ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Zhiquan Li,Xiucheng Zou,Guigang Zhu,Xiaoya Liu,Ren Liu
Developing efficient unimolecular visible light-emitting diode (LED) light photoinitiators (PIs) with photobleaching capability, which are essential for various biomedical applications and photopolymerization of thick materials, remains a great challenge. Herein, we demonstrate the synthesis of a series of novel PIs, containing coumarin moieties as chromophores and oxime ester groups as initiation functionalities and explore their structure–activity relationship. The investigated oxime esters can effectively induce acrylates and thiol-based click photopolymerization under 450 nm visible LED light irradiation. The initiator O-3 exhibited excellent photobleaching capability and enabled photopolymerization of thick materials (∼4.8 mm). The efficient unimolecular photobleachable initiators show great potential in dental materials and 3D printings.
研究领域:
材料科学
·
化学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Microbiology Spectrum
·
2022
·
IF 9.043
Chenghua Song,Ruichao Wen,Jiaxuan Zhou,Xiaoyan Zeng,Zi Kou,Yufeng Li,Feng Yun,Rongqian Wu
Due to the changes in pathogenic species and the absence of research on topical skin antibiotics, the therapy of skin and soft tissue infections (SSTIs) is facing more and more severe challenges. It is particularly urgent to look for alternative therapies without induction of drug resistance. UV C (UVC) light within the range of 200 to 280 nm is one of the most common techniques used to kill and/or inactivate pathogenic microorganisms. However, the traditional most commonly used wavelength of 254 nm irradiated from a low-pressure mercury lamp is hazardous to human health, being both carcinogenic and damaging to eye tissues, which limits its applications in vivo. This research aimed to investigate the antimicrobial properties and influence of 275-nm UVC light from a light-emitting diode (UVC-LED light) on wound healing time. Five bacteria, three fungi, and scalded-mouse models combined with SSTIs were used to evaluate the antimicrobial effect in vitro and in vivo. 275-nm UVC-LED light inactivated both bacteria and fungi with a very short irradiation time in vitro and induced neither DNA damage nor epidermal lesions in the mice’s skin. Furthermore, in mouse models of SSTIs induced by either methicillin-resistant Staphylococcus aureus (MRSA) or Candida albicans, the 275-nm UVC-LED light showed significant antimicrobial effects and shortened the wound healing time compared with that in the no-irradiation group. UVC-LED light at 275 nm has the potential to be a new form of physical therapy for SSTIs.IMPORTANCE As a common clinical problem, the therapy of SSTIs is facing growing challenges due to an increase in the number of drug-resistant bacteria and fungi. UV C (UVC) light sterilization has been widely used in all aspects of daily life, but there are very few reports about in vivo therapy using UVC light. It is well known that prolonged exposure to UVC light increases the possibility of skin cancer. In addition, it is also very harmful for eyes. UV irradiation with 254-nm UVC light can cause corneal damage, like thinning of the corneal epithelial layer, superficial punctate keratitis, corneal erosion, etc. In this study, we focused on looking for a more accessible light source and safer UVC wavelength, and 275-nm UVC LED light was chosen. We investigated its applicability for SSTIs therapy with relative skin safety and expected that it could be used as a new physical therapy method for SSTIs.
研究领域:
微生物学
·
生物医学工程
·
传染病
·
光疗
·
伤口护理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Chemistry
·
2021
·
IF 8.301
Wei Li,Nan Ma,Balaji Devakumar,Xiaoyong Huang
The current commercial white light-emitting diodes (LEDs) are generally based on the combination of blue LED chips and Y 3 Al 5 O 12 :Ce 3+ yellow phosphors. However, because of the lack of red component, such white LED devices exhibit cool white-light emissions with low color rendering index (Ra < 75, R9 < 0). Therefore, it is urgent to discover new blue-light-excitable yellow-emitting phosphors with enhanced red emissions for fabricating high color-quality white LEDs. In the present work, we demonstrate a novel broadband yellow-emitting CaGd 2 HfScAl 3 O 12 :Ce 3+ garnet phosphor for blue-light-excited white LEDs with improved color rendering index. The as-prepared CaGd 2 HfScAl 3 O 12 :Ce 3+ garnet phosphor possesses a cubic structure with Ia 3 ¯ d space group, and the unit cell parameters of the representative CaGd 2 HfScAl 3 O 12 :2%Ce 3+ phosphor are a = b = c = 12.450 Å, α = β = γ = 90°, and V = 1,929.59(4) Å 3 . Impressively, we find that the CaGd 2 HfScAl 3 O 12 :Ce 3+ garnet phosphor shows an intense absorption band in the 300–500 nm wavelength range with a maximum at 452 nm owing to the 4f→5d transition of Ce 3+ ions. On 452 nm excitation, the optimal CaGd 2 HfScAl 3 O 12 :2%Ce 3+ sample exhibits a broad asymmetric yellow emission band in the wavelength range of 470–750 nm with peak at 564 nm and full width at half maximum of 151 nm. The Commission Internationale de l’Eclairage chromaticity coordinates and internal quantum efficiency of the CaGd 2 HfScAl 3 O 12 :2%Ce 3+ sample are (0.4485, 0.5157) and 30.4%, respectively. Finally, a white LED device is fabricated by combing a 450 nm blue LED chip with commercial Y 3 Al 5 O 12 :Ce 3+ yellow-emitting phosphor, which generates white light with low color rendering index (CRI; Ra = 74.7, R9 = −12.7) and high correlated color temperature (CCT = 6,554 K) under the 60 mA driving current. In sharp contrast, another white LED device, which is made by coating our as-prepared CaGd 2 HfScAl 3 O 12 :2%Ce 3+ yellow-emitting phosphors onto the surface of a 450 nm blue LED chip, produces white-light emission with high CRI value (Ra = 84.5, R9 = 26.3) and relatively low CCT of 5,649 K. This work reveals that the newly discovered broadband yellow-emitting CaGd 2 HfScAl 3 O 12 :Ce 3+ phosphors can serve as a potential color converter in high-color-quality phosphor-converted white LEDs.
研究领域:
材料科学
·
光学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 35
·7046-7054
·
IF 4.726
Liru Cui,Feng Zhang,Qian Wang,Huiming Lin,Chunyu Yang,Ting Zhang,Ruihan Tong,Na An,Fengyu Qu
A novel near infrared (NIR)-triggered anticancer drug delivery system has been successfully constructed. Firstly, upconversion nanoparticles (UCNPs, NaYF4:Tm,Yb@NaYF4) were synthesized as a core and mesoporous silica (mSiO2) as a shell to assemble the core–shell nanostructure (UCNP@mSiO2) as the host. Supramolecular nanovalves based on α-cyclodextrin (α-CD) torus encircling a pimelic acid thread and being held in place by a cleavable stopper (nitrobenzyl alcohol) were used as nanoscopic caps to block the pore and inhibit drug diffusion. Upon irradiation with a 980 nm laser on the nanocomposites, the emitted ultraviolet light (UV, 360 nm) photocleaved the o-nitrobenzyl (ONB) photolabile group, causing these α-CD caps to dissociate from the stalk and release the drug. The “Ladder” pulsatile release-profiles, regulated by varying the intensity and time duration of NIR irradiation, further reveal the light-triggered release performance. In addition, without NIR irradiation, few immaturities ensure the high pharmacological efficacy. Moreover, the elaborate cell experiments, by using HeLa as model cancer cells, were also carried out to reveal the good biocompatibility, fast uptake and NIR light-sensitive toxicity. Therefore, the novel NIR light-triggered drug delivery system displays great potential for cancer therapy.
研究领域:
生物医学工程
·
纳米医学
·
癌症治疗
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2021
·Vol. 38
·期 2
·516-521
·
IF 1.307
Kang Xiaoying,Yuan Yuan,Xu Huaping,Chen Yulan
T hermal- and light-driven diselenide metathesis reactions with different types of diselenides are investigated systematically. Their exchange reaction rates and equilibrium conversions are compared in the aspects of the different diselenide structures, activation conditions and solvents. As a result, the metathesis reactions between diselenide small molecules are demonstrated with high dynamic and sensitive features, which can be broadly tuned by varying the electron affinity and aromaticity of the diselenide substituents and external conditions( e.g. , solvent, stimulus mode). The current work thus will not only advance our understanding on diselenide metathesis chemistry, but also promote concrete and impactful studies in selenium-containing materials.
研究领域:
化学
·
材料科学
✓ 已验证
DOI
高影响因子
Scientific Reports
·
2018
·Vol. 8
·期 1
·1-6
·
IF 4.122
Chen Yingying,Lu Hang,Xiu Fei,Sun Tao,Ding Yamei,Liu Juqing,Huang Wei
Building transient electronics are promising and emerging strategy to alleviate the pollution issues from electronic waste (e-waste). Although a variety of transient devices comprising organic and inorganic materials have been described, transient light emitting devices are still elusive but highly desirable because of the huge amount of lighting and display related consumer electronics. Here we report a simple and efficient fabrication of large-area flexible transient alternating current electroluminescent (ACEL) device through a full-solution processing method. Using transparent flexible AgNW-polymer as both electrodes, the devices exhibit high flexibility and both ends side light emission, with the features of controlled size and patterned structure. By modulating the mass ratio of blue and yellow phosphors, the emission color is changed from white to blue. Impressively, the fabricated ACEL device can be thoroughly dissolved in water within 30 min. Our strategy combining such advances in transient light emitting devices with simple structure, widely used materials, full solution process, and high solubility will demonstrate great potential in resolving the e-waste from abandoned light-emitting products and expand the opportunities for air-stable flexible light emitting devices.
研究领域:
材料科学
·
柔性电子学
·
环境可持续性
·
光电子学
✓ 已验证
DOI
高影响因子
MATERIALS LETTERS
·
2015
·
IF 2.489
Jingzhong Zhao,Weiqiang Xing,Yang Li,Kathy Lu
Oxygen-deficient anatase TiO 2 sheets with dominant (001) facets are becoming a hot research topic due to their promising high activity in heterogeneous reactions . In this work, a series of (001) facets dominated TiO 2 with distributed oxygen vacancies and Ti 3+ was prepared by a simple hydrothermal method with the TiB 2 as a precursor. The as-prepared powders were characterized by X-ray diffraction (XRD), Scanning electron microscope (SEM), Transmission Electron Microscope (TEM), X-ray photoelectron spectroscopy (XPS) and UV–visible diffuse reflectance spectroscopy (UV–vis). The results show that the particle size of as-prepared TiO 2 increases and its band gap narrows with the hydrothermal temperature increasing from 140 °C to 180 °C. Besides, oxygen vacancies and Ti 3+ are generated during the TiB 2 hydrolysis, which leads to new absorption spectrum in the visible light region. Photocatalytic test shows that sample prepared at 180 °C presents the highest degradation efficiency.
研究领域:
材料科学
·
光催化
·
纳米材料
·
表面化学
·
半导体材料
✓ 已验证
DOI
高影响因子
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
·
2006
·Vol. 1758
·期 7
·846-857
·
IF 4.224
Lisa M. Miller,Paul Dumas
Fourier transform infrared micro-spectroscopy (FTIRM) and imaging (FTIRI) have become valuable techniques for examining the chemical makeup of biological materials by probing their vibrational motions on a microscopic scale. Synchrotron infrared (S-IR) light is an ideal source for FTIRM and FTIRI due to the combination of its high brightness (i.e., flux density), also called brilliance, and broadband nature. Through a 10-μm pinhole, the brightness of a synchrotron source is 100–1000 times higher than a conventional thermal (globar) source. Accordingly, the improvement in spatial resolution and in spectral quality to the diffraction limit has led to a plethora of applications that is just being realized. In this review, we describe the development of synchrotron-based FTIRM, illustrate its advantages in many applications to biological systems, and propose some potential future directions for the technique.
研究领域:
生物物理学
·
分析化学
·
光谱学
·
分子生物学
·
组织学
✓ 已验证
DOI
高影响因子
Journal of Physical Chemistry Letters
·
2024
·
IF 4.8
Fuyi Zhou,Chang Yi,Jianhong Wu,You Ke,Yuyang Zhang,Nana Wang,Jianpu Wang
Mixing iodide and bromide in three-dimensional metal-halide perovskites is a facile strategy for achieving red light-emitting diodes (LEDs). However, these devices often face challenges such as instability in electroluminescence spectra and low brightness due to phase segregation in mixed-halide perovskites. Here, we demonstrate spectrally stable and bright red perovskite LEDs by substituting some of the halide ions with pseudohalogen thiocyanate ions (SCN–). We find that SCN– can occupy halogen vacancies, thereby releasing microstrain and passivating defects in the perovskite crystals. This leads to the suppression of mixed-halide phase segregation under electrical bias. As a result, the red perovskite LEDs exhibit a high brightness of >35 000 cd m–2 with stable Commission Internationale de l’Eclairage (CIE) coordinates of (0.713, 0.282). This brightness surpasses that of the best-performing red perovskite LEDs, showing great promise for advancing perovskite LEDs in display and lighting applications.
研究领域:
材料科学
·
光电子学
·
固体物理学
·
纳米技术
✓ 已验证
DOI
高影响因子
Journal of Physical Chemistry Letters
·
2016
·
IF 8.539
Xiaoyu Zhang,Chun Sun,Yu Zhang,Hua Wu,Changyin Ji,Yahui Chuai,Peng Wang,Shanpeng Wen,Chunfeng Zhang,William W. Yu
The high photoluminescence efficiency, high color purity, and easy tunable bandgap make inorganic perovskite nanocrystals very attractive in luminescent display applications. Here, we report a color-saturated, red light-emitting diode (LED) using an inverted organic/inorganic hybrid structure and perovskite nanocrystals. We demonstrated that through a simple post treatment to the perovskite nanocrystals with polyethylenimine, the surface defects of the perovskite nanocrystals could be well passivated, leading to great enhancements on their absolute photoluminescence quantum yield and photoluminescence lifetime. Through using a well-passivated perovskite nanocrystal film and optimizing the charge balance, we achieved an electroluminescence LED with a current efficiency of 3.4 cd A–1, corresponding to an external quantum efficiency (EQE) of 6.3%, which is the highest value reported among perovskite NC LEDs so far.
研究领域:
材料科学
·
光电子学
·
纳米技术
·
固体物理
✓ 已验证
DOI
高影响因子
Research
·
2020
·
IF 0
Fengtong Ji,Ben Wang,Li Zhang
Micro/nanomachines have attracted extensive attention in the biomedical and environmental fields for realizing functionalities at small scales. However, they have been rarely investigated as active nanocatalysts. Heterogeneous nanocatalysts have exceptional reusability and recyclability, and integration with magnetic materials enables their recovery with minimum loss. Herein, we propose a model active nanocatalyst using magnetic nanomotor ensembles (MNEs) that can degrade contaminants in an aqueous solution with high catalytic performance. MNEs composed of a magnetite core coated with gold nanoparticles as the nanocatalyst can rotate under the action of a programmable external field and carry out rapid reduction of 4-nitrophenol (4-NP). The hydrogen bubbles generated in the catalytic reaction provide random perturbations for the MNEs to travel in the reaction solution, resulting in uniform processing. The reduction can be further boosted by irradiation with near-infrared (NIR) light. Magnetic field induces the rotation of the MNEs and provides microstirring in the catalysis. Light enhances the catalytic activity via the photothermal effect. These MNEs are also capable of moving to the targeted region through the application of a programmable magnetic field and then process the contaminant in the targeted region. We expect that such magnetic MNEs may help better in applying active heterogeneous nanocatalysts with magnetic field and light-enhanced performance in industrial applications due to their advantages of low material cost and short reaction time.
研究领域:
纳米技术
·
环境科学
·
生物医学工程
✓ 已验证
DOI
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Zizheng Fang,Yunpeng Shi,Yuhua Zhang,Qian Zhao,Jingjun Wu
To realize a wide range of applications using three-dimensional (3D) printing, it is urgent to develop 3D printing resins with different functions. However, the design freedom of the resin formulation is greatly limited to guarantee fast gelation during 3D printing. Herein, we report a reconfigurable polymer network that is compatible with digital light processing (DLP) 3D printing. The properties of the printed objects can be remanipulated by post-thermal treatment, during which the polymer network undergoes significant changes through the amidation of ester. The Young’s modulus could be significantly reduced by 50 times. Specifically, a well-printed rigid part can be completely turned into a low-viscosity liquid. This strategy decouples the printing process and the final material properties, providing an efficient approach to print various functional objects.
研究领域:
材料科学
·
3D打印技术
·
高分子化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）