experiments confirmed effective antitumor activity and reduced side effects.
研究领域:
肿瘤学
·
生物材料科学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanophotonics
·
2020
·Vol. 9
·期 7
·2063-2075
·
IF 7.491
Mengdi Zhang,Zengliang Wang,Pengzhou Huang,Guanwei Jiang,Changpeng Xu,Wentao Zhang,Rui Guo,Wenqiang Li,Xintao Zhang
Visually monitoring of the residual morphology and quantitatively determining the degradation degree of hydrogels applied in tissue repair therapy in a real-time and noninvasive manner were a crucial technological mean. Despite conventional organic fluorescent molecules commonly used as probe to capture the real-time clues of the labeled hydrogels, they still encounter obstacles, including intrinsic photobleaching, cytotoxicity, and unknown interference factor of degradation caused by the change from polymer structure of hydrogels, thus making it difficult to accurately obtain the information of the hydrogels in vivo . To address the hard nut, we designed the multifunctional hydrogel system with a real-time quantitative aggregation-induced emission fluorescent detection and photoacoustic imaging tracking based on tetraphenylethene (TPE) that possesses the trait of aggregation-induced emission and low photobleaching, bound on the surface of mesoporous dopamine microspheres (MPDAs), and subsequently loaded into the photo-crosslinked injectable hydrogels. In vitro results showed that MPDA-TPE had good compatibility, emitted strong fluorescence when embedded in hydrogels, and maintained stable fluorescence property unless the hydrogels were degraded. Meanwhile, a mathematical formula for the kinetic degradation of hydrogels was established between gravitational and visual degradation in vitro , which can be used to predict in vivo degradation. Furthermore, MPDA possessed the clear photoacoustic imaging effect to provide more accurate clues. The designed hydrogel system holds a potential role in prediction of the in vivo degradation of implanted materials in an accurate, convenient, and real-time noninvasive manner and is a meaningful treatment aid in tissue engineering.
研究领域:
生物材料学
·
医学影像
·
组织工程
✓ 已验证
产品关联
DOI
高影响因子
DYES AND PIGMENTS
·
2023
·
IF 4.5
Jian Cao,Meijuan Zhang,Yanan Li,Chuanxiao Wang,Linlin Wang,Yiyi Qiao
Heparin is a common blood anticoagulant, and is widely used in biomedical fields . Herein, we design a readily effective fluorescent probe for the detection and quantitation of Heparin. A nonemissive quinoline-malononitrile derivative QM-CO is affected to emit by Heparin, showing a near-infrared aggregation-induced emission (AIE), which produces the AIE effect more 4.62-fold fluorescence emission intensity than free QM-CO. The AIE probe enjoys a good linear relationship with the Heparin concentration is in the range of 0–1.75 μg/mL (R 2 = 0.9937), a low detection limit (down to 0.139 μg/mL), and a superior selectivity to correlative substances. Utilizing the AIE feature of QM-CO and the electrostatic adsorption from Heparin to QM-CO, the AIE-based near infrared fluorescent probe QM-CO achieved a long wavelength (665 nm) emission and good selectivity for Heparin. Scanning electron microscopy (SEM) suggests that the loose aggregate QM-CO ensembles are disassembled and respectively condensed to form many tightly packed QM-CO/Heparin ensembles, offering mechanistic insight into the microenvironment of QM-CO/Heparin ensembles with the aid of the zeta potential .
研究领域:
生物医学
·
分析化学
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产品关联
DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2022
·
IF 6.064
Ju Jian,Zhang Xinyu,Li Lin,Regmi Sagar,Yang Guoqiang,Tang Shixing
Understanding the dynamic changes in antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for evaluating the effectiveness of the vaccine and the stage for the recovery of the COVID-19 disease. A rapid and accurate method for the detection of SARS-CoV-2-specific antibodies is still urgently needed. Here, we developed a novel fluorescent lateral flow immunoassay (LFA) platform for the detection of SARS-CoV-2-specific IgM and IgG by the aggregation-induced emission carbon dots conjugated with the SARS-CoV-2 spike protein (SSP). The aggregation-induced emission carbon dots (AIE-CDs) are one of the best prospect fluorescent probe materials for exhibiting high emission efficiency in both aggregate and solid states. The AIE-CDs were synthesized and displayed dual fluorescence emission, which provides a new perspective for the design of a high sensitivity testing system. In this work, the novel LFA platform adopted the AIE carbon dots, which are used to detect SARS-CoV-2-specific IgM and IgG conveniently. Furthermore, this sensor had a low LOD of 100 pg/ml. Therefore, this newly developed strategy has potential applications in the areas of public health for the advancement of clinical research.
研究领域:
医学诊断
·
生物化学
·
纳米技术
·
公共卫生
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）