查找使用阿拉丁产品的科研文献

A highly sensitive sandwich-type electrochemical sensor for detection glypican-3 based on H-rGO-CMC@Pt NPs and aptamers

Xiaohong Tan,Wenzhan Li,Wei He,Tingting Yu,Bingbing Wan,Yong Huang,Jintao Liang,Guiyin Li

Glypican-3 (GPC3), which is a surface heparan sulfate proteoglycan, has been widely known the ideal biomarker for diagnosis and treatment of hepatocellular carcinoma (HCC). Accurate and sensitive detection of serum GPC3 level is an important and challenging task. In this paper, a sandwich electrochemical aptasensor was designed to specifically detect serum GPC3 level through aptamer-target-aptamer recognition. A GPC3 aptamer (GPC3 Apt ) immobilized on the surface of gold nanoparticles@reduced graphene oxide modified screen-printed electrode (Au NPs@rGO/SPCE) was used as the capture probe. Hemin-reduced graphene oxide-carboxymethyl chitosan@platinum nanoparticles (H-rGO-CMC@Pt NPs), with good mimicking peroxidases activity, were labeled with amination GPC3 aptamer, which was employed as the signal probe. Once the target GPC3 was anchored on the surface of GPC3 Apt /Au NPs@rGO/SPCE, the H-rGO-CMC@Pt NPs-GPC3 Apt was further specifically bound to the GPC3, forming the aptamer-target-aptamer sandwich structure, which can catalyze the oxidation of hydroquinone (HQ) to benzoquinone (BQ) and lead the oxidation current of HQ recorded by DPV to changing. The linear relationship between the current signal of oxidation of HQ and GPC3 concentration range of 0.0001–3.0 µg/mL and 3.0–60.0 µg/mL, with a low detection limit (LOD) of 0.0685 ng/mL. Additionally, the electrochemical aptasensor was successfully applied for the detection of GPC3 in human serum samples with the recovery of 99.95–104.06 % and relative standard deviation (RSD) of 1.31–5.22 %. Thus, the sandwich aptasensor could provide a new strategy for detection of serum GPC3 level and improve the early diagnosis rate of HCC.

Cascade-Targeting of Charge-Reversal and Disulfide Bonds Shielding for Efficient DOX Delivery of Multistage Sensitive MSNs-COS-SS-CMC

Lan Cui,Wentao Liu,Hao Liu,Qian Qin,Shuangxia Wu,Suqin He,Zhenya Zhang,Xinchang Pang,Chengshen Zhu

Fabrication and evaluation of a novel polymeric hydrogel of carboxymethyl chitosan-g-polyacrylic acid (CMC-g-PAA) for oral insulin delivery

Jing Zhang,Xiaoyang Liang,Ying Zhang,Qing Shang

A novel pH-sensitive hydrogel consisting of carboxymethyl chitosan (CMC) and acrylic acid (AA) was fabricated via free radical grafting polymerization. The effective factors on the swelling ratio of the hydrogel were studied. The successful fabrication of the CMC-g-PAA hydrogel was confirmed by Fourier transform infrared spectroscopy (FTIR). The inner morphology of the final hydrogel was observed with scanning electron microscopy (SEM). Insulin (INS) was used as a model drug and encapsulated into the CMC-g-PAA hydrogel. The release profile of the INS loaded-CMC-g-PAA (INS-CMC-g-PAA) hydrogel was obtained in phosphate buffer solution (PBS) at pH 1.2 and 7.4. The hypoglycemic effect of orally administered INS-CMC-g-PAA hydrogel was also studied. SEM photographs showed that the CMC-g-PAA hydrogel had a 3D network structure. In vitro release tests showed that only 16.3 ± 2.6% of INS was released at pH 1.2, while over 93.2 ± 3.8% of INS was diffused into PBS (pH 7.4). This phenomenon illustrated that the INS-CMC-g-PAA hydrogel had a good pH response, and could direct INS to release in basic environments. The animal experiments demonstrated that the oral INS-CMC-g-PAA hydrogel had a persistent and effective hypoglycemic effect. Therefore, the CMC-g-PAA hydrogel has a potential application for the oral delivery of protein drugs.

Schiff Base functionalized CMC/PVA composites for efficient adsorption of Cu(II) and Zn(II): From molecular design to economic evaluation

Karim Youssef Nabat,Ali Raza Ayub,Ahmed E. Mansy,Tesfa Oluma Fufa,Niu Zhang,Xiyan Xu,Hansheng Li,Hui Li

Green CMC/PVA based Schiff base bio-composite material successfully Fabricated • CMC/PVA-LH35 composite achieved adsorption capacity of 532.15 mg/g for Cu(II) • CMC/PVA-LA35 composite achieved adsorption capacity of 516.49 mg/g for Zn(II) • High reusability after 6 cycles with low-cost adsorbents for desalination • DFT computational analysis to elucidate the structural and binding mechanism Metal contamination in water sources is a critical threat to human health and water ecosystems, which reduces the efficiency of water desalination. Therefore, the development of materials for metal removal is essential for water purification. In this study, two novel Schiff bases (LA35 and LH35) were immobilized in a carboxymethyl cellulose/polyvinyl alcohol (CMC/PVA) matrix via robust hydrogen bonding. The CMC/PVA-LA35 and CMC/PVA-LH35 composite adsorbents achieved a maximal adsorption of 474.38 mg/g and 532.15 mg/g for Cu(II) and 516.49 mg/g and 468.04 mg/g for Zn(II), respectively, at optimum conditions, pH 5, 318 K, and 300 mg/L. The data fit the Langmuir isotherm model, suggesting that adsorption occurred on a homogeneous mono-layer surface with uniform binding sites. Additionally, a thermodynamic analysis confirmed the reaction was both spontaneous and endothermic. After six cycles of adsorption/desorption, the CMC/PVA-LA35 and CMC/PVA-LH35 maintained outstanding reusability with efficiencies of 76.72% and 81.69% for Cu(II) and 71.33% and 67.32% for Zn(II), respectively. DFT calculations revealed effective metal-ligand interactions via charge transfer and reduced bandgap. These findings were consistent with the large experimental adsorption capacities and confirm the importance of chemisorption for Cu(II) and Zn(II) removal. These findings reveal that metal chelation strength and complexation control the adsorption process. The results of the cost-effectiveness analysis showed that the total cost of reusability was extremely low. This discovery unveils its potential use in water desalination, offering new bio-composites to decrease metal contamination and protect aquatic life. Download: Download high-res image (171KB) Download: Download full-size image

Multifunctional soft anti-swelling hydrogel-based sensor reinforced with carboxylated-MWCNTs and CMC for human motion detection and air–underwater communication

Ibrar Ahmad,Azaz Ali Khan,Zafran Ud Din,Daixin Ye,Luqman Ali Shah

Wearable hydrogel-based strain sensors that can operate reliably in both air and water are difficult to develop because conventional hydrogels tend to swell, weaken, and lose signal stability in aqueous environments. In this work, a structurally stable, anti-swelling, conductive hydrogel was designed by combining a hydrophobically associated polymer network with nanoscale conductive reinforcement. The material was synthesized from acrylamide (AAm) and stearyl methacrylate (SMA) in the presence of cetyltrimethylammonium bromide to generate reversible hydrophobic junctions. At the same time, carboxymethyl cellulose (CMC) and carboxylated multiwalled carbon nanotubes (COO-MWCNTs) were incorporated to strengthen the network and establish efficient electrical pathways. The hydrogel is soft due to its wide linear viscoelastic region (0.01–68% strain). This cooperative structural design produced a flexible and mechanically resilient hydrogel (0.57 MPa stress, 1254% strain, and toughness of 271.9 kJ m−3) with a conductivity of 82.6 S m−1, and a rapid response/recovery time (110/100 ms in air and 210/250 ms in water). The sensor displayed stable strain sensitivity, with gauge factors of about 17.52 in air and 9.54 in water, with a swelling ratio of only 20%, indicating good anti-swelling behavior and stable sensing performance under both dry and aqueous conditions. It successfully tracked a wide range of large and small human motions in both environments, demonstrating reliable performance under dynamic mechanical conditions. In addition, the device translated mechanical stimuli generated during writing, speech-related vibrations, and Morse-code tapping into distinct electrical signals, indicating its capability for multimodal communication sensing. These results demonstrate an effective materials design approach for producing environmentally stable hydrogel sensors suitable for wearable electronics, underwater monitoring, and interactive human–machine systems.

Impact mechanisms of humic acid on the behavior of CMC-stabilized nZVI in groundwater: Implications for long-term chlorinated contaminant remediation

Bo Chen,Shichao Cai,Liwei Yang,Dong Cheng,Yuhan Hang,Liyuan Liang,Bo Fan,Tianming Chen,Feng He

Stabilized nanoscale zero valent iron (nZVI) is commonly used as a reductant during groundwater remediation of halogenated hydrocarbons. However, humic acid (HA) in groundwater can affect the environmental behavior of nZVI during contaminant degradation. This study investigated the effects of HA on carboxymethyl cellulose-stabilized nZVI (CMC-nZVI) by studying hydrogen evolution, Fe 0 corrosion and carbon tetrachloride (CT) degradation kinetics. The results show that, during the early stage (≤ 24 h), low-concentration HA (HA/CMC-nZVI: 2–8) enhanced the hydrogen evolution reaction (HER) of CMC-nZVI up to 1.36 fold by forming Fe 2 + -HA complexes that prevented passivation. In contrast, high-concentration HA (mass ratio: 24) inhibited HER during the entire reaction period, as HA rapidly and directly consumed Fe 0 from the start of the reaction (final Fe 0 consumption by HA: 62.0 %). In this study we also developed a modified differential HER approach to quantitatively determine HA-induced Fe 0 consumption. This confirmed that quinone moieties in HA compete for electrons and are reduced to hydroquinones, thereby consuming Fe 0 . In CT degradation, HA accelerated the initial reaction (rate constant k CT increased from 0.010 min −1 to 0.038 min −1 ) but significantly reduced electron efficiency (from 6.4 % to 1.3 %) and material longevity at HA/CMC-nZVI ratio of 2–24. Due to HA-mediated depletion of CMC-nZVI, the residual Fe 0 had limited capacity for CT degradation after 24 h. The column experiments further confirmed this adverse effect of HA. However, the coexisting ions in actual groundwater were found to mitigate the Fe 0 consumption induced by HA. This study reveals HA's dual role in CT remediation: initially HA enhances ZVI reactivity, but subsequently HA reduces ZVI reactivity due to electron competition. This provides novel insights for the optimization of ZVI dosing in groundwater remediation.

Hydrogen-bonding network tailoring via EG-based DES/CMC-Na synergy enables longevous and dendrite-free flexible aqueous zinc-ion batteries

Geliang Dai,Yixin Zhou,Zeqi Liu,Jialin Liu,Kaixiang Tan,Lijian Xu,Yi Chen,Jingjing Du,Aokui Sun

To overcome critical challenges in flexible aqueous zinc-ion batteries (AZIBs)—specifically zinc dendrite proliferation, recurrent side reactions, and electrolyte mechanical-electrochemical incompatibility—we engineered a hydrogel electrolyte (PZEC). Synthesized in one step, PZEC integrates polyacrylamide (PAM)/ZnSO₄ with synergistic enhancements from ethylene glycol (EG)-based deep eutectic solvent (DES) and sodium carboxymethyl cellulose (CMC Na). A synergistic multi-component modification strategy reconstructing the hydrogen bond network yielded concurrent, major gains in mechanical strength and electrochemical stability. Hydrogen bond deconvolution analysis revealed a 3.1 % increase in strong hydrogen bonds within PZEC, accompanied by a significant reduction in the phase transition temperature to −29.46 °C, indicative of enhanced bound water confinement and low-temperature adaptability. PZEC manifests excellent mechanical properties (90 kPa fracture stress, 1280 % elongation) while attaining high ionic conductivity (29.26 mS·cm −1 ) and zinc ion transference number (0.63) via zinc solvation sheath compression and guided ion transport. The Zn//Zn symmetric battery exhibited exceptional cycling endurance, operating for 700 h at 5 mA·cm −2 and over 2000 h at 0.5 mA·cm −2 . Notably, PZEC maintained superior rate performance and cycling stability at 0 °C, retaining high reversible capacity and near-100 % coulombic efficiency (CE) even under high-rate conditions. Consequently, this work outlines a new methodology for high-performance flexible AZIBs and delivers significant insights for hydrogen bond-functionalized electrolyte engineering.

Mechanism of carboxymethyl chitosan hybrid montmorillonite and adsorption of Pb(II) and Congo red by CMC-MMT organic-inorganic hybrid composite

Hongling Zhang,Jianzhe Ma,Fengyun Wang,Yuting Chu,Lei Yang,Mingzhu Xia

The carboxymethyl-chitosan-montmorillonite (CMC-MMT) organic-inorganic hybrid material was applied to adsorb Pb(II) and Congo red (CR) anionic dye from aqueous solution. Molecular dynamics(MD) simulation was carried out to reveal the mechanism of CMC hybrid MMT. The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT. Batch experiments were executed to investigate the adsorption effect of CMC-MMT was compared with Na-MMT and CMC. The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH 2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR. The kinetic and isotherm studies indicated that the pseudo-second-order and the Langmuir model well described the adsorption equilibrium of Pb(II) and CR on CMC-MMT.

Natural cellulose-based multifunctional architecture for electrochemical removal and detection of nanoplastic

Qingqing Wang,Wenqin Zhong,Jian Du,Jinwen Hu,Chenglong Fu,Jie Lu,Yanna Lv,Haisong Wang,Yehan Tao

This study presents a novel cellulose-based composite electrode material, CMC/PEI/Co/PANI, designed for efficient electrochemical adsorption and in-situ detection of polystyrene nanoplastics. The material integrates a three-dimensional (3D) carboxymethyl cellulose/polyethyleneimine (CMC/PEI) network with two-dimensional (2D) cobalt hydroxide nanoplates and a polystyrene (PANI) conductive layer, addressing the limitations of poor conductivity and water solubility in pure CMC. Electrochemical adsorption experiments show that the composite achieves a removal rate of 77.91 % for 10 mg/L polystyrene nanoparticles within 3 h at 1.0 V, outperforming many reported materials. Meanwhile, electrochemical detection via cyclic voltammetry (CV) and differential pulse voltammetry (DPV) exhibits high sensitivity, achieving a detection sensitivity of 0.2866 μA/ppb·cm 2 , a correlation coefficient of 0.9917, and a detection limit of 0.63 ppb. Theoretical calculations reveal that the adsorption mechanism involves synergistic effects of electrostatic attraction, van der Waals forces, hydrogen bonding, π-π stacking, and hydrophobic interactions. These findings underscored the potential of CMC/PEI/Co/PANI composite in the removal and detection of nanoplastic contaminants within the context of environmental pollution management, offering a novel approach for controlling and mitigating nanoplastic contamination in the future.

Antibacterial aerogels with nano‑silver reduced in situ by carboxymethyl cellulose for fresh meat preservation

Jingwen Yang,Xianhao Zhang,Lin Chen,Xi Zhou,Xiaojing Fan,Yayun Hu,Xuening Niu,Xinglian Xu,Guanghong Zhou,Niamat Ullah,Xianchao Feng

Bacterial cellulose (BC) was used as a reinforcing agent, citric acid (CA) as a cross-linking agent, and CMC@AgNPs as antibacterial nanomaterials, in which CMC@AgNPs were reduced from AgNO 3 in situ by carboxymethyl cellulose (CMC) as a reducing agent and stabilizer to fight microbial corruption. Its potential application in packaging fresh meat has been investigated. Results showed that the antibacterial CMC@AgNPs/BC/CA aerogels with excellent structural integrity and outstanding water absorption were developed by adding 0.3% BC and 0.25% CA. The CMC@AgNPs/BC/CA aerogel significantly reduced the color change and the total viable bacterial counts (TVC) in fresh meat after 7 days of refrigerated storage. The results indicated that CMC@AgNPs/BC/CA aerogels can effectively extend the shelf life of fresh meat, and can be used for meat packaging as a biologically active absorption pad.

Fabricating biodegradable calcium phosphate/calcium sulfate cement reinforced with cellulose: in vitro and in vivo studies

Xiao-Dan Li,Da-Wei Yan,Hao-Hao Ren,Qi-Yi Zhang,Yong-Gang Yan

Osteoporosis is a growing public health concern worldwide. To avoid extra surgeries, developing biodegradable bone cement is critical for the treatment of osteoporosis. Herein, we designed calcium phosphate/calcium sulfate cement reinforced with sodium carboxymethyl cellulose (CMC/OPC). It presents an appropriate physicochemical performance for clinical handling. Meanwhile, CMC/OPC bone cement promotes osteogenic differentiation in vitro. Results of the immune response in vitro and in vivo confirmed that increasing the cellulose content triggered macrophage switching into the M2 phenotype and CMC/OPC exhibited significant anti-inflammation. Furthermore, in vitro and in vivo degradation demonstrated that cellulose tailors the degradation rate of composite bone cement, which achieved a linear degradation process and could degrade by more than 90% for 12 weeks. In summary, the composite bone cement CMC/OPC is a promising candidate for bone repair applications.

Engineering bidirectional CMC-foam-supported HKUST-1@graphdiyne with enhanced heat/mass transfer for the highly efficient adsorption and regeneration of acetaldehyde

Hanzhuo Zhang,Yaseen Muhammad,Xinfang Cui,Zhengsheng Zhang,Long Liu,Zhe Chu,Jing Li,Yanjuan Zhang,Syed Jalil Shah,Zhenxia Zhao

Carboxymethyl cellulose-foam-supported HKUST-1@graphdiyne (HK@GDY/CMC-B) was constructed with high thermal conductivity and directional channels to enhance the ad-/de-sorption efficiency of acetaldehyde. Characterization results showed that (1) HKUST-1 grew within CMC and GDY via an in situ tri-phase cross-linking strategy, forming a special “alkynyl|Cu|COOH” interface, which maintained the high BET surface area (945.1 m2 g−1) of the HK@GDY/CMC-B foam and established a tight connection among the different components of the composite; (2) the π-conjugated carbon structure of GDY and the unique “alkynyl|Cu|COOH” interface within HK@GDY/CMC-B accelerated the phonon conduction and significantly enhanced the thermal conductivity of HK@GDY/CMC-B (336 mW m−1 K−1); (3) the directional channels and the hierarchical pore structure with a unique interface in the HK@GDY/CMC-B foam facilitated the diffusion and adsorption of VOCs; (4) the compact “alkynyl|Cu|COOH” interface generated more unsaturated Cu(II) and Cu(I) sites and increased adsorbent surface polarity to capture acetaldehyde. Consequently, the obtained HK@GDY/CMC-B exhibited an excellent acetaldehyde adsorption capacity of up to 11.0 mmol g−1, which was 1.3–3.4 times higher than that of many state-of-the-art adsorbents. Kinetics performance data revealed that the diffusivity of acetaldehyde on the HK@GDY/CMC-B foam increased by 60% compared to that of the pristine HKUST-1. Similarly, the desorption rate of HK@GDY/CMC-B was 2.2–6.5 times faster than that of several state-of-the-art adsorbents under similar temperature programmed desorption. This greatly realized an energy-conserving approach for adsorbent regeneration. Based on these findings, the current tri-phase cross-linking strategy can be deemed as an efficient tactic to further improve the adsorption efficiency of MOFs for fast adsorption of VOCs on the commercial level.