MACROMOLECULAR RESEARCH
·
2023
·Vol. 31
·期 6
·625-633
·
IF 2.4
Fan Zhuanzhuan,Xu Weizhong,Wang Ruofei,Wu Huaping,Liu Aiping
Hydrogel actuators have potential applications in many fields because of their multiple responsiveness to environmental stimuli. However, it is still very challenging to design a hydrogel actuator with simple preparation, fast response, and good mechanical properties. In this work, a facile and convenient method to obtain a fast responsive hydrogel actuator has been successfully developed by embedding uniform inorganic particles into Poly(N-isopropylacrylamide) hydrogel network to form an asymmetric structure. By controlling the types and contents of inorganic particles, a wide range of adjustable actuation property can be achieved. At the same time, the introduction of inorganic particles greatly increases the mechanical properties of hydrogels, which is also very important for actuation performance improvement of hydrogel actuators. The optimized hydrogel exhibits relatively fast bending deformation under thermal stimulation (60 ℃), with a bending velocity of about 13.0° s −1 within first 10 s and a bending amplitude of about 328.1° within 1 min. The hydrogel can be designed to be temperature-controlled claw actuators with programmable shapes, indicating its application prospects in encapsulating, grasping, and transporting objects in water environment. Graphical We successfully designed and manufactured hybrid hydrogels with an asymmetric structure and improved mechanical property by adding inorganic particles to the PNIPAM hydrogel. The hybrid hydrogel with optimized SiO 2 particles shows superior actuation properties due to bigger different in the swelling rates on both sides of hybrid hydrogels. The flexible and controllable deformation of the hydrogel actuator provides an inspiration for intelligent soft actuator in water environmental applications.
研究领域:
材料科学
·
高分子科学
·
软体机器人
·
智能材料
·
驱动器
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry C
·
2023
·Vol. 11
·期 20
·6741-6749
·
IF 6.4
Changhao Qian,Yueqin Li,Lingke Liu,Chen Chen,Lin Han
Integration of mechanical and actuation properties with sensory feedback function in soft actuators remains a challenge. Herein, a highly stretchable and electrically conductive hydrogel with fast stimuli-responsive actuating performance is prepared by in situ growth of polyaniline (PANI) nanoparticles in the Pluronic F127 diacrylate (F127DA) cross-linked poly(N-isopropyl acrylamide) (PNIPAM) hydrogel matrix. The obtained PNIPAM/PANI hydrogel exhibits high stretchability (730%) and fast deswelling properties upon heating. Taking advantage of highly efficient photothermal conversion of the embedding PANI, this hydrogel shows a significant temperature rise of ∼50 °C within 150 s and large volume shrinkage of 65% upon near-infrared (NIR) light irradiation. Accordingly, the hydrogel is explored as an underwater actuator, which has achieved programmable deformations to simulate hand-like gestures and Venus flytrap-type locomotion under local NIR irradiation. In addition, the hydrogel is able to translate the local strain into electrical signals. The light-triggered actuation, including bending, weight lifting and moving objects can be monitored by real-time resistance change. These results confirm that actuating and real-time sensory feedback could be integrated in a single homogeneous material, which make it an outstanding candidate in soft actuators and even intelligent biomimetic devices.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2016
·Vol. 16
·期 1
·246-252
·
IF 1.338
Jiang Wei,Chen Binhua,Wu Juan,Xu Shanshan,Tian Renbing
The thermo-sensitive magnetic fluorescent trifunctional nanocomposite (Fe3O4/ZnS@PNIPAM) has been synthesized via a facile route. The obtained biocompatible nanocomposite was composed of monodisperse heterostructural Fe3O4/ZnS core and a thermo-sensitive
poly(N-isopropyl acrylamide) (PNIPAM) shell. Fe3O4/ZnS acted as magnetic response and fluorescence luminous body, PNIPAM acted as drug loaded platform which can adsorb and release drug controllably. Fe3O4/ZnS@PNIPAM was characterized and all
of the results showed that it had excellent magnetic response, photostability and thermo-sensitivity. Moreover, the drug release studies in vitro showed that the release rate increased with increasing temperature. MTT assays in model HepG2 cells demonstrated that Fe3O4/ZnS@PNIPAM
was practically non-toxic. Thus, our results revealed that Fe3O4/ZnS@PNIPAM would be used in biomedical fields such as targeted drug delivery, as well as cancer diagnosis and treatment in the nearly future.
研究领域:
生物医学工程
·
材料科学
·
药理学
✓ 已验证
DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2013
·
IF 2.505
Guofeng Zhou,Yanbing Zhao,Jindong Hu,Liang Shen,Wei Liu,Xiangliang Yang
pNIPAM nanogels, which exhibited rich sol–gel transition behavior, have been used extensively in the biomedical fields such as drug delivery, blood vessel embolization and tissue-engineering Owing to their limitation of 3D networks, pNIPAM nanogels have low drug-loading amount and poor sustained releasing properties. In the present research, Pickering emulsion combined with solvent evaporation (PESE) is developed firstly as a new drug-loading technique of pNIPAM nanogels in our knowledge. The entrapment efficiency (EE%) reached nearly 100%, and DOX loading amount (DL%) could reach 15%. Owing to ionic bonding interaction of DOX molecules and sulfonamide groups, DOX loaded PNS nanogels by PESE (PNS-D nanogels) show a slow releasing behavior, only 13.2% for 48 h in pure water, without any burst release. As the ionic strength of media increased, the DOX-releasing amount from PNS-D-10 nanogels increased to 29.5%, 41.6% and 48.0% respectively in 0.9 wt%, 3.0 wt% and 5.0 wt% of NaCl solutions for 48 h. The loading DOX has significant effect on the rheologic behavior of nanogel dispersions. PESE technique is hopeful to be developed as a universal hydrophobic drug loading method of nanogels, and will be extensively applied in drug delivery and tissue engineering.
研究领域:
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2014
·Vol. 21
·期 7
·1-8
·
IF 1.897
Wang Jun,Zhao Weiqian,Lu Xuelian,Li Wuke
In this paper, the temperature-sensitive luminescent particles with core-shell structure were synthesized by grafting poly (N-isopropylacrylamide) (PNIPAM) to the exterior surface of lanthanide-polyoxometalates (Ln-POM). The Ln-POM/PNIPAM nanoparticles were characterized by FT-IR, UV–vis spectra, thermogravimetric analysis, transmission electron microscopy, scanning electron microscope, dynamic light scattering and luminescence spectra. The results showed that the smart nanoparticles were spherical and had fine core-shell structure. The luminescent spectra showed that the luminescence properties of smart Ln-POM/PNIPAM nanoparticles were changeable in response to temperature stimuli. The luminescent nanoparticles have potential applications in luminescent probes and labels for biomedicine.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Wen Deng,Xingyue Liu,Yuzhou Yang,Liucheng Meng,Yanling Lou,Peng Li,Lei Zhang,Weibing Wu
Surface-enhanced Raman scattering (SERS) is a highly sensitive technology to detect target analytes. The construction of dynamic “hot-spots” represents a significant approach to enhancing detection sensitivity. Herein, a hybrid plasma platform with dynamic “hot-spots” was developed for SERS recognition based on the assembly of gold nanospheres (AuNSs) on temperature-sensitive bacterial cellulose (BC) film grafted with poly( N -isopropylacrylamide) (PNIPAM). The dynamic “hot-spots” structure was regulated in-situ by local conformational contraction of the grafted thermoresponsive PNIPAM around the BC backbone without changing the overall morphology of the substrate. Moreover, the heating process was simplified by utilizing the plasma photothermal effect of AuNSs to regulate the “hot-spot” structure. The dynamic regulation measured value of the Raman signal of Rhodamine 6G (R6G) was increased by 6.5-times, and the SERS substrate exhibited extremely high sensitivity with a limit of detection (LOD) of 8.47 × 10 −9 g/L and a relative standard deviation (RSD) of 9.24 %. Meanwhile, it can accurately detect the pesticide residues of thiram on apple peel with the detection limit of 6.54 × 10 −11 g/L. This dynamic “hot-spot” modulation strategy via local structural regulation has significant potential to improve the convenience, flexibility, and sensitivity of on-site SERS detection.
研究领域:
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2013
·
IF 3.172
Yecang Tang,Li Liu,Jianhua Wu,Jixiong Duan
We report on the synthesis and self-assembly behavior of a well-defined double hydrophilic brush–coil copolymer with poly( N -isopropylacrylamide)- b -poly(glycidly methacrylate) (PNIPAM- b -PGMA) as backbone and poly( l -glutamic acid) (PLGA) as brush. The PNIPAM- b -PGMA was firstly prepared by the sequential reversible addition–fragmentation chain transfer polymerization of N -isopropylacrylamide and glycidly methacrylate. The obtained diblock copolymer was reacted with ethylenediamine (EDA) yielding the aminated macroinitiator (PNIPAM- b -PGMA-EDA), which was then used to initiate ring-opening polymerization of γ -benzyl- l -glutamate- N -carboxyanhydride (BLG-NCA) to give PNIPAM- b -(PGMA- g -PBLG) copolymer. After the deprotection of benzyl groups on PBLG, double hydrophilic brush–coil copolymer, PNIPAM- b -(PGMA- g -PLGA), was obtained. The thermo- and pH-responsive micellization behaviors of PNIPAM- b -(PGMA- g -PLGA) in aqueous solution were investigated by fluorescence spectroscopy, 1 H NMR, dynamic light scattering, scanning electron microscopy, and circular dichroism. It can self-assemble into PNIPAM-core micelles at pH 10 and elevated temperature and PLGA-core micelles at pH 4 and room temperature. Such brush–coil copolymers have the potential applications as biomedical and intelligent materials.
研究领域:
高分子化学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Advances
·
2021
·Vol. 2
·期 6
·2120-2131
·
IF 0
Chaoshi Chen,Muhammad Atif,Kang He,Miao Zhang,Lijuan Chen,Yanmei Wang
In this work, binary mixed polymer brushes based on poly[(2-methyl-2-oxazoline)-random-glycidyl methacrylate] (PMOXA-r-GMA) and poly(glycidyl methacrylate)-block-poly(N-isopropyl acrylamide)-block-polystyrene (PGMA-b-PNIPAM-b-PSt) were used as thermoresponsive coating to control protein adsorption. Firstly, PMOXA-r-GMA was synthesized via cationic ring opening polymerization of 2-methyl-2-oxazoline followed by its copolymerization with glycidyl methacrylate (GMA); PGMA-b-PNIPAM-b-PSt was synthesized by reversible addition–fragmentation chain transfer polymerization of GMA, N-isopropyl acrylamide, and styrene sequentially. Then the mixed brushes were fabricated successfully by spin coating the mixture of PMOXA-r-GMA and PGMA-b-PNIPAM-b-PSt solutions onto silicon or glass substrates followed by an annealing protocol using GMA segments as an anchor. Afterwards, the investigation for adjusting the hydrophobic property of mixed brushes was performed. The results showed that when the environmental temperature is lower than the lower critical solution temperature (LCST) of PNIPAM, the tethered PNIPAM blocks are swollen and could bring the hydrophobic PSt block with optimum molar mass to the surface; when the environmental temperature is higher than the LCST of PNIPAM, the PNIPAM blocks collapse and could bring the hydrophobic block inside the hydrophilic PMOXA grafted polymer layer. Finally, the protein adsorption on mixed polymer brushes was investigated using a fluorescein isothiocyanate-labelled protein assay and ellipsometrys. The results showed that under the optimum molar mass of PSt block, mixed brushes could adsorb proteins in large quantities below the LCST of PNIPAM, and display resistance to protein adsorption above the LCST of PNIPAM.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2018
·
IF 3.141
Yu Wang,Fang Zhao,Jie Wang,Ali Raza Khan,Yulin Shi,Zhang Chen,Kaiqiang Zhang,Li Li,Yanfeng Gao,Xuhong Guo
VO2/PNIPAm hybrid thermochromic material has been verified as promising to improve optical performance of smart windows. However, VO2 can be easily oxidized especially when being dispersed in the hydrogel matrix, and also the nonuniform dispersion of VO2 in a host will worsen the material’s optical performance. Herein, pure VO2(M)@SiO2 nanoparticles (NPs) were first prepared using a surfactant-free method. Then VO2(M)@SiO2/PNIPAm hybrid microgels were synthesized through suspension polymerization. The VO2(M)@SiO2 NPs in the hydrogel matrix exhibited obviously improved resistance to oxidation. Monodispersed hybrid microgel with uniformly distributed VO2(M)@SiO2 NPs (Sample I) was obtained. Meanwhile, compared with the best VO2 film reported, our composite microgel (Sample III) demonstrated a 164% increase in the solar modulating ability at a relatively high average luminous transmittance (38.4%). All these remarkable features of VO2(M)@SiO2/PNIPAm microgel synthesized in our work will help a lot in the practical application of the inorganic–organic hybrid nanothermochromic materials.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 89
·86012-86018
·
IF 3.289
Mengmeng Li,Xiaoyan Song,Tingbin Zhang,Lintao Zeng,Jinfeng Xing
In this study, an organic–inorganic temperature-sensitive polymer encapsulating tetraphenylethene (TPE) was designed. Its fluorescence intensity is sensitive to temperature changes and reaches a maximum at normal cell temperature. Firstly, the organic–inorganic hybrid polymer, polyhedral oligomeric silsesquioxane-based-poly(N-isopropylacrylamide) (POSS-b-PNIPAM) with a particular LCST of 37.5 °C, was synthesized by atom transfer radical polymerization. POSS-b-PNIPAM self-assembled in aqueous solutions to form stable micelles and then TPE was assembled into the micelles in water. The fluorescence intensity of TPE encapsulated in POSS-b-PNIPAM can be tuned by changing the temperature. The fluorescence intensity of TPE encapsulated in POSS-b-PNIPAM reached a maximum at 37 °C, which is much higher than the TPE fluorescence intensity at the same temperature. TPE encapsulated in POSS-b-PNIPAM still showed high fluorescence intensity after entering HeLa cells at 37 °C.
研究领域:
材料科学
·
高分子化学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS A-PHYSICAL
·
2024
·
IF 4.1
Wenguang Yang,Qinghao Guo,Xiangyu Teng,Zezheng Qiao,Haibo Yu
Drawing inspiration from the movement behaviour of rays in nature, we have successfully developed a ray-inspired flexible robot fish driven by visible light. A composite made of poly(N-isopropylacrylamide) (PNIPAM) and multi-walled carbon nanotubes (MWCNTs) has excellent biocompatibility and photo-responsive deformability . The PNIPAM hydrogel flexible material of the robot fish was prepared by light curing printing technology. Under the control of visible light, the robot fish swims in a straight line at an average speed of about 0.42 mm/s. The photoinduced asymmetric deformation mechanism is used to control the deformation of the fins on both sides of the robot fish, so that the robot fish can turn and realize directional swimming control. These findings have important implications for the development of flexible bionic robots and provide valuable insights for the research of bionic robots driven by visible light.
研究领域:
材料科学
·
仿生学
·
生物工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Electronic Materials
·
2024
·
IF 4.3
Chen Yue,Hanlin Zhai,Hong Zhang,Tingting Wang,Zhangpeng Li,Limin Ma,Jinqing Wang,Shengrong Yang
Herein, a poly(N-isopropylacrylamide)-based conductive composite hydrogel system coenhanced by clay and polydopamine-modified MXene was synthesized to achieve strain and temperature sensibility simultaneously. The noncovalently cross-linked network via MXene, clay, and polymer chains endowed the synthesized hydrogel with excellent mechanical properties (tensile strength at a break of 117 kPa and elongation at a break of 1723%). This hydrogel also exhibits strong adhesion and good electrical conductivity (0.13 S/m). Regarding the sensing properties, its temperature sensitivity is 2.749 °C–1, while its strain detection limit is as low as 0.05%. Based on the unique characteristics of the prepared hydrogel, the as-assembled sensor can detect stress and temperature simultaneously, exhibiting great application potential in human physiological monitoring.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）