ACS Chemical Neuroscience
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2020
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IF 4.486
Yaojun Ju,Harapriya Chakravarty,Kin Yip Tam
Alzheimer’s disease (AD) is a complex neurodegenerative disorder affecting millions of people worldwide. The underlying pathologic mechanisms of AD are unclear. Over the decades, the development of single target agent did not lead to any successful treatment for AD. A multitarget agent that could tackle more than one AD phenotype may be helpful as a treatment strategy. Cholinesterases (ChEs) including acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), are currently the drug targets with approved treatments. Moreover, amyloid beta (Aβ) deposition is a hallmark of AD that receives considerable attention. Herein, 9Q, a previously reported dual target inhibitor dealing with cholinergic dysfunction and amyloid deposition for AD treatment, has undergone thorough investigations. In vitro studies revealed that 9Q exhibited over 80% inhibition of ChE activity at 100 μM and more than 30% inhibition of Aβ aggregation at 1 mM concentration. Moreover 9Q was able to penetrate the blood–brain barrier (BBB) and enhance the cerebral acetylcholine level in triple transgenic AD (3xTg-AD) mice. Following one month treatment with 9Q, the amyloid burden and the cognitive deficits in 3xTg-AD mice were significantly ameliorated. It was observed that 9Q treatment mitigated synapse dysfunction, decreased amyloidogenic APP processing, and reduced the tau pathology in 3xTg-AD mice. Taken together, our results suggested that dual inhibition of cholinesterases and Aβ aggregation could be a promising approach in AD treatment.
研究领域:
神经科学
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药理学
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神经退行性疾病
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DOI
PubMed
高影响因子
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
·
2020
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IF 3.292
Zuntao Wu,Lin Bai,Runqi Tu,Lijie Zhang,Yue Ba,Huizhen Zhang,Xing Li,Xuemin Cheng,Wenjie Li,Hui Huang
Lead (Pb) is recognized as a potent inducer of synaptic toxicity generally associated with reduced synaptic transmission and increased neuronal fiber excitability, becoming an environmental risk for neurodegenerative processes. Despite numerous toxicological studies on Pb have been directed to the developing brain, attention concerning long-term consequences of pubertal chronic Pb exposure on neuronal activity is still lacking. Thus, we exposed 4-week-old male mice to 0.2 % lead acetate solution for one month, then, conducted behavioral tests or extracted brain homogenate from mice prefrontal cortex (PFC) and hippocampus at the age of 4, 13 and 16-month-old respectively. Our results showed that treated mice exhibited an evident increase in latency to reach platform following pubertal Pb exposure and aging. The increase of 8-OHdG revealed evident neural DNA oxidative damage across time upon pubertal Pb exposure. In the hippocampus of lead exposed mice at three age nodes, the expression of brain-derived neurotrophic factor precursor (proBDNF) increased, while that of mature BDNF (mBDNF), cAMP-response element binding protein (CREB) and phosphorylated CREB (pCREB) decreased compared with the control group. Furthermore, the expression of BACE1 protein and tau phosphorylation level in PFC and hippocampus increased, APP mRNAs in PFC and prolonged induction of BACE1 in hippocampus. Our results show that chronic Pb exposure from pubertal stage onward can either initiate divergent synaptic-related gene expression patterns in adulthood or trigger time-course of neurodegenerative profile within the PFC or hippocampus, which can contribute consistent deficits of cognition across subsequent age-nodes.
研究领域:
神经毒理学
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神经科学
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分子生物学
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行为科学
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DOI
PubMed
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 10
·2306
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IF 4.2
Danyang Zhang,Xiaoshi He,Ting Wang,Yan Xing,Zhilong Xiu,Yongming Bao,Yuesheng Dong
Methylglyoxal-induced ROS elevation is the primary cause of neuronal damage. Metformin is a traditional hypoglycemic drug that has been reported to be beneficial to the nervous system. In this study, flavonoids were found to enhance the protective effect of metformin when added at a molar concentration of 0.5%. The structure–activity relationship (SAR) analysis indicated that ortho- substitution in the B ring, and the absence of double bonds between the 2 and 3 position combined with the gallate substitution with R configuration at the 3 position in the C ring played crucial roles in the synergistic effects, which could be beneficial for designing a combination of the compounds. Additionally, the mechanism study revealed that a typical flavonoid, EGCG, enhanced ROS scavenging and anti-apoptotic ability via the BCL2/Bax/Cyto C/Caspase-3 pathway, and synergistically inhibited the expression of GSK-3β, BACE-1, and APP in PC-12 cells when used in combination with metformin. The dose of metformin used in the combination was only 1/4 of the conventional dose when used alone. These results suggested that ROS-mediated apoptosis and the pathways related to amyloid plaques (Aβ) formation can be the targets for the synergistic neuroprotective effects of flavonoids and metformin.
研究领域:
药理学
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神经科学
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细胞生物学
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分子生物学
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DOI
PubMed
高影响因子
ACS Chemical Neuroscience
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2021
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IF 4.418
Zhenquan Xuan,Xinmei Gu,Sicheng Yan,Yanfei Xie,Yiying Zhou,Hui Zhang,Haibo Jin,Shengquan Hu,Marvin S. H. Mak,Dongsheng Zhou,Karl Wah Keung Tsim,Paul R. Carlier,Yifan Han,Wei Cui
Alzheimer’s disease (AD) is a neurodegenerative disorder with multiple pathological features. Therefore, a multitarget-directed ligands (MTDLs) strategy has been developed to treat AD. We have previously designed and synthesized dimeric tacrine(10)-hupyridone (A10E), a novel tacrine derivative with acetylcholinesterase (AChE) inhibition and brain-derived neurotrophic factor (BDNF) activation activity, by linking tacrine and a fragment of huperzine A. However, it was largely unknown whether A10E could act on other AD targets and produce cognitive-enhancing ability in AD animal models. In this study, A10E could prevent cognitive impairments in APP/PS1 transgenic mice and β-amyloid (Aβ) oligomers-treated mice, with higher potency than tacrine and huperzine A. Moreover, A10E could effectively inhibit Aβ production and deposition, alleviate neuroinflammation, enhance BDNF expression, and elevate cholinergic neurotransmission in vivo. At nanomolar concentrations, A10E could inhibit Aβ oligomers-induced neurotoxicity via the activation of tyrosine kinase receptor B (TrkB)/Akt pathway in SH-SY5Y cells. Furthermore, Aβ oligomerization and fibrillization could be directly disrupted by A10E. Importantly, A10E at high concentrations did not produce obvious hepatotoxicity. Our results indicated that A10E could produce anti-AD neuroprotective effects via the inhibition of Aβ aggregation, the activation of the BDNF/TrkB pathway, the alleviation of neuroinflammation, and the decrease of AChE activity. As MTDLs could produce additional benefits, such as overcoming the deficits of drug combination and enhancing the compliance of AD patients, our results also suggested that A10E might be developed as a promising MTDL lead for the treatment of AD.
研究领域:
神经科学
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药理学
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分子生物学
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神经退行性疾病
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DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Yubo Liu,Zhenghao Li,Shiwen Xie,Dezhi Lu,Daoyuan Liu,Huiping Xu,Peifeng Wu,Boyu Si,Chaoyi Zhang,Xiangde Lin,Hui Yang
Green hydrogels hold promise for biomedical applications but are limited by weak mechanical properties. Here, we report a chitosan (CS)–reinforced polyvinyl alcohol hydrogel (PVA) fabricated via eco-friendly freeze–thaw cycles, achieving dual enhancement in mechanical strength and antibacterial efficacy. Incorporating 3 wt% chitosan increased compressive strength from 0.36 MPa in pure PVA to 2.92 MPa at 80% strain, while maintaining over 80% recovery after cyclic compression. The porous structure of the fabricated hydrogel and hydrogen-bonded network enabled sustained ciprofloxacin (CIP) release over 72 h. Antibacterial performance against Escherichia coli and Staphylococcus aureus improved significantly with CS addition, reaching 99% efficiency at 3% CS content, while CIP integration achieved complete bacterial eradication (100% efficiency). Synergistic action between the contact-based bactericidal activity of CS and CIP sustained release eliminated colony formation, demonstrating superior inhibition of both Gram-negative and Gram-positive bacteria. This green strategy delivers a mechanically robust, multifunctional hydrogel for infection-resistant biomedical applications.
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DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
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IF 2.8
Ruobing Xu,Qingming Xu,Wenfei Li,Yuming Liu,Yunhui Li,Jianwei Zhu,Jianhua Tang
This paper addresses the issue of high post-baking temperature (230°C) in the photolithography process of liquid crystal displays under ultraviolet irradiation by designing and preparing a low-temperature curing cationic photosensitive resin. First, a monomer containing carbon – carbon double bonds and bis-epoxy groups, (Z)-1,4-bis(oxiran - 2-ylmethoxy)but-2-ene (EPBT), was synthesized via the Williamson ether synthesis method. Subsequently, poly(methacrylic acid/methylmethacrylate/ N- phenylmaleimide/(Z)-1,4-bis(oxiran - 2-ylmethoxy)but-2-ene/oxetane methacrylate) photosensitive resin (PMMENL) was prepared by radical polymerization of various monomers. The structure of the EPBT monomer and the polymer was characterized, along with their properties. Finally, the prepared resin was uniformly mixed with photoinitiators, solvents, and other components, and micro-patterns on the mask were obtained through the photolithography process. The resolution and morphology of the patterns were examined. The results indicate that the thermal stability of the resin improved after the incorporation of N- phenylmaleimide, with a thermal decomposition temperature of approximately 225°C when the weight loss reached about 10%. Compared to the conventional post-baking temperature of 230°C required for LCD photoresists, the post-baking temperature of PMMENL resin with EPBT monomer was significantly reduced to 150°C, while maintaining an adhesion strength of 8 MPa, equivalent to that of commercially available polyacrylic photosensitive resins baked at 230°C.
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2025
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IF 2.8
Zhipeng Luo,Peng Cai,Wenhui Chen,Jiaxing Chen,Silong Cai,Haochen Huang,Zixin Liu,Hefeng Zhang,Yifu Huang
Applying a nonchemical approach of polymer crystallizing for altering micro-conformations of a nonconjugated linear polymer can promisingly achieve enhanced photoluminescence without sacrificing mechanical properties of the matrix. Herein, to pursue an excellent nucleating agent for tuning the crystallization micro-conformation, a new type of two-dimensional polymer nanosheet (2DP) with benzimidazole-linked structure, with high specific surface area and unique shape morphology, was synthesized for frozen/thawed (F/T) polyvinyl alcohol (PVA)-based ionogel, which could provide an efficient way to significantly enhance the fluorescence of PVA by inducing crystalline conformation without changing chain topology. Notably, incorporating a mere ~0.05 wt.% of 2DP elevated the quantum yield of the PVA ionogel from 9.2% to an impressive 85.7%. Besides, at a higher 2DP doping of ~0.7 wt.%, a distinct afterglow effect originating from 2DP was also observed. It was revealed for the first time that the F/T cycle during the preparation of the PVA ionogel could effectively increase the photoluminescent intensity, mainly ascribed to PVA but not 2DP. The fluorescence enhancement within the ionogel could be predicted by quantum chemistry calculations and a deep learning model. This new ionogel shows great potential as smart luminescent polymer for flexible lampshade.
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2025
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IF 2.8
Zhaoqi Liu,Yaqi Ge,Baochang Dai,Quanwang Feng,Longyu Wang,Xiaoyong Hao,Huiguang Bian,Chuansheng Wang
In order to reduce the reliance of rubber composites on carbon black (CB) and enhance their cost-effectiveness and environmental sustainability, this paper proposes a green, deep eutectic solvent (DES) for surface modification of ground calcium carbonate (GCC). It replaces part of the carbon black with the DES in a natural rubber matrix. The effects of this modification on the vulcanization, mechanical, dynamic and microstructural properties of rubber are systematically investigated. The DES employed consisted of choline chloride and glycerol in a 1:2 M ratio, with the aim of improving the interfacial bonding between GCC and the rubber matrix through the hydrogen bonding network. The results demonstrated that DES-modified GCC could effectively enhance the dispersion of filler, strengthen the crosslink density of rubber, and improve the mechanical properties. In the present study, the replacement of CB with 15 and 20 parts of GCC was investigated, with a particular focus on the tensile strength of the rubber composites prepared with DES-modified GCC in a 1:10 ratio. The results demonstrated a significant enhancement in tensile strength, with an increase of 16.0%, as well as a notable increase in the (TS*EB), reaching 22.6%. Additionally, a substantial reduction in rolling resistance of tyres was observed, amounting to 52.7%. These findings offer a novel approach for the development of environmentally friendly and cost-effective rubber fillers.
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Wang Zhiqin,Li Wei,Xiao Ningyu,Wang Chenxing
Conductive hydrogels show great potential for flexible sensors, yet their applications are limited by low strength, poor freeze resistance, and easy dehydration. To address these issues, this paper developed a multifunctional PVA (polyvinyl alcohol)/CMC (carboxymethyl cellulose sodium)/PANI (polyaniline)/PA (phytic acid)/BA (boric acid)/Fe 3+ hydrogel (denoted as PMNF) with a double-network structure formed via the Hofmeister effect and in situ polymerization. The hydrogel exhibits excellent mechanical properties (tensile strength: 236 kPa; elongation: 541%), high conductivity (2 S/m), and improved antifreezing behavior. At −12°C, it retains a conductivity of 0.86 S/m and over 300% elongation. It also demonstrates strong water retention after 15 days and stability in acidic/alkaline salt environments. Based on these properties, PMNF-based sensors reliably detect both subtle and large human motions under various conditions. This work offers a practical strategy for developing robust wearable electronics suited for real-world use.
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Shiqi Hong,Yongqiang Lan,Yanhong Zhang,Bingbing Fu,Ping Peng
Inspired by natural biomineralization, high-performance pervaporative desulfurization membranes were engineered through a one-step synthesis strategy. Cysteamine served as both an inducer and catalyst, steering the deposition of silica (SiO 2 ) onto graphene oxide (GO) nanosheets that were pre-dispersed in a polydimethylsiloxane (PDMS) matrix. The Fourier transform infrared spectroscopy and x-ray diffraction results demonstrated that in situ-formed SiO 2 was attached firmly onto the GO sheets. The scanning electron microscopy results showed that the GO/SiO 2 fillers were uniformly dispersed in the PDMS matrix. The incorporation of GO/SiO 2 within the lipophilic PDMS matrix markedly enhanced the desulfurization performance of the resultant biomineralized membranes. The fabricated membranes were evaluated for the separation of thiophene from an n -octane/thiophene mixture by pervaporation. It was demonstrated that the membrane displayed high selectivity towards thiophene. The sulfur enrichment factor reached a maximum of 6.30 for the biomineralized membrane containing 0.3 wt% GO, accompanied by a permeation flux of 6973 g m −2 h −1 in a 1312 ppm thiophene/ n -octane mixture at 303 K. The desulfurization performance of the biomineralized membranes maintained practically constant over 168 consecutive hours, displaying long-term stability. This facile one-step strategy offers a readily scalable route to fabricate high-performance pervaporative membranes for deep gasoline desulfurization.
研究领域:
材料科学
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化学工程
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膜技术
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环境修复
·
石油炼制
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Jingya Dai,Yusong Xu,Tao Zhang,Xianming Zhang
Waterborne polyurethane (WPU) is a promising surface finishing agent for polyethylene terephthalate (PET) ropes used in marine operations, industrial lifting, outdoor activities, and agricultural settings. However, WPU exhibits poor flame retardancy, and developing a WPU coating that enhances the flame retardancy of PET ropes while maintaining good mechanical properties remains a challenge. Herein, we report PET ropes coated with flame-retardant waterborne polyurethane (FRWPU) synthesized from epoxidized soybean oil-based phosphorus-containing polyol and poly(propylene glycol). The breaking strength of FRWPU coated PET rope (PET–FRWPU) reaches 8092 N, which is more than twice that of pristine PET rope; the elongation at break reaches 82.30%, nearly twice that of pristine PET rope. The PET–FRWPU achieves a V-0 rating in the UL-94 test, and the time required for a vertical flame to burn through the horizontal rope is extended to 90 s, more than twice that of pristine PET rope. In the cone calorimetry test, the PET–FRWPU inhibits heat release and smoke release more effectively compared to the pristine PET rope. Moreover, the FRWPU coating can withstand 800 cycles of abrasion and bending tests. This study provides insights into the design and manufacture of flame-retardant coatings for PET ropes.
研究领域:
材料科学
·
高分子化学
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消防安全工程
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涂层技术
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纺织工程
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DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2025
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IF 2.8
Caixia Zhang,Shoubing Chen,Qian Dou,Yanhui Li,Qihua Wang,Tingmei Wang
This study pioneers the grafting of oleylamine onto halloysite nanotubes (HNTs) to synthesize a low-temperature composite modifying agent for rubber (HNTs-Y). It enables the synergistic regulation of the low-temperature performance of nitrile butadiene rubber (NBR) via a “plasticization-reinforcement” mechanism, addressing both the migration propensity of conventional small-molecule plasticizers and the insufficient low-temperature modification efficacy of pristine HNTs. This work thereby provides a novel multifunctional modification strategy for optimizing the low-temperature performance of elastomers. Experimental results demonstrate that HNTs-Y significantly enhances the low-temperature resistance of NBR. Specifically, at a loading of 6 phr, the hardness difference of 4 # NBR between −40°C and 40°C is reduced by 45.2% compared to 1 # NBR, indicating improved hardness stability over a broad temperature range. Additionally, the tensile strength of 4 # NBR at −20°C is 79% higher than that at 20°C and 77% higher than that of 1 # NBR, reflecting enhanced resistance to tensile fracture under low-temperature conditions. Furthermore, with the increase in HNTs-Y content, the brittle temperature ( T b ) and glass transition temperature ( T g ) of NBR exhibit an overall downward trend. For 4 # NBR, the T b reaches −52°C and the T g is −29.5°C, manifesting excellent low-temperature resistance.
研究领域:
材料科学
·
聚合物纳米复合材料
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橡胶技术
·
低温性能
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）