BIORESOURCE TECHNOLOGY
·
2024
·
IF 9.7
Lidong Feng,Tianxiao Leng,Yangbo Qiu,Chao Wang,Long-Fei Ren,Haoyu Sun,Liang Tang,Jiahui Shao,Minghong Wu
Efficient phosphate adsorption from eutrophic waters remains challenging, fundamentally due to inherent trade-off in common adsorbents: high-binding energy between adsorbent and phosphate compromises reusability while low-binding energy suppresses selectivity. Herein, an innovative arginine-functionalized imprinted aerogel (AFIA-1:4) was fabricated by click chemistry and imprinting modification for overcoming this trade-off through synergistic weak interactions. Results shown that AFIA-1:4 exhibited high adsorption capacity ( Q max of 40.65 mg/g, 30.44 % higher than phoslock), rapid kinetics (15 min), and broad pH applicability (3–11) at 2 mg P/L solution. Moreover, its selectivity coefficient ranged from 10 to 90 even with 15- to 125-fold excess interfering anions, surpassing common adsorbents. After 10 cycles, AFIA-1:4 still maintained 98.15 % regeneration rate with 99.14 % phosphate desorption. Characterizations and calculations confirmed core roles of multiple hydrogen bonds and shape screening in maintaining selectivity and reusability. These findings advanced development of next-generation of phosphate adsorbents, which contributed to sustainable prevention and management of eutrophication.
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Regenerative Biomaterials
·
2025
·
IF 8.1
Wang Hong,Yao Shun,Mo Qingyun,Chen Mingyue,He Danfeng,Yan Lingfeng,Wang Chang,Zou Tao,Luo Gaoxing,Deng Jun
Excessive oxidative stress and dysregulated macrophage polarisation—characterised by M1/M2 imbalance—drive chronic, persistent inflammation and represent key pathological mechanisms underlying impaired tissue repair in diabetic wounds; however, therapeutic strategies targeting both these processes remain limited. L-Arginine (L-Arg) shows therapeutic potential through its antioxidant properties and ability to promote M1 macrophage polarization. Nevertheless, the mechanisms by which L-Arg regulates mitochondrial homeostasis to exert antioxidant effects remain unclear. Moreover, its clinical translation is hindered by poor retention, inadequate tissue penetration, and damage induced by hypertonicity, thereby necessitating the development of innovative delivery systems. To address these limitations, we developed an L-Arg-loaded microneedle (L-Arg-MN) patch for controlled delivery. Our findings demonstrate that L-Arg alleviated hydrogen peroxide (H2O2)-induced cellular damage through activation of the Kelch-like ECH-associated protein 1(KEAP1)- nuclear factor erythroid 2-related factor 2 (Nrf2)-Heme Oxygenase-1(HO-1) pathway, boosting antioxidant enzyme (superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), and lowering malondialdehyde (MDA) levels. Mechanistically, L-Arg maintained mitochondrial homeostasis by upregulating peroxiredoxin 1 (PRDX1) expression, restoring mitochondrial membrane potential, and enhancing adenosine triphosphate production. Furthermore, L-Arg suppressed M1 macrophage polarisation and promoted M2 polarisation through PRDX1-mediated mitochondrial metabolic pathways. In models of diabetic wounds, the L-Arg-MN patch markedly enhanced the wound healing process, accelerated wound closure, reduced concentration of reactive oxygen species (ROS), enhanced granulation tissue, collagen formation, and increased M2 macrophage infiltration. This study elucidates how L-Arg reduces oxidative stress and enhances M2 macrophage polarisation by regulating mitochondrial metabolism through the PRDX1 pathway. By integrating the metabolic and immunomodulatory properties of L-Arg with advanced drug delivery technology, the L-Arg-MN patch presents an innovative and efficient approach to treating diabetic wounds.
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SOLAR ENERGY
·
2019
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IF 4.674
Jianfeng Li,Ningning Wang,Yufei Wang,Zezhou Liang,Yichun Peng,Chunyan Yang,Xichang Bao,Yangjun Xia
Proper interfacial modification is a necessary condition for high-performance organic solar cells (OSCs). In this work, l -Arginine ( l -Arg) with the advantages of low price, friendly environment and widespread existence in natural was successfully introduced into inverted OSCs as electron transport layer (ETL). Compared to the devices without ETL (bare ITO), the open circuit voltage ( V OC ), short circuit current density ( J SC ) and power conversion efficiency (PCE) of the ITO/ l -Arg /PTB7-Th:PC 71 BM/MoO 3 /Ag device was increased to 0.77 V, 17.25 mA·cm −2 and 9.00% from 0.36 V, 14.99 mA·cm −2 , 1.90%, respectively. What’s more, the photovoltaic performance of the device with ZnO/ l -Arg double ETL was further improved (PCE (9.31%)). The excellent PCE resulting from the improved work function and the increased interface conductivity, and thus more effective carrier extraction and collection. Furthermore, the lifetime of the device with ZnO/ l -Arg double ETL was significantly increased in comparison with that of with pure ZnO ETL. The results indicated that double ETL formed by the introduction of l -Arg, which provides an efficient, low-cost, green and healthy method for the preparation of high-performance OSCs.
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Science Immunology
·
2026
·Vol. 11
·期 121
·
IF 16.4
Weiwei Yu,Ruya Sun,Xiaoyang Lu,Qiqi Deng,Heng Zhang,Sheng Chen,Siqi Dai,Tianyi Hu,Xiangyuan Li,Yidong Yang,Lihao Chen,Zhexu Chi,Jian Zhang,Siwen Zhang,Yiyi Zhu,Dehang Yang,Qianzhou Yu,Zhen Wang,Quanquan Wang,Fan Yang,Qian Xiao,Kefeng Ding,Di Wang
Tumor cells promote metabolic dysregulation of immune cells by controlling the metabolic landscape of the tumor microenvironment. It is unclear whether tumors restrict specific nutrients to drive rapid growth and immune evasion in addition to the overconsumption of nutrients to support anabolism. We identified that up-regulation of solute carrier family 7 member 1 (SLC7A1) increased arginine utilization and promoted tumor growth, whereas down-regulation of SLC7A2 decreased lysine catabolism to support immune evasion. Repression of lysine catabolism in tumor cells reduced glutaconic acid (GC), a medium-chain acyl-CoA dehydrogenase–dependent lysine catabolite that has immunostimulatory effects on antitumor CD8 T cells. GC modified pyruvate kinase M2 (PKM2) through posttranslational glutaconylation at key lysine residues Lys 336 (K336) and K337. This modification reinforced PKM2 dimers, transcriptionally driving metabolic reprogramming and reinvigorating antitumor CD8 T cells. Our study highlights an amino acid trade-off that dynamically optimizes the metabolic preferences of tumors to promote proliferation and immune evasion.
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APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Dongyun Que,Zihan Li,Fan Chen,Youwei Zeng,Junchi Liu,Yuyuan Yao
Designing highly efficient iron-based catalysts with adsorption and degradation of pollutants is a great challenge in the field of environmental remediation. Herein, a dual strategy of anchoring-separation was adopted to prepare novel iron-based nitrogen doped porous carbon catalysts (Fe-pNC). Arginine was innovatively selected as the anchoring agent to coordinate with Fe 3+ and even form oligomers with glucose, which was conducive to the dispersion of iron species during high-temperature pyrolysis. Fe-pNC achieved high iron loading of 16.48 wt% and large specific surface area of 480.19 m 2 /g. The Freundlich model determined a maximum SMX adsorption capacity (Qm) of 82.38 mg/g for Fe-pNC, surpassing most of recently reported SMX adsorbents. Interestingly, even after multiple PMS regenerations, Fe-pNC still exhibited excellent adsorption performance. Surprisingly, Fe-pNC exhibited better adsorption performance at low temperature, achieving 90.58 % adsorption rate at 0 °C. More importantly, the Fe-pNC/PMS system achieved 99.11 % SMX removal in 15 min with a superior apparent rate constant (k obs ) of 0.54 min −1 . Of particular significance, Cl − markedly enhanced the catalytic efficacy of the Fe-pNC for SMX removal, remarkably enhancing the catalytic degradation performance even at high concentrations. Quenching experiments combined with electron paramagnetic resonance (EPR) detections demonstrated that single-linear oxygen 1 O 2 ) and superoxide radicals (O 2 •− ) were the major reactive oxygen species (ROSs). This study provides a significant guidance into developing efficient iron-based catalysts for adsorption and removal of organic pollutants.
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FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Xin-Chuang Wang,Feng-Xian Luo,Yu Xu,Li-Hang Chen,Di Wu,Yi-Nan Du,Jiang-Ning Hu
An arginine-functionalized poly(γ-glutamic acid)-based hydrogel was constructed via dynamic disulfide cross-linking. • The hydrogel displayed enhanced mucoadhesion and prolonged gastric retention in mice. • Arginine incorporation enabled NO-related antioxidant and anti-inflammatory effects. • The hydrogel significantly protected against alcohol-induced gastric injury with favorable biosafety. Alcohol-induced gastric injury caused by excessive alcohol consumption is characterized by oxidative stress and inflammatory cascades that form a vicious cycle, leading to progressive gastric mucosal damage. Existing interventions, which are limited in their functional scope, are unable to effectively address this complex condition, underscoring the urgent need to develop safe and effective protective strategies. Here, a novel disulfide-crosslinked hydrogel was constructed using poly(γ-glutamic acid) (γ-PGA) and lipoic acid (LA), with arginine (Arg) incorporated via hydrogen bonding to obtain Arg-gel, as characterized by NMR and FT-IR. The 8% ( w / v ) gel exhibits excellent mucosal adhesion and extends the retention time in the stomach from 15 to 30 min to 2–4 h. In vitro, Arg-gel demonstrated dose-dependent antioxidant activity and significantly reduced intracellular ROS in alcohol-stimulated GES-1 cells, while also suppressing pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) and restoring mitochondrial function. In a mouse model of acute alcohol-induced gastric injury, Arg-gel markedly reduced the ulcer index and facilitated the restoration of mucosal architecture and PGE2 levels. No significant toxicity was observed in a 14-day biosafety assessment. Collectively, Arg-gel exhibits promising gastroprotective effects and biosafety, offering a novel strategy for gastric mucosal protection. Synthesis of the Arg-gel hydrogel and its evaluation in alleviating alcohol-induced gastric injury in mice. (a)The primary synthetic raw materials and structural formulae of hydrogels based on polyglutamic acid. (b) Cross-linking mechanism driven primarily by disulfide bond formation. (c) In vivo evaluation using an acute alcohol-induced gastric injury model. Download: Download high-res image (188KB) Download: Download full-size image
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ACS Omega
·
2023
·
IF 4.1
Housen Jiang,Qin Xu,Xiaolin Wang,Lin Shi,Xuedong Yang,Jianmin Sun,Xifan Mei
Diabetic foot ulcers with complex healing wounds accompanied by bacterial infection are considered a significant clinical problem which are made worse by the lack of effective treatments. Traditional antibiotics and dressings have failed to address wound infection and healing, and multifunctional combination therapies are attractive for treating chronic wounds. In this study, arginine (Arg) was loaded onto the surface of silver nanoclusters and encapsulated in a hydrogel to achieve antibacterial, anti-inflammatory, angiogenic, and collagen deposition functions through the slow release of Arg combined with silver nanoclusters. In vitro studies indicated that Arg-Ag@H composites inhibited methicillin-resistant Staphylococcus aureus and Escherichia coli by 94 and 97%, respectively. The inhibition of bacterial biofilms reached 85%, and the migration ability of human venous endothelial cells (HUVECs) increased by 50%. In vitro studies showed that Arg-Ag@H composites increased the healing area of wounds by 26% and resulted in a 98% skin wound-healing rate. Safety studies confirmed the excellent biocompatibility of Arg-Ag@H. The results suggest that Arg-Ag@H offers new possibilities for treating chronic diabetic wounds.
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JOURNAL OF FOOD ENGINEERING
·
2022
·
IF 6.203
Jun Qi,Hui-min Yan,Wen-wen Zhang,Xiu-ning Yao,Qing-yuan Cai,Kuo Xu,Wen-ping Xu,Guo-yuan Xiong
Effects of pH (5, 7, or 9) and arginine level (0, 0.6%, 1.2%, or 1.8%, w/v) on the stabilization of emulsions prepared by a novel thermal-assisted stirring method were evaluated. The results of physical stability showed that thermal-assisted stirring was effective in manufacturing heat-insensitive o/w emulsions. As the arginine level increased, the emulsifying ability and the absolute zeta potential of each pH-treated group first increased significantly and then decreased significantly, reaching a maximum at 1.2% (w/v) addition. When pH increased, the emulsifying ability and the absolute zeta potential of each arginine-treated group increased significantly. The results of particle size, storage modulus, and loss modulus were in accordance with changes in the emulsifying ability and the zeta potential, which were confirmed by the microstructure. As a result, the emulsion prepared at pH 9 with 1.2% (w/v) arginine had the largest levels of emulsion stability and surface protein load (145.69 mg/m 2 ). In conclusion, the major reason for the formation of heat-insensitive emulsions by thermal-assisted stirring might be attributed to a high level of surface protein load, and increasing pH and arginine addition might enhance the adsorption of gelatin-arginine complexes on the surface of oil droplets, thereby improving the stability of emulsions.
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Asian Journal of Pharmaceutical Sciences
·
2022
·
IF 9.273
Linping Jiang,Kesi Wang,Liyan Qiu
Drug resistance is accountable for the inadequate outcome of chemotherapy in clinics. The newly emerging role of nitric oxide (NO) to conquer drug resistance has been recognized as a potential strategy. However, it remains a great challenge to realize targeted delivery as well as accurate release of NO at desired sites. Herein, we developed a PEGylated indocyanine green (mPEG-ICG) integrated nanovesicle system (PIDA) to simultaneously load doxorubicin hydrochloride (DOX⋅HCl) and the NO donor L-arginine (L-Arg), which can produce NO triggered by NIR light irradiation and exert multimodal therapy to sensitize drug-resistant cancers. Upon 808 nm irradiation, the NO released from PIDA led to a decrease in mitochondrial membrane potential, an increase in ROS and significant ATP depletion in K562/ADR cells, thus inhibiting cell growth and resolving the problem of drug resistance. Consequently, the in vivo experiment on K562/ADR-bearing nude mice indicated that PIDA nanovesicles achieved significant anticancer efficacy with a tumor inhibition rate of 80.8%. Above all, PIDA nanovesicles offer guidance for designing nanoplatforms for drug-resistant cancer treatment.
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Journal of Environmental Chemical Engineering
·
2022
·
IF 7.968
Yongwu He,Songling Han,Gaomei Zhao,Jiaohua Luo,Changsheng Jia,Yin Chen,Qi Liu,Jining Gao,Cheng Wang,Junping Wang
Microcystin-leucine arginine (Mc-LR) and antibiotic residual in water bodies threaten human health and necessitate the development of efficient processing scheme. Photocatalytic composites are promising alternatives for eliminating these hazardous substances. Herein, we prepared a nanohybrid composed of zinc oxide (ZnO) and carboxyl-riched graphene oxide (cGO). The sustainable material termed [email protected] rapidly degraded Mc-LR ( k = 0.68 min −1 , t 1/2 = 1.02 min, pH 7) under visible light. Mc-LR degradation products were nontoxic to human L0–2 cells. Animal experiments revealed that oral administration of Mc-LR impaired the hepatic function and caused mice death, which could be inspiringly relieved once the toxin was processed by [email protected] Furthermore, [email protected] efficiently degraded three quinolone antibiotics, ciprofloxacin ( k = 2.30 min −1 , t 1/2 = 0.30 min), ofloxacin ( k = 2.11 min −1 , t 1/2 = 0.33 min), and norfloxacin ( k = 0.94 min −1 , t 1/2 = 0.74 min) at pH 7 under visible light. Owing to the antibiotic removal, [email protected] dramatically suppressed the development of drug resistance of sensitive bacteria. This study characterizes an easy-to-produce photocatalysed nanohybrid to eliminate Mc-LR and antibiotics in water that enriches the existing measures for water detoxication and benefits environmental improvement.
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PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2023
·Vol. 25
·期 37
·25116-25121
·
IF 3.3
Min Kou,Young-Ho Oh,Sungyul Lee,Xianglei Kong
We present the origin of the observed differentiation of lactose and lactulose achieved by complexation with sodiated L-arginine (ArgNa+). We find that the infrared multiphoton dissociation (IRMPD) bands in 3600–3650 and >3650 cm−1 regimes for gas phase lactose and lactulose, respectively, vanish when forming host–guest complexes with ArgNa+. We interpret these differences in the IRMPD spectra by scrutinizing the interactions between the functional groups (guanidium, –CO2−Na+) in ArgNa+ and –OHs in lactose/lactulose. Our calculated structures and infrared spectra of lactose/ArgNa+ and lactulose/ArgNa+ host–guest pairs indicate that the functional groups interact with the low- and high-frequency –OH stretch modes of lactose and lactulose, respectively, in the 3600–3720 cm−1 window.
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Analytical Methods
·
2021
·Vol. 13
·期 43
·5179-5186
·
IF 2.896
Yumei Yan,Yuan Qu,Rui Du,Wenfeng Zhou,Haixiang Gao,Runhua Lu
In this paper, a simple and innovative colorimetric method is established, which is based on DBP-induced aggregation of arginine functionalized gold nanoparticles (ARG-AuNPs), and can be used for the sensitive determination of dibutyl phthalate (DBP) in Baijiu samples. The morphological characteristics and the color changes of ARG-AuNPs caused by aggregation show good sensitivity, and can be observed through ultraviolet-visible spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS) and zeta potential technology. The color change of ARG-AuNPs from red to blue is due to the strong non-covalent interactions between DBP and ARG-AuNPs (electrostatic, van der Waals force and hydrogen bonding), which leads to the reduction of the electrostatic repulsion between the nanoparticles and aggregation. A two-stage linear equation was established between the absorption ratio (A690/A530) and the DBP concentration (0.0–2.8 mg L−1); the correlation coefficient (R2) was 0.9914–0.9940, and the detection limit (LOD) was estimated at 0.05 mg L−1. The designed ARG-AuNPs acting as a dependable sensor for the detection of Baijiu samples equally acquired satisfactory recoveries. When the concentration of DBP in the solution is more than 1.0 mg L−1, the color change can be clearly observed by the naked eye; so there is no need for sample preparation techniques and tedious operations to quickly and semi-quantitatively detect DBP. The successful application of the proposed method in Baijiu samples indicates its potential to detect DBP in more complex environment samples.
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