JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
·
IF 9.6
Li-Lei Zhang,Xing-Yu Liu,Yu-Lan Wang,Ying Li,Xiao-Ge Zhu,Rong-Hui Cao,Hui-Ju Zhang,Xi-Yan Dong,Jian-Hua Qin
The development of efficient and stable photocatalysts for solar-driven hydrogen production remains a significant challenge, primarily limited by inadequate light harvesting and rapid charge recombination. This work addresses these issues through the rational design of a host-guest system within a metal-organic framework (MOF). We report a novel two-dimensional anionic porphyrinic MOF ( 1 ) synthesized using 1-butyl-3-methylimidazolium (BMI) as a structure-directing agent, and replaced the inert BMI guests with photoactive 4,4-Difluoro-8-(1-methylpyridin-4-ium-4-yl)-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene (Bodipy)-based cations by cationic exchange strategy, yielding the composite Bodipy@1 . The Bodipy units act as complementary antennas, broadening the visible-light absorption range, while the favorable energy-level alignment between the porphyrinic host (donor) and the Bodipy guest (acceptor) establishes an efficient intramolecular charge-transfer pathway. Density functional theory calculations and spectroscopic studies confirm a spatial separation of frontier orbitals, with the highest occupied crystal orbital localized on the porphyrin linker and the lowest unoccupied crystal orbital on the Bodipy cation, which effectively suppresses charge-carrier recombination. Consequently, Bodipy@1 exhibits a remarkable enhancement in photocatalytic hydrogen evolution activity (∼2.5 mmol·g −1 ·h −1 ), outperforming the pristine MOF 1 . This work highlights a potent strategy of energy-level engineering via host-guest assembly, demonstrating that precise post-synthetic modification of anionic MOFs with functional cations is a powerful avenue for designing advanced, stable photocatalysts for solar fuel production. A 2D anionic porphyrinic MOF host undergoes post-synthetic cation exchange, replacing inert [BMI] + with photoactive Bodipy cations. The favorable energy-level alignment drives intramolecular electron transfer from the porphyrin linker (donor) to the Bodipy guest (acceptor), achieving spatial charge separation. This, combined with broadened light absorption, leads to significantly enhanced photocatalytic H₂ evolution. Download: Download high-res image (140KB) Download: Download full-size image
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2018
·Vol. 53
·期 13
·9368-9381
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IF 2.993
Liu Le,Li Tuanwei,Ruan Zheng,Yan Lifeng
Photodynamic therapy (PDT) combining with near infrared (NIR) imaging is attractive. However, the intrinsic hypoxia in tumor and consumption of oxygen during treatment will decrease PDT. Here an artificial red cell was prepared using polypeptides conjugated hemoglobin as an oxygen carrier. A NIR photosensitizer-brominated 4,4-difluoro-4-bora-3a,a-diaza-s-indacene (BODIPY-Br 2 ) possessing both high fluorescence emission and singlet oxygen generation efficiency was synthesized and also conjugated to polypeptides to achieve NIR imaging-guided PDT. In vitro studies performed on HepG2 cancer cells verified the oxygen carrier, cancer tracing and curing abilities of the as-prepared polymeric nanoparticles. Even under hypoxia condition, it also obviously increases the cell killing rate when exposed light at a low energy (25 mW/cm 2 , 10 min). Meanwhile, the fluorescence of BODIPY in NPs would light up cells for real-time imaging. These results show the potential of the biocompatible and biodegradable P-Hb-B NPs for enhancement of simultaneous tracing and treating of cancer.
研究领域:
生物医学工程
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癌症研究
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分子影像
·
诊疗一体化
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DOI
高影响因子
DYES AND PIGMENTS
·
2020
·
IF 4.613
Dan Lin,Jiamin Zhong,Shaomin Ji,Zhanxiang Yuan,Longjiang Xing,Qin He,Haoli Zhang,Yanping Huo
Movement of molecules are always affected by the surrounding solvent molecules , so solvents have an essential effect in triplet-triplet annihilation (TTA) upconversion. In this article, the TTA upconversion system with Diiodo-BODIPY ( MBDP-2I ) as sensitizer and perylene as acceptor in six solvents of differing viscosity were investigated (toluene, 1,4-dioxane and four high viscosity phthalate ester solvents DMP, DBP, DNOP and DOP). The upconversion efficiency was positively correlated with the solvent viscosity . Among the six solvents, the highest upconversion quantum efficiency of 9.59% was observed in high viscosity DOP (η = 72.4 mPa s), almost 1.5 times higher than that in 1,4-dioxane (η = 3.2 mPa s, Φ UC = 6.36%). The efficient upconversion was attributed to the long-lived triplet excited states of MBDP-2I , efficient fluorescence quantum yield of perylene and efficient TTA in high viscosity phthalate esters solvents. The mechanism underlying the highly efficient TTA upconversion in the high viscosity phthalate esters solvents was investigated by solvent cage effect. In addition, significant room temperature phosphorescence of MBDP-2I at 765 nm was observed in the viscous phthalate esters solvents.
研究领域:
化学
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材料科学
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光学
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
·
IF 8.2
Lin Yun,Jiao He,Jinlei Xu,Xinjian Cheng
Improving the water solubility of natural product cellulose and using it to treat heavy metal ions is very important. In this work, cellulose-based fluorescent probes containing BODIPY fluorophore were synthesized by simple chemical method, which realized the selective recognition and removal of Hg 2+ /Hg 2 2+ ions in an aqueous system. Firstly, fluorescent small molecule (BOK-NH 2 ) bearing -NH 2 group was synthesized through Knoevenagel condensation reaction between BO-NH 2 and cinnamaldehyde. Secondly, via the etherification of -OH on the cellulose, substituents bearing -C ≡ CH groups with different lengths at the end are grafted on the cellulose. Finally, cellulose-based probes (P1, P2, and P3) were prepared by amino-yne click reaction. The solubility of cellulose is improved greatly, especially the cellulose derivative with branched long chains has excellent solubility in water (P3). Benefiting from the improved solubility, P3 could be processed into solutions, films, hydrogels, and powders. Upon the addition of Hg 2+ /Hg 2 2+ ions, the fluorescence intensity enhanced, which are “turn-on” probes. At the same time, the probes could be utilized as efficient adsorbents for Hg 2+ /Hg 2 2+ ions. The removal efficiency of P3 for Hg 2+ /Hg 2 2+ is 79.7 %/82.1 %, and the adsorption capacity is 159.4 mg·g −1 /164.2 mg·g −1 . These cellulose-based probes are expected to be employed in the treatment of polluted environments.
研究领域:
环境化学
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材料科学
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分析化学
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
·
IF 8.2
Jiao He,Lin Yun,Xinjian Cheng
Chitosan as the plentiful and easily available natural polymer, its solubility in organic solvents is still a challenge. In this article, three different chitosan-based fluorescent co-polymers were prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization. They could not only dissolve in several organic solvents, but also could selectively recognize Hg 2+ /Hg + ions. Firstly, allyl boron-dipyrrolemethene (bodipy) was prepared, and used as one of the monomers in the subsequent RAFT polymerization. Secondly, chitosan-based chain transfer agent (CS-RAFT) was synthesized through classical reactions for dithioester preparation. Finally, three methacrylic ester monomers and bodipy bearing monomers were polymerized and grafted as branched-chains onto chitosan respectively. By RAFT polymerization, three chitosan-based macromolecular fluorescent probes were prepared. These probes could be readily dissolved in DMF, THF, DCM , and acetone. All of them exhibited the ‘turn-on’ fluorescence with selective and sensitive detection for Hg 2+ /Hg + . Among them, chitosan-g-polyhexyl methacrylate-bodipy (CS-g-PHMA-BDP) had the best performance, its fluorescence intensity could be increased to 2.7 folds. In addition, CS-g-PHMA-BDP could be processed into films and coatings. When loading on the filter paper, fluorescent test paper was prepared and it could realize the portable detection of Hg 2+ /Hg + ions. These organic-soluble chitosan-based fluorescent probes could enlarge the applications of chitosan.
研究领域:
材料科学
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分析化学
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生物医学工程
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PubMed
高影响因子
Biomaterials Science
·
2019
·Vol. 7
·期 12
·5211-5220
·
IF 5.251
Qiansai Qiu,Ya Wen,Haiqing Dong,Aijun Shen,Xingxing Zheng,Yongyong Li,Feng Feng
Timely and precise diagnosis of malignant tumors is of great value to patients’ treatment and prognosis. Although nanotechnology-based molecular imaging represents a major advancement in the field of tumor imaging diagnosis, it is restricted by the rapid blood clearance of nanoparticles and the diverse physiological barriers in vivo; hence, its further application is greatly hindered. Cell carriers, ascribed to their natural biological properties, are thus gaining increasing attention for addressing such issues. Here, taking full advantage of the inflammation-homing capability of neutrophils, we constructed a highly sensitive cell probe in which reduced bovine-serum albumin (BSA) nanoparticles, loaded with imaging agents (gadolinium (Gd) and BODIPY), were covalently fixed onto the cellular surface by 5-thio-2-nitrobenzoate (TNB)-mediated fast and efficient disulfide–thiol exchange. Impressively, the remodeling process exerted a negligible effect on the neutrophils’ biological profiles with regard to cell viability, morphology, and cell-surface protein markers. Compared with nanoparticle-based imaging agents in a lung-cancer xenograft model, the living neutrophil probe demonstrated faster targeting and stronger accumulation in the tumor site, as revealed by fluorescence and magnetic-resonance (MR) imaging. These results indicate the great potential of neutrophil-based living probe for precision tumor-diagnosis applications.
研究领域:
生物医学工程
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纳米技术
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癌症研究
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分子成像
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PubMed
高影响因子
Materials Chemistry Frontiers
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2020
·Vol. 5
·期 1
·406-417
·
IF 6.788
Mengqian Yang,Jingran Deng,Huifang Su,Shuangxi Gu,Jie Zhang,Aiguo Zhong,Fengshou Wu
Organic nanomaterials with efficient ROS generation and high photothermal conversion efficiency have emerged as a new generation therapeutic agent for PDT/PTT synergistic cancer treatment. However, most of the organic nanomaterials exhibited weak emission in water because of the aggregation-caused quenching (ACQ) effect, which seriously hampers their biological application in fluorescence bioimaging. In this study, we design and synthesize a new organic small molecule (T-BDP) with a donor–acceptor–donor (D–A–D) structure by the conjugation of boron-dipyrromethene (BODIPY) and triphenylamine (TPA). Moreover, a 1,8-naphthalenediimide (NI) structure with electron-withdrawing ability is introduced onto the core of BODIPY to further enhance the intramolecular charge transfer, leading to the redshift of absorption to the near-infrared region. T-BDP displays significant aggregation-induced emission (AIE) performance, probably due to the presence of two twisted TPA groups onto the BODIPY core. Accordingly, after self-assembly into nanoparticles, T-BDP NPs exhibit strong near-infrared emission in water. Under single 635 nm laser irradiation, T-BDP NPs could generate reactive oxygen species and heat simultaneously. The photothermal conversion efficiency of T-BDP NPs is determined to be 50.9%. The low dark toxicity and high photocytotoxicity of T-BDP NPs are verified against A549 cells using the MTT assay and the AM/PI staining method. Due to the strong emission of T-BDP NPs, their accumulation and subcellular localization in cancer cells are observed using a laser confocal fluorescence microscope. The results demonstrate that T-BDP NPs are mainly located in the lysosomes of cancer cells. Thus, the as-prepared small molecule-based AIE nanoparticles hold great potential for fluorescence imaging-guided PDT/PTT synergistic tumor therapy.
研究领域:
纳米技术
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癌症治疗
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生物医学工程
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材料科学
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光学
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DOI
高影响因子
Biomaterials Science
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2023
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IF 6.6
Min Li,Ziyi Cheng,Heng Liu,Kun Dou,Huan Xiao,Linlu Zhao,Fabiao Yu
Photodynamic therapy (PDT) has emerged as a promising modality for cancer treatment, but its efficacy is often limited by tumour hypoxia. Here, we report the development of a novel protein-based, self-assembled nanoplatform, CAT-I-BODIPY NPs (CIB NPs), to address this limitation. We first design and synthesize an I-BODIPY photosensitizer based on the heavy atom effect and modification of the electron-donating group, which exhibits excellent capabilities in generating reactive oxygen species and enabling near-infrared (NIR) fluorescence imaging. The incorporation of an oxygen-producing enzyme, catalase (CAT), within these nanoassemblies enables in situ oxygen generation to counteract hypoxic constraints. Controllable self-assembly by multiple supramolecular interactions into highly ordered architecture not only guarantees CAT's catalytic activity but also leads to excellent NIR fluorescence imaging ability and enhanced PDT efficacy. Notably, the visualization of optimal accumulation of CIB NPs within tumour sites 18 h post-injection offers precise PDT application guidance. Both in vitro and in vivo studies corroborate the remarkable anti-tumour efficacy of CIB NPs under NIR illumination, providing a significant advancement in PDT. The favourable biosafety profile of CIB NPs further emphasizes their potential for clinical application in hypoxic tumour therapy.
研究领域:
癌症治疗
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纳米技术
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生物医学工程
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分子生物学
·
成像
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PubMed
高影响因子
BIOORGANIC CHEMISTRY
·
2023
·
IF 5.1
Huanxian Wu,Lishun Zhang,Boyu Chen,Baofang Ou,Jiahuan Xu,Nannan Tian,Danni Yang,Yangcheng Ai,Qianqing Chen,Dongling Quan,Tingting Zhang,Lin Lv,Yuanxin Tian,Jiajie Zhang,Shaoyu Wu
Abnormal activation of Hedgehog (Hh) signaling pathway mediates the genesis and progression of various tumors [1] . Currently, three drugs targeting the Hh signaling component Smoothened (Smo) have been marketed for the clinical treatment of basal cell tumors or acute myeloid leukemia. However, drug resistance is a common problem in those drugs, so the study of Smo inhibitors that can overcome drug resistance has important guiding significance for clinical adjuvant drugs. MTT assay, clone formation assay and EdU assay were used to detect the proliferation inhibitory activity of the drugs on tumor cells. The effect of B13 on cell cycle and apoptosis were detected by flow cytometry. An acute toxicity test was used to detect the toxicity of B13 in vivo , and xenograft tumor model was used to detect the efficacy of B13 in vivo . The binding of B13 to Smo was studied by BODIPY-cyclopamine competitive binding assay and molecular docking. The effect of B13 on the expression and localization of downstream target gene Gli1/2 of Smo was investigated by Western Blot and immunofluorescence assay. Smo D473H mutant cell line was constructed to study the effect of B13 against drug resistance. (1) B13 had the strongest inhibitory activity against colorectal cancer cells. (2) B13 can effectively inhibit the clone formation and EdU positive rate of colon cancer cells. (3) B13 can block the cell cycle in the G2/M phase and cell apoptosis. (4) B13 has low toxicity in vivo , and its efficacy in vivo is better than that of the Vismodegib. (5) Molecular docking and BODIPY-cyclopamine experiments showed that B13 could bind to Smo protein. (6) B13 can inhibit the protein expression of Gli1, the downstream of Smo, and inhibit its entry into the nucleus. (7) B13 could inhibit the expression of Gli1 in the HEK293 cells with Smo D473H , and the molecular docking results showed that B13 could bind Smo D473H protein. B13 with the best anti-tumor activity was screened out by MTT assay. In vitro , pharmacodynamics experiments showed that B13 could effectively inhibit the proliferation and metastasis of colorectal cancer cells, induce cell cycle arrest, and induce cell apoptosis. In vivo pharmacodynamics experiments showed that B13 was superior to Vismodegib in antitumor activity and had low toxicity in vivo . Mechanism studies have shown that B13 can bind Smo protein, inhibit the expression of downstream Gli1 and its entry into the nucleus. Notably, B13 overcomes resistance caused by Smo D473H mutations.
研究领域:
肿瘤学
·
药理学
·
分子生物学
·
细胞生物学
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PubMed
高影响因子
Advanced Healthcare Materials
·
2025
·
IF 9.6
Guoqing Cui,Ziyao Lu,Jiangnan Shi,Xinyu He,Yuwei Wang,Hui Chen,Zixiang Jia,Junchang Chen,Jie Han,Hui He,Zhengqing Guo
Overcoming resistance to radiotherapy remains a significant challenge in breast cancer management. A one-step coordinated synthesis of BODIPY -integrated photodynamic nanozymes ( FZBNPs ) that facilitate an orthogonal catalytic cascade for radiotherapy potentiation is presented. The engineered FZBNPs simultaneously alleviate tumor hypoxia through catalase-mimetic oxygen (O 2 ) generation and amplify reactive oxygen species (ROS) production via peroxidase-like activity, synergizing with BODIPY -mediated singlet oxygen ( 1 O 2 ) generation under 660 nm light irradiation. Crucially, FZBNPs deplete intracellular glutathione (GSH) and trigger ferroptosis through lipid peroxidation (LPO) accumulation, directly countering radiotherapy resistance. In vivo validation revealed that the FZBNPs -driven multi-enzymatic cascades achieved near-complete tumor ablation in breast cancer models during radiotherapy. This work establishes a therapeutic paradigm that integrates oxygen modulation, ROS amplification, redox homeostasis disruption, and ferroptosis induction, offering a conceptual basis for the application of enzyme-mimetic nanoplatforms in precision radiation oncology.
研究领域:
纳米医学
·
放射肿瘤学
·
癌症治疗
·
酶模拟
·
光动力治疗
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活性氧生物学
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铁死亡研究
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PubMed
高影响因子
Bioactive Materials
·
2024
·
IF 18
Tian Zhang,Dongsheng Tang,Pengfei Wu,Shaoping Jiang,Yuquan Zhang,Abid Naeem,Yong Li,Chunhui Li,Bo Hu,Shuai Guo,Caixia Sun,Haihua Xiao,Ran Yan,Yuhua Weng,Yuanyu Huang
Immune checkpoint blockade (ICB) therapy is a widely favored anti-tumor treatment, but it shows limited response to non-immunogenic “cold” tumors and suffers from drug resistance. Photodynamic therapy (PDT), as a powerful localized treatment approach, can convert a “cold tumor” into a “hot tumor” by inducing immunogenic cell death (ICD) in tumor cells, thereby enhancing tumor immunogenicity and promoting tumor immunotherapy. However, the effectiveness of PDT is largely hindered by the limited penetration depth into tumor tissues. To address these issues, we proposed an all-in-one drug system with NIR-II photo-accelerated PDT effects, efficient immune checkpoint gene silencing, and a facile manufacturing process. The so-called all-in-one drug system comprises a multi-modal designed polymer PPNP and siRNA. PPNP is an amphipathic polymer that includes the near infrared-II (NIR-II) photosensitizer Aza-boron-dipyrromethene (Aza-BODIPY), a glutathione (GSH)-cleavable linker, and a cationic monomer derived from cholesterol. PPNP can self-assemble and efficiently load siRNA. Under laser irradiation, PPNP triggers a potent ICD cascade, causing the on-demand release of siPD-L1, reshaping the tumor's immunosuppressive microenvironment, effectively inhibiting the growth of various tumors, and stimulating the immune memory. This study represents a generalized platform for PDT and gene silencing, designed to modulate immune-related signaling pathways for improved anticancer therapy.
研究领域:
肿瘤学
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免疫治疗
·
药理学
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生物医学工程
·
纳米技术
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）