查找使用阿拉丁产品的科研文献

Electrospun Ta-doped TiO2/C nanofibers as a high-capacity and long-cycling anode material for Li-ion and K-ion batteries

Die Su,Li Liu,Zhixiao Liu,Jing Dai,Jiaxing Wen,Min Yang,Sidra Jamil,Huiqiu Deng,Guozhong Cao,Xianyou Wang

Ta-doped TiO2/C nanofibers are synthesized by an electrospinning method. First-principles calculations reveal that the Ta dopant can lower the Li/K diffusion barrier, which is beneficial for improving the rate capability. According to the electronic structure analysis, the dopant can obviously shift the conduction band of TiO2 downward, resulting in significantly improved electronic conductivity. Ta doping causes phase transformation from anatase to rutile, and increases the specific surface area. The well-designed rutile Ta-doped TiO2/C nanofibers show outstanding electrochemical properties in both Li-metal half cells and K-metal half cells, which are much better than those of pristine anatase TiO2/C nanofibers. At 2 A g−1, 5% rutile Ta-doped TiO2/C nanofibers could deliver high reversible specific capacities of 399 mA h g−1 in Li-ion batteries after 1000 cycles whereas deliver 148 mA h g−1 in K-ion batteries after 800 cycles. When assembled, the full cells with 5% rutile Ta-doped TiO2/C nanofibers as the anode and commercial LiFePO4/perylene-3,4,9,10-tetracarboxylic dianhydride as the cathode show excellent cycling performance and can light up more than 18 LEDs. These results demonstrate that Ta-doped TiO2/C nanofibers are a promising anode material for Li/K ion batteries.

Equilibrium study and diversified models of drug Norfloxacin in eight pure organic and binary solvents at T = (278.15–328.15) K

Yemin Yu,Tao Li,Yonghong Hu,Wenge Yang,Yuhao zhang,Renlun Deng,Min Jiang

Research on relevant solid–liquid equilibrium of drug Norfloxacin (NFLX) in different solvents is necessary for an elementary study of industrial implantation. In this work, the solid–liquid equilibrium of NFLX in ethanol, 1-butanol, isopropanol, acetone, acetonitrile , ethyl acetate , N-hexane, N,N-dimethylformamide single pure solvent and in (N,N-dimethylformamide + ethyl acetate) binary solvent mixtures were probed under atmosphere pressure at desired temperatures from 278.15 K to 328.15 K. The Gibbs energy , enthalpy, and entropy of solution were obtained from these solubility data. The modified Apelblat model, the Buchowski–Ksiazaczak λh model, Redich-Kister (CNIBS/R-K) model, Jouyban-Acree model, ideal model and the Van't Hoff analysis were applied to depict and forecast the diversification tendency of solubility. The satisfactory simulation results were obtained. Moreover, the thermodynamic functions for NFLX dissolution from calculation, using the van't Hoff and Gibbs equations, imply that in each studied solvent and in binary solvent mixtures, the process of NFLX dissolution is endothermic. Based on the above analysis, N,N-dimethylformamide is checked as the best solvent and ethyl acetate can be used as an effective anti-solvent in the crystallization process of NFLX.

Determination and Analysis of Solubility of 4-[2-(N-Methylcarbamyl)-4-pyridyloxy]aniline in Ten Pure Solvents and Three Binary Solvent Mixtures at Different Temperatures (T = 278.15–323.15 K)

Zhi Wang,Liang Yao,Ting Wang,Zilong Cui,Jingling Ye,Yonghong Hu

In this study, the data on solid–liquid equilibrium of 4-[2-(N-methylcarbamyl)-4-pyridyloxy]aniline were studied by the gravimetric method. The solubility of 4-[2-(N-methylcarbamyl)-4-pyridyloxy]aniline was measured in 10 pure solvents (ethyl acetate, tetrahydrofuran, acetonitrile, dichloromethane, acetone, methanol, acetylacetone, n-propanol, n-butanol, and water) and three binary solvent mixtures (water + tetrahydrofuran, acetone + n-butanol, and ethyl acetate + n-propanol) in the temperature range of 278.15 to 323.15 K under atmospheric pressure. The experimental results show that the solubility of 4-[2-(N-methylcarbamyl)-4-pyridyloxy]aniline in the abovementioned solvents increases with the increase of temperature. Among the 10 pure solvents, ethyl acetate has the highest solubility. The improved Apelblat model, Buchowski–Ksiazaczak λh model, Redlich–Kister (CNIBS/R-K) model, and Jouyban–Acree model are used for nonlinear fitting of experimental data, and the KAT-LSER model is also used to study the relationship between the solubility of 4-[2-(N-methylcarbamyl)-4-pyridyloxy]aniline in pure solvents and the interaction between solvent and solute molecules. The physical and chemical information of 4-[2-(N-methylcarbamyl)-4-pyridyloxy]aniline provided in this report may help its extraction/separation, recrystallization, purification, and formulation development.

Orally Administered Diosgenin Alleviates Colitis in Mice Induced by Dextran Sulfate Sodium through Gut Microbiota Modulation and Short-Chain Fatty Acid Generation

Yushu He,Ruilin Luo,Manying Xia,Jiayu Liu,Yanpeng Yao,Fenyi Min,Ruyi Jin,Ruolin Wang,Xiaoli Peng

Diosgenin (DIO) is a kind of steroid sapogenin derived from natural plants. It exerts strong anti-infection, antiallergy, antiviral, and antishock pharmacological properties. In this article, the protective effects of DIO against dextran sulfate sodium (DSS)-induced colitis in mice were researched. Compared with the 2.5% DSS treatment group, 15 mg/kg body weight of diosgenin alleviated colitis disease, evidenced by the increased body weight, the decrease in the disease activity index, and the histological scores. Furthermore, 16S rRNA high-throughput sequencing results demonstrated that DIO improved the colon homeostasis through modulating the gut microbiota, including increases in the relative abundance of several probiotic bacteria, such as Prevotellaceae (from 1.4% to 5.8%), Lactobacillus (from 12.3% to 29.7%), Mucispirillum (from 0.07% to 0.49%), and decreases in the pathogenic bacteria, such as Streptococcus (from 1.6% to 0.6%) and Pseudomonadaceae (from 0.004% to 0%).In addition, the concentration of gut microbial metabolites, total short-chain fatty acids (SCFAs), acetic acid, and propionic acid were significantly increased after DIO supplementation. In conclusion, our findings suggested that DIO attenuates DSS-induced colitis in mice by means of modulating imbalanced gut microbiota and increases in SCFA generation.

Hesperidin Protects Against High-Fat Diet-Induced Lipotoxicity in Rats by Inhibiting Pyroptosis

Ruixi Luo,Yudie Hu,La Wang,Wenjia Wang,Ping Wang,Zunli Ke,Didong Lou,Weiyi Tian

It is currently thought that excess fatty acid-induced lipotoxicity in hepatocytes is a critical initiator in the development of nonalcoholic fatty liver disease (NAFLD). Lipotoxicity can induce hepatocyte death; thus, reducing lipotoxicity is one of the most effective therapeutic methods to combat NAFLD. Abundant evidence has shown that hesperidin (HSP), a type of flavanone mainly found in citrus fruits, is able to ameliorate NAFLD, but the molecular mechanisms are unclear. We previously reported that pyroptosis contributed to NAFLD development and that inhibiting pyroptosis contributed to blunting the progression of NAFLD in rat models. Therefore, we questioned whether HSP could contribute to ameliorating NAFLD by modulating pyroptosis. In this study, a high-fat diet (HFD) induced dyslipidemia and hepatic lipotoxicity in rats, and HSP supplementation ameliorated dyslipidemia and insulin resistance. In addition, the HFD also caused pyroptosis in the liver and pancreas, while HSP supplementation ameliorated pyroptosis. In vitro, we found that HSP ameliorated palmitic acid-induced lipotoxicity and pyroptosis in HepG2 and INS-1E cells. In conclusion, we showed for the first time that HSP has a protective effect against liver and pancreas damage in terms of pyroptosis and provides a novel mechanism for the protective effects of HSP on NAFLD.

Liquid Chromatography-Tandem Mass Spectrometry-Based Metabolomics Analysis of Indigo Naturalis Treatment of Ulcerative Colitis in Mice

Anqi Fan,Bao-Long Hou,Zhishu Tang,Ting Wang,Dongbo Zhang,Yanni Liang,Zheng Wang

Screening of Platycodonis Radix Fractions for Antiobesity Activities and Elucidation of Its Molecular Mechanisms in High-Fat Diet-Fed C57BL/6 Mice

Nannan Zhi,Xiangwei Chang,Xinrui Wang,Xiaobo Zhang,Jutao Wang,Liangping Zha,Shuangying Gui

Obesity is a threat to public health and effective new medications are required. Platycodonis Radix (PR) is a traditional medicinal/dietary plant with activities against obesity. Using mice given a diet rich in fat, the antiobesity components of PR were identified and their molecular mechanisms were clarified further in this investigation. Initially, the impacts of PR fractions on liver histology and biochemical markers were assessed. Subsequently, the degrees of lipogenic and lipolytic gene and protein expressions were determined. Oral administration of PR polysaccharides (PG) (0.80 g/kg body weight) improved liver function (alanine aminotransferase and aspartate aminotransferase) and its antioxidant activities (total superoxide dismutase, glutathione peroxidase, and malondialdehyde), as well as alleviated blood lipid (total cholesterol, total triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol) values, inflammatory systemic (TNF-α and IL-1β), and histological abnormalities within the liver. Furthermore, PG administration downregulated the expression for lipogenic genes (ACC and FAS) and upregulated the expression for the lipolytic gene (PPARα, LPL, CPT1, and HSL). Importantly, PG raised AMPK phosphorylation and decreased SREBP-1c protein synthesis. Thus, it is possible that PG stimulates the AMPK-LPL/HSL path (lipolytic route) plus the AMPK-ACC/PPARα-CPT1 path (associated to β-oxidation of fatty acids), while inhibiting the AMPK/(SREBP-1c)-ACC/FAS path (lipogenic route). In summary, PG has the ability to regulate lipid metabolism, and it may be useful to pharmacologically activate AMPK with PG to prevent and cure obesity.

Compensation for K+ loss of K-doped Na0.7MnO2 by K+ supply source for high-performance sodium-ion batteries

Yuzhu Qian,Xuewei Sui,Jintao Shi,Ting Song,Xiongwei Wu,Qing Zhang,Xuejun Zheng,Bei Long

K 0.5 MnO 2 @Na 0.7 MnO 2 composite is prepared by a KCl@Na 2 CO 3 molten salt. • Electrochemically induced conversion of KMO@NMO into K-doped NMO is achieved. • K doping enhances structural stability of NMO and facilitates Na + migration. • KMO as K + supply source compensates K + loss in NMO upon cycling. • KMO@NMO shows high capacity retention after 800 cycles. P2-type layered Na 0.7 MnO 2 is regarded as a promising cathode material for sodium-ion batteries due to its high specific capacity. However, Mn 3+ -induced Jahn-Teller distortion and Mn 2+ dissolution result in the structural instability of Na 0.7 MnO 2 , thereby restricting its large-scale application. In this study, a K 0.5 MnO 2 @Na 0.7 MnO 2 composite is prepared by a molten salt method and used as a cathode. In particular, partial K + in K 0.5 MnO 2 substitutes for the Na + sites in Na 0.7 MnO 2 during the charge-discharge process, which decreases the Mn 3+ /Mn 4+ ratio and provides wide Na + channels, achieving fast reaction kinetics and long-term cycling stability. The persistent K 0.5 MnO 2 throughout the entire testing process works as a robust K + supply source and compensates for the K + loss of K-doped Na 0.7 MnO 2 during cyclic tests. Consequently, the cathode shows a high discharge capacity of 148 mA h g −1 at 0.04 A g −1 and outstanding cycling stability, with a capacity retention of 69% after 800 cycles at 0.5 A g −1 . This research provides important references for designing high-performance layered cathode materials in sodium-ion batteries. Download: Download high-res image (135KB) Download: Download full-size image

Liquid-liquid equilibrium of glycerol – acetone – solketal – water quaternary system at 303.2 K, 308.2 K and 313.2 K

Qing Zhang,Danru Xu,Miaoli Hao,Zhiqiang Wu,Chunhai Yi,Jingjun Liu

Solketal obtained by ketalization of glycerol with acetone is a value-added glycerol derivative that can be used as a solvent, plasticizer and fuel additive. Phase splitting and merging exist in the ketalization due to the low solubilities of the two reactants. The liquid-liquid equilibrium data for a quaternary system (glycerol – acetone – solketal – water) involved in the ketalization were measured at reaction-relevant temperatures (303.2 K, 308.2 K, and 313.2 K) and atmospheric pressure. The equilibrium data were correlated using the NRTL model to calculate activity coefficients, to estimate the binary interaction parameters. The NRTL model with the regressed parameters could reproduce the phase equilibrium behavior of the studied system.

What roles do alkali metal ions play in the pathological crystallization of uric acid?

Mengya Li,Dandan Han,Junbo Gong

Uric acid (UA) is the end product of purine metabolism and is widely found in nature. Excess uric acid will result in the deposition of pathological uric acid crystals in the kidney. However, few studies have focused on the effects of components in the human body on the crystallization of uric acid. Herein, we found multiple effects of alkali metals (Na+, K+) on uric acid dihydrate (UAD) crystal growth, which is one of the main components of urinary stones. Optical microscopy (OM) and scanning electron microscopy (SEM) were employed to detect the crystal morphology, and long rod-like crystals and hierarchical crystals were found in the presence of Na+ and K+, respectively. Powder X-ray diffraction (PXRD) and micro-Raman spectroscopy verified that the crystal structure remained unchanged in the presence of ions. In addition, single-crystal growth experiments revealed that Na+ inhibited growth along [010] and [100], and K+ promoted growth along [100] but suppressed growth along [010]. The step growth of the UAD crystal was measured by atomic force microscopy (AFM), which indicated the inhibition of crystal growth by Na+ due to kink blocking, yet the promotion of crystal growth by K+ resulted from rough growth. Our studies showed that ions in the human body not only can maintain electrolyte balance but also can affect the crystallization of pathological crystals, which provides a suggestion for a rational diet for patients with hyperuricemia and urinary stones.

Polygonati rhizoma fermentation by Monascus ruber and evaluation of fermentation products in vitro

Zijun Tao,Jian Zhang,Fuge Niu,Huien Zhang,Zhongfa Chen,Shanfu Wang,Yuli Zhang,Jie Li,Peng Liu

This study investigated the conditions for polygonati rhizoma (PR) fermentation by Monascus ruber and the lipid-lowering activity of the resulting product. Monascus ruber was used for the solid-state fermentation of PR, and the response surface method was used to optimize the fermentation culture medium parameters. The optimal fermentation system yielded a maximum monacolin K concentration of 21.82 ± 0.34 mg/g. The fermentation conditions were as follows: 12.5 mmol/kg of L-glutamic acid, 0.64 mmol/kg of cyclic adenosine monophosphate , 3.0 wt% of yeast extract powder, a fermentation period of 15 days, and a fermentation temperature of 30 ℃. The binding capacities of unfermented PR, “Nine-Steam-Nine-Bask” processed Polygonati rhizoma (NPR), and Monascus ruber solid-state fermented polygonati rhizoma (MPR) to sodium cholate, sodium taurocholate , and sodium glycolate were determined. MPR showed a stronger bile acid-binding capacity than unfermented PR. In addition, MPR exhibited the highest cholesterol inhibitory capacity of 51.43±1.41 %. Thus, MPR can be used as a potential antilipemic agent with potent hypolipidemic effects.

Screening for Safe and Efficient Monascus Strains with Functions of Lowering Blood Lipids, Blood Glucose, and Blood Pressure

Chuling Liu,Li Cheng,Mingtian Yang,Zhengli He,Yanan Jia,Li Xu,Yuansong Zhang

Monascusis a fungus widely used in food fermentation. This study employed microbial technology, combined with microscopic morphological observations and ITS sequence analysis, to isolate, purify, and identify 10 strains of red yeast mold from variousMonascusproducts. After the HPLC detection of metabolic products, the M8 strain containing the toxic substance citrinin was excluded. Using the EWM-TOPSIS model, the remaining nine safeMonascusstrains were evaluated for their inhibitory activities against pancreatic lipase, α-glucosidase, α-amylase, and the angiotensin-converting enzyme. The M2 strain with the highest comprehensive scores for lowering blood sugar, blood lipids, and blood pressure was selected. Its fermentation product at a concentration of 3 mg/mL had inhibition rates of 96.938%, 81.903%, and 72.215%, respectively. The contents of the blood lipid-lowering active substance Monacolin K and the blood sugar and blood pressure-lowering active substance GABA were 18.078 mg/g and 5.137 mg/g, respectively. This strain can be utilized for the biosynthesis of important active substances such as Monacolin K and GABA, as well as for the fermentation production of safe and effective functional foods to address health issues like high blood lipids, high blood sugar, and high blood pressure in people. This study also provides insights into the use of natural fungi to produce healthy foods for combating chronic diseases in humans.