ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
·
2026
·
IF 3.5
Pingping Bai,Zhuhua Wu,Yan Qiao,Xinran Nie,Gege Niu,Yan Zhang,Xiaohan Yang,Li Wei,Yong Qi
Sitosterol-Beta alleviated hypoxia and SU5416-induced pulmonary hypertension in mice. • Sitosterol-Beta suppressed excessive proliferation and migration of pulmonary artery smooth muscle cells. • Sitosterol-Beta inhibited SPHK1 expression and S1P production in pulmonary artery smooth muscle cells. • Sitosterol-Beta blocked S1P-mediated inflammation in macrophages. Pulmonary hypertension (PH) is an irreversible and life-threatening disease, characterized by sustainedly elevated pulmonary arterial pressure. The excessive proliferation and migration of pulmonary artery smooth muscle cells (PASMCs) and perivascular inflammation are primary pathological features. Sitosterol-Beta is a phytosterol with extensive anti-inflammatory roles. This study aims to investigate the effects of Sitosterol-Beta on PH. In our study, the PH was induced in mouse by chronic hypoxia insult (10% O 2 ) and subcutaneous injection of vascular endothelial growth factor receptor inhibitor SU5416, and Sitosterol-Beta was delivered into mouse via orally taken. Mouse primary PASMCs were cultured with 1% O 2 to mimic hypoxic condition, and treated with Sitosterol-Beta. The results revealed that Sitosterol-Beta restrained PH-induced right ventricular systolic pressure increase, right ventricular hypertrophy, thickening and fibrosis of pulmonary artery, and perivascular inflammation. Sphingosine kinase 1 (SPHK1) was screened as the potential target of Sitosterol-Beta. Sitosterol-Beta inhibited SPHK1 expression and sphingosine-1-phosphate (S1P) production in lung. In vitro , Sitosterol-Beta suppressed hypoxia-induced excessive proliferation, migration and endothelial-to-mesenchymal transition of primary PASMCs, and blocked S1P-mediated inflammation in macrophages. The effects of Sitosterol-Beta on PASMCs were abrogated by overexpression of SPHK1. In conclusion, this study demonstrated that Sitosterol-Beta improved PH in mouse by targeting SPHK1, which may provide novel insights for prevention and therapy of PH. Download: Download high-res image (275KB) Download: Download full-size image
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PubMed
高影响因子
RSC Advances
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2019
·Vol. 9
·期 45
·26109-26115
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IF 3.049
Shuang Gao,Chao Bie,Qiuyu Ji,Haiyang Ling,Chunyan Li,Ying Fu,Lixia Zhao,Fei Ye
Due to its poor water solubility, the herbicide cyanazine is usually dissolved in organic reagents when used, which poses a great threat to the environment. Poor water solubility also causes limited herbicidal activity. In our study, the water solubility of cyanazine was increased by forming a cyanazine/hydroxypropyl beta-cyclodextrin (HPβCD) inclusion complex. The formation of the inclusion complex was confirmed by FT-IR, XRD, SEM and other characterization methods. Phase solubility study showed that HPβCD could improve the water solubility of cyanazine. Thermogravimetric analysis indicated that the thermal stability of cyanazine was improved by forming inclusion complex and the biological activity test showed that better herbicidal activity was obtained on the inclusion complex compared with the cyanazine. The results showed that the formation of inclusion complex could improve the application of cyanazine in agricultural production and reduce the risk to the environment.
研究领域:
农业化学
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环境科学
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材料科学
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PubMed
高影响因子
SPECTROSCOPY LETTERS
·
2020
·
IF 0.88
Yanbin Su,Xuwei Sun,Ruixue Wu,Xing Zhang,Yunzhou Tu
The purpose of this study was to explore the molecular spectroscopic behaviors of the beta-arbutin on the toxic aldehyde of trans-crotonaldehyde in anti-skin cancer. Results revealed that both hydroxymethyl and phenolic hydroxyl of beta-arbutin led to the shift of the maximum ultraviolet peak of trans-crotonaldehyde from a very significant absorption peak at 300 nm to a very weak absorption peak at 310 nm and the significant shift of the aldehyde Raman band at 1689/cm of the toxic trans-crotonaldehyde in mitochondria and aldehyde dehydrogenase, respectively. The beta-arbutin acting on the toxic trans-crotonaldehyde highlighted the potential of anti-skin cancer and provided a valuable clue for the new application of the beta-arbutin.
研究领域:
药学化学
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光谱学
·
癌症研究
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DOI
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 35
·21235-21247
·
IF 3.361
Guang Xiong,Feifei Meng,Jiaxu Liu,Liping Liu,Leping Zhao
An innovative hydrothermal method has been successfully applied to the synthesis of hierarchical ZSM-5/beta composite zeolites with different mass ratios. Firstly, the ZSM-5 zeolites were coated with amorphous silica and aluminum species by a spray drying process. Then, the precursor powder was hydrothermally crystallized for only 1–2 days with the addition of tetraethyl ammonium hydroxide (TEAOH). The obtained products were characterized by XRD, SEM, TEM, N2 physical adsorption–desorption, 27Al MAS NMR, ICP, pyridine-IR and NH3-TPD techniques. The characterization results imply that the ZSM-5/beta composite zeolites exhibit hierarchical-pores, higher external surface areas and larger mesopore volumes as compared to those of the pure ZSM-5 and beta zeolite. Moreover, the pore structure and acid sites of the ZSM-5/beta composite can be adjusted by changing the mass ratio of ZSM-5/beta. Finally, the ZSM-5/beta composite catalysts exhibit good catalytic performances in the cracking of 1,3,5-triisopropylbenzene (1,3,5-TIPB).
研究领域:
化学工程
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材料科学
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DOI
PubMed
高影响因子
FUEL
·
2020
·
IF 5.578
Huimin Chen,Fengjiao Yi,Caiping Ma,Xiang Gao,Suyao Liu,Zhichao Tao,Baoshan Wu,Hongwei Xiang,Yong Yang,Yong-wang Li
The bifunctional catalysts capable of regulating the metal dispersion and location through encapsulating palladium (Pd) nanoparticles inside Beta and mordenite (MOR) zeolites were used for n-heptane hydroisomerization. Several characterizations such as X-ray powder diffraction (XRD), scanning electron microscope (SEM), N 2 -adsorption and so on suggested that the difference in the phase, textural property, morphology, and acidity of zeolites between the catalysts with encapsulation structure and prepared by impregnation method was negligible whether Beta- or MOR-series catalysts. Nevertheless, the higher Pd dispersion, smaller Pd particle size, and higher aggregation resistance can be achieved on the encapsulation catalysts as determined by H 2 -pulse and transmission electron microscopy (TEM). Compared to the palladium-loading catalyst prepared by conventional impregnation method, the encapsulation structure guaranteed the higher selectivity and yield in n-heptane isomerization due to the significantly improved balance and intimacy. Furthermore, the catalyst with the complete encapsulation structure for the Beta-series catalysts and the catalyst with partial encapsulation structure for the MOR-series catalysts respectively exhibited the highest isomer selectivity and yield. All results may be resulted from that the zeolite topology and crystal size acted a significant role in determining the intimacy of the bifunctional catalysts with encapsulation structure, due to the different diffusion hurdles of the channels structure.
研究领域:
催化化学
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材料科学
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DOI
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2025
·
IF 3.5
Xiaomei Yang,Ziqing Huang,Zhihao Chen,Zhongcheng Guo,Shuang Wang,Chen Chen,Fayi Wang,Lipeng Zhou
Crystal size is one of the most important parameters of zeolite, which greatly affects its properties and performance. Here, the crystal size of Sn-Beta synthesized by hydrothermal route was tailored by adjusting the amount of crystal nuclei in the gel. Si-Beta that was treated with tetraethylammonium hydroxide (TEAOH) was used as the seed for synthesizing Sn-Beta. The seeds were studied by FT-IR, SEM, XRD and laser particle size analysis. It was found that the crystal size of the synthesized Sn-Beta depended on the concentration of TEAOH. Sn-Beta with minimum crystal size (about 500 nm) can be obtained using 0.5 mol L –1 TEAOH. Additionally, the crystal size distribution of Sn-Beta synthesized by the supernatant as seed was narrower than that synthesized by the solid residue as seed. The catalytic performance of Sn-Beta was tested in the conversion of ethyl levulinate to γ-valerolactone by Meerwein-Ponndorf-Verley reduction. Sn-Beta with small crystal size showed higher catalytic activity.
研究领域:
材料科学
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催化
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纳米技术
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化学合成
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DOI
高影响因子
AICHE JOURNAL
·
2024
·
IF 3.5
Dong Lin,Xiuhui Zheng,Ze Zong,Yang Xu,Qiuming He,Zhe Ma,De Chen,Chaohe Yang,Xiang Feng
Comprehensive mechanistic explorations and profound understandings of the interactions between water molecules and active intermediates harbors tremendous significance in the field of zeolite catalysis. Herein, we envision a strategy to accelerate alkene epoxidation reactions (e.g., 1-pentene, 1-hexene, cyclohexene, cyclooctene) with preformed H 2 O 2 inside confined channels of Ti-beta by water molecules. Combined with in situ UV–vis, kinetic experiments, and DFT calculations, it is found that keen control of water molecules could effectively enhance H 2 O 2 adsorption and stabilize crucial oxygen intermediates (Ti-OOH) by hydrogen bonding interactions. As a result, the yields of corresponding epoxides increased up to 20.5%. However, excessive water clusters construct a dense and robust hydrogen-bond network, blocking the activation of reactants and further epoxidation over Ti sites. This finding not only sheds new light on the mechanism of water-accelerated reaction, but also opens up new opportunities to enhance the efficiency of industrial epoxidation reactions involving H 2 O 2 .
研究领域:
催化化学
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材料科学
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理论化学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Tengteng Ji,Bing Fang,Ming Zhang,Le Cheng,Xinlei Yuan,Yutong Jin,Fang Wu,Chenyan Zheng,Yumeng Ma
Oat beta-glucan has been reported to be beneficial to glucose and lipid metabolism in human and animal studies. However, weight-loss was shown only in animal studies, whereas human studies reported an improvement in hyperlipidemia. This study investigated the effects of oat beta-glucan on obesity and related metabolic disturbances at the doses based on the Chinese recommended daily intake of 100 g of whole grains which contain approximately 10 % β-glucan. Our data showed that 200 mg/kg efficiently blocked the process of obesity as determined by significantly decreased body weight (7.57 g) and adipose tissue mass (5.24 g) after the 4-week intervention. Lower serum low-density lipoprotein cholesterol (0.32 mmol/L) and reduced atherosclerosis were also observed. Oat beta-glucan improved hepatic lipid metabolism at the low dose (100 mg/kg) and restored it to normal levels in lean mice at the high dose. To our knowledge, our study is the first to analyze the effects of oat beta-glucan on adipose stem cells and reveal the anti-obesity mechanism of oat β-glucan is modulating the adipose stem cell microenvironment. This study determined an efficient supplementary dose for blocking high-fat diet-induced obesity, which not only improved lipid metabolism but also altered stem cell composition in adipose tissue.
研究领域:
营养学
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代谢生物学
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细胞生物学
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PubMed
高影响因子
ELECTROPHORESIS
·
2014
·
IF 3.161
Xu Chen,Yong Luo,Bo Shi,Zhigang Gao,Yuguang Du,Xianming Liu,Weijie Zhao,Bingcheng Lin
β-Agonists are a group of illegal feed additives. In this paper, it was found that the light emission produced by the oxidation of luminol by potassium ferricyanide was enhanced by the β-agonists (ractopamine, salbutamol, and terbutaline). Based on chemiluminescence phenomenon, a novel, rapid, and sensitive microflow injection analysis system on a microfluidic glass chip was established for determination of the β-agonists. The chip was fabricated from two glass plates (64 mm × 32 mm) with microchannels of 200 μm width and 100 μm depth. The detection limits were achieved at 2.0 × 10 −8 mol/L of ractopamine, 1.0 × 10 −8 mol/L of terbutaline and 5.0 × 10 −7 mol/L of salbutamol. In this report, our method was applied for determination of the β-agonists in swine hair from three different sources with satisfactory results.
研究领域:
分析化学
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食品安全
·
微流控技术
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环境与农业监测
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DOI
高影响因子
Nanomaterials
·
2019
·Vol. 9
·期 10
·1429
·
IF 4.034
Yuehua Deng,Yani Li,Wenjie Nie,Xiang Gao,Shentan Liu,Xiaochun Tan,Mingming Chen,Dongzhuang Hou
As a nano-adsorbent, magnetic graphene oxide (GO/Fe3O4) was synthesized to potentially adsorb propranolol (PRO) from water. The synthetic material was characterized by SEM, TEM, VSM, FTIR, XRD, zeta potential, and XPS. The environmental factors, such as pH, humic acid concentration, PRO concentration, and contact time, were investigated regarding their effect on the adsorption process. The kinetics data fitted the pseudo first-order and second-order kinetics equations. The Langmuir equation, the Freundlich equation, and the Sips equation were used to analyze the adsorption isotherms. Electrostatic attraction, hydrogen bonding, and the π–π interaction all contributed to the adsorption process of PRO onto GO/Fe3O4. The discovery of this study emphasized the feasibility of GO/Fe3O4removal of PRO and expanded the scope of the application of GO.Keywords:magnetic graphene oxide;propranolol;Fe3O4;adsorption
研究领域:
环境科学
·
材料科学
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DOI
PubMed
高影响因子
Genes & Genomics
·
2022
·Vol. 44
·期 7
·867-878
·
IF 2.164
Li Mo,She Jiang,Ma Louyan,Ma Li,Ma Xiaorui,Zhai Jiajia
Background Destruction of pancreatic beta cells is the most typical characteristic of diabetes. Objective We aimed to evaluate the effect of berberine (BBR), a bioactive isoquinoline derivative alkaloid, on beta cell injury. Methods Rodent pancreatic beta cell line INS-1 was treated with 0.5 mM palmitate (PA) for 24 h to establish an in vitro beta cell injury model. Results BBR at 5 µM promoted cell viability, inhibited cell apoptosis and enhanced insulin secretion in PA-induced INS-1 cells. BBR treatment also suppressed PA-induced oxidative stress in INS-1 cells, as evidenced by the decreased ROS production and increased activities of antioxidant enzymes. In addition, suppressed ATP production and reduced mitochondrial membrane potential were restored by BBR in PA-treated INS-1 cells. It was further determined that BBR affected the expressions of mitophagy-associated proteins, suggesting that BBR promoted mitophagy in PA-exposed INS-1 cells. Meanwhile, we found that BBR facilitated nuclear expression and DNA-binding activity of Nrf2, an antioxidative protein that can regulate mitophagy. Finally, a rescue experiment was performed and the results demonstrated that the effect of BBR on cell viability, apoptosis and mitochondrial function in PA-induced INS-1 cells were cancelled by PINK1 knockdown. Conclusions BBR protects islet β cells from PA-induced injury, and this protective effect may be achieved by regulating mitophagy. The present study may provide a novel therapeutic strategy for β cell injury in diabetes mellitus.
研究领域:
药理学
·
细胞生物学
·
糖尿病
·
分子生物学
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DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2014
·
IF 4.331
Saou-Hsing Liou,Gordon C.C. Yang,Chih-Lung Wang,Yu-Han Chiu
This 5-month study contains two parts: (1) to monitor the concentrations of 11 phthalate esters metabolites (PAEMs) and two beta-agonists in human urine samples collected from a small group of consented participants including 16 females and five males; and (2) to analyze the residues of phthalate esters (PAEs) and beta-agonists in various categories of drinking water consumed by the same group of subjects. Each category of human urine and drinking water had 183 samples of its own. The analytical results showed that nine PAEMs were detected in human urine and eight PAEs were detected in drinking water samples. It was found that average concentrations of PAEMs increased as the age increased, but no significant difference between sexes. Further, using the principal component analysis, the loadings of age effect were found to be two times greater than that of gender effect in terms of four DEHP metabolites. Regarding beta-agonists of concern (i.e., ractopamine and salbutamol), they were neither detected in human urine nor drinking water samples in this study.
研究领域:
环境科学
·
毒理学
·
公共卫生
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）