ACS Nano
·
2024
·
IF 15.8
Wenhao Shi,Xitang Qian,Chuankai Zou,Meng Zhang,Chenhui Huang,Xiangshui Miao,Lei Ye
Ion transport is a critical phenomenon underpinning numerous biological, physical, and chemical systems. Proton transistors leveraging proton transport face significant limitations, such as a low on–off ratio and deficient carrier mobility, which restrict their applicability in biological and other scenarios. This study explores the use of two-dimensional (2D) vacancy-residing transition metal phosphorus trichallcogenide-based membranes as the active layer for proton field-effect transistors. The synthesized Cd0.85PS3Li0.15H0.15 membrane exhibits a well-organized layered structure and high hydrophilicity, with nanometer-sized interlayers containing interconnected water networks. These distinct features facilitate proton conduction, leading to a high proton conductivity value of 0.83 S cm–1 at 98% relative humidity and 90 °C, with an activation energy of 0.26 eV. The Cd0.85PS3Li0.15H0.15-based proton transistor demonstrates tunability via gate voltage, thereby enabling effective modulation of proton flow across source and drain electrodes. The transistor notably showcases superior switching characteristics, with an on/off ratio surpassing 5.51 and a carrier mobility of 8.84 × 10–2 cm2 V–1 s–1. The underlying mechanism for this performance enhancement is attributed to electric-field-induced switching in Cd vacancies. This research boosts the development of highly versatile ionotropic devices by introducing advanced 2D ion-conductive membranes.
研究领域:
材料科学
·
电子学
·
纳米技术
·
质子学
·
器件物理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Xuefang Guo,Xiaoyong Liu,Shengxiao Cao,Yile Zhang,Ying Sun,Jing Qiao,Ben Fan,Xueqin Zhang
Silicone hydrogels have emerged as promising candidates for ocular drug delivery due to their exceptional oxygen permeability. However, their inherent hydrophobicity often results in suboptimal drug-loading capacity and patient discomfort. To address these limitations, this study introduces an innovative dual-network silicone/β-CD-HA hydrogel. In this design, the primary silicone network preserves high oxygen permeability, while the secondary β-CD-HA network enhances hydrophilicity and introduces additional drug-loading sites via host-guest interactions. Levofloxacin (LVF), a broad-spectrum antibiotic, was incorporated into the hydrogel through non-covalent binding with β-CD, and the system’s drug-loading capacity, sustained release profile, in vitro bactericidal activity, and post-loading properties were systematically evaluated. The results demonstrated a total LVF loading of 959.90 ± 36.60 μg/lens in the silicone/β-CD-HA hydrogel, with sustained release extending up to 8 h. Bactericidal assays revealed markedly reduced E. coli survival rates in treated groups: 14.46 ± 0.76 % (p < 0.0001) for LVF-loaded silicone hydrogel and 10.42 ± 1.66 % (p < 0.0001) for the β-CD-HA/silicone hydrogel, underscoring the enhanced antimicrobial efficacy of the dual-network system. The integration of β-CD-HA significantly improved hydrogel hydrophilicity, increasing equilibrium water content (EWC) from 27.69 ± 0.18 % to 45.60 ± 0.19 % and reducing the surface contact angle from 99.41 ± 0.24° to 70.36 ± 0.14°. Crucially, the modified hydrogel retained functionality-critical properties, exhibiting 93.45 ± 0.42 % light transmittance and 110.45 ± 0.32 barrer oxygen permeability values well within practical application standards. Post-drug-loading characterization showed minimal changes in oxygen permeability (105.47 ± 0.18 barrer), transmittance, or mechanical integrity, confirming structural stability. These findings collectively highlight the dual-network silicone/β-CD-HA hydrogel as a robust platform for extended ocular drug delivery, effectively balancing enhanced drug loading, sustained release kinetics, without compromising essential material properties.
研究领域:
生物材料
·
药物递送系统
·
眼科学
·
高分子科学
·
药剂技术
·
材料科学
·
抗菌治疗
✓ 已验证
产品关联
DOI
高影响因子
PLoS One
·
2016
·Vol. 11
·期 4
·e0151479
·
IF 3.057
Huiqing Wu,Qingping Wu,Guojie Wu,Qihui Gu,Linting Wei
The goal of this study was to identify Cd-resistant bacterial strains with endurance capacity and to evaluate their ability to remove cadmium ions from cadmium-polluted water. The Bacillus cereusS5 strain identified in this study had the closest genetic relationship with B . cereus sp. Cp1 and performed well in the removal of Cd 2+ ions from solution. The results showed that both the live and dead biomasses of the Cd 2+ -tolerant B . cereus S5 strain could absorb Cd 2+ ions in solution but that the live biomass of the B . cereus S5 strain outperformed the dead biomass at lower Cd 2+ concentrations. An analysis of the cadmium tolerance genes of B . cereus S5 identified ATPase genes that were associated with cadmium tolerance and involved in the ATP pumping mechanism. The FTIR spectra revealed the presence of amino, carboxyl and hydroxyl groups on the pristine biomass and indicated that the cadmium ion removal ability was related to the structure of the strain. The maximum absorption capacity of the B . cereus S5 strain in viable spore biomass was 70.16 mg/g (dry weight) based on a pseudo-second-order kinetic model fit to the experimental data. The Langmuir and Langmuir-Freundlich isotherm adsorption models fit the cadmium ion adsorption data well, and the kinetic curves indicated that the adsorption rate was second-order. For Cd 2+ concentrations (mg/L) of 1–109 mg/L, good removal efficiency (>80%) was achieved using approximately 3.48–10.3 g/L of active spore biomass of the B . cereus S5 strain. A cadmium-tolerant bacteria-activated carbon-immobilized column could be used for a longer duration and exhibited greater treatment efficacy than the control column in the treatment of cadmium-polluted water. In addition, a toxicity assessment using mice demonstrated that the biomass of the B . cereus S5 strain and its fermentation products were non-toxic. Thus, the isolated B . cereus S5 strain can be considered an alternative biological adsorbent for use in emergency responses to severe cadmium pollution and in the routine treatment of trace cadmium pollution.
研究领域:
环境微生物学
·
生物修复
·
水处理
·
毒理学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING RESEARCH & DESIGN
·
2023
·
IF 3.9
Lan Zhang,Keli Zhang,Shengle Kang,Shanshan He,Xiang Dong,Yan Zhao,Fangfang Li,Qihong Cen
Crystalline celluloses , such as microcrystalline cellulose (MCC) and nanocrystalline cellulose (NCC), which are originated from biomass, were utilized as templates to prepare hierarchical LTA zeolites . The effect of both size and surface properties of crystalline cellulose on the zeolite synthesis were carefully discussed. As-prepared zeolite based on surface-modification NCC showed hierarchical porous structure with monolithic morphology inherited from nanocrystalline cellulose. Its specific surface area was measured to be 18.3 m 2 /g, which was approximately 3.4 times that of the traditional zeolite A (Z0, 5.4 m 2 /g). Owing to its unique structure, ZNSC facilitated fast Cd(II) adsorption with the adsorption equilibrium time shortened by 81.3%. Kinetics study revealed that intraparticle diffusion was significantly enhanced and the effective diffusion coefficient increased by near 5 times. Furthermore, the maximum adsorption capacity achieved by ZNSC was 324.3 mg/g at 283 K, as calculated from the Langmuir model, which was 1.3 times that of Z0. These results are obtained when the grain size of ZNSC is larger than that of Z0, reflecting the superiority of the hierarchical structure in enhancing adsorption performance and thus providing a facile yet robust strategy for designing hierarchically structured zeolites for rapid and efficient wastewater treatment .
研究领域:
材料科学
·
环境工程
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Xiang-Hua Ling,Yue-Feng Tang,Guo-Zhi Han
The composite of hydrogels and noble metal nanoparticles has wide applications in the field of functional materials . In this paper, we developed a novel and green strategy to synthesize a kind of composite hydrogel microspheres containing silver nanoparticles and β-cyclodextrin (β-CD) modified sodium alginate (β-CD@SA@Ag) without use of strong reducing reagent. First, β-CD was chemical linked to SA by epichlorohydrin (ECH) to form the β-CD modified polymer (β-CD@SA). then AgNO 3 was added to the as-prepared polymer solution , in which silver nanoparticles were formed by the reducing power of β-CD units. Subsequently, by reversed-phase emulsion method and ionic cross-linking, a kind of β-CD@SA@Ag hydrogel microspheres were obtained. The structure and morphology of the composite material were characterized in detail by Fourier infrared spectroscopy (FT-IR), thermogravimetric analysis (TG), scanning electron microscope (SEM), transmission electron microscope (TEM) and X-ray diffraction (XRD). Test data indicated that silver nanoparticles evenly dispersed in the composite material. On the basis, the adsorption and catalytic performances of the β-CD@SA@Ag hydrogel microspheres were studied towards to the reduction of aromatic nitro compounds. Research results showed that the β-CD@SA@Ag hydrogel microspheres had excellent catalytic activity along with high environmental adaptability. whether in pure water, tap water or river water, aromatic nitro compounds can be completely reduced within 2–13 min. Moreover, the morphology of microspheres of the composite material endows the composite material with high stability and reusability. We believe that our work would provide a new idea for the green synthesis of organic-inorganic composite functional materials .
研究领域:
材料科学
·
环境化学
·
纳米技术
·
催化
✓ 已验证
产品关联
DOI
高影响因子
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
·
2016
·
IF 2.429
Hailong Zhang,Xiaoyan Huang,Yongjing Zhang,Yang Gao
Context: Oral bioavailability of some hydrophilic therapeutic macromolecules was very poor, thus leading to their limited application in clinic.Objective: To investigate the efficacy, safety and mechanism of HP-β-CD-PEI polymers on the intestinal absorption of some poorly absorbable drugs in rats.Methods: Effects of HP-β-CD-PEI polymers on the intestinal absorptions of drugs were investigated by an in situ closed loop method in rats. The safety of HP-β-CD-PEI polymer was evaluated by measurement of lactate dehydrogenase (LDH) activity and amount of protein released from rat intestinal perfusate. The absorption enhancing mechanisms were explored by the measurement of zeta potential, transepithelial electrical resistance (TEER) and in vitro transport of FD4 (a paracellular marker) across rat intestinal membranes, respectively.Results: HP-β-CD-PEI polymers, especially HP-β-CD-PEI1800, demonstrated excellent absorption enhancing effects on drug absorption in a concentration-dependent manner and the enhancing effect was more efficient in the small intestine than that in the large intestine. Five percent (w/v) HP-β-CD-PEI1800 obviously decreased the TEER, accompanied with increase in the intestinal transport of FD4, indicating that absorption enhancing actions of HP-β-CD-PEI polymers were possibly performed by loosening tight junctions of intestinal epithelium cells, thereby increasing drug permeation via a paracellular pathway. A good liner relationship between absorption enhancing effects of HP-β-CD-PEI polymers and their zeta potentials suggested the contribution of positive charge on the surface of these polymers to their absorption enhancing effects.Conclusion: HP-β-CD-PEI polymers might be potential and safe absorption enhancers for improving oral delivery of poorly absorbable macromolecules including peptides and proteins.
研究领域:
药剂学
·
药物递送
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Wenqian Nong,Honglin Luo,Gang Wang,Qicong Chen,Xiaosu Zou,Weiwei Miao,Jun Wu,Weiliang Guan,Shenhong Qu
The development of safe, environmentally friendly, edible antimicrobial packaging films represents a promising alternative to conventional plastic packaging for reducing spoilage and extending the shelf life of fresh food. Here, we propose a novel strategy to construct edible β-CD-MOF/carvacrol@zein (BCCZ) composite films by intertwining β-CD-MOF loaded with the antimicrobial essential oil carvacrol, and zein. The resulting BCCZ films exhibit high humidity-triggered, long-lasting bactericidal efficacy, effective fruit preservation, and excellent biosafety. Characterization revealed that BCCZ films possess a compact texture, hydrophilic surface, low water vapor permeability, and high humidity sensitivity. Additionally, this film act as a “storehouse” for carvacrol, enabling humidity-controlled release (96.3% release at 100% RH and only 12.0% at 43% RH on day 7). BCCZ film effectively inhibited Gram-positive Staphylococcus aureus , Gram-negative Escherichia coli , and fungi ( Botrytis cinerea ) through the release of liquid-phase and vapor-phase carvacrols under both direct contact and indirect contact conditions in high humidity. Owing to the film's humidity-triggered, long-term release of carvacrol, strawberries packed in BCCZ films maintained their freshness and appearance significantly better after seven days of storage at 21 °C. This work provides valuable insights and holds promise for the design and commercial application of safe, environmentally friendly freshness-preserving packaging films.
研究领域:
食品科学
·
材料科学
·
生物技术
·
微生物学
·
包装工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2021
·
IF 4.821
Yanyan Niu,Yuxue Chen,Xiaoping Zhang,Hui Xie,Guiling Luo,Wei Sun
In this paper a photoelectrochemical (PEC) aptasensor based on specific recognition between aptamer and target cadmium ion (Cd(II)) with change of the sensing interface structure was constructed. A ZnO-TiO 2 nanocomposites and Au nanochains (Au NCs) modified electrode as photosensitive substrate was prepared and further covalently bound with graphite-like carbon nitride (g-C 3 N 4 ) on the free end of the aptamers to amplify the detection signal, which was applied to Cd(II) detection. Graphite-like carbon nitride with narrow band gap exhibited unique photoelectric property under UV and visible light irradiation. When the target Cd(II) was detected by the modified interface of the aptasensor, the structure of sensing interface was changed with the signal sensitizer g-C 3 N 4 closed to the interface, which caused the changes of photocurrent signal more sensitive and exhibited a good linear relationship with the Cd(II) concentration, so as to realize the quantitative analysis of the target. This PEC aptasensor showed a high sensitivity with a detection limit as 1.1 × 10 −11 mol/L and was further applied to the water sample detection successfully.
研究领域:
分析化学
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Small Structures
·
2024
·
IF 13.9
Wenxue Zhao,Aihua Yan,Zigao Su,Fei Huang,Quande Wang,Shihang Li,Shijian Lu,Chuanjian Wang,Tongyang Zhang,Jixu Zhang,Ye Gao,Huaqi Yuan
Photocatalytic water splitting into hydrogen production provides a new avenue to produce clean chemical fuels. However, developing high-efficiency photocatalytic materials still remains a challenge till now. Herein, multiobjective-optimization MoS 2 /Cd-ZnIn 2 S 4 /CdS (MS/CZIS/CS) composites are successfully constructed by an in situ structure-tailored technique. Benefiting from the synergistic feature integrating sulfur vacancy, II-type CZIS/CS heterojunction and Schottky-type MS/CS heterojunction, such composites not only effectively steer photogenerated carrier transfer but also markedly expedite surface reaction kinetics for hydrogen reduction reaction. As a result, an optimal hydrogen evolution rate of 11.49 mmol g −1 h −1 is achieved over the MS/CZIS/CS catalysts, which is approximately 4.79 times higher than that of pristine ZIS (2.40 mmol g −1 h −1 ). This work provides some new inspirations for the steering of carrier transfer and the design of multiobjective-optimization photocatalysts with high efficiency.
研究领域:
材料科学
·
化学工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 55
·34487-34497
·
IF 3.361
Hui Cao,Pu Yang,Tai Ye,Min Yuan,Jinsong Yu,Xiuxiu Wu,Fengqin Yin,Yan Li,Fei Xu
Edible vegetable oils are easily contaminated by heavy metals, resulting in the oxidative degradation of oils and various health effects on humans. Therefore, it is very important to develop a rapid and efficient method to extract trace heavy metals from vegetable oils. In this work, a highly hydrophobic ion-imprinted polymer (IIP) was synthesized on a novel raspberry (RS)-like particle surface. The synthesized IIP@RS was characterized and used in solid-phase extraction (SPE) for the selective and fast adsorption of Cd(II) from vegetable oils. The results showed that IIP was successfully coated onto RS particles with a high specific surface area (458.7 m2 g−1) and uniform porous structure. The contact angle (θ) value (141.8°) of IIP@RS was close to the critical value of super-hydrophobic materials, which is beneficial to their adsorption in hydrophobic vegetable oils. The IIP@RS also exhibited excellent adsorption ability and selectivity to Cd(II) with a maximum adsorption capacity of 36.62 mg g−1, imprinting factor of 4.31 and equilibrium adsorption rate of 30 min. According to isothermal titration calorimetry results, the recognition behavior of IIP@RS for Cd(II) was mainly contributed by Cd(II)-induced cavities during gel formation and coordination between Cd(II) and –SH groups in imprinted cavities. Furthermore, the adsorption process driven by entropy and enthalpy was spontaneous at all temperatures. In real vegetable oil samples, IIP@RS-SPE adsorbed approximately 96.5–115.8% of Cd(II) with a detection limit of 0.62 μg L−1. Therefore, IIP@RS has wide application prospects in enriching and detecting Cd(II) from vegetable oil.
研究领域:
环境科学
·
材料科学
·
分析化学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Junying Wu,Ruijie Guo,Houting Kang,Yanming Wang,Jingyuan Tian,Jierong Wang,Hong Yan
Metal–organic frameworks (MOFs) have great potential in improving the fire safety of polymer materials. To improve the fire resistance and smoke suppression of polypropylene (PP), a flame-retardant system ZIF-67@γ-CD-MOFs@APP incorporating multiple flame-retardant elements was designed and applied to PP. The coated PP passed UL-94 V-0 level with the LOI up to 36.2% and char residue of 12.47%. The PHRR, PSPR, COP, and CO 2 P of coated PP were reduced by 52.65%, 24.72%, 36.49%, and 52.29%, respectively, compared to neat PP. In addition, the tPHRR, tPSPR, tCOP, and tCO 2 P were prolonged by 405.3%, 345.4%, 427.8%, and 405.3% compared to pure PP, allowing more escape time when facing a real fire. Integrating the hierarchical porous structure provided by ZIF-67 and γ-CD-MOFs, catalytic carbonization of transition metal Co and the nitrogen-containing ligand, ZIF-67@γ-CD-MOFs@APP played a flame-retardant role both in the condensed and gas phase, endowing PP with enhanced flame retardancy and smoke suppression. The “all-in-one” strategy provides helpful insights for constructing fire retardant system with multi-level nanostructure.
研究领域:
材料科学
·
高分子科学
·
消防安全工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
BIOMACROMOLECULES
·
2024
·
IF 5.5
Danyu Lv,Wanjun He,Wei Liu,Yuqiang Cheng,Yan Cui,Xiujuan Zhou,Yanwen Xue,Siming Yu,Ningjin Zhang,Hecheng Meng,Yongguang Guan,Jian-He Sun,Xian-Ming Shi
The γ-cyclodextrin (γ-CD) metal–organic frameworks (CD-MOF-1) consist of γ-CD and potassium (K+) ions through coordinating an eight-coordinated K+ ion with two C5-linked oxygen and C6-linked hydroxyl (C5–O/C6–OH) groups in the primary faces of adjacent γ-CD units and two C2- and C3-linked hydroxyl (C2–OH/C3–OH) groups in the secondary faces. Herein, we found polysaccharide gels with only C2–OH/C3–OH or C5–O/C6–OH groups in pyranoid rings can form four-coordinated K+ ions and then coordinate γ-CD in a KOH solution for CD-MOF-1 growth. Exposure of C2–OH/C3–OH or C5–O/C6–OH groups in polysaccharide gels is important to form active four-coordinated K+ ions. Mechanism supporting this work is that four-coordinated K+ ion sites are first formed after coordinating C2–OH/C3–OH groups in pectin and then coordinating C5–O/C6–OH groups in the primary faces of γ-CD units. Alternatively, four-coordinated K+ ions with C5–O/C6–OH groups in chitosan can coordinate the C2–OH/C3–OH groups in the secondary faces of γ-CD units. Mechanism of CD-MOF-1 growing on pectin and chitosan gels through the proposed four-coordinated K+ ions is also universally applicable to other polysaccharide gels with similar C2–OH/C3–OH or C5–O/C6–OH groups such as alginate gel. Based on this mechanism, we developed pectin and chitosan gel-based CD-MOF-1 composites and exemplified applications of them in antibacterial and organic dye removal. To help future research and applications of this mechanism, we share our theoretical assumption for further investigations that any matrices with an ortho-hydroxyl carbon chain or ortho-hydroxyl ether structures may form four-coordinated K+ ions for CD-MOF-1 growth. The proposed mechanism will broaden the development of novel CD-MOF-1 composites in various fields.
研究领域:
材料科学
·
化学
·
生物材料
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）