APPLIED RADIATION AND ISOTOPES
·
2022
·
IF 1.787
Yunyun Bao,Yan Liu,Changfu Wang,Yun Wang,Dingzhong Yuan,Jianda Xu,Zuqing Zhu,Yan He,Jinbiao Liu
The adsorption and recovery of uranium from wastewater is of positive significance to the development of nuclear industry and environmental remediation. The ternary polymer (PZS-co-TA) was prepared from hexachlorocyclotriphosphazene (HCCP), 4,4-sulfonyldiphenol (BPS) and tannic acid (TA) under ultrasonic . TAC was then obtained after carbonization under high temperature from PZS-co-TA. The structure and performance of TAC were analyzed using SEM , EDS, FT-IR, XRD, Raman, BET and TG. The adsorption capacity of TAC for uranium under different static adsorption conditions was investigated. The adsorption process was more consistent with pseudo-second-order model. The maximum adsorption capacity calculated by non-linear Langmuir model was 492.5 mg/g at pH 5.5. The thermodynamic values suggested that the adsorption process was spontaneous and endothermic. Moreover, after five cycles of adsorption-desorption tests, TAC remained effective at adsorbing uranium, implying the introducing of TA to the precursor (PZS-co-TA) could enhance the adsorption capacity for uranium.
研究领域:
环境科学
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材料科学
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核工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2024
·
IF 4.5
Yuman Zhang,Yao Yu,Qi Wang,Wenjun Shi,Hanying Hu,Danqing Hou,Zhi Li
Non-alcoholic fatty liver disease (NAFLD) was a pathological syndrome characterized by excessive lipid deposition in the liver. Excessive lipid in the liver produced reactive oxygen species (ROS), the occurrence of oxidative stress and lipid peroxidation was accelerated, which aggravated liver function damage. Based on these, resveratrol, a natural antioxidan, was encapsulated in liposoluble interior by amphiphilic phosphatidylserine, and then self-assembled with chitosan oligosaccharide complexed with zinc ions to form Zn-Cos/Res@Ps nanoparticles. The size of the Zn-Cos/Res@Ps was about 168.57 ± 4.35 nm, and the zeta potential was about 17.45 ± 1.79 mV. Furthermore, Zn-Cos/Res@Ps could significantly inhibition of lipid deposition, decreased the contents of reactive oxygen species (ROS) and synergistically decreased the levels of malondialdehyde (MDA) in HepG2 cells. Zn-Cos/Res@Ps could also reduce the content of serum total cholesterol (TC), triglyceride (TG), aspartate aminotransferase (AST) and alanine aminotransferase (ALT), improved the liver injury and reduced the degree of liver fibrosis in mice. The Zn-Cos/Res@Ps group showed better results than the single-drug nanoparticle group. In conclusion, Zn-Cos/Res@Ps nanoparticles could effectively alleviate the disease progression by inhibiting oxidative stress and lipid peroxidation, promoted fatty acid catabolism, and effectively reverse and prevent the progress of nonalcoholic steatohepatitis.
研究领域:
纳米技术
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药理学
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肝病学
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分子生物学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry A
·
2015
·Vol. 3
·期 10
·5608-5616
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IF 7.443
Chan Wang,Miao Yang,Peng Tian,Shutao Xu,Yue Yang,Dehua Wang,Yangyang Yuan,Zhongmin Liu
A spherical self-assembly of SAPO-34 nanosheets was hydrothermally synthesized by using a quaternary ammonium-type organosilane surfactant [3-(trimethoxysilyl)propyl]octadecyldimethylammonium chloride (TPOAC) as the mesoporogen and a part of the silica source, and diethylamine (DEA) as the microporous template. The prepared materials were well characterized by XRD, XRF, SEM, TEM, N2 adsorption–desorption, NH3-TPD, NH3-adsorbed IR and pyridine-adsorbed IR measurements. It revealed that the morphologies, compositions and acidity of the SAPO-34 products changed significantly with the increased TPOAC/TEOS ratio, showing that the TPOAC/TEOS ratio had a significant impact on the crystallization process of SAPO-34. Solid state 13C, 29Si NMR and TG-DTA analyses were further conducted to investigate the status of TPOAC in the final products. A possible crystallization process involving TPOAC was proposed. The catalytic performances of the synthesized SAPO-34s were evaluated using the MTO reaction. The optimal SAPO-34 nanosheet assemblies with a hierarchical porous structure displayed a remarkably enhanced catalytic lifetime and high yields of light olefins.
研究领域:
材料科学
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化学工程
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催化
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无机化学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2023
·Vol. 13
·期 4
·2635-2648
·
IF 3.9
Ying Li,Yingxin Tian,Qixue Wang,Xinyi Gu,Long Chen,Yiqun Jia,Shan Cao,Ting Zhang,Mingmei Zhou,Xiaojun Gou
Gynura segetum (Lour.) Merr. (GS), has been widely used in Chinese folk medicine and can promote circulation, relieve pain and remove stasis. In recent years, the hepatotoxicity caused by GS has been reported, however its mechanism is not fully elucidated. Metabolomic techniques are powerful means to explore the toxicological mechanism and therapeutic effects of traditional Chinese medicine. The purpose of this study was to establish a serum metabolomics method based on Gas Chromatography-Mass Spectrometry (GC-MS) to explore the hepatotoxicity mechanism of different exposure times and doses of GS in rats. Sprague Dawley (SD) rats were administered daily with distilled water, 7.5 g kg−1 GS, or 15 g kg−1 GS by intragastrical gavage for either 10 or 21 days. The methods adopted included enzyme-linked immunosorbent assay (ELISA), Hematoxylin and Eosin (H&E) staining and GC-MS-based serum metabolomics. Serum biochemistry analysis showed that the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglycerides (TG), total bilirubin (TBIL) and total bile acid (TBA) significantly (P < 0.05) increased while the levels of albumin (ALB) and high-density lipoprotein (HDL) significantly (P < 0.05) decreased in GS-treated groups, compared with the control group. Interestingly, the ALT, AST, TG and ALB levels changed in a time- and dose-dependent manner. The results of H&E staining showed the degree of liver damage after administration of GS gradually deepened with the extension of administration time and the increase of the dose. According to the results of metabolomics analysis, 26 differential metabolites were identified, which were involved in 8 metabolic pathways including phenylalanine metabolism, glyoxylic acid and dicarboxylic acid metabolism and so on. Meanwhile, the number of differential metabolites in different GS-treated groups was associated with GS exposure time and dose. Therefore, we concluded that GS might induce hepatotoxicity depending on the exposure time and dose.
研究领域:
药理学
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毒理学
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代谢组学
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传统中药
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2023
·Vol. 34
·期 10
·3125-3136
·
IF 3.4
Longwei Shi,Zheng Zhao,Lishuai Zong,Jinyan Wang,Xigao Jian
Limiting molecules' polarized motion effectively reduces the dielectric loss of materials. This article synthesized side chains with different lengths using p-ethoxyphenol, p-hydroxybenzoic acid, and long-chain halohydrins through a two-step process. These chains' movement was almost unaffected by the main chain of polymers, so they can fill up the free volume of polymers under certain conditions. 1,2-dihydro-4-(4-hydroxyphenyl)phthalazine-1-(2H)-one(DHPZ), 4,4'-Difluorophenyl sulfone(DFS), and 4,4-Bis(4-hydroxyphenyl) valeric acid(HPV) obtained three polymers with different carboxyl groups (10%, 30%, and 50%) through nucleophilic substitution. They were then grafted and treated with hot-pressing. The introduction of side chains could reduce the free volume of polymers under hot-pressing conditions, so further reducing the dielectric loss of materials. Polymer with the shortest and least (10%) side chains showed the most obvious dielectric loss tangent, the reduction rate of the film's dielectric loss tangent was 13.11% (at T g + 15°C, while the non-grafted one was only 3.69%) and 20.70% (at T g + 80°C, while the non-grafted one was only 8.35%), respectively. In addition, WXRD and DMA tests showed that films' intermolecular chain spacing (“ d ”) and T g changed after the hot-pressing process, respectively. The change law of both was consistent with that of dielectric loss tangent. Confirm that grafting high-motility side chains can significantly reduce polymer's dielectric loss by enhancing the free volume reduction effect after hot-pressing.
研究领域:
材料科学
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高分子化学
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电气工程
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产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Hongju Qiu,Weiwei Huang,Yanqiong Zhang,Jin Chen,Lei Gao,Mamdouh Omran,Li Nan,Guo Chen
In the family of inorganic nanomaterials , zirconia is a highly promising functional ceramic with a high refractive index , hardness, and dielectric constant, as well as excellent chemical inertness and thermal stability. These properties are enhanced in nano-zirconia ceramics, because nanopowders have a small particle size, good morphology, and uniform and dispersive distribution. In this study, a co-precipitation process was proposed to synthesise highly dispersed MgO–Y 2 O 3 co-stabilized ZrO 2 nanopowders. The effects of different calcination temperatures on the crystallisation degree and particle dispersion of zirconia nanopowders were characterised by X-ray diffraction (XRD), thermogravimetry-differential scanning calorimetry (TG-DSC), Raman spectroscopy , Fourier transform infrared spectroscopy (FTIR), nitrogen adsorption using the Brunauer–Emmett–Teller (BET) theory, transmission electron microscopy (TEM), and field emission scanning electron microscopy (FESEM). The optimum synthesis conditions were obtained as follows: 6 h of high-energy planetary grinding and calcination at 800 °C in an electric furnace. Under these optimum conditions, the average particle size of the prepared powder was 28.7 nm. This process enriches the literature on the controllable preparation of Mg–Y/ZrO 2 nanopowders obtained by the co-precipitation method.
研究领域:
材料科学
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纳米技术
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陶瓷工程
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化学工程
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Binbin Dong,Zong Hou,Zhong Zheng,Junpeng Xing,Ningning Zhao,Zhiqiang Liu,Shu Liu
The abundant ginseng neutral polysaccharide (GPN) has been neglected due to its lower activity compared to acidic polysaccharide in ginseng. Herein, the composite enzymes were used to modify the GPN and obtained the enzymatic-degradation-GPN (EGPN). The structural changes were further characterized by GPC, FT-IR, Congo red, XRD, zeta potential, TG, cryo-SEM and AFM. The antioxidant activity of GPNs in vitro was investigated by in vitro chemical experiments and oxidative stress-related indicators on PC12 cells damaged by Aβ 25 – 35 , and EGPN showed favorable antioxidant activity. In addition, EGPN metabolized by intestinal microbiota also significantly increased the viability of injured PC12 cells. Furthermore, in vitro fermentation model was used to investigate the differences of physicochemical properties of GPNs and their regulatory effects on the microbiota. EGPN enhanced the diversity of the microbiota and increased the concentration of short-chain fatty acids (SCFAs). Importantly, EGPN demonstrated a significant reduction in the presence of detrimental bacteria such as Enterococcus and Allobaculum , while simultaneously promoting the growth of beneficial microorganisms including Lactobacillus , Prevotella , and Ruminococcu . This study highlights the potential use of EGPN prepared by composite enzymatic degradation in antioxidant, neuroprotection and restoration of intestinal homeostasis.
研究领域:
药理学
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生物化学
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微生物学
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神经科学
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生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMEDICINE & PHARMACOTHERAPY
·
2020
·
IF 4.545
Yan Li,Chunyi Wang,Yu Jin,Haibo Chen,Meiqun Cao,Weimin Li,Huanmin Luo,Zhengzhi Wu
Numerous researches supported that non-alcoholic fatty liver disease (NAFLD) was an emerging problem associated with increased visceral adiposity (obesity), diabetes and related metabolic disorders. Huang-Qi San (HQS) is composed of three traditional Chinese medicines (Astragali Radix, Pueraria Radix and Cortex Mori Radicis) with a weight ratio of 1:2:1. HQS has been reported to be effective in improving glucose-lipid metabolism, but its underlying mechanism on NAFLD has not been fully understood. The purpose of the present study was to assess the protective effects of HQS on obesity-induced hepatic steatosis in rats fed with high fat diet (HFD). Our data revealed that administration of HQS (1.2 and 2.4 g/kg body weight) resulted in significant reduction in body weight (BW) and organs coefficients of visceral fat. The full-Body CT scan demonstrated that HQS reduced liver fat ratio, visceral and subcutaneous fat mass in a dose-dependent manner. Additionally, HQS decreased plasma TC, TG, FFA and FABP4 levels, normalized glucose and insulin levels, and improved the glucose tolerance. Pathological examination showed that HQS alleviated hepatic steatosis and reduced the cell size of epididymal visceral adipose tissue. Hepatic lipid accumulation was also reduced by HQS treatment compared with HFD fed rats. RNA-Seq analysis combining with qPCR demonstrated that the mRNA expression of some important glucose and lipid metabolism-related genes including Acat2, Apoc4, Bhmt, Cyp3a62, Cyp51, Egln3 (Phd3), Fads1, Fads2, Gnmt, Hmgcs1 and Pemt, were significantly changed by HQS treatment. Taken together, these results suggested that HQS had beneficial effects on glucose-lipid metabolism and hepatic steatosis, and its mechanism might be related to the functions of the genes in regulating glucose and lipid metabolism.
研究领域:
药理学
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营养学
·
代谢学
·
分子生物学
·
基因组学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Renjie Chen,Xinyu Huang,Ruizhi Zheng,Delong Xie,Yi Mei,Ruqiang Zou
Organic phase change materials are flammable, which limits their applications in heat storage and conversion. In the presented study, a phosphorus-grafted hexadecanol was blended with pentaerythritol phosphate (PEPA) to prepare flame-retardant phase change material (FRPCM). The thermal properties of FRPCM were evaluated by means of differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and cone calorimetry. The flame-retardant mechanism was examined by thermogravimetric analysis-Fourier transform infrared spectrometry (TG-FTIR) and scanning electron microscopy (SEM) tests. The FRPCM maintains a promising heat storage capacity (186.9 J/g) and thermal stability after grafting and blending. The flame retardance analysis reveals that the grafted phosphorus group helps to promote char formation. PEPA extends the time before exposed combustible material ignites. The cone calorimeter test demonstrated that the peak heat release rate and total heat release are further decreased by more than 50%, owing to the synergistic effect between the phosphorus group and PEPA. The SEM results showed that a porous structure is formed during combustion. Self-extinguishment testing indicates that the FRPCM is extinguished in a much shorter time than is hexadecanol.
研究领域:
材料科学
·
热能工程
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
PHYTOMEDICINE
·
2022
·
IF 6.656
Chang-Long He,Yong Tang,Xue Chen,Tao Long,Yan-Ni He,Jing Wei,Jian-Ming Wu,Cai Lan,Lu Yu,Fei-Hong Huang,Cong-Wei Gu,Jian Liu,Chong-Lin Yu,Vincent Kam-Wai Wong,Betty Yuen-Kwan Law,Da-Lian Qin,An-Guo Wu,Xiao-Gang Zhou
Background Protein aggregates are considered key pathological features in neurodegenerative diseases (NDs). The induction of autophagy can effectively promote the clearance of ND-related misfolded proteins. Objective In this study, we aimed to screen natural autophagy enhancers from traditional Chinese medicines (TCMs) presenting potent neuroprotective potential in multiple ND models. Methods The autophagy enhancers were broadly screened in our established herbal extract library using the transgenic Caenorhabditis elegans ( C. elegans ) DA2123 strain. The neuroprotective effects of the identified autophagy enhancers were evaluated in multiple C. elegans ND models by measuring Aβ-, Tau-, α-synuclein-, and polyQ40-induced pathologies. In addition, PC-12 cells and 3 × Tg-AD mice were employed to further validate the neuroprotective ability of the identified autophagy enhancers, both in vitro and in vivo . Furthermore, RNAi bacteria and autophagy inhibitors were used to evaluate whether the observed effects of the identified autophagy enhancers were mediated by the autophagy-activated pathway. Results The ethanol extract of Folium Hibisci Mutabilis (FHME) was found to significantly increase GFP::LGG-1-positive puncta in the DA2123 worms. FHME treatment markedly inhibited Aβ , α-synuclein, and polyQ40, as well as prolonging the lifespan and improving the behaviors of C. elegans , while siRNA targeting four key autophagy genes partly abrogated the protective roles of FHME in C. elegans . Additionally, FHME decreased the expression of AD-related proteins and restored cell viability in PC-12 cells, which were canceled by cotreatment with 3-methyladenine (3-MA) or bafilomycin A1 (Baf). Moreover, FHME ameliorated AD-like cognitive impairment and pathology, as well as activating autophagy in 3 × Tg-AD mice. Conclusion FHME was successfully screened from our natural product library as a potent autophagy enhancer that exhibits a neuroprotective effect in multiple ND models across species through the induction of autophagy. These findings offer a new and reliable strategy for screening autophagy inducers, as well as providing evidence that FHME may serve as a possible therapeutic agent for NDs.
研究领域:
神经科学
·
药理学
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中药
·
自噬研究
·
神经退行性疾病
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymer Chemistry
·
2020
·Vol. 11
·期 40
·6529-6538
·
IF 5.342
Xiaoqiang Xue,Yangjing Chen,Kang Liang,Wenyan Huang,Hongjun Yang,Li Jiang,QiMin Jiang,Bibiao Jiang,Hongting Pu
The ring-forming behavior of polymers with an odd number of arms in highly dilute solutions has been studied using tri-arm polystyrene (PSt3) as a model through combining atom transfer radical polymerization (ATRP) and atom transfer radical coupling (ATRC) technologies. The star polymer, PSt3, with three arms and a central core was obtained by ATRP of styrene using a designed initiator with three active Br terminals and ester groups, followed by the Br terminal–Br terminal radical coupling of PSt3, which was implemented via intramolecular ATRC under high dilution conditions. A tadpole-shaped cyclic polymer (tadpole-PSt) was successfully prepared, proving that there no intermolecular side reactions that occur during the intramolecular ATRC of PSt3. Interestingly, the tadpole-PSt not only possesses a cyclic topology, but also contains a living chain, in contrast to other cyclic analogues that have been previously reported. Finally, the tadpole-PSt was used as a building block to construct a type of barbell polymer (barbell-PSt) by removing most of the solvent via vacuum distillation at the end of the intramolecular ATRC of PSt3. Size exclusion chromatography, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, 1H nuclear magnetic resonance spectroscopy and hydrolysis experiments proved that high-purity cyclic polymers (tadpole-PSt and barbell-PSt) were successfully prepared. The thermal properties of the cyclic and star polymers were analyzed using differential scanning calorimetry and thermogravimetric analysis. The results demonstrated that the formation of a cyclic topology makes a huge contribution to the increase in the glass transition temperature (Tg) and thermal stability of the polymer.
研究领域:
聚合物科学
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材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
COMPOSITES PART B-ENGINEERING
·
2021
·
IF 9.078
Hao Wang,Jun Yuan,Zongmin Zhu,Xianze Yin,Yunxuan Weng,Zhaojia Wang,Feihua Yang,Jiayu Zhan,Hua Wang,Luoxin Wang
It is always a challenge to prepare multifunctional epoxy resins (EP) composites with excellent flame retardance, mechanical property and high transparency. In this work, a reactive flame-retardant (BDO) was synthesized from DOPO, 3,5-diamino-triazolz and thiophene-2-formaldehyde, and taken to prepare EP/BDO composites. Surprisingly, benefitting from the synergy of efficient flame retardant unit (DOPO structure), catalytic curing unit (triazole structure) and optical functional structure (thiophene-2-formaldehyde), the EP composites with excellent comprehensive performance was obtained. In detailed, after adding only 5 wt% BDO, the EP composites passed the UL-94 V-0 level, and the limiting oxygen index was increased to 33% from 22.5% of neat EP. At the same time, EP/BDO-5 showed obvious heat suppression and smoke suppression effects. Besides, EP/BDO-5 presented excellent mechanical strength , that the tensile strength and bending strength were increased by 25% and 30% compared with neat EP. Moreover, EP/BDO composites maintained the same good light transmittance as neat EP, and also presented enhanced T g and dielectric property . In addition, the dual phase flame-retardant mechanism was revealed through systematically analyzing residues after combustion and the gaseous phase products of flame retardant. The above results indicated EP/BDO composites with excellent comprehensive performance possessed a great potential application in high-performance composites fields.
研究领域:
材料科学
·
高分子化学
·
复合材料
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）