JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
·
IF 6.371
Wei Wen,Xiaoqiang Du,Xiaoshuang Zhang
Replacing fossil fuels by electrocatalytic water splitting for producing hydrogen and oxygen is one of the most promising ways to solve the energy crisis and environmental pollution. In this work, a series of M doped N-Ni 3 S 2 (M = Cu, Fe, Co and Ce) material was firstly synthesized and in situ grown on nickel foam substrate by a typical two-step hydrothermal synthesis method. Two probe reactions, water oxidation and urea oxidation, were selected to investigate the catalytic performance of these materials. What is noteworthy is that the Fe doped N-Ni 3 S 2 material exhibits superior water oxidation properties with requiring only 270 mV of overpotentials to drive current densities of 100 mA cm −2 , which is one of the best activities reported so far. After a long time of durability measurement, the current density of the Fe doped N-Ni 3 S 2 material will be attenuated, suggesting that the surface of the material will be in situ oxidized to oxide or hydroxide, which is the true active species. For urea oxidation, the Co doped N-Ni 3 S 2 material shows superior catalytic performance with requiring only 1.36 V potentials to drive 100 mA cm −2 current densities. Density functional theory (DFT) calculation shows that different adsorption energy of water for N-Ni 3 S 2 , N-Cu-Ni 3 S 2 , N-Fe-Ni 3 S 2 and N-Co-Ni 3 S 2 leads to the different catalytic activity. Experimental results demonstrate that the improved catalytic performance is assigned to faster electron transfer rates, exposure of abundant active center and better conductivity due to N and cation doping. This work provides new lessons for doping engineering for water splitting reactions.
研究领域:
材料科学
·
能源化学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry C
·
2024
·Vol. 12
·期 28
·10513-10531
·
IF 5.7
Xiaoqiang Xiong,Xiaodong Jing,Zitao Chen,Qianqian Zhao,Zuoguang Li,Xi Yang,Qun Wang,Tongyun Zhao,Huayang Gong
Using single loss type media as microwave absorbers to simultaneously achieve low reflection loss, wide-band absorption and thin thickness is a huge challenge. In this work, to combine the high dielectric loss of Pr-doped M-type strontium ferrite and the high magnetic loss of W-type hexaferrites, we improved the traditional sol–gel auto-combustion method via increasing an extra sintering process and successfully prepared xSrPr0.5Fe11.5O19/yBaCo2Pr0.5Fe15.5O27 (x : y = 2 : 1, 1.5 : 1, 1 : 1, 1 : 1.5 and 1 : 2) M/W (M-type hexaferrite/W-type hexaferrite) composite materials with a unique “inlay structure”. The M-phase and PrFeO3-type phase were partially wrapped by the huge W-phase, which resulted in enhanced exchange coupling. Benefitting from the exchange coupling and huge grains, the coercivity and anisotropy fields of composite hexaferrites decreased. Therefore, the natural resonance frequencies of some samples reduced to within 18.00 GHz. High magnetic loss occurs while dielectric loss is preserved due to strong resonance interaction and multiple polarization relaxation mechanisms. Hence, the composite hexaferrites exhibit satisfactory microwave absorption performance on account of the magnetic–dielectric synergistic effect. The effective absorption bandwidth of the prepared materials can cover X and Ku bands at thin matching thicknesses (<2.00 mm). The minimum reflection loss reaches −56.30 dB (d = 1.97 mm), and the maximum effective absorption bandwidth reaches 8.17 GHz (d = 1.63 mm). This work will provide new ideas for improving the absorption performance of ferrite composite materials.
研究领域:
材料科学
·
电磁学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Hui Lu,Hongbo Wang,Changfei Gao,Lifen Liu,Tingting Yu,Yihua Li,Shaoying Lin
Lanthanum and cerium are widely used as important raw materials for energy storage batteries due to excellent natural electrical, magnetic, and optical properties. However, with the explosive growth of new energy generation and the environmental degradation-resistant of lanthanum and cerium, it is difficult to balance environmental sustainability and resource scarcity to achieve lanthanum-cerium removal by conventional chelate salt precipitation. Herein, a laboratory-scale self-powered electro-membrane bioreactor (SPEMBR), integrating high-active nitrogen-doped carbon nanotube-loaded iron and molybdenum bimetallic conductive composite electrode membrane (M−N−CNTs@Fe/Mo) by hydrothermal and phase inversion processes was successfully constructed and evaluated for removing lanthanum cerium from industrial wastewater. The prepared bi-functional M−N−CNTs@Fe/Mo5% electrode membrane exhibited a uniform morphology and excellent hydrophilicity, with nano pore lattice spacing only 0.2637 nm. Electrochemical test results demonstrated that the novel electrode indicated excellent redox properties (i 0 = 8.35 × 10 −3 A cm −2 , C dl = 1.13 mF cm −2 ) and efficient electron transfer efficiency (R ct = 4.69 Ω, n = 3.9). Based on optimized conditions (5)% doping ratio, pH = 10, C = 20 mg/L), the SPEMBR assisted by M−N−CNTs@Fe/Mo catalytic electrode membrane achieved approximately complete removal efficiency of lanthanum and cerium (>99.2 %), superior to most publicly available related studies (86.3 %-99.0 %), but with a calculation cost of only $8.54. Identification of membrane interface products and system precipitates demonstrated that the outstanding removal efficiency was attributed to the combined reaction mechanism of electroreduction, electrocoagulation and electromembrane filtration. This work provides a bright application prospect for low-cost and effective removal of lanthanum cerium metal based on electrode membranes.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Inflammation Research
·
2025
·
IF 4.1
Yuan Zhang,Longbin Huang,Ningning Yue,Zhiliang Mai,Chen Kong,Chengmei Tian,Dao-ru Wei,Jun Yao,Lisheng Wang,Defeng Li
Background Although cytokines have been implicated in the development of ulcerative colitis (UC), the potential mediating role of metabolite levels in this association remains unclear.Methods Utilizing data from genome-wide association studies (GWAS) encompassing 91 circulating cytokines, 1400 blood metabolites, and 178,689 UC cases, we performed a two-sample Mendelian randomization (MR) analysis to investigate the effect of metabolites mediated cytokines on the development of UC. A two-step MR analysis was conducted to quantitatively evaluate the mediation effect. Additionally, dextran sodium sulfate (DSS)-induced colitis mice were used to further confirm our results.Results Mendelian randomization (MR) analysis indicated that macrophage colony-stimulating factor (M-CSF) had a causal and positive relationship with aconitate (OR: 1.10, 95% CI: 1.00–1.20, p = 0.043, IVW beta 1 = 0.095). Moreover, MR analysis revealed that high level of aconitate were associated with reduced risk of UC (OR: 0.44, 95% CI: 0.24–0.80, p = 0.008, IVW beta 2 = −0.818). In addition, MR analysis showed M-CSF had an inverse correlation with the disease onset of UC (OR: 0.31, 95% CI: 0.15–0.80, p = 0.002, IVW beta all = −1.16). Furthermore, the mediation effect of aconitate mediated M-CSF on the risk of UC was −0.0777 (95% CI: −0.154 to −0.0018, p = 0.045), accounting for 6.69% of the total effect, and indicating a modest contribution to the protective effect of M-CSF against UC. Subsequently, as an in vivo validation model, DSS-induced colitis was employed to demonstrate that M-CSF treatment significantly ameliorated weight loss, disease activity index (DAI) scores, colon shortening, and histological damage. Additionally, M-CSF treatment also significantly reduced M1 macrophage infiltration, elevated levels of aconitate as well as itaconate, and decreased the levels of pro-inflammatory cytokines in colitis. These results demonstrated that aconitate inhibited the expression of pro-inflammatory cytokines through its enzymatic conversion into the immunometabolite itaconate by aconitate decarboxylase 1 (Acod1), and downregulated the levels of M1 macrophages, thereby ameliorating colitis.Conclusion These findings suggest that M-CSF is an important anti-inflammatory cytokine in UC, which may be a promising therapeutic target in the treatment of UC.
研究领域:
免疫学
·
胃肠病学
·
遗传学
·
代谢组学
·
炎症研究
·
生物医学研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENERGY
·
2023
·
IF 9
Wei Lu,Ao Gao,Yuntao Liang,Zhenglong He,Jinliang Li,Yong Sun,Shuanglin Song,Shaocong Meng
A stable and highly efficient 1, 1, 3, 3, 3-hexamethyldisilazane (HMDS) terminated m-Cresol inhibitor was synthesized based on the protection-deprotection strategy. The inhibitory effect of HMDS terminated m-Cresol inhibitor on spontaneous combustion of lignite was explored through temperature-programmed oxidation tests, in-situ infrared analysis and thermogravimetric analysis. Results show that, the oxidation of active phenolic hydroxyl groups in the m-Cresol inhibitor can be hindered by the protection of HMDS. After encountering coal, the HMDS terminated inhibitor can be gradually deprotected to regenerate the m-Cresol inhibitor that contains massive active phenolic hydroxyl groups, thus improving the chemical inhibition efficiency of coal spontaneous combustion. For the coal sample inhibited with HMDS terminated m-Cresol inhibitor, the initial contents of the active functional groups are lower and more stable during heating, and the inhibition rate reaches 70% at 130 °C. Moreover, the crossing-point temperature rises by 32.4 °C–181.2 °C. The activation energy increases by 11 kJ/mol and 18 kJ/mol at below and above 130 °C respectively. The peak temperature at maximum weight loss rate rises by 65 °C–431.2 °C, and the corresponding residual carbon rate increased by 31.3%–61.6%. The inhibition mechanism of the HMDS terminated m-Cresol inhibitor on coal spontaneous combustion was deduced.
研究领域:
化工工程
·
材料科学
·
煤化学
·
热分析
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2025
·
IF 3.1
Yingxia Guo,Jiaxin Zhang,Runran Mei,Zihan Tang,Meichen Liu,Xixian Weng,Meiyun Shi,Lei Yin
Addressing critical gaps in understanding the in vivo behavior of polyethylene glycol (PEG)-based excipients, this study systematically elucidates the biological fate of methoxy-PEG₆-hydroxyl (M-PEG₆-OH) through comprehensive pharmacokinetic and metabolic investigations in rats. Employing a validated ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) methodology, we reveal distinctive biodistribution characteristics including rapid systemic clearance (Half-life (t 1/2 ) = 1.92 ± 1.16 h) and extensive tissue penetration (Apparent volume of distribution (V d ) = 0.84 ± 0.45 L/kg), suggesting efficient extravascular dissemination. Excretion pathways analysis demonstrated predominant renal elimination, with 59.03 % of the administered dose recovered in urine within 48 h post-IV injection, contrasting with minimal fecal excretion (0.99 %). Quantitative metabolite profiling identified M-PEG₅-CH₂COOH as the oxidative transformation product through terminal hydroxyl modification. The significantly higher relative abundance of metabolites (M-PEG 5 -CH 2 COOH) in urine compared to feces within the same time period provides critical insights into the biotransformation processes and metabolic pathways of the PEG polymer. These findings establish the first systematic evidence of metabolic trajectory and elimination mechanisms for M-PEG-OH, offering vital references for optimizing PEGylated drug delivery systems with enhanced biocompatibility and predictable safety profiles.
研究领域:
药代动力学
·
分析化学
·
生物化学
·
药剂学
·
代谢
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2022
·Vol. 414
·期 6
·2065-2078
·
IF 4.478
Ou Panpan,Wu Jiawen,Lin Yu,Tan Xuecai,Wu Yeyu,Chen Zhifan,Wei Fucun,Huang Kejing
Chloramphenicol (CAP) is widely used in the food industry and animal husbandry due to its effective antibiotic effect active against gram-positive and gram-negative microorganisms. However, research shows that it can cause serious adverse reactions and side effects in the human body. In order to effectively monitor the residues of CAP, a novel and simple photoelectrochemical (PEC) sensor for sensitive detection of CAP is fabricated based on M-TiO 2 -CdTe QDs/CdS QDs composite. The results show that the prepared M-TiO 2 not only retains the original morphology and structure of MIL-125(Ti), but also exhibits more abundant pore structure and good photoelectrochemical properties. Compared with M-TiO 2 , the as-prepared M-TiO 2 -CdTe QDs/CdS QDs composite exhibits excellent PEC performances including about ninefold enhancement of photocurrent intensity, which is ascribed to the large surface of M-TiO 2 and the introduction of CdTe QDs and CdS QDs. Based on the selective inhibitory effect of CAP in the photocurrent intensity of the M-TiO 2 -CdTe QDs/CdS QDs PEC system, a novel PEC sensor for CAP concentration determination is constructed. The designed PEC sensor demonstrates a linear range from 1 to 140 nmol L −1 with a detection limit of 0.14 nmol L −1 (S/N = 3). Moreover, the method is applied to real milk samples to quantify the CAP residues with spiked recoveries in the range of 96.3–106%, and the possible detection mechanism of the M-TiO 2 -CdTe QDs/CdS QDs PEC system is also discussed. Graphical abstract
研究领域:
分析化学
·
材料科学
·
环境科学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2019
·
IF 3.42
Haihua Wang,Pan Zhang,Guiqiang Fei,Yongning Ma,Nana Rang,Yongmook Kang
The waterborne biocompatible alkyd/polyaniline (WARA/PANI) coatings have gained a unique position in anticorrosion coating industry. However, the dispersion and compatibility between WARA and PANI still remain big challenge. Here copolymerization of aniline with aniline derivatives was adopted to prepare PANI, m-aminobenzenesulfonic acid-aniline (SPANI) copolymer, and SPANI copolymer end-capped with p-phenylenediamine (SPANIP terpolymer) aqueous dispersions. The chemical structure of PANI, SPANI and SPANIP was characterized by FT-IR spectra, XRD and UV–vis spectra. PANI displayed spherical particle morphology, while SPANI and SPANIP showed interconnected rod-like structure. The water dispersibility for SPANIP was significantly superior to that of PANI and SPANI, as well as the compatibility between SPANIP and WARA. The as-prepared SPANIP/WARA films also displayed enhanced thermal property and water resistance. The impedance modulus of SPANIP3/WARA coating increased by 4 orders in comparison with WARA coating, and increased by 2 orders compared with PANI/WARA and SPANI/WARA. In comparison with PANI/WARA, E corr of SPANIP/WARA shifted from -805 mV to -401 mV, I corr of SPANIP/WARA decreased by one order, and the corrosion inhibition efficiency increased from 73.8% to 94.3%. SPANIP/WARA coating was also endowed with improved long-term corrosion resistance, and the anticorrosion mechanisms were proposed.
研究领域:
材料科学
·
防腐蚀工程
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CELLULAR PHYSIOLOGY
·
2019
·Vol. 235
·期 3
·2911-2924
·
IF 4.522
Qiuyue Ding,Wenda Zhang,Cheng Cheng,Fengbo Mo,Lei Chen,Guangfu Peng,Xianyi Cai,Jinglong Wang,Shuhua Yang,Xianzhe Liu
Pyroptosis is a form of programmed cell death (PCD) that plays a vital role in immunity and diseases. Although it was recently reported that chemotherapy drugs can induce pyroptosis through caspase-3-dependent cleavage of gasdermin E (GSDME), the role of pyroptosis in osteosarcoma (OS) with dioscin is less understood. In this study, we explored the effects of dioscin on OS in vitro and in vivo and further elucidated the underlying molecular mechanisms and found that dioscin-triggered pyroptosis in GSDME-dependent cell death and that GSDME-N was generated by caspase-3. Furthermore, dioscin inhibited cancer cell growth by inducing G2/M arrest and apoptosis through the JNK/p38 pathway. In vivo, dioscin significantly inhibited OS proliferation. Taken together, our results demonstrate that dioscin can induce apoptosis through the JNK/p38 pathway and GSDME-dependent pyroptosis in OS, identifying it as a potential therapeutic drug for treatment of this disease. HIGHLIGHTS Dioscin triggers pyroptosis in osteosarcoma. Gasdermin E is a mediator of dioscin-induced osteosarcoma (OS) cell death. Dioscin induces apoptosis and G2/M arrest. Dioscin inhibits OS proliferation in vitro and in vivo.
研究领域:
肿瘤学
·
细胞生物学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Jing Bai,Wencheng Chen,Freeman Bwalya Kabwe,Xutao Shang,Guozhen Lin,Qian Jiang,Chenguang Wang
Amid growing global energy demands and the imperative to reduce carbon emissions, sustainable aviation fuel (SAF) production via Fischer–Tropsch (FT) synthesis has emerged as a pivotal solution. This study focuses on enhancing the selectivity of C8–C16 hydrocarbons for jet fuel through the integration of mesopore confinement effects and acid hydrocracking by developing novel Co/M-TUD-1 catalysts with a uniform, continuous three-dimensional mesoporous architecture. Utilizing sol–gel and melt infiltration methods for catalyst preparation and incorporating metals such as Al, Zr, La, and Ce, we explored how different supports influence FT synthesis outcomes. Characterization techniques, including N2 physisorption, H2-TPR, XRD, NH3-TPD, and Py-FTIR, were employed to understand the physicochemical properties of these catalysts. Experimental results demonstrated significant improvements in jet fuel selectivity, achieving up to 51.3% selectivity and a productivity of 174.7 g/kgcat/h with the Co/Al-TUD-1 catalyst. Further optimization through adjustment of reaction conditions confirmed the potential for industrial-scale SAF production, offering a cleaner, more sustainable approach to addressing fossil fuel shortages.
研究领域:
化学工程
·
能源科学
·
催化材料
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CATALYSIS
·
2022
·
IF 8.047
Han He,Shuqian Xia,Dan Luo
Refining lignin for aromatic hydrocarbons was crucial in the development of clean energy. The most effective way to enhance the carbon efficiency of the raw materials was to reduce the hydrogen consumption and maximize the retention of aromatic ring by directly breaking the C Ar O bond. In this regard, Sn was introduced to regulate the selectivity of Ni/SiO 2 for m-cresol hydrodeoxygenation (HDO) products at low hydrogen consumption. Thanks to the formation of the Ni-Sn alloy in the system, the bimetallic sites synergistically catalyze the C Ar O bond scission through lowering the reaction energy barrier. Further from charge analysis, it was concluded that the charge transfer from Sn to Ni promotes the hydrogenolysis, and the charge transfer between the slab and the adsorbate provides the possibility for the occurrence of direct deoxygenation reaction. The COHP analysis resulted that the introduction of Sn accelerated the C Ar O bond cleavage. Interestingly, another deoxygenation pathway was proposed from the isomerization conversion of m-cresol to dienone intermediate (3-methyl-3,5-cyclohexadienone) in the calculation of transition state. Further HDO can form toluene effortlessly due to the presence of the oxyphilic metal Sn. This also explains the high selectivity of Ni-Sn to toluene. Moreover, the introduction of the Sn promoter effectively prolongs the lifetime of the catalyst by enhancing the tolerance to carbon deactivation.
研究领域:
化学工程
·
催化科学
·
可再生能源
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Yi Yang,Huiping Zhang,Haoxin Huang,Ying Yan,Xinya Zhang
Degradation of organic pollutant through catalytic wet peroxide oxidation (CWPO) is becoming more and more important in modern industry. As a commonly used organic synthetic material, excessive discharge of m-cresol may lead to severe damage of the environment and become a potential threat to human health. In this study, m-cresol was degraded over novel iron loaded carbon nanotube microfibrous composite (Fe-CNT-MF) catalyst packed fixed bed reactor. The kinetic parameters were first optimized, and then the deactivation mechanism of catalyst was also studied. The optimization model showed that total organic carbon (TOC) conversion of m-cresol degradation can reach about 70% under optimum conditions. Then the catalyst deactivation test was conducted with four consecutive runs (32 h in total). Fe-CNT-MF performed high m-cresol and TOC conversions (99% and 40%, respectively) as well as high H 2 O 2 decomposition efficiency (100%) with no iron leaching. Besides, the effect of co-existing organic pollutants on m-cresol degradation was investigated with presence of 4-Ethylphenol and 2,5-dimethylphenol. Fe-CNT-MF exhibited good catalytic activity in multi-pollutant wastewater with 99% conversion for all pollutants. Finally, deactivation analysis results showed that the deactivation mechanism of Fe-CNT-MF included carbon deposition, surface property change and additional oxygen functionalities. A regeneration study was proceeded to further confirm the suggested mechanism, indicating that Fe-CNT-MF has a good regenerability.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）