Journal of Materials Chemistry C
·
2021
·Vol. 9
·期 7
·2455-2463
·
IF 7.393
Hongjing Wen,Xianzhi Zeng,Xiaoxuan Xu,Wanyi Li,Fei Xie,Zhong Xiong,Shichao Song,Bin Wang,Xiangping Li,Yaoyu Cao
In this work, based on a pH-responsive hydrogel, we report on a reversible data encryption–decryption technique in which the pH channel is employed for data manipulation. Upon alkali or acid stimulation, the hydrogel exhibits a network expansion or shrinkage in response to the pH variations. In particular, pre-doping the hydrogel with silver ions, we demonstrate that data input can be encoded in the hydrogel platform through the direct writing and patterning of silver nanodots. By this means, the scattering signals from the patterned nanodot pixels are converted to the binarized data. Meanwhile, we show the threshold behaviour of the hydrogel system in which dynamic switching of the encoded plasmonic pattern to the optically resolvable/irresolvable state is viable only at finite pH values. By delicately matching pixel spacings of the encoded pattern and the diffraction limit of the deciphering microscopic system, reversible sub-diffraction limit data encryption is achieved by selectively imposing acid and alkali stimulations. The suggested strategy offers a potential solution for optical storage, multiplexed data manipulation, and optical data security.
研究领域:
材料科学
·
光学工程
·
化学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2021
·
IF 5.268
Beibei Zhang,Lan Zhang,Erzhen Duan,Ruirui Zhang,Jun Liu,Peipei Shi,Yuying Mei,Ruifang Li,Lianzhong Zhang
Nanomedicine which delivers therapeutics to tumours holds great potential for cancer treatment. However, endosomal trapping and uncontrollable release usually limit the efficiency of nanomedicine. Herein, a smart mesoporous silica based nanoplatform was constructed, in which mesoporous silica nanoparticles (MSNs) serve as the core, capped with pH-induced charge-reversal polymer -PAH-cit- and cationic polyelectrolyte polyethyleneimine (PEI). The oppositely charged polymer can not only act as a gatekeeper for controlled release, but also mediated efficient endosomal escape of the therapeutics. Under the acidic endosomal environment, the hydrolysis of acid-cleavable bonds in PAH-Cit would trigger the charge reversal and endosomal escape of the nanoplatform for efficient drug release. Furthermore, the prepared nanoplatform demonstrated a higher tumor cell proliferation inhibition rate than free theruputics in vitro assays and significantly inhibited tumour growth in the 4T1 tumour model in mice. Therefore, our strategy offers a simple and general nanoplatform to delivery therapeutics to tumours with efficient endosomal escape and controlled release.
研究领域:
药学
·
生物医学工程
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
LUMINESCENCE
·
2020
·Vol. 36
·期 1
·28-34
·
IF 1.855
Fan Zheng,Jun Guo,Abdul Jamil Khan,Pandeng Miao,Feng Zhang
Fluorescent nanostructures have been widely applied to biomedical researches and clinical diagnosis such as biolabeling/imaging/sensing and have even acted as therapy reagents. Peptide-based fluorescent nanostructures attract recent interest from biomedical researchers. Inspired by the natural existence of GHK-Cu complex with a growth factor-like effect in human blood, here we have developed a novel approach for designing nanosensors through the co-assembling of two kinds of biomolecules. By making best use of both π-π stacking between carbon rings and the easy-oxidation property of an important transmitter molecule, dopamine (DA), we successfully built up a supersensitive and robust fluorescent pH nanosensor by co-assembling oxidized DA (DA ox ) with a tripeptide GHK. The GHK-DA ox nanostructures have a quantum yield of 20.82%, which might be the brightest one among all the current co-assembling structures merely through unmodified biomolecules. We envision this approach could open a new avenue for not only hybrid nanostructure construction, but also may inspire the bioengineering of in vivo luminescent probes.
研究领域:
生物医学
·
纳米技术
·
化学传感
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Shuxia Li,Jia-Horng Lin,Hai-Tao Ren,Bing-Chiuan Shiu,Fei Sun,Ching-Wen Lou,Ting-Ting Li
Oil spills and the discharge of organic wastewater have posed a severe danger to environmental security. To address this issue, various functional oil/water separation materials for wastewater purification have been developed. In this work, MXene/PPy was loaded on PP fiber by simple in-situ polymerization and vacuum-assisted filtration technology. Polypropylene was modified by dopamine (PDA) through in-situ polymerization, to improve the loading fastness of MXene/PPy on the surface of PP. To increase the durability of the fiber membrane, the pH-responsive polymer (PDM) was simply immersed on the outer layer. The successfully prepared PP-MXene/PPy-PDM has excellent pH response and photothermal conversion performance. When pH= 2, the water contact angle (WCA) was 52°. When pH= 12, WCA was 125°. The surface of PP-MXene/PPy-PDM was heated to 104.6 ℃ in ten minutes under the irradiation of 2 kW·m −2 . PP-MXene/PPy-PDM could continuously separate oil/water mixture for 12 h, and the highest separation flux was 3.87 kg·m −2 ·h −1 . Moreover, PP-MXene/PPy-PDM has excellent stability, corrosion resistance and recyclability . This study provided a new strategy for preparing intelligent responsive fiber composite membrane for oil-water separation, which has a wide range of practical applications in the treatment of oily wastewater.
研究领域:
材料科学
·
环境工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Qing Meng,Zhou Xue,Shunli Chen,Min Wu,Peng Lu
Responsive antimicrobial materials can control and slow the release of antimicrobial agents smartly by responding to the stimulation of environmental conditions. In this study, we designed the pH-responsive cellulose-based nanoparticles (TOCNC- g -PEI) with amino and carboxyl groups by grafting polyethyleneimine (PEI) to carboxylated cellulose nanocrystals. Finally, the Pickering emulsion was endowed with smart antimicrobial properties by emulsifying the oregano essential oil (OEO) with nanoparticles. The TOCNC- g -PEI 25000 had uniform size, greater dispersion, and excellent antimicrobial properties. The contact angles of nanoparticles were 78.70 ± 1.13°, 55.80 ± 1.58° and 55.35 ± 1.56° at neutral conditions, pH 4.0 and 8.0, respectively. The nanoparticles were responding to pH stimulation. The developed emulsion (4:6, 1.30 wt%) had exceptionally stabilized and encapsulated 98.56 ± 1.22 % of the oil phase. The OEO released rapidly within 0–12 h and slowly at 12–36 h. The cumulative release rates quickly reached 93.60 ± 3.73 % (pH 4.0) and 83.25 ± 0.36 % (pH 8.0) and stabilized gradually. The antimicrobial rates of emulsion stimulated for 4 h reached 100 % at pH 4.0, and both of them exceeded 96.10 ± 2.49 % at pH 8.0. The response of Pickering emulsion to pH stimulating controlled release antimicrobial agents and achieved smart antimicrobial.
研究领域:
材料科学
·
微生物学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2020
·
IF 4.845
Lei Liu,Shuaichao Wang,Peilan Qi,Shiyong Song,Yanwei Yang,Jiahua Shi,Guang Han
Poly(ethylene glycol)-poly(ε-caprolactone) (PEG-b-PCL) micelles have been widely used as drug delivery vehicles for cancer therapies. Because of the lack of functional groups, the use of PEG-b-PCL in drug delivery system is greatly limited and structural modifications is needed. In this work, chemical modification at the terminus of PEG-b-PCL was performed via the “grafting from” polymerization method. A poly(dopamine methyl acrylamide) segment was introduced containing multiple catechol groups, which could attach bortezomib (BTZ) to the chain of the polymer through the formation of a pH-sensitive borate bond. This method greatly enhanced the loading capacity of BTZ into the micelles. Additionally, the controlled release of BTZ in response to the acidic environment of a tumor was realized. High loading capacity, stimuli-responsiveness, biodegradability, and compatibility were integrated in the PEG-b-PCL-based system. In vitro and in vivo studies demonstrated that superior tumor inhibition without obvious side effects can be achieved by the BTZ-loaded PEG-b-PCL-b-PDMA micelles.
研究领域:
药学
·
材料科学
·
纳米技术
·
肿瘤学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PHARMAZIE
·
2019
·Vol. 74
·期 10
·590-594
·
IF 0.82
Wang Jin,Zhang Hai-Hong,Liu Fengxi,Zhang Yu-Ping,Zhao Yong-Ming
Inclusion complexes of essential oils with cyclodextrins are an effective way to improve stability and solubility, and turn liquid materials into easy to handle powders. In this work, an essential oil of Myristica fragrans Hott. (MFEO), already used in the food and cosmetics
industries, was formulated with beta-cyclodextrins (β-CD) using a co-precipitation method. The orthogonal array scheme was adapted for the optimization of preparation process. DSC and FT-IR spectroscopy analysis indicated the successful formation of MFEO/β-CD inclusion complexes,
which improved the thermal stability of MFEO. Furthermore, comparing the antimicrobial activity of MFEO/β-CD inclusion complexes and free essential oil against Staphyloccocus aureus, Staphyloccocus epidermidis, Escherichia coli, Klebsiella pneumoniae, yeast
Saccharomyces cerevisiae and Bacillus subtilis, it was found that the antimicrobial effect was enhanced after the formation of inclusion complexes. This study demonstrates the potential for the use of MFEO/β-CD inclusion complexes in the treatment of bacterial infection.
研究领域:
食品科学
·
微生物学
✓ 已验证
DOI
高影响因子
PHARMAZIE
·
2013
·Vol. 68
·期 6
·396-400
·
IF 0.962
Shi Zheng,Liu Jian,Hu Xing-Jiang,ShenTu Jian-Zhong
The purpose of this study was to design a simple, sensitive and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for a febuxostat bioequivalence study in healthy Chinese male volunteers. In this method, febuxostat and etodolac (internal standard) were isolated
from plasma samples by protein precipitation with acetonitrile. The supernatant was chromatographed on a Zorbax SB-C18 (150 × 3.0 mm, 3.5-μm particle size, Agilent) column with a SecurityGuard Inertsil Symmetry C18 column (12.5 × 4.6 mm, 5-μm particle size, Waters). The lower
limit of quantification for febuxostat in 0.2 mL of human plasma was 13.40 ng•mL–1, and the linearity was achieved over a concentration range from 13.40 to 21440 ng•mL–1. Febuxostat tablets from Hengrui Medicine Co., Ltd (test, Jiangsu, China) and
from Takeda pharmaceuticals america, Inc. (reference, Deerfield, IL) were evaluated following a single 80 mg oral dose to 18 healthy volunteers. Bioequivalence was determined by calculating 90% confidence intervals (90% CI) for the ratio of C
max, AUC
0-t,
and AUC
0-∞ values for the test and reference products, using logarithmic transformed data. The calculated 90% CIs for the ratio of C
max (88.7∼131.2%), AUC
0-t (99.2∼ 122.7%) and AUC
0-∞ (99.5∼123.1%)
values for the test and reference products were all located within the bioequivalence criteria range (80∼125% for AUC, and 70∼143% for C
max), proposed by State of Food and Drug Administration [SFDA, 2005. China]. It was concluded that the two febuxostat formulations
(test and reference) analyzed were bioequivalent in terms of rate and extent of absorption and the method met the principle of quick and easy clinical analysis.
研究领域:
药理学
·
分析化学
·
临床药学
✓ 已验证
DOI
高影响因子
PHARMAZIE
·
2021
·Vol. 76
·期 9
·412-415
·
IF 1.267
Xuan G. S.,Zhan J. H.,Zhang A. M.,Li W.,Zheng K.
A series of sulfonamide derivatives were synthesized, and the enzyme inhibitory activity of the synthesized compounds on carbonic anhydrase II was evaluated. Through molecular docking studies, it was found that compounds 1b, 1e, 2a, 2b, 3a have a strong
binding affinity to carbonic anhydrase II. The IC50 values of the four compounds 1e, 2b, 3a, and 3b were lower than that of the positive control drug acetazolamide. What's more, the compounds had a high inhibitory activity for A549 lung cancer cell growth,
among them, 1e and 3a could inhibit both carbonic anhydrase II and lung cancer cell proliferation.
研究领域:
药理学
·
肿瘤学
·
生物化学
✓ 已验证
DOI
PubMed
高影响因子
PHARMAZIE
·
2014
·Vol. 69
·期 4
·281-286
·
IF 1.003
Sun Xiaoyi,Chen Jinliang,Gu Xiaohui,Liang Wenquan,Wang Junbo
The polycation transfection agent, polyethylenimine (PEI) was introduced into cisplatin (CDDP)-encapsulated liposomes by modification with amphiphilic PEI-cholesterol (PEI-Chol) to evaluate its potential application in chemotherapeutic drug delivery. Compared with unmodified neutral
liposomes (CDDP-NL), the remarkable features of PEI-modified cationic liposomes (CDDP-CL) increased cytotoxicity attributed to enhanced cellular uptake and extended cellular retention resulting from endosome escape in vitro. In a H22 hepatoma-bearing mouse model, CDDP-CL reduced the
nephrotoxicity associated with CDDP and had an antitumor activity similar to free drug, without inducing obvious system toxicity. These results confirm that the cationic modification of liposomes with PEI is efficient and safe for antitumor drug delivery.
研究领域:
药学
·
肿瘤学
·
生物医学工程
✓ 已验证
DOI
高影响因子
PHARMAZIE
·
2018
·Vol. 73
·期 8
·465-468
·
IF 1.016
Ma Wenxue,Yao Yawen,Gu Yuyan,Li Fang,Cai Jiaxuan,He Baozhu,Chen Qiuyan,Fang Jian,Ouyang Zizhang
Acute phase protein pentraxin 3 (PTX3) is increased in patients with atherosclerotic cardiovascular diseases, such as acute coronary syndrome and coronary artery vulnerability, thereby serving as an important biomarker for the prognosis of cardiovascular diseases. This study was designed
to evaluate the effects of statins on the expression of PTX3 in human endothelial cells. We observed that PTX3 is a TNFα inducible protein in human endothelial cells. In contrast, treatment with simvastatin reduces basal as well as TNFα induced gene and protein expression of PTX3
in a dose- and time-dependent manner. Our study suggests that reducing PTX3 expression by statins could contribute to its protective effects against endothelial dysfunction and coronary artery plaque destabilization.
研究领域:
心血管疾病
·
药理学
·
分子生物学
✓ 已验证
DOI
高影响因子
PHARMAZIE
·
2022
·
IF 1.515
Zhou Huiping,Peng Yuxuan,Liu Hongyun,Li Xiaohui,Mei Wenqiu,Li Hao,Xu Kangyan,Hu Meichun,She Tonghui
As a common vegetable, Momordica charantia (M. charantia), also known as bitter melon, has the pharmacological activity of reducing blood sugar and body fat. This experiment explored the effect of M. charantia on the mice liver by adding freeze-dried M. charantia
to the feed intake of high-fat diet mice. Among the three groups of normal diet mice (Control), high-fat diet mice fed with lyophilized bitter melon powder (BM) and single high-fat diet mice (HFD), it was seen that the body weight of BM mice did not change apparently (p>0.05), while the
body weight of HFD mice increased significantly (p<0.01). Serum triglycerides, total cholesterol, high density lipoprotein cholesterol (HDL-C), Low density lipoprotein cholesterol (LDL-C) of HFD mice was significantly higher than those of Control and BM mice (p<0.01). The results of
RT-PCR and Western blot showed that the transcription and protein expression levels of acetyl-CoA carboxylases alpha (ACACA) and fatty acid synthase (FASN) genes in HFD mice were significantly increased (p<0.01), while BM administration could reduce the transcription and expression of these
two genes (p<0.01). It is concluded that M. charantia powder alleviates the lipid metabolism disorder of liver in HFD mice via downregulating ACACA and FASN both in the transcription and protein expression levels, and thus exhibits protective effects for the liver.
研究领域:
营养学
·
药理学
·
分子生物学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）