ACS Omega
·
2025
·
IF 4.3
Wenwen Chen,Rong Chen,Yutong Sun,Han Wang,Zhenyu Chen,Liqun Chen,Guoming Huang,Guifang Lin,Dengke Hong
The gut bacteria not only play a crucial role in maintaining human health but also exhibit close associations with the occurrence of numerous diseases. Understanding the physiological and pathological functions of gut bacteria and enabling early diagnosis of gut diseases heavily relies on accurate knowledge about their in vivo distribution. Consequently, there is a significant demand for noninvasive imaging techniques capable of providing real-time localization information regarding gut bacteria. In this work, we developed a second near-infrared (NIR-II) fluorescent nanoprobe labeling-based visualization strategy for real-time tracking of the biodistribution of Gram-negative bacteria in the gastrointestinal tract of mice. By utilizing positively charged silver sulfide quantum dots (Ag2S QDs) as NIR-II nanoprobes and exploiting electrostatic interactions to efficiently label the Gram-negative probiotic Escherichia coli Nissle 1917 with negative surface charges, we have achieved rapid and effective labeling. Leveraging the exceptional NIR-II fluorescent performance of Ag2S QDs, our approach enables high spatiotemporal resolution visualization via NIR-II imaging in mouse gastrointestinal areas where Ag2S QD-labeled probiotics are present, facilitating real-time in vivo tracking capabilities for these labeled probiotics. This work not only establishes a powerful intestinal bacterial imaging strategy but also introduces novel concepts for constructing nanomaterial-bacteria hybrid systems.
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Yi Li,Dongfang Liu,Ting Chen,Jianwen Song,Xuya Yu,Qian Liu,Ji Qi,Wen Li
Acute lung injury (ALI) poses a significant and escalating medical challenge, where precise diagnosis and timely intervention hold utmost importance in halting its deterioration. Nevertheless, persistent obstacles arise from the lack of agents proficient in both real-time diagnosis and efficient mitigation of ALI. Here, a biocatalytic and second near-infrared (NIR-II) fluorescence-illuminating nanoplatform is designed to simultaneously facilitate real-time monitoring and robust inflammation alleviation in ALI. The study first develops a new aggregation-induced emission luminogen with trifluoromethyl substitutions, which simultaneously increase NIR-II emission wavelength and fluorescence brightness. The molecular probe is further integrated into biocatalytic hollow ceria nanostructures, and cloaked with pre-activated macrophage membranes for targeted inflammation intervention. Upon inhalation administration in ALI mice, the theranostic nanoagents leverage the bright NIR-II emission and active inflammation-tropic properties for in vivo sensitive NIR-II imaging of ALI, which also facilitates real-time tracking of the nanoagents’ distribution and dynamic fate within pneumonia milieu. Concurrently, the catalytic prowess of the nanoplatforms efficaciously scavenges excess reactive oxygen species, dampens proinflammatory cytokines, and promotes macrophage repolarization, substantially alleviating acute lung damage. The multifaceted nanoplatform integrates NIR-II bioimaging with nanocatalysis-mediated immunoregulation, offering a versatile and promising approach for addressing the intricate challenges posed by acute inflammation diseases.
✓ 已验证
产品关联
DOI
高影响因子
Inorganic Chemistry Frontiers
·
2024
·Vol. 11
·期 15
·4711-4720
·
IF 6.1
Zhexuan Gao,Yi Zhang,Yinyan Li,Shilong Zhao,Peng Zhang,Xiaolong Dong,Degang Deng,Shiqing Xu
The second near-infrared window (NIR-II, 1000–1700 nm) emitting phosphor is a key component for the phosphor-converted light-emitting diode (pc-LED), which has garnered significant attention. However, it remains a major challenge to discover efficient NIR-II broadband phosphors that can be excited by blue LEDs. Herein, Cr3+ and Ni2+ ions were co-doped into the Li2ZnSn3O8 (LZSO) host. LZSO:Cr3+,Ni2+ phosphor achieves a broadband NIR-II emission peak at 1465 nm with a large full width at half maximum (FWHM) of 300 nm and internal quantum efficiency (IQE) of 43.31% under excitation at 426 nm because of the efficient energy transfer (ET) from Cr3+ to Ni2+. In addition, a dual-emissive doped phosphor across the NIR-I (700–1000 nm) and NIR-II regions with a higher sensitivity at physiological temperatures was obtained. The relative sensitivity value (Sr) reaches 1.44% K−1 at 293 K, indicating that the LZSO:Cr3+,Ni2+ phosphor is a potential candidate for NIR optical thermometers in biotechnological applications. The manufactured NIR-II pc LED provides a radiative flux of 8.26 mW with a photoelectric conversion efficiency of 2.71% at a drive current of 100 mA and has promising potential in night vision, medical imaging, and spectral analysis applications.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Guodong Ren,Xuewei Wang,Jianbo Cao,Haolin Pu,Jinyao Li,Lili Yan,Sufang Ma,Lihong Li,Lixia Guo,Boye Zhang,Haojiang Wang,Bin Wang,Haipeng Diao,Wen Liu,Chengwu Zhang
Colon cancer is one kind of malignant digestive tract tumor with high morbidity and mortality worldwide, treatments for which still face great challenges. Recently emerged intervention strategies such as phototherapy and gas therapy have displayed promising effects in the treatment of colon cancer, but their application are still hindered due to insufficient tumor targeting and deeper tissue penetrating capacity. Herein, in the present study, we developed one theranostic nanoplatform Cet-CDs-SNO (CCS) to realize multimodal imaging-guided synergistic colon cancer therapy. Among the CCS, Cetuximab (Cet), one first-line clinical drugs for colorectal cancer, endowed CCS with tumor-targeting capacity and enhanced drug accumulation in tumor cells; CDs doped by Ni2+ and Mn2+ served as NIR-II photothermal therapy (PTT), chemodynamic therapy (CDT), and photothermal/magnetic resonance/fluorescence imaging (PTI/MRI/FLI) agents; SNO, a nitric oxide (NO) donor, exerted gas therapeutic (GT) effects under thermal stimulation derived from PTT. In vitro and in vivo experiments proved that CCS had excellent colon cancer-targeting ability. Proliferation of colon cancer cells and tumor growth were significantly inhibited by the administration of CCS without detectable cytotoxicity. This study presented one strategy for developing a multifunctional nanoplatform to be applied in imaging-guided precise tumor therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2025
·
IF 12.1
Pengrui Wang,Chao Zhang,Lingkai Meng,Sixin Xu,Jieying Zhang,Hao Wang,Huai-Bin Liang,Wei-Kan Wang,Jian-Ren Liu,Xingjun Zhu
As the gold-standard neuroprotective intervention against cerebral ischemia-reperfusion injury, therapeutic hypothermia (TH) exhibits clinical efficacy while the current TH strategies are limited in application due to their non-specific cooling effect causing severe side effects. Developing targeted TH strategies still remains a problem. In this work, a near infrared emissive, ischemic targeted nanocomposite is demonstrated to achieve localized TH at the ischemic-reperfusion site. Rare earth doped nanoparticle as the core of the nanocomposite generates near infrared II luminescence for the guidance of delivery process. 2H,3H-decafluoropentane and ammonium nitrate loaded in the mesoporous silica layer of the nanocomposite serve as physical and chemical cooling agents for temperature reduction in the brain. Surface ligands modified with stroke-homing peptide and reactive oxygen species cleavable ketone moieties of the nanocomposite can target the inflammatory ischemic region and the promote cooling effects. By the intranasal administration of the nanocomposite in ischemic stroke mice model, infract area and pro-inflammatory factors levels of the brain are effectively reduced and the neurological functions are preserved. This work points to a concept of localized hypothermia method via nanomaterials, which may inspire the development of TH therapy for stroke in the future.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
npj Precision Oncology
·
2025
·Vol. 9
·期 1
·1-21
·
IF 8
Li Xiaoli,Wang Jiashuo,Guo Jiaxing,Zhang Ming
Cisplatin resistance is a major challenge in laryngeal cancer treatment. Tumor necrosis factor-alpha-induced protein 2 (TNFAIP2) has been implicated in chemoresistance, though its role in laryngeal cancer remains unclear. We identified TNFAIP2 as a key gene associated with cisplatin resistance and developed a second near-infrared (NIR-II) light-responsive CRISPR-Cas9 nanosystem (APC@RBCs) to target it. In cisplatin-resistant Tu177/CDDP cells, light-activated knockout of TNFAIP2 significantly increased cisplatin sensitivity (IC50 reduced from 12.55 to 4.37 µg/mL). Mechanistic studies revealed that TNFAIP2 modulates cisplatin resistance via the NRF2 pathway, affecting oxidative stress response and epithelial-mesenchymal transition. TNFAIP2 deletion also suppressed cancer cell migration and invasion. Our results establish TNFAIP2 as a critical mediator of chemoresistance and demonstrate the potential of APC@RBCs as a precise, non-invasive gene therapy platform. This strategy offers a promising approach to overcoming cisplatin resistance and improving treatment outcomes in laryngeal cancer patients.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Jie Meng,Shuang Xie,Zhanlin Zhang,Pan Ran,Xia Lei,Long He,Xiaohong Li
Pyroelectrodynamic therapy (PEDT) of tumors faces challenges due to its low electrocatalytic efficiency at mild temperature and the potential for off-target toxicity to healthy tissue. To overcome these issues, we have engineered pyroelectric nanoparticles (NPs) that feature a pH-triggered heterojunction structure and tumor-selective reactive oxidative species (ROS) production, faclitating synergistic PEDT and mild photothermal therapy (PTT). Herein, molybdenum trioxide (MoO 3 ) was deposited in-situ on the surface of tetragonal BaTiO 3 (tBT) to create tBT@MO. Subsequently, a metal-acid treatment was utrilized to hydrogenate MoO 3 , and the yielded HMO was grafted with poly(ethylene glycol) (PEG) to produce tBT@HMO-PEG. In contrast to vulnerability in normal tissues, hydrogen-doped NPs exhibit stability against H + attacks in the slightly acidic microenvironment of tumors, faclitating efficient near-infrared II (NIR-II) absorption, and the enhanced photothermal conversion enables tumor-selective mild PTT and PEDT. The formation of heterojunctions between tBT and HMO markedly improves electron-hole separations and ROS productions, and the generated pyroelectric field selectively disrupts the membrane potentials of tumor cells, theraby promoting NP internalization. In a tumor-bearing model, NPs exhibit deep tumor penetration and widesperead ROS distribution, overcoming the limitations of the short lifespan and diffusion distance of ROS to achieve potent antitumor efficacy. Moreover, the tumor-selective PEDT and mild hyperthermia ensure treatment safety. Therefore, the innovative design of pH-triggered Schottky heterojunctions effectively mitigate off-target toxicity to normal tissue while improving the precision and efficacy of tumor therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Zhenfeng Yu,Jialing Zhou,Zi-Han Chen,Zhihua Wang,Aliyah Almomen,Ahmed Mohamed El-Toni,Aibin Liang,Yong Fan,Fan Zhang
Cancer remains a leading cause of mortality worldwide. Although chemotherapeutic agents can effectively induce tumor regression, they often cause severe vascular damage that adversely affects patient prognosis. To address this issue, using the representative chemotherapeutic agent doxorubicin (DOX) as the model, a biocompatible rare-earth nanoagent capable of dual-wavelength emission in the UV and NIR-IIb (1500–1700 nm) regions upon excitation at 980 and 808 nm is reported. This unique property endows the spatiotemporally controlled release of Angiopoietin-1 (Ang-1), guided by NIR-IIb imaging, to promote vascular repair following DOX chemotherapy. Furthermore, the system allows for real-time monitoring of angiogenesis to assess therapeutic efficacy. In a 4T1 tumor-bearing mouse, this combined strategy reduced the number of abnormal vascular branches by ≈50% at each time point and significantly prolonged the survival time of mice. This study introduces a novel therapeutic paradigm that integrates tumor eradication with concurrent nanomedicine-driven vascular repair, paving the way for more effective and durable treatment strategies for tumors.
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-10
·
IF 17.694
Yin Xiumei,Xu Wen,Zhu Ge,Ji Yanan,Xiao Qi,Dong Xinyao,He Ming,Cao Baosheng,Zhou Na,Luo Xixian,Guo Lin,Dong Bin
The second near-infrared (NIR II) response photon up-conversion (UC) materials show great application prospects in the fields of biology and optical communication. However, it is still an enormous challenge to obtain efficient NIR II response materials. Herein, we develop a series of Er 3+ doped ternary sulfides phosphors with highly efficient UC emissions under 1532 nm irradiation. β-NaYS 2 :Er 3+ achieves a visible UC efficiency as high as 2.6%, along with high brightness, spectral stability of lights illumination and temperature. Such efficient UC is dominated by excited state absorption, accompanied by the advantage of long lifetimes ( 4 I 9/2 , 9.24 ms; 4 I 13/2 , 30.27 ms) of excited state levels of Er 3+ , instead of the well-recognized energy transfer UC between sensitizer and activator. NaYS 2 :Er 3+ phosphors are further developed for high-performance underwater communication and narrowband NIR photodetectors. Our findings suggest a novel approach for developing NIR II response UC materials, and simulate new applications, eg., simultaneous NIR and visible optical communication.
✓ 已验证
DOI
高影响因子
Advanced Science
·
2022
·Vol. 9
·期 12
·2102220
·
IF 17.521
Chenle Dong,Chen Yang,Muhammad Rizwan Younis,Jing Zhang,Gang He,Xingdi Qiu,Lian-Hua Fu,Dong-Yang Zhang,Hao Wang,Wenli Hong,Jing Lin,Xueqing Wu,Peng Huang
Intrauterine adhesions (IUAs) caused by mechanical damage or infection increase the risk of infertility in women. Although numerous physical barriers such as balloon or hydrogel are developed for the prevention of IUAs, the therapeutic efficacy is barely satisfactory due to limited endometrial healing, which may lead to recurrence. Herein, a second near-infrared (NIR-II) light-responsive shape memory composite based on the combination of cuprorivaite (CaCuSi 4 O 10 ) nanosheets (CUP NSs) as photothermal conversion agents and polymer poly( d , l -lactide- co -trimethylene carbonate) (PT) as shape memory building blocks is developed. The as-prepared CUP/PT composite possesses excellent shape memory performance under NIR-II light, and the improved operational feasibility as an antiadhesion barrier for the treatment of IUAs. Moreover, the released ions (Cu, Si) can stimulate the endometrial regeneration due to the angiogenic bioactivity. This study provides a new strategy to prevent IUA and restore the injured endometrium relied on shape memory composite with enhanced tissues reconstruction ability.
✓ 已验证
DOI
PubMed
高影响因子
Advanced Science
·
2021
·Vol. 8
·期 20
·2100894
·
IF 16.806
Chen Yang,Hongshi Ma,Zhiyong Wang,Muhammad Rizwan Younis,Chunyang Liu,Chengtie Wu,Yongxiang Luo,Peng Huang
Various bifunctional scaffolds have recently been developed to address the reconstruction of tumor-initiated bone defects. Such scaffolds are usually composed of a near-infrared (NIR) photothermal conversion agent and a conventional bone scaffold for photothermal therapy (PTT) and long-term bone regeneration. However, the reported photothermal conversion agents are mainly restricted to the first biological window (NIR-I) with intrinsic poor tissue penetration depth. Also, most of these agents are non-bioactive materials, which induced potential systemic side toxicity after implantation. Herein, a NIR-II photothermal conversion agent (Wesselsite [SrCuSi 4 O 10 ] nanosheets, SC NSs) with tremendous osteogenic and angiogenic bioactivity, is rationally integrated with polycaprolactone (PCL) via 3D printing. The as-designed 3D composite scaffolds not only trigger osteosarcoma ablation through NIR-II light generated extensive hyperthermia, but also promote in vitro cellular proliferation and osteogenic differentiation of rat bone marrow mesenchymal stem cells (rBMSCs) and human umbilical vein endothelial cells (HUVECs), respectively, and the ultimate enhancement of vascularized bone regeneration in vivo owing to the controlled and sustained release of bioactive ions (Sr, Cu, and Si). The authors' study provides a new avenue to prepare multifunctional bone scaffolds based on therapeutic bioceramics for repairing tumor-induced bone defects.
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2018
·Vol. 28
·期 51
·1803815
·
IF 13.325
Lingyu Zhang,Shengnan Li,Xiangjun Chen,Tingting Wang,Lu Li,Zhongmin Su,Chungang Wang
The development of novel Janus nanostructure with desired compositions and functionalities is essential for various applications, especially as drug delivery system to deliver multiple payloads with total different solubility. Here, a unidentified flying object (UFO)-like cyclodextrin–palladium nanosheet/zeolitic imidazolate framework-8 Janus nanoparticle (CD–PdNS/ZIF-8 JNP) prepared via a selective coating of polyacrylic acid (PAA) on one of the flat surfaces of 2D PdNS followed by further formation of ZIF-8 on a PAA template, and alternative modification of CDs on exposed PdNS surface is reported. The CD-PdNS and PAA-ZIF-8 parts are designed to load hydrophobic10-hydroxycamptothecin (HCPT) and hydrophilic doxorubicin (Dox) independently for synergistic chemotherapy (combination index = 0.65). Because of the broad near-infrared (NIR) absorption band of PdNSs, the photothermal effect of UFO-like CD-PdNS/ZIF-8 JNPs in NIR-II biowindow is studied. The in vitro and in vivo results show that the dual-drug loaded JNPs under a laser-irradiation group present highest cancer therapeutic efficiency. The good performance is due to the synergistic chemotherapy and photothermal therapy in NIR-II biowindow. This work significantly broadens the application prospects of metal–metal organic framework JNPs by rationally designing their compositions and discovering related physiochemical properties.
研究领域:
纳米技术
·
癌症治疗
·
材料科学
·
药物递送系统
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）