ACS Food Science & Technology
·
2023
·
IF 2.3
Yuqian Zhou,Bushra Huma,Zhongxin Tan
Plant polyphenols’ antibacterial capabilities are just beginning to be applied in the environment. In this study, solvent recovery and concentration techniques were used to achieve zero-waste extraction of pineapple peel polyphenol (PPP) powder on an industrial scale. For environmental sterilization, PPP antibacterial agents (PAAs) were created. Their physicochemical and antibacterial qualities were examined, and technical and financial analysis was done. The results showed that (1) among the major PPP components, protocatechuic acid content was the highest (48.90 mg/L), followed by quercetin dihydrate (17.56 mg/L); (2) PAA sprays passed the tests for physicochemical properties like pH and heat resistance; (3) at the 8 mg/mL concentration, PAA achieved 100% bacterial inhibition below 40 °C; and (4) the production cost of 8 mg/mL PAA spray was only $273.41/t at 100,000 t industrial scale. These findings might offer an application prospect in the development of renewable bacteriocins from fruit and vegetable waste materials.
研究领域:
环境科学
·
生物技术
·
废物管理
·
药学
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2023
·
IF 14
Yu Wang,Ye Wu,Bo Zhang,Cheng Zheng,Cheng Hu,Chuan Guo,Qingquan Kong,Yunbing Wang
Intervertebral disc degeneration (IDD) progresses due to local inflammatory response, gradually unbalanced anabolic/catabolic activity, and progressive functional impairment within the nucleus pulposus. Antagomir-21, a cholesterol-modified miRNA-21 inhibitor, has potential extracellular matrix (ECM) regenerative ability , but its application for IDD is limited by inadequate local delivery systems. An injectable hydrogel gene delivery system encapsulating a modified tannic acid nanoparticles (TA NPs) vector was engineered for on-demand and sustained delivery of antagomir-21 into the nucleus pulposus. After nucleus pulposus cell uptake, antagomir-21 was released from TA NPs and regulated the ECM metabolic balance by inhibiting the MAPK/ERK signaling pathway . TA NPs scavenged intracellular ROS and reduced inflammation by downregulating TNF-α expression. In vivo , synergistic anti-inflammatory effects and ECM regeneration effectively promoted therapeutic efficacy against IDD. This hydrogel gene delivery system represents a creative, promising strategy for IDD repair.
研究领域:
生物医学工程
·
骨科
·
基因治疗
·
纳米技术
·
再生医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2023
·
IF 7
Zeng Yi,Yaqin Ran,Xiangyu Chen,Qiulan Tong,Lei Ma,Yunfei Tan,Xiaomin Ma,Xudong Li
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by synovial inflammation, cartilage damage and bone erosion. In the progression of RA, the inflammatory mediators including ROS, NO, TNF-α, and IL-6 play important roles in the aggravation of inflammation. Hence, reducing the generation and release of inflammatory mediators is of great importance. However, the high dose and frequent administration of clinical anti-inflammatory drugs such as glucocorticoids (GCs) usually lead to severe side effects. The development of nanotechnology provides a promising strategy to overcome these issues. Here, polyphenol-based nanoparticles with inherent anti-oxidative and anti-inflammatory activities were developed and used as a kind of nanocarrier to deliver dexamethasone (Dex). The in vitro experiments confirmed that the nanoparticles and drugs could act synergistically for suppressing inflammatory mediators in the LPS/INF-γ-induced inflammatory cell model. After intravenous administration, the Dex-loaded nanoparticles with good biosafety showed effective accumulation in inflamed joints and improved therapeutic efficacy by inducing anesis of synovial inflammation and cartilage destruction over free Dex in a collagen-induced arthritis (CIA) mouse model. The results demonstrated that polyphenol-based nanoparticles with therapeutic functions may serve as an innovative platform to synergize with chemotherapeutic agents for enhanced treatment of inflammatory diseases.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOID AND POLYMER SCIENCE
·
2025
·
IF 2.3
Peng Jiani,Shi Liangliang,Zhu Shiqi,Wu Xinyi,Gao Yong
Pickering emulsions with antioxidative properties have significant applications across various fields such as biomedicine, skincare, and food. The fabrication of antioxidant Pickering emulsions using core cross-linked diblock copolymer nanoparticles bearing polyphenol groups as both Pickering emulsifiers and the interfacial reservoirs of antioxidants was demonstrated in this study. Poly[oligo(ethylene glycol) methyl ether methacrylate] 18 -poly(diacetone acrylamide) 50 (POEGMA 18 -PDAAM 50 , E 18 D 50 ) diblock copolymer nanoparticles were first synthesized via RAFT-mediated dispersion polymerization in water. Subsequently, PDAAM cores of E 18 D 50 were chemically cross-linked using 4,6-diaminoresorcinol dihydrochloride (DAR.2HCl) as the cross-linker. The cross-linking process involved the Schiff base reaction between carbonyl groups of the PDAAM core-forming blocks and the amine groups of DAR.2HCl. Polyphenols were readily introduced into the cores of nanoparticles while the cross-linking of PDAAM core, affording core cross-linked copolymer nanoparticles bearing polyphenols (CCE 18 D 50 -P). The prepared CCE 18 D 50 -P nanoparticles exhibited excellent emulsification performances and outstanding free radical scavenging ability. Antioxidant dodecane-in-water Pickering emulsions were formulated using CCE 18 D 50 -P as Pickering emulsifiers, which demonstrated a desired effect in preserving vitamin E, with retentions of 88.4% and 82.1% after 28 days and 45 days of storage at room temperature, respectively. Graphical
研究领域:
材料科学
·
食品科学
·
生物医学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Tingting Liu,Yanfan Yang,Li Yan,Biying Lin,Lin Dai,Zhanhua Huang,Chuanling Si
Adhesives are used extensively in the wood industry. As resource and environmental issues become increasingly severe, the development of green and sustainable biomass-based adhesives has attracted increasing attention. In this work, a green wood adhesive is developed from poly(vinyl alcohol) and lignin with molecular designs of lignin extending beyond those in nature. The lignin undergoes extraction from corncob residue, aldehydration, and phenolisation (phenol, resorcinol, and catechol) to significantly increase the phenolic hydroxyl groups (over 7.92 mmol/g), which has the effect of enhancing the hydrogen bonding force between the adhesive and the wood, thereby greatly improving adhesive performance. Compared with pure PVA, polyphenol lignin-containing PVA showed improved adhesion strength and hydrophobicity . PVA/resorcinol-lignin has the significantly improved wood lap shear strength (6.27 MPa, 77.6 % improvement) and hydrophobicity (almost 100 % increase in wet shear strength). This research not only provides a green and high-performance alternative raw material for wood adhesives but also broadens the path for large-scale application of biomass.
研究领域:
材料科学
·
林业工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Rongrong Luo,Zimeng Peng,Na Wu,Li Zhang,Bin Peng,Rong Shao,Wei Xu,Lei Yang
In this study, arabinoxylan (AX) was used as a substrate, and tea polyphenol (TP) as a functional additive to create degradable, non-polluting, and antioxidant packaging materials. The effects of different TP concentrations on light transmittance and antioxidant activity of the AX-TP composite films were analyzed. The colors of the films gradually deepened with increasing TP content. The maximum scavenging rate of 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals using the AX-TP composite film solution of 59.13 ± 2.19 % was achieved at the TP concentration of 2.0 %. AX-TP composite films with different TP concentrations were applied to the surfaces of grapes, and the sensory quality, shriveling and decay rates, titratable acid, and weight loss rate of grapes during storage were evaluated using data from different experimental groups. The AX-TP composite films coated on grapes reduced the transpiration of water in the fruit and delayed grape spoilage, demonstrating an excellent preservation effect. These results show that AX-TP composite films increase the shelf life of fresh grapes.
研究领域:
食品科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Foods
·
2025
·Vol. 14
·期 24
·4337
·
IF 5.1
Zhiwen Hu,Zhenzhen Wu,Lingxin Yu,Shuyi Zou,Yaxuan Hu,Tengjun Jiang,Yanlei Lin,Yueyue Cai,Qibiao Weng,Jie Pang,Jiebo Chen
Tea polyphenols (TPs) are promising natural bioactive compounds; however, their practical application is hindered by poor stability and low bioavailability. To address this challenge, we synthesized TP–iron nanoparticles (TP-Fe NPs) through coordination-driven self-assembly. Comprehensive characterization (SEM, TEM, FTIR, and XRD) confirmed the successful formation of stable TP-Fe NPs, primarily mediated by phenolic hydroxyl and carbonyl groups. Among TP-Fe NPs, the TP3-Fe1 NPs exhibited superior performance, achieving DPPH and ABTS radical scavenging rates of 65.71% and 89.64%, respectively, and inhibition rates of 91.44% against E. coli and 88.67% against S. aureus . Furthermore, TP3-Fe1 NPs demonstrated excellent biocompatibility, showing no significant cytotoxicity to L929 cells at 0.01–0.1 mg/mL. These findings highlight the potential of TP3-Fe1 NPs as a safe and effective material with dual functionality for antioxidant and antibacterial applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS & DESIGN
·
2022
·
IF 9.417
Xiao Yang,Ning Zhang,Gen Li,Mingzhe Zhang,Chunli Pang,Shenzhen Ren,Hailong An
Recently, the development of multifunctional nanoplatforms for synergistic therapy is highly attractive in cancer treatment. Herein, a cancer cell membrane-coated biomimetic nanoplatform (termed as mPAGT) was designed through a simple and versatile polyphenol-mediated coating strategy for a catalytic cascades-enhanced tumor targeted combination therapy. Porphyrin MOFs (PCN) were selected as a nano-photosensitizer and then an endogenous nitric oxide (NO) donor l -arginine ( l -Arg) was loaded into the framework to obtain PA nanoplatforms; Subsequently, glucose oxidase (GOx) was coated on the surface through the interactions between protein and polyphenol and the purified murine breast cancer cell membrane was further decorated to form the resulting nanoplatforms mPAGT NPs. The prepared nanoplatforms exhibited an excellent drug loading capability (9.59% for l -Arg and 33.75% for GOx) and homologous targeting ability. Meanwhile, the mPAGT NPs could initiated a cascade reaction included GOx catalyzed oxidation of glucose, nano-photosensitizer based 1 O 2 -producing, and ROS-mediated the release of NO, and induce an obvious apoptosis with the highest apoptotic ratio of 86.2%. Moreover, the in vivo experimental results further confirmed that our multifunctional nanoplatforms possessed negligible systemic toxicity and promising potential for the treatment of tumor through the catalytic cascades-enhanced synergistic therapy.
研究领域:
纳米技术
·
癌症治疗
·
材料科学
·
生物化学
·
药学
✓ 已验证
DOI
高影响因子
ACS Applied Bio Materials
·
2020
·
IF 0
Min Mu,Yuelong Wang,Shasha Zhao,Xiaoling Li,Rangrang Fan,Lan Mei,Min Wu,Bingwen Zou,Na Zhao,Bo Han,Gang Guo
Chemotherapy works against tumors by inducing cell apoptosis; however, evasion of apoptosis is recognized to result in resistance to anticancer therapy. Ferroptosis is an iron-dependent cell death pathway that differs from apoptosis in morphological, biochemical, and genetic levels. Combined ferroptosis and apoptosis may shed light on strategies for cancer treatment. Therefore, we have designed a nanoparticle (NP) that can simultaneously cause tumor cell apoptosis and ferroptosis. This NP is composed of epigallocatechin gallate (EGCG) and Fe3+ through a simple and green process and can be used to deliver doxorubicin hydrochloride (DOX) and iron ions to the tumor site at the same time. DOX/Fe3+/EGCG (DF) NPs display a great resolubility and long-term storage stability, and efficient DOX and Fe3+ release is realized after cellular internalization under the high level of glutathione and acidic nature in tumor. EGCG is likely to chemically reduce the released Fe3+ to Fe2+. The generated Fe3+/Fe2+ converts intracellular H2O2 to hydroxyl radicals (•OH) via the Fenton reaction. In addition, the generated •OH subsequently induces lethal ferroptosis to improve DOX-induced apoptosis. In vitro and in vivo investigations indicate that a great therapeutic effect was achieved, suggesting that the formation of the DF NP delivery system is a promising strategy to fight against tumors by an apoptosis and ferroptosis combination modality.
研究领域:
纳米技术
·
癌症生物学
·
药学科学
·
材料科学
✓ 已验证
DOI
PubMed
JOURNAL OF FOOD SCIENCE
·
2024
·
IF 3.2
Ying Yuan,Ziqi Chai,Yuxue Zheng,Yanming Ren,Xingqian Ye,Xiangli Kong,Jinhu Tian
To investigate the effect of hawthorn polyphenols on the physicochemical properties and digestibility of corn starch, different proportions (1%, 2%, 3%, and 4% [w/w]) of hawthorn polyphenol extracts (HPEs) were mixed with corn starch, and their physicochemical properties and digestive properties were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, Rapid Visco Analysis, differential scanning calorimetry, and in vitro/in vivo analysis. Results indicated that small V-type crystal starch tended to be formed in the samples, and the addition of HPEs reduced the viscosity, prolonged the gelatinization temperature of corn starch, and increased the proportion of slowly digestible starch and resistant starch of the corn starch, which accounted for 36.32% ± 1.05% and 33.32% ± 4.07%, respectively. Compared with the raw corn starch, the postprandial blood glucose of mice that were administered the hawthorn polyphenols decreased significantly: the blood glucose peak (30 min) decreased from 14.30 ± 1.52 to 11.77 ± 1.21 mmol/L. Our study might provide some basic theoretical support for the application of hawthorn polyphenols in healthy starchy food processing.
研究领域:
食品科学
·
营养学
·
生物化学
✓ 已验证
DOI
PubMed
高影响因子
ACS Omega
·
2019
·
IF 2.584
Mei Li,Haiyang Ding,Xiaohua Yang,Lina Xu,Jianling Xia,Shouhai Li
A tung-oil-based polyphenol (ATOM), containing the phenolic hydroxyl group, was synthesized from tung oil and 4-maleimidophenol by the Diels–Alder addition reaction. Then self-healing thermosetting polyurethanes were prepared from ATOM and the polyurethane prepolymer. The chemical structure and cross-link network were confirmed by Fourier transform infrared spectroscopy (FTIR) and swelling tests. The products partially dissolved in trichlorobenzene when the temperature rose to 110 °C. Temperature-variable FTIR confirmed that the phenolic urethane starts to partially dissolve at 100 °C, which can be explained by the experimental phenomenon in swelling tests. Tensile property analysis showed that the broken and healed thermosets maintained about 46–64% of their original tensile strengths and 81–88% of their original elongations at break, respectively.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
PubMed
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 9
·3831
·
IF 4.6
Ying Huang,Changzheng Gao,Wei Song,Wanqing Wei,Xiulai Chen,Cong Gao,Jia Liu,Jing Wu,Liming Liu
Theaflavins (TFs) are good for health because of their bioactivities. Enzymatic synthesis of TFs has garnered much attention; however, the source and activity of the enzymes needed limit their wide application. In this study, a microbial polyphenol oxidase fromBacillus megateriumwas screened for the synthesis of theaflavin-3,3′-digallate (TFDG). Based on structural and mechanistic analyses of the enzyme, the O-O bond dissociation was identified as the rate-determining step. To address this issue, a transition state (TS) conformation optimization strategy was adopted to stabilize the spatial conformation of the O-O bond dissociation, which improved the catalytic efficiency of tyrosinase. Under the optimum transformation conditions of pH 4.0, temperature 25 °C, (−)-epigallocatechin gallate/epicatechin gallate molar ratio of 2:1, and time of 30 min, Mu4(BmTyrV218A/R209S) produced 960.36 mg/L TFDG with a 44.22% conversion rate, which was 6.35-fold higher than that of the wild type. Thus, the method established has great potential in the synthesis of TFDG and other TFs.Keywords:polyphenol oxidase;protein engineering;transition state;theaflavin-3,3′-digallate
研究领域:
生物化学
·
酶学
·
蛋白质工程
·
食品科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）