COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Xin Lei,Meining Li,Yueguang Wang,Yang Li,Zhenfu Zhu,Chengrong Wen,Di Zhang,Jie Pang
This work introduced paper industry by-product dealkalized lignin (DL) as a natural modifier into the konjac glucomannan (KGM) system to overcome the deficiencies of KGM, such as poor mechanical properties and weak ultraviolet (UV)-blocking performance, addressing the urgent demand for renewable and biodegradable functional materials in packaging. Through the chemical crosslinking action of epichlorohydrin (EPI), the effects of DL content (0.1%, 0.3%, and 0.5% w/v) on the microstructure, thermal stability, mechanical properties, gas barrier properties, antioxidant activity, UV-blocking properties, and biodegradability of the composite films were systematically investigated. The results showed that EPI could successfully promote the formation of a stable three-dimensional (3D) network structure between KGM and DL, particularly at 0.3% (w/v) DL content. When the DL concentration was 0.5%, the ductility of the composite films was significantly enhanced, with a maximum elongation at break (EAB) of 57.61%. In addition, the antioxidant activities (ABTS radical scavenging rate: 85.83%) and UV-blocking properties of the composite films were remarkably improved. Experiments on fresh-cut eggplants preservation further confirmed that the KGM/DL films effectively delayed weight loss, hardness reduction, total phenolic content (TPC) reduction, and lipid peroxidation of eggplants, demonstrating good application potential. Therefore, this study provides an effective strategy for the high-value utilization of industrial by-products and the development of new green materials.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Yiqiong Zhang,Guangtai Chi,Xiaojing Xu,Guo Li,Jianan Hu,Guiping Gong,Linjuan Huang,Zhongfu Wang,Yuxia Liu
Oxidized KGM derivatives (ODKGMs) were prepared via a sequential degradation-oxidation strategy. • ODKGM-50%-0.2 M exhibited superior antioxidant activity and activated the Keap1/Nrf2/ARE pathway in RAW264.7 macrophages. • The retained β-1,4-backbone and selective C6-oxidation are identified as the structural basis for superior bioactivity. • This study offers a potential strategy for developing bioactive KGM derivatives for functional foods and biomedicine. To elucidate the relationship between structural modifications and bioactivity in konjac glucomannan (KGM) derivatives, this study developed a “degradation–oxidation” sequential modification strategy to overcome the intrinsic bioactivity limitations of native KGM. Using low-molecular-weight degraded KGM (DKGM-5k) as the precursor, we synthesized a series of oxidized derivatives (ODKGMs) with controlled oxidation degrees (30%, 50%, and 90%) via the (2,2,6,6-tetramethylpiperidin-1-yl) oxyl (TEMPO)/NaClO/NaBr system. Structural analysis combined with in vitro antioxidant assays identified 50% oxidation degree as optimal for enhancing the radical-scavenging capacity of degraded KGM. Subsequent DEAE-52 cellulose chromatography yielded three homogeneous fractions, among ODKGM-50%-0.2 M exhibited the most potent cytoprotective effects by activating the Keap1/Nrf2/ARE signaling pathway. Methylation analysis confirmed that ODKGM-50%-0.2 M retains the β-1,4-glycosidic backbone, with TEMPO-mediated oxidation selectively targeting the C6 primary hydroxyl groups. These structural features, together with the degree of oxidation, appear critical for the observed cellular bioactivity. However, the present findings are limited to in vitro models, and the precise molecular interactions between ODKGM-50%-0.2 M and the Keap1-Nrf2 complex remain to be verified. Collectively, this study provides a scientific basis for the rational design of bioactive polysaccharide-based antioxidants and positions ODKGM-50%-0.2 M as a promising candidate for functional food and biomedicine applications; its in vivo efficacy and mechanism will be investigated in future studies. Download: Download high-res image (173KB) Download: Download full-size image
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Food Chemistry-X
·
2026
·
IF 9.2
Lihua Zhang,Zhenwei Li,Siqi Yu,Guanchen Wu,Jiawei Xue,Lala Li,Wei Xu
KGM addition decreases droplet size and improves uniformity in CAS-based emulsions. • CRG addition transformed the emulsion into gel, improving the system's stability. • The emulsion gel has excellent textural properties and water-holding capacity. • The emulsion gel improved β-carotene storage stability and photostability. This study investigated the effect of κ-carrageenan (CRG) concentration on konjac glucomannan (KGM)/sodium caseinate-based emulsion gels and evaluated their protective effect on β-carotene. Adding CRG induced a sol-gel transition, resulting in structured emulsion gels. Microstructural analysis showed that the synergistic interaction between CRG and KGM facilitated the formation of a denser and more stable gel network, within which oil droplets were uniformly distributed. These structural enhancements enhanced the rheological and textural properties of the gel and increased its water-holding capacity to 98.1%. Furthermore, the gels effectively protected β-carotene during storage and ultraviolet exposure. At 1.5% CRG, 62% of the β-carotene was retained after 15 days of storage, indicating reduced oxidative degradation. Notably, 1.0% CRG provided superior photoprotection, with more than 50% of the β-carotene retained after 8 h of ultraviolet irradiation. Overall, these findings highlight the potential of KGM/CRG emulsion gels as a delivery system for lipophilic nutrients.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
·
IF 8.7
Yiren Wang,Tian Zhang,Mo Zhu,Haotian Deng
Cation–anion synergy boosts KC/KGM double-network gels, breaking single-ion regulation limits. • KGM deacetylation at high temperature and KC helical cross-linking at low temperature. • K + + CO₃ 2− /PO₄ 3− forms dense 3D network with enhanced hardness, water retention and stability. • Synergistic gels show non-Fickian diffusion and excellent water-holding capacity. Binary gels composed of κ-carrageenan (KC) and konjac glucomannan (KGM) possess broad application prospects in the food industry, pharmaceuticals and other fields. Current studies mainly focus on single-ion regulation strategies, which fail to realize the precise performance optimization of binary gels and limit their high-performance applications. This work proposed a cation-anion synergistic enhancement hypothesis and constructed high-performance KC-KGM double-network gels. With multiple characterization techniques, the regulation rules and intrinsic mechanism of different cation-anion combinations on gel properties were systematically explored. The results revealed that the synergistic system followed a two-step gelation pathway: high-temperature deacetylation of KGM and subsequent low-temperature helical cross-linking of KC. The alkaline environment induced KGM deacetylation, while K + strengthened hydrogen bonding between KC and KGM to form a dense and homogeneous three-dimensional network. For the K 2 CO 3 group, gel hardness increased significantly from 308.41 g to 1034.69 g. Moreover, the gel swelling behavior conformed to non-Fickian diffusion ( n = 0.63) mechanism, exhibiting excellent water retention capacity and structural stability. This study clarified the cation-anion-driven dual-network coupling mechanism of rigid KC network and elastic KGM network, providing theoretical basis and feasible regulation strategies for the precise design and high-performance application of such materials.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Yixiu Zhong,Youfan Zhang,Yuting Liu,Kang Zeng,Lei Fan,Qi Wang,Jianglin Zhang
Background Keloids, dermal fibroproliferative disorders, frequently reemerge after surgical intervention, potentially due to skin tension, a factor often overlooked in treatment strategies. Methods In this study, we identified Alpha cardiac muscle 1 (ACTC1) as a key cytoskeletal target in the mechano-transduction of keloids through bioinformatic analysis and in vitro experiments. We developed an adhesive hydrogel based on lipoic acid-modified konjac glucomannan (KGM-LA) , a natural polysaccharide, loaded with siACTC1. This hydrogel serves as a tension-free wound dressing to mitigate keloid proliferation. Results ACTC1 was significantly upregulated in keloid tissues and fibroblasts compared to normal controls. siACTC1 effectively reduced the proliferation, invasiveness, and levels of F-actin, α-SMA, and collagen I in keloid fibroblasts. The KGM-LA hydrogel demonstrated excellent adhesiveness, biocompatibility, injectability, and degradability, making it ideal for sustained siRNA release and tension reduction at wound sites. Notably, the siACTC1-loaded hydrogel significantly suppressed keloid growth in a mouse model by sustainably inhibiting ACTC1 and reducing mechanical tension. Conclusions Our study demonstrates that the KGM-LA-based adhesive hydrogel loaded with siACTC1 effectively inhibits keloid growth post-surgery, highlighting its potential for future clinical applications in keloid treatment.
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CARBOHYDRATE POLYMERS
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2026
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IF 13.2
Hongchao Wang,Yurong Zhao,Danting Dang,Liming Huang,Zhangming Pei,Jianxin Zhao,Hao Zhang,Wei Chen,Wenjun Wu,Wenwei Lu
Prediabetes, a prevalent metabolic condition characterised by elevated blood glucose levels not reaching type 2 diabetes mellitus criteria, represents a critical intervention window for diabetes prevention. Konjac glucomannan (KGM) exhibits efficacy in diabetes management, but the structure–function relationships underlying its bioactivity are poorly defined. This study investigated the impact of acetylation degree (DS) on KGM's anti-prediabetic potential. Structural characterisation revealed that acetylation and deacetylation altered DS while preserving the KGM's backbone, accompanied by changes in molecular weight and viscosity. Given the pivotal role of gut microbiota in the development of diabetes, in vitro fermentation experiments using faeces from prediabetic individuals revealed that KGM with varying DS (AcKGM) enriched Bacteroides uniformis and Bacteroides coprocola , with enrichment positively correlating with DS. Consistently, mono-culture assays demonstrated preferential utilization of highly acetylated AcKGM by both species. Prediabetic animal experiments further demonstrated that AcKGM improved glucose and lipid metabolism, suppressed inflammation, and ameliorated hepatosteatosis, in a DS-dependent manner. Notably, these effects were associated with DS-dependent enrichment of B. uniformis and upregulation of beneficial faecal metabolites, including D-pantothenic acid. Collectively, these findings establish that higher DS enhances KGM's efficacy in modulating gut microbiota and alleviating prediabetes, providing mechanistic insights for structure-guided optimisation of KGM-based therapeutics.
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Food Chemistry-X
·
2026
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IF 9.2
Jianwei Fan,Haoyuan Wang,Zhilong Zeng,Yijia Li,Xiaoli Qin,Yao Li,Xiong Liu
The cryoprotective effects of deacetylated konjac glucomannan (DKGM) on gluten and its components in frozen dough remain unclear. This study aimed to investigate the impact of DKGM with varying degrees of deacetylation (DD) on the structural stability of gluten and its components during freeze–thaw (FT) cycles. Compared with konjac glucomannan, DKGM effectively alleviated the gluten structural “depolymerization–aggregation” process during FT cycles, with DK2 (DD, 50.21%) exhibiting the optimal cryoprotective effect. The DK2 group retained higher noncovalent interactions and disulfide bonds during FT cycles, thereby stabilizing the gluten structure. Studies on glutenin and gliadin suggest that glutenin is more susceptible to FT damage. DK2 provided the best protection for glutenin, whereas DK3 (DD, 66.61%) provided the most effective protection for gliadin. These distinct effects were likely attributable to differences in the particle size and steric hindrance of DKGM, as well as the inherent structural characteristics of the protein components.
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Polymers
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2018
·Vol. 11
·期 1
·6
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IF 2.935
Rongfei Zhang,Xiangyou Wang,Juan Wang,Meng Cheng
In this study, thekonjac glucomannan(KGM)/carrageenan(KC)/nano-silica film was prepared and characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD). The preservation quality of white mushrooms (Agaricus bisporus) packed using the films was also determined. The nano-silica dosage was found to affect the properties of the nanocomposite KGM/KC films. The results indicated that the properties of the films were significantly improved with the addition of nano-silica. The water vapor permeability, water solubility, moisture absorption, and light transmittance of KGM/KC/nano-silica films were significantly affected by the nano-silica dosage. In this study, the optimal nano-silica dosage to incorporate into the film in order to achieve excellent performance was 0.3%. Strong intermolecular hydrogen bonds were also observed between KGM/KC and nano-silica in the KGM/KC/nano-silica film by FTIR. In addition, the KGM/KC/nano-silica film markedly reduced the browning index, delayed the weight loss and softening, and extended the shelf life of mushrooms during storage at 4 °C. The KGM/KC film modified using nano-silica can provide a potential method for improving the preservation quality of white mushrooms during storage.
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Food Chemistry-X
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2026
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IF 8.2
Geng Cao,Zuoqian Yang,Xiangzheng Li,Xiaoyang He,Shuang Song,Chengrong Wen
The novel alternative of nutrition balance with plant and animal proteins is becoming the main component of nutrition in the modern diet. The properties of gluten, surimi and gluten/surimi mixture (GS) were analyzed after treatment with Konjac glucomannan (KGM), ultrasound (U) and Konjac glucomannan ultrasound (UKGM). Molecular weight, fluorescence intensity, intermolecular force, free sulfhydryl, microstructure, SDS-soluble protein and free amino acid content were investigated. All treatments increased the maximum fluorescence intensity (I max ), free sulfhydryl (SH), and free amino groups of gluten. Treatment with KGM and ultrasound (U) decreased the SDS-soluble protein content, SH groups, and Imax of surimi protein, whereas the UKGM treatment showed the opposite trend. In the GS, all treatments decreased the I max and SH groups, with UKGM reducing the SH content from 1.95 to 1.12 μmol/g. Consequently, the UKGM improved the interaction of gluten and surimi protein and resulted in better structural properties of the GS.
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FOOD HYDROCOLLOIDS
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2026
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IF 13.8
Jing Zhang,Yanhui Yang,Bingjie Xue,Xiangchen Lu,Zhengshi Chang,Wupeng Ge,Lili Zhao
This study investigated the structural and functional properties of composite hydrogels prepared from cold plasma (CP)-modified goat whey protein isolate (GWPI) and konjac glucomannan (KGM) for β-galactosidase (β-Gal) encapsulation. CP treatment (40 W-50 W, 10-40 s) modified GWPI structure, yielding peak surface hydrophobicity and free amino content at 50 W/40 s, which facilitated cross-linking with KGM. Composite hydrogels were fabricated under optimal CP condition (50 W/40 s) across GWPI: KGM ratios of 5:0 to 2:3. At a 4:1 GWPI:KGM ratio, the hydrogel exhibited superior network strength, mechanical properties (hardness and elasticity), water holding stability (particularly bound water retention), and crystallinity, achieving 99.36 ± 0.48% of β-Gal encapsulation efficiency and 98.57 ± 0.65% in vitro β-Gal digestion release rate. Excessive KGM content triggered phase separation, elevated free water content, and structural heterogeneity, which collectively reduced β-Gal encapsulation efficiency. These findings confirmed that synergistic modulation of CP-modified GWPI and GWPI: KGM ratios enabled simultaneous optimization of hydrogel structure, β-Gal encapsulation efficiency, and in vitro release kinetics.
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POLYMER ENGINEERING AND SCIENCE
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2026
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IF 3.6
Hong Qian,Huiwen Chen,Si Ouyang,Yanlin Tian,Kai Chen,Kao Wu,Qian Zhang,Fatang Jiang
The skin-friendliness of aerogels has been gradually extended into the biomedical and personal care fields. The purpose of this study is to define the skin-friendly properties as three aspects, namely comfort and fit, slippage, and irritation, and to systematically evaluate the skin-friendliness of the deacetylated konjac glucomannan (KGM)/sodium alginate (D-KS) aerogel facial mask substrate. The results indicated that deacetylated KGM interacted with sodium alginate through hydrogen bonds, showing good compatibility and forming a continuous three-dimensional network structure. The deacetylation and sodium alginate optimized the microstructure of the aerogels, resulting in a low density of 72.5 mg/cm 3 and a high porosity of 98%, as well as a high shrinkage rate of 43%, which met the requirements of a facial mask. Compared with non-woven fabric, the aerogels exhibited comfortable and fitting characteristics and had the same wettability and moisture permeability. The elongation at break of the aerogel increased by 1.5 times, the compressive strain reached 60%, the slip height decreased by 68%, and the maximum peel force increased by 53.8%. Human skin tests demonstrated that the moisture content of the stratum corneum increased by 35% to 48%. In the biosafe assays, the D-KS aerogels did not cause any negative irritation on mouse cells and skin. The D-KS aerogel retained a compressive strength retention rate of 85.3%. For the loaded allantoin, the aerogels achieved sustained release, with a cumulative release rate of 88%. Summary The skin-friendly properties of biomass aerogel were defined. It showed good compatibility between D-KGM and SA based on hydrogen bonds. The D-KS aerogels exhibited comfortable and fitting characteristics. The D-KS aerogels showed good wettability and moisture permeability. The D-KS aerogels did not cause any negative irritation to the skin.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Liying Huang,Huanglong Lin,Nitong Bu,Jie Pang,Ruojun Mu
In this work, we prepared polyvinyl pyrrolidone (PVP) microfibers incorporated water-in-oil (W/O) emulsions. The W/O emulsions were fabricated by hexadecyl konjac glucomannan (HKGM, emulsifier), corn oil (oil phase) and purple corn anthocyanins (PCAs, water phase). The structures and functions of emulsions and microfibers were characterized by confocal laser scanning (CLSM) and scanning electron microscopy (SEM), Fourier transform infrared (FT-IR), Raman and nuclear magnetic resonance (NMR) spectroscopy. The results showed that W/O emulsions exhibited good storage stability for 30 d. Microfibers presented ordered and uniform arrays. Compared with pure PVP microfiber films, the addition of W/O emulsions with PCAs improved the water resistance (WVP from 1.28 to 0.76 g mm/m 2 day kPa), mechanical strength (Elongation at break from 18.35 % to 49.83 %), antioxidation (free radical scavenging rate from 2.58 % to 16.37 %), and antibacterial activity (inhibition zone against E. coli : 27.33 mm and inhibition zone against S. aureus : 28.33 mm) of microfiber films. Results showed that microfiber film exhibited controlled release of PCAs in W/O emulsions, and about 32 % of the PCAs were released from the microfiber film after 340 min. The as-prepared microfiber films exhibited potential applications for food packaging.
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