JOURNAL OF APPLIED POLYMER SCIENCE
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2026
·
IF 3.1
Jingwen Qu,Min Wang,Xiankui Qian,Haijiao Xie,Xiaohua Shi
A series of tris(2-hydroxyethyl) isocyanurate (THEIC) acrylate derivatives modified with few ε-caprolactone (ε-CL) segments were synthesized via a one-pot copolymerization. The properties of the modified THEIC acrylates exhibited regular variations depending on the average caprolactone segment number (N(CL)). Specifically, as N(CL) decreased, the glass transition temperature ( T g ) increased, and the thermal stability was enhanced. A balance between toughness and strength was achieved at N(CL) = 1. Furthermore, the modified material demonstrated improved compatibility with the system and enhanced ease of use. In this one-pot procedure, the ring-opening polymerization of ε-CL and its esterification with acrylic acid proceeded concurrently. Combined DFT calculations and HPLC-MS analysis revealed that this synergistic mechanism was key to controlling the PCL segment number while significantly simplifying the process. This strategy is equally applicable to preparing other polyol acrylates. The simple procedure and good controllability hold potential for industrial application.
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ANALYTICAL CHEMISTRY
·
2019
·
IF 6.35
Jing Ye,Guoyong Liu,Mengxia Yan,Qiuju Zhu,Liping Zhu,Jianshe Huang,Xiurong Yang
Inspired by the coreactive activity of carbon nanodots (CDs) and branched polyethylenimine (BPEI) toward electrochemiluminescence (ECL) of Ru(bpy)32+, a highly luminescent and self-enhanced ECL nanohybrid (Ru-BCDs) was synthesized through covalently linking BPEI-coated carbon dots (BCDs) with Tris (4,4′-dicarboxylic acid-2,2′-bipyridyl) ruthenium(II) dichloride (Ru(dcbpy)32+). The composition and morphological characterization demonstrated that the spherical Ru-BCDs particles with 12.1 ± 1.4 nm diameter were obtained. The enhanced ECL property of Ru-BCDs was proved to originate from the dual coreactive contribution of BPEI and CDs as coreactants as well as the intramolecular electron transfer process, which could shorten the electron transfer path and minimize energy loss. A carbon nitride nanosheet (CNN) was utilized to stabilize the Ru-BCDs-modified glassy carbon electrode, which greatly improved the stability of solid-state ECL. By utilizing the affinity discrepancy of the CNN to single-stranded and double-stranded nucleic acids, a label-free and signal-on ECL biosensor was constructed for the determination of microRNA-133a (miR-133a), a potential biomarker of acute myocardial infarction. The designed biosensor exhibited good performance of miR-133a detection with a detection limit of 60 fM and could be used for the detection of real human serum with satisfactory results. The self-enhanced ECL nanohybrid with distinguished ECL efficiency holds a promising prospect in biosensing and bioimaging applications.
研究领域:
分析化学
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生物医学工程
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纳米技术
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高影响因子
Nanomaterials
·
2019
·Vol. 9
·期 2
·298
·
IF 4.034
Shufang Wu,Xunjun Chen,Minghao Yi,Jianfang Ge,Guoqiang Yin,Xinming Li,Ming He
In this study, feather keratin/polyvinyl alcohol/tris(hydroxymethyl)aminomethane (FK/PVA/Tris) bionanocomposite films containing two types of nanoparticles, namely one-dimensional sodium montmorillonite (MMT) clay platelets (0.5, 1, 3, and 5 wt%) and three-dimensional TiO2nanospheres (0.5, 1, 3, and 5 wt%), are prepared using solvent casting method. X-ray diffraction studies confirm the completely exfoliated structure of FK/PVA/Tris/MMT nanocomposites. The successful formation of new hydrogen bonds between the hydroxyl groups of the film matrix and the nanofillers is confirmed by Fourier transform infrared spectroscopy. The tensile strength, elongation at break, and initial degradation temperature of the films are enhanced after MMT and TiO2incorporation. The water vapor permeability, oxygen permeability, and light transmittance decrease with increase in TiO2and MMT contents. In summary, nanoblending is an effective method to promote the application of FK/PVA/Tris blend films in the packaging field.Keywords:feather keratin;tris(hydroxymethyl)aminomethane;sodium montmorillonite;TiO2;solvent casting;nanocomposite
研究领域:
材料科学
·
生物学
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高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2023
·
IF 9.8
Yan Yang,Mingyuan Li,Hairui Yu,Yi Tong,Qiqing Chen
Fibrous microplastics are abundant in water, and the additives on fibers could also be transported jointly, which is a combined pollution scenario prevalent in the environment. Organisms ingest microplastics directly from the environment or indirectly through trophic transfer. However, there is a dearth of available information on the uptake and effects of fibers and their additives. This study investigated the uptake and depuration of polyester microplastic fibers (MFs, 3600 items/L) by adult female zebrafish via waterborne and foodborne exposure routes and the effects on the fish behavior. Moreover, we used brominated flame-retardant tris(2,3-dibromopropyl) isocyanurate (TBC, 5 μg/L) as a representative plastic additive compound and explored MFs' effects on the accumulation of TBC in zebrafish. Results substantiated that the highest MF concentrations in zebrafish from waterborne exposure (12.00 ± 4.59 items/tissue) were approximately three times higher than foodborne exposure, suggesting waterborne exposure as the primary ingestion route. In addition, environmentally relevant MF concentrations did not affect TBC bioaccumulation via aqueous exposure. However, MFs could decrease TBC accumulation via foodborne exposure by ingesting contaminated D. magna , which was probably because MF co-exposure decreased the TBC burden in daphnids. MF exposure also considerably increased behavioral hyperactivity in zebrafish. Moved speed, travelled distance, and active swimming duration all increased when exposed to MFs-containing groups. This phenomenon remained apparent in the foodborne exposure experiment with a low MF concentration (0.67–6.33 items/tissue) in zebrafish. This study offers a deeper understanding of MF uptake and excretion in zebrafish and the accumulation of the co-existing pollutant. We also confirmed that waterborne and foodborne exposure may lead to abnormal fish behavior even at low in vivo MF burdens.
研究领域:
环境科学
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生态毒理学
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水生生物学
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高影响因子
Journal of Materials Chemistry B
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2015
·Vol. 3
·期 41
·8170-8179
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IF 4.726
Mo Sun,Heng-Yi Zhang,Qian Zhao,Xin-Yue Hu,Li-Hua Wang,Bo-Wen Liu,Yu Liu
Accurate imaging of soft tissues is one of the ultimate goals in biomedical imaging. Different imaging modalities can improve their disadvantages, and promote the imaging ability. However, once an imaging agent has been prepared, it is usually hard to adjust it according to the actual needs. Herein, we developed a supramolecular brush polymer (SBP) as a versatile imaging agent platform. The SBP platform (SBPP) is constructed by the intermolecular inclusion complexation of bridged tris(β-cyclodextrin) (1) with Mn(III)-porphyrin-bearing poly(ethylene glycol) (PEG) side chains (Mn(III)-TPP), and can further bind other functional groups by host–guest interactions of cyclodextrin and adamantine. The SBPP is characterized by UV/vis absorption spectroscopy, NMR, dynamic light scattering (DLS), atomic force microscopy (AFM) and transmission electron microscopy (TEM). We demonstrated that this SBPP not only has no cellular toxicity against NIH 3T3 cells in in vitro cell experiments, but it also shows an efficient enhanced T1 relaxivity in in vitro MR imaging experiments. When used as multifunctional imaging agents, different imaging probes and/or targeting agents can be introduced to this SBPP as needed through simple host–guest interactions. In in vitro imaging experiments, it shows accurate imaging of different kinds of cancer cells by choosing on-demand targeting agents. These results suggest a promising strategy for engineering multifunctional imaging agents with SBPs.
研究领域:
生物医学工程
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材料科学
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医学影像学
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高影响因子
CHEMOSPHERE
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2023
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IF 8.8
Zhujun Luo,Wantang Huang,Wenyan Yu,Shaoyu Tang,Kun Wei,Yuanyuan Yu,Lei Xu,Hua Yin,Junfeng Niu
Tris (2-butoxyethyl) phosphate (TBOEP) has gained significant attention due to its widespread presence and potential toxicity in the environment. In this study, the degradation of TBOEP in aquatic media was investigated using electrochemical oxidation technology . The anode Ti/SnO 2 –Sb/La–PbO 2 demonstrated effective degradation performance, with a reaction constant ( k ) of 0.6927 min −1 and energy consumption of 1.24 kW h/m 3 at 10 mA/cm 2 . CV tests, EPR tests, and quenching experiments confirmed that indirect degradation is the main degradation mechanism and ·OH radicals were the predominant reactive species, accounting for up to 93.8%. The presence of various factors, including Cl − , NO 3 − , HCO 3 − and humic acid (HA), inhibited the degradation of TBOEP, with the inhibitory effect dependent on the concentrations. A total of 13 intermediates were identified using UPLC-Orbitrap-MS/MS, and subsequent reactions led to their further degradation. Two main degradation pathways involving bond breaking, hydroxylation, and oxidation were proposed. Both Flow cytometry and the ECOSAR predictive model indicated that the intermediates exhibited lower toxic than the parent compound, resulting in a high detoxification rate of 95.9% for TBOEP. Although the impact of TBOEP on the phylum-level microbial community composition was found to be insignificant, substantial alterations in bacterial abundance were noted when examining the genus level. The dominant genus Methylotenera , representing 17.4% in the control group, decreased to 6.9% in the presence of TBOEP and slightly increased to 8.7% in the 4-min exposure group of degradation products . Electrochemical oxidation demonstrated its effectiveness for the degradation and detoxification of TBOEP in aqueous solutions, while it is essential to consider the potential impact of degradation products on sediment microbial communities.
研究领域:
环境科学
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化学工程
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分析化学
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毒理学
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微生物学
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高影响因子
JOURNAL OF COORDINATION CHEMISTRY
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2017
·
IF 1.795
Wen Zhang,Qi Tang,Yan-Fang Feng,Kai-Liang Luo,Zhong Zhang,Yu-Ning Liang
Four new d-block metal complexes formulated as [NiII(H3thptacn)]Cl2·H2O (1), [MnIV(thptacn)]ClO4 (2), [CuII3(Hthptacn)2](ClO4)2 (3), and [CdII2(H3thptacn)2Cl2][B(C6H5)4]2 (4) were obtained from the macrocyclic ligand 1,4,7-tris(3-hydroxypropyl)-1,4,7-triazacyclononane (H3thptacn) either through solvent diffusion or by evaporation of their solutions. These complexes were characterized by single crystal X-ray structural determination, elemental analysis, and routine spectroscopic methods. Complexes 1 and 2 exhibit similar mononuclear structures with the metal centers being surrounded by both the backbone nitrogen atoms and the pendant coordinating alcohol/alkoxide groups. Complex 3 is a linear trinuclear cluster, where three Cu(II) centers are combined together by the bridging alkoxide groups in a centro-symmetric pattern. Two chloride groups join two Cd(II) atoms each chelated by one triply protonated ligand H3thptacn to afford dinuclear compound 4 with a symmetry center. When coordinating to different d-block metals, the macrocyclic ligand exhibits four types of binding modes with various dissociation status on its pendant alcohol groups and different numbers of these pendant groups participating in coordination. The magnetic measurements revealed significant zero-field splitting for mononuclear Ni(II) and Mn(IV) complexes. A moderate antiferromagnetic interaction between the neighboring Cu(II) centers governs the magnetic properties of 3 with J = −166(3) cm−1.
研究领域:
化学
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材料科学
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配位化学
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2026
·
IF 6.6
Ya Zhu,Jie Yang,Ning Liu,Ruohan Liang,Huiying Zhang,Qiling Xiong,Yingying Chen,Jianing Mi,Haoran Ma,Renfang Zhou,Bo Shao,Shaokui Yi,Xuan Cao,Jingjuan Ju,Jiejie Guo
Environmental contaminants are increasingly recognized as key risk factors for chronic diseases, including neurodegenerative disorders. Tris(2-butoxyethyl) phosphate (TBOEP) is a representative organophosphate ester that is widely detected in environmental matrices and human tissues, yet whether chronic exposure to environmentally relevant concentrations of TBOEP drives progressive neurodegenerative pathology remains unclear. Here, using Caenorhabditis elegans as a model organism, we performed a 20-day, time-resolved life-cycle exposure to environmentally relevant concentrations of TBOEP (50–5000 ng/L) to systematically assess chronic neurotoxicity. TBOEP exposure induced progressive, age-dependent neurodegenerative phenotypes. Early effects were characterized by selective impairment of locomotor performance starting at 50 ng/L, followed by broader systemic toxicity, including growth retardation, feeding deficits, and accelerated aging. Consistent with a Parkinson’s disease-like trajectory, hallmark pathological features progressively worsened with exposure duration, including dopamine-dependent functional impairment, while α-synuclein aggregation and dopaminergic neuronal impairment were mainly observed at concentrations ≥ 500 ng/L. Mechanistically, time-resolved transcriptomics identified the lysosomal pathway as a central target of TBOEP. Functional assays further confirmed that TBOEP significantly impaired lysosomal acidification. Pharmacological validation with the lysosomal chaperone ambroxol showed that improving lysosomal function mitigated TBOEP-induced neurotoxicity, supporting lysosomal dysfunction as a primary contributor to the observed pathology. Collectively, our findings identify TBOEP as a potential environmental risk factor for neurodegeneration, providing important insights that could inform further studies assessing the environmental health risks of organophosphate esters.
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高影响因子
ENVIRONMENTAL POLLUTION
·
2026
·
IF 7.2
Li Ma,Shiyi Tan,Wei Wang,Xulei Zuo,Hao Gao,Yuepu Pu,Juan Zhang
Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) is a widely used organophosphate flame retardant that is ubiquitously detected in environmental matrices and human biological samples, raising concerns about its potential health risks. However, the mechanisms underlying TDCPP-induced hepatotoxicity remain incompletely understood. Here, we investigated the hepatic effects of TDCPP using an integrated in vivo–in vitro approach combining a mouse exposure model, human-derived 3D liver organoids, and network toxicology analysis. Sub-chronic oral exposure to TDCPP in mice induced evident liver injury, characterized by histopathological alterations, elevated serum aminotransferase activities, and hepatic triglyceride accumulation accompanied by systemic lipid metabolism disorders. TDCPP exposure also disrupted hepatic redox homeostasis, as evidenced by glutathione depletion, enhanced lipid peroxidation, and downregulation of glutathione peroxidase 4, a key suppressor of ferroptosis. Consistently, TDCPP exposure reduced cell viability, promoted lipid droplet accumulation, increased reactive oxygen species levels, and suppressed GPX4 expression in human 3D liver organoids, recapitulating the major pathological features observed in vivo. Network toxicology analysis identified peroxisome proliferator-activated receptor gamma (PPARG) as a central node potentially involved in TDCPP-induced hepatotoxicity and ferroptosis, which was further supported by molecular docking analysis. Experimental validation confirmed that TDCPP exposure significantly upregulated PPARG expression in both mouse liver tissues and liver organoids. Overall, these findings indicate that TDCPP induces hepatic injury and lipid metabolic disturbance in association with ferroptosis, potentially mediated through a PPARG–GPX4 regulatory axis, providing human-relevant mechanistic insight into the hepatotoxic risk of this environmental contaminant.
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高影响因子
EUROPEAN POLYMER JOURNAL
·
2025
·
IF 6.3
Xiao Dai,Enting Deng,Wei Zhao,Lili Zhang,Ting Zheng,Jun Shen
In order to explore the influence of helical polymers on the polymerization behavior of methacrylate monomers, the helical cellulose tris(3,5-dimethylphenylcarbamate)s (CDMPC) was synthesized via “one-pot” procedure. Then a series of poly(methyl methacrylate)s (PMMAs) were synthesized through radical polymerization in the presence of CDMPC. The structure and properties of the resulting CDMPC and PMMAs were characterized by 1 H NMR, GPC, DSC and nitrogen absorption, respectively. The influence of the feed ratio of CDMPC to MMA and initiator concentration on the properties of PMMAs was carefully investigated. Interestingly, the PMMAs synthesized in the presence of CDMPC exhibited much higher molecular weight with a narrower distribution than those of PMMAs obtained without CDMPC. The former PMMAs possessed much higher content of chain segments from coupling termination than those from disproportionation termination. It indicated that the chain propagation was probably significantly accelerated with the modulation of CDMPC and the polymerization was then effectively ended via coupling termination, which agreed well with the observation in the real-time exothermic monitoring of the polymerization process. Furthermore, the end-group structure was investigated based on the structure of MMA oligomers synthesized in the presence of CDMPC, to gain a better understanding of the related mechanism. The helical CDMPC exhibited an efficient control on the molecular weight, its distribution and polymerization kinetics of PMMAs in the radical system, providing a valuable strategy for modulation of the radical polymerization of methacrylates. The influence of CDMPC on the tacticity of PMMAs was further examined.
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高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2020
·
IF 3.807
Xiao-Lei Zhang,Ji-Lan Qi,Fang Feng,Gong-Jun Yang
A novel molecularly imprinted electrochemiluminescene (ECL) sensor was fabricated for the detection of ethosuximide . The new Ru(pby) 3 2+ @N-GQDs (tris(2,2′-bipyridyl) ruthenium(II)@nitrogen doped graphene quantum dots) nanocomposite was synthesized by electrostatic interaction between Ru(pby) 3 2+ and N-GQDs, which showed excellent and stable ECL properties. And then dopamine as functional monomer and ethosuximide as template molecule were co -polymerized by hydrogen bonding on the surface of Ru(pby) 3 2+ @N-GQDs/Nafion. After ethosuximide was extracted with H 2 SO 4 , the molecularly imprinted cavities in film were formed. When ethosuximide rebound onto imprinted cavities again, the ECL intensity of Ru(pby) 3 2+ @N-GQDs decreased. Based on this principle, the quantitative relationship between the concentration of ethosuximide ( c ) and the variation of ECL intensity (Δ I ECL ) was established. Namely the Δ I ECL depended linearly on the log c in the range from 5.00 × 10 −7 to 1.00 × 10 −4 mol/L with a detection limit of 3.00 × 10 −7 mol/L (S/N = 3), and the correlation coefficient was 0.9984. The proposed sensor was also applied in plasma and urine samples with recovery in range from 97.80% to 106.2% (RSD < 6.3%).
研究领域:
分析化学
·
生物医学工程
·
材料科学
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高影响因子
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
·
2018
·
IF 2.015
Dong-Xu Jia,Teng Wang,Zi-Jian Liu,Li-Qun Jin,Jia-Jia Li,Cheng-Jun Liao,De-Shui Chen,Yu-Guo Zheng
Glucose isomerase (GI) responsible for catalyzing the isomerization from d -glucose to d -fructose, was an important enzyme for producing high fructose corn syrup (HFCS). In a quest to prepare HFCS at elevated temperature and facilitate enzymatic recovery, an effective procedure for whole cell immobilization of refractory Thermus oshimai glucose isomerase (ToGI) onto Celite 545 using tris(hydroxymethyl)phosphine (THP) as crosslinker was established. The immobilized biocatalyst showed an activity of approximate 127.3 U/(g·immobilized product) via optimization in terms of cells loading, crosslinker concentration and crosslinking time. The pH optimum of the immobilized biocatalyst was displaced from pH 8.0 of native enzyme to neutral pH 7.0. Compared with conventional glutaraldehyde (GLU)-immobilized cells, it possessed the enhanced thermostability with 70.1% residual activity retaining after incubation at 90°C for 72 h. Moreover, the THP-immobilized biocatalyst exhibited superior operational stability, in which it retained 85.8% of initial activity after 15 batches of bioconversion at 85°C. This study paved a way for reducing catalysis cost for upscale preparation of HFCS with higher d -fructose concentration.
研究领域:
生物化学
·
酶工程
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高影响因子
危险品化学品经营许可证（带存储）