NEUROSCIENCE
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2022
·
IF 3.708
Chunyan Chen,Ping Fan,Lirong Zhang,Kaige Xue,Jiaheng Hu,Juan Huang,Weitian Lu,Jin Xu,Shiye Xu,Guoping Qiu,Jianhua Ran,Shengwei Gan
Aquaporin-4 (AQP4) regulates retinal water homeostasis and participates in retinal oedema pathophysiology. β-dystroglycan (β-DG) is responsible for AQP4 polarization and can be cleaved by matrix metalloproteinase-9 (MMP9). Retinal oedema induced by ischemia–reperfusion (I/R) injury is an early complication. Bumetanide (BU) has potential efficacy against cytotoxic oedema. Our study investigated the effects of β-DG cleavage on AQP4 and the roles of BU in a rat retinal I/R injury model. The model was induced by applying 110 mm Hg intraocular pressure to the anterior eye chamber. BU and U0126 (a selective ERK inhibitor) were intraperitoneally administered 15 and 30 min, respectively, before I/R induction. Rhodamine isothiocyanate extravasation detection, quantitative real-time PCR, transmission electron microscopy, hematoxylin-eosin staining, immunofluorescence staining, western blotting, and TUNEL staining were performed. AQP4 lost its polarization in the retinal perivascular domain as a result of β-DG cleavage. BU rescued AQP4 depolarization, suppressed AQP4 protein expression, attenuated retinal cytotoxic oedema, and downregulated β-DG and AQP4 mRNA expression. BU suppressed glial responses and mitochondria-mediated apoptotic protein expression, including that of Caspase-3 and Cyto C, raised the Bcl-2/Bax ratio, and lowered the number of apoptotic cells in the retina. Both BU and U0126 downregulated p-ERK and MMP9 expression. Thus, BU treatment suppressed β-DG cleavage, recovered AQP4 polarization partially via inhibiting ERK/MMP9 signaling pathway, and possess potential neuroprotective efficacy in the rat retinal ischemia–reperfusion injury model.
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高影响因子
ELECTROCHIMICA ACTA
·
2022
·
IF 7.336
Lei Jin,Zhi-Hao Liang,Jia-Qiang Yang,An-Ni Zheng,Zhao-Yun Wang,Fang-Zu Yang,De-Yin Wu,Zhong-Qun Tian,Dongping Zhan
5,5-Dimethylhydantoin (DMH), as a heterocyclic compound with N and O atoms, is an excellent complexing agent for trivalent gold ions . In this work, the tautomeric structures of DMH at different pH values in the solution are determined via theoretical calculations and Raman spectra . Only the ketonic form of DMH exists in weakly acidic and neutral mediums, and only the enolic form of DMH exists in highly alkaline mediums. In the weakly alkaline medium of pH 9, a large number of ketonic forms and a small number of enolic forms coexist. The coordination behavior between DMH and Au(Ⅲ) is clarified in the weakly alkaline medium of pH 9. The DMH in ketonic form is fully coordinated with Au(Ⅲ) at pH 9 and the optimal coordination structure is N2-Au with an N-Au bond energy of 16.17 eV. The electrochemical study reveals that Au(DMH) 4 − coordination ions are in the two-step electro-reductions with the first Au(Ⅲ) to Au(Ⅰ) and the second Au(Ⅰ) to Au on the gold electrode surface. The EC-SERS experiments further verify the interfacial process of tautomeric structures and Au(DMH) 4 − coordination ions.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2022
·
IF 9.136
Yu Feng,Yanan Wang,Zijin Pang,Yunqing Zhuang,Yu-Shi He,Weimin Zhang,Jinglin Mu,Xin Huang
Electro-Fenton (EF) is a promising and green technology for environmental remediation. However, traditional EF often suffers from iron sludge production, leading to poor pH adaptation and secondary pollution. In this work, we synthesized a three-dimensional (3D) carbon nanotube architecture containing nitrogen and oxygen heteroatoms on carbon fibre paper (3D-NOCNTs/CFP) as an indirect catalyst for a metal-free EF process for the removal of 4-chlorophenol (4-CP). The dependence of the content and the type of the functional groups in the carbon plane on the pyrolysis temperature was studied through XPS measurements. This binder-free electrode has been identified as a bifunctional catalyst that can catalyze a high H 2 O 2 yield process and a subsequent in-situ generation of ⋅OH via an O 2 reduction reaction (ORR). Thus the generated ⋅OH radicals can directly participate in the oxidative degradation of 4-CP and the utilization of iron can be avoided in the EF process. The optimized electrode could remove 99.3 % 4-CP in 120 min and exhibits a broad suitability upon pH, an excellent capability, and a prominent stability for the degradation of 4-CP. The mechanism was explained by density function theory (DFT) calculations and the controlled experiments. Such a metal-free EF process features a promising green technology for the oxidative degradation of organic pollutants.
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Journal of Cleaner Production
·
2022
·
IF 11.072
Wei-Dong Xiao,Ling-Ping Xiao,Wen-Zhe Xiao,Qiang Wang,Shang-Ru Zhai,Run-Cang Sun
The uniquely interconvertible transformation of cellulose pulp and paper shows great potential as smart materials for environment remediation. However, performing liquid-phase catalytic reactions involving hydrogenation steps under mild conditions and ambient temperature remains challenging. Herein, we report a facile and eco-friendly strategy to fabricate low-cost, highly effective, and stable pulp-supported silver nanoparticles (AgNPs/pulp). The pulp phase is used to maintain the high catalytic efficiency of the AgNPs/pulp catalyst, while the paper phase remains high stability as the filling material in the reaction column. The as-prepared AgNPs/pulp catalyst exhibits excellent catalytic activity toward NaBH 4 -mediated reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) with a turnover frequency of 605.1 h −1 and a k value of 24.9 × 10 −3 s −1 at room temperature, which outperforms most of reported cellulose-supported catalysts. Impressively, the AgNPs/pulp catalyst shows outstanding durability during a continuous operation for 72 h. Such excellent performance can be attributed to the uniform dispersion of the AgNPs/pulp in solution and uniform distribution of Ag NPs on the fiber surface of cotton pulp, which greatly improve the accessibility of reactants and active sites as well as metal-support interactions. This work provides new insights into the understanding of catalytic hydrogenation of 4-NP, which could pave the way for rational design of novel cellulose-based catalysts for organic wastewater treatment .
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CHEMPHYSCHEM
·
2022
·Vol. 23
·期 6
·e202200002
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IF 3.52
Jingfang Zhou,Rukang Li
Graphical Ba 3 Sc 2 (BO 3 ) 4 displays a beneficial layered structure in which BO 3 units are parallelly arranged by the modulation of ScO 6 octahedra and BaO n (n=9, 12) polyhedrons. The parallel arrangement of planar BO 3 units generates a large basic birefringence of 0.096, further enhanced by distorted ScO 6 octahedra up to Δn=0.149@550 nm, which is similar to the values reported in TiO 2 , LiNbO 3 , BaTi(BO 3 ) 2 . Transition metal ions with d 0 electronic states (Ti 4+ , Zr 4+ , Nb 5+ and Ta 5+ ) are widely investigated as functional materials. This work first illustrates that Sc 3+ ion, long-time ignored, displays a second-order Jahn-Teller (SOJT) effect similar to asymmetric oxide-coordinated transition metal ions, thus providing a new ground to seek for asymmetric functional materials with enhanced performances. In Ba 3 Sc 2 (BO 3 ) 4 , BO 3 groups are parallelly arranged, satisfying the ideal arrangement to produce large birefringence. Importantly, distorted octahedral ScO 6 with Sc 3+ ion in its d 0 electronic state enlarges birefringence unexpectedly up to 0.149 @ 550 nm, which is larger than previously reported borates containing solely BO 3 , even to B 3 O 6 units. Subsequently, the SOJT influence of distorted ScO 6 octahedra on birefringence is verified by a comparison between experimental data and theoretical calculations. In addition, Ba 3 Sc 2 (BO 3 ) 4 also displays a high transmittance in the range of 230 nm–3.5 μm with a UV cut-off wavelength at 198 nm and a large laser induced damage threshold (2.7 GW/cm 2 ), comparable to α-BaB 2 O 4 . Above characteristics imply that the title compound may be a promising birefringent material.
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FOOD AND CHEMICAL TOXICOLOGY
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2022
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IF 5.572
Dongxu Han,Yujie Yao,Lu Chen,Zhiying Miao,Shiwen Xu
Di(2-ethylhexyl) phthalate (DEHP) is a widely artificial persistent organic pollutant, the contamination of which infiltrates daily human life from many aspects, imperceptibly causing damage to multiple organs in the body, including the liver. Apigenin (APG) is widely distributed in vegetables and fruits and can relieve or prevent the injuries caused by exogenous chemicals through various pharmacological effects, such as antioxidant effects. To investigate the mechanism of DEHP-induced liver injury and the antagonistic effects of APG, we treated AML12 cells with 1 mM DEHP and/or APG. Ultrastructural morphology analysis indicated that DEHP induced typical ferroptosis-like damage. In addition, we found that DEHP exposure induced ferroptosis by enhancing reactive oxygen species (ROS) levels, disrupting iron homeostasis and lipid peroxidation, and regulating the expression of ferroptosis-related genes. Notably, supplementation with APG significantly inhibited these abnormal changes, and molecular docking further showed evidence of the activating effects of APG ligand on glutathione peroxidase 4 (GPX4). These results demonstrated that the protective effects of APG on DEHP-induced ferroptosis were achieved by activating GPX4 and suppressing intracellular iron accumulation. This information not only adds to DEHP toxicological data but also provides a basis for the practical application of APG.
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CHEMICAL ENGINEERING JOURNAL
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2022
·
IF 16.744
Tianran Lin,Ying Sun,Chunsuo Tian,Di Wang,Li Hou,Fanggui Ye,Shulin Zhao
Investigating the hydrogen-bonded organic frameworks (HOFs) with intrinsic functions has been a great challenge for the development of HOF materials. In this paper, an efficient way of obtaining a HOF with intrinsic catalytic activity is presented. A microporous HOF-PyTTA was self-assembled by using 4,4′,4′',4′''-(pyrene-1,3,6,8-tetrayl) tetraaniline (PyTTA) as an organic monomer. The monomer has a pyrene ring with a conjugated structure, which is conducive to the construction of large-area π-π interactions, therefore improving the stability of the HOF structure. The amino-functional group of the monomer serves as the active site which enables the HOF-PyTTA, which acts as a non-metallic catalyst to catalyze the conversion of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP). The permanent pore structure of the HOF-PyTTA was confirmed by X-ray single-crystal diffraction and CO 2 isotherm adsorption experiments. To broaden the application of HOF-PyTTA, we propose growing HOF-PyTTA on the filter membranes of diverse materials and making a catalytic column by filling the HOF-PyTTA/glass fiber membrane into the syringe. After pouring the mixture of 4-NP and NaBH 4 into the catalytic column, 4-NP was converted into 4-AP with a high rate of conversion. This work develops a simple, robust, and flexible HOF with intrinsic catalytic reduction activity for 4-NP, and broadens the application of HOF for functional modification and catalytic application.
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Acta Biomaterialia
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2022
·
IF 10.633
Xiaokang Zhu,Qifang Chen,Li Xie,Wenjie Chen,Yang Jiang,Erqun Song,Yang Song
Ferroptosis shows promising potential in tumor treatment; however, factors that compromise the efficiency of the Fenton catalyst have limited its therapeutic effectiveness. We developed a polydopamine-based nanoplatform constructed with ferric ion and sulfasalazine-loaded nanoparticles (Fe(III) [email protected] NPs) for dual-functional ferrotherapy strategy of “sword and shield” through enhanced Fenton reaction and inactivation of glutathione peroxidase 4 (GPX4), respectively. Both the Fenton reaction-based hydroxyl radical ( · OH) production and sulfasalazine-driven GPX4 inhibition induced ferroptotic cell death, thus achieving synergistic cancer therapy. Near-infrared light irradiation and acidic tumor microenvironment enhanced the release of ferric ions and sulfasalazine from the Fe(III) [email protected] NPs. In addition, the released iron ions underwent valence state change due to Fenton reaction and thus provided a supplementary T1-weighted signal for in situ visualization of the tumor based on magnetic resonance imaging. The Fe(III) [email protected] NPs exhibited high pro-ferroptosis performance by utilizing · OH radicals as a “sword” to attack cancer cells and the GPX4 inhibitor to break down the “shield” of cancer cells, thus showing potential for cancer treatment. Statement of significance Several strategies of cancer therapy based on ferroptosis have emerged in recent years, which have provided new insights into designing materials for therapeutic applications. The antitumor efficacy of ferroptosis is, however, still unsatisfactory, mainly because of insufficient intracellular pro-ferroptotic stimuli. In the current study, we report a multifunctional theranostic nanoplatform, namely Fe(III) [email protected] , with three-fold synergistic effect; this nanoplatform has excellent theranostic potential with multifunctional ferrotherapy.
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高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2022
·Vol. 169
·期 9
·097501
·
IF 4.386
Dongmei Ren,Xingwen Wang,Chunpeng Leng,Wei Meng,Jingrui Zhang,Chao Han
4-Nitrophenol (4-NP) is a typical organic pollutant, thus it is urgent to detect it in environmental samples. This study rationally designed a novel electrode material of P-doping Fe/Fe3O4@C (P-Fe/Fe3O4@C) prepared with MIL-88 as precursor. P2h-Fe/Fe3O4@C-700 was synthesized by calcining MIL-88 at 700 °C, followed by annealing process with NaH2PO2 for 2 h. The P2h-Fe/Fe3O4@C-700 modified glassy carbon electrode (P2h-Fe/Fe3O4@C-700/GCE) showed a high electrocatalytic activity toward 4-NP reduction due to its active metal center, fine-tuned electronic structure by P-doping, as well as good electrical conductivity. It exhibited excellent sensing behaviors in 4-NP detection with rather high sensitivities of 1415.43 μA·mM−1·cm−2 and 424.63 μA·mM−1·cm−2 in the 4-NP concentration of 5 to 100 μM and 100 to 1200 μM, respectively, with a low detection limit of 0.462 μM. The P2h-Fe/Fe3O4@C-700/GCE still had good selectivity for 4-NP detection in the presence of common interferences. In addition, it was found that the current response towards 4-NP at P2h-Fe/Fe3O4@C-700/GCE retained more than 97% of its initial value after one week, indicating a good long-term stability. Furthermore, the P2h-Fe/Fe3O4@C-700/GCE exhibited a good reproducibility. The constructed P2h-Fe/Fe3O4@C-700/GCE achieved practical uses for the sensing of 4-NP in tap water with satisfactory recoveries.
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Royal Society Open Science
·
2022
·Vol. 9
·期 8
·
IF 3.653
Lin Li,Ting Yu,Zhenghua Qian,Xiaoling Wu,Hui He,Guoan Ye,Yanbo Qiao
Two new metal-organic frameworks (MOFs) (Th/ Ce -TCPE) based on 1,2,4,5-tetrakis(4-carboxyphenyl)ethylene were obtained using a straightforward reaction under moderate conditions. Th and Ce formed the central units of this MOF in the mononuclear and in the unusual trinuclear cluster configurations, respectively. The resulting MOFs were analysed by fluorescence spectroscopy to understand their luminescence. The obtained data revealed that benzene's electron cloud density and torsion angle on the ligand were affected by the acetic acid molecule and Th(IV), which caused Th-TCPE to irradiate stronger blue emission, but Ce-TCPE showed no fluorescence due to the self-quenching. Such a unique luminescence property could be used for fluorescence or radiopharmaceutical sensing.
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MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Lei Sun,Hao Guo,Zhilan Pan,Bingqing Liu,Ning Wu,Yinsheng Liu,Zongyan Lu,Xiaoqin Wei,Wu Yang
Owing to the high toxicity of acetaminophen (ACOP) and 4-aminophenol (4-AP) when they are overused, the simultaneous determination of ACOP and 4-AP is crucial. In this present paper, an electrochemical sensor based on the nanocomposite of sulfurbridged covalent triazine frameworks (S-CTFs) and in situ formed nickel cobaltite (NiCo 2 O 4 ) nanoflowers on S-CTFs, denoted as S-CTFs@NiCo 2 O 4 , was fabricated for the first time for sensitive detection of ACOP and 4-AP. S-CTFs@NiCo 2 O 4 modified electrode exhibited the outstanding synergetic effects of S-CTFs (prominent enrichment ability and large surface area) and NiCo 2 O 4 (excellent electrocatalytic activity). The developed electrode had the advantages of high reproducibility, repeatability, anti-interference and stability, and it exhibited a wide linear concentration range (2 ∼ 360 μM) and a low limit of detection (0.18 μM and 0.35 μM) for ACOP and 4-AP, respectively. In addition, the designed electrochemical sensor was evaluated towards the detecting ACOP and 4-AP in real samples with satisfactory recovery, illustrating that electrode has a broad prospect in the clinical application.
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MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Jiang Chang,Deying Zou,Honglin Ren,Xilin Liu,Meng Li,Zhaozhao Si,Cheng Han,Zengshan Liu,Shiying Lu,Pan Hu
The 10-kDa chemokine interferon-gamma-inducible protein 10 (IP-10) is considered one of the most promising biomarkers for diagnosing both tuberculosis and COVID-19 infections. The blood samples of patients at different disease states contain different levels of IP-10, which need to be detected in a rapid, specific and ultrasensitive manner. Here, we report a bienzymatic chemiluminescence sandwich immunoassay (BCSI) assay for the ultrasensitive and stable detection of IP-10. In this assay, IP-10 is first efficiently captured using a double-antibody sandwich strategy. The detection antibody is linked to catalase (CAT) via a streptavidin–biotin signal amplification system to achieve highly efficient conversion of hydrogen peroxide (H 2 O 2 ) to oxygen and water. In the chemiluminescence (CL) reaction, horseradish peroxidase (HRP) acts as an efficient catalyst, and 4-bromophenol acts as an enhancer for the cyclic transition of HRP, which results in a strong and durable CL signal. The bienzymatic catalysis with CAT and HRP and the potentiation of 4-bromophenol enables the assay to be ultrasensitive and stable. The CL intensity was found to be well correlated with the detection of IP-10 at levels in the range of 0.71 to 125,000 pg/mL, which covers more than 6 orders of magnitude, with a detection limit of 0.63 pg/mL. The coefficient of variation was 1.49%, and the recovery range of IP-10 in serum was 86.21%-104.57%. This assay provides a wide linear range and high sensitivity and may be a promising method for the high-throughput detection of IP-10 in the diagnosis of tuberculosis and COVID-19.
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