JOURNAL OF POLYMER RESEARCH
·
2023
·Vol. 30
·期 6
·1-13
·
IF 2.8
Su Hao,Yang Jin
Using 3-aminopropyltriethoxysilane (KH550), γ-glycidyloxypropyltrimethoxysilane (KH560) and silica with different particle sizes as raw materials, the grafting reaction through layer-by-layer assembly strawberry-like silica particles with multi-scale effects were prepared, and their structures were characterized by infrared spectroscopy (FT-IR), hydrogen nuclear magnetic resonance (NMR), X-ray diffraction (XRD), transmission electron microscopy (TEM) and other testing methods. Then it was physically blended with laboratory-made water-based epoxy resin WEP, and the coating with superhydrophobic properties was prepared by the low surface energy modification of methyltrimethoxysilane (MTMS). Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) to characterize the blending stability and heat resistance of the coating, and to analyze its morphological characteristics with scanning electron microscopy (SEM), and to analyze its abrasion resistance by measuring the change in the surface contact angle of the coating under certain conditions, Chemical resistance. The results showed that the prepared strawberry-like silica particles reached the expected structure, and formed Pickering emulsion similar to oil-in-water after blending with WEP, which was a stable emulsion system of solid particles. At the same time, due to the introduction of strawberry-like silica particles and the low surface energy modification of MTMS, the modified WEP has superhydrophobic properties, as well as excellent abrasion resistance, corrosion resistance and self-cleaning effect.
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2023
·Vol. 39
·期 6
·976-984
·
IF 3.1
Hou Huipeng,Tang Shanshan,Wang Wei,Liu Miao,Liang Axin,Xie Bingteng,Yi Yue,Luo Aiqin
I n this work, an electrochemical chiral sensor of a nanowire-like chiral metal-organic framework/multiwalled carbon nanotube-chitosan/glassy carbon electrode( D -MOF/MWCNTs-CS/GCE) was proposed for the enantiorecognition of L / D -tryptophan( L / D -Trp). The asymmetrical spatial structure of D -MOF provides the feasibility for the enantiorecognition of Trp enantiomers. Moreover, differential pulse voltammetry(DPV) was carried out to be the detection method and the DPV peak potential difference(Δ E p ) between L -Trp and D -Trp was referred as the index of the enantiorecognition performance. Several parameters, such as mass ratios and drop-coated volume of MWCNTs-CS, drop-coated volume and concentration of D -MOF, pH and detection temperature of D -MOF/MWCNTs-CS/GCE were optimized for the largest Δ E p value. And the molecular dynamics(MD) simulation was used to elucidate the enantiorecognition mechanism. Furthermore, the proportions of D -Trp( D -Trp%) in Trp mixtures were detected in a good linear relationship with the DPV peak potentials( E p ), and the proposed electrochemical chiral sensor exhibited good reproducibility, stability and enantiorecognition ability. Additionally, the proposed electrochemical chiral sensor( D -MOF/MWCNTs-CS/GCE) has a good application prospect in the fields of biomedicine, clinical diagnosis, chemical production, pharmaceuticals safety and so on.
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Friction
·
2023
·Vol. 11
·期 11
·2091-2106
·
IF 6.8
Zhou Yongjun,Zhang Yuanya,Liu Meng,Wang Yanling,Yuan Junya,Men Xuehu
Epoxy resin (EP) composites with satisfactory thermal and tribological performance are highly required for engineering moving components. However, the simple addition of fillers leaded to the serious filler agglomeration and limited promotion in tribological properties. In this work, we constructed a new kind of three-dimensional (3D) reduced graphene oxide (RGO)/Si 3 N 4 hybrid aerogel for EP composites, which was prepared by a facile hydrothermal self-assembly method followed by freeze-drying technique. As a result, the dispersibility of Si 3 N 4 whiskers was greatly improved through wrapping of polydopamine—polyethyleneimine copolymer (PDA—PEI) copolymer and physical spacing of 3D skeleton. Furthermore, benefiting from the synergistic effect of RGO and Si 3 N 4 @PDA—PEI in the thermal network, the thermal conductivity of RGO/Si 3 N 4 hybrid aerogel (GSiA)—EP increased by 45.4% compared to that of the neat EP. In addition, the friction coefficient and wear rate of GSiA—EP decreased by 83.7% and 35.8%, respectively. This work is significant for opening a tribological performance enhancement strategy though constructing 3D hybrid architecture.
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APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
·
2023
·Vol. 107
·期 5
·1725-1736
·
IF 5
Li Jing,Li Ziyi,Gong Hui,Ma Mengyi,Li Shuolei,Yang Huilin,Zhang Hailin,Liu Jianguo
Abstract In this study, a novel high-activity amylosucrase from Salinispirillum sp. LH10-3-1 (SaAS) was identified and characterized. The recombinant enzyme was determined as a monomer with a molecular mass of 75 kDa. SaAS protein exhibited the maximum total and polymerization activities at pH 9.0 and maximum hydrolysis activity at pH 8.0. The optimum temperature for total, polymerization, and hydrolysis activities were 40, 40, and 45 °C, respectively. Under the optimal pH and temperature, SaAS had a specific activity of 108.2 U/mg. SaAS also showed excellent salt tolerance and could retain 77.4% of its original total activity at 4.0 M NaCl. The addition of Mg 2+ , Ba 2+ , and Ca 2+ enhanced the total activity of SaAS. When the conversion of 0.1 M and 1.0 M sucrose was catalyzed at pH 9.0 and 40 °C for 24 h, the ratios of hydrolysis, polymerization, and isomerization reactions were 11.9:77.4:10.7 and 15.3:53.5:31.2, respectively. The α-arbutin yield of 60.3% was achieved from 20 mM sucrose and 5 mM hydroquinone catalyzed by SaAS. Key points
• A novel amylosucrase from Salinispirillum sp. LH10-3-1 (SaAS) was characterized.
• SaAS has the highest specific enzyme activity among all known amylosucrase.
• SaAS has hydrolysis, polymerization, isomerization, and glucosyltransferase activities.
Graphical Abstract
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MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 3
·1-11
·
IF 5.7
Chen Cizhi,Kang Jiao,Wang Siyi,Chen Siyu,Guo Hong,Chen Mei
The incidence rate of cardiovascular diseases (CVDs) remains high, and their mortality rate is significantly higher than that of other diseases. Growth differentiation factor-15 (GDF-15) is a recently developed biomarker for the early diagnosis and prognostic evaluation of CVDs because its concentration in serum increases substantially after a cardiovascular injury or an inflammatory reaction. In this study, a sandwich-type immunosensor was constructed for the sensitive detection of GDF-15. Specifically, peony-like zinc gallinate (ZnGa 2 O 4 ) prepared using a hydrothermal method, which exhibits excellent electrocatalytic performance, was coupled with Au nanoparticles (NPs) to obtain golden-peony-like ZnGa 2 O 4 /Au NPs. They preserved the immune activity of GDF-15 antibody molecules and further enhanced the conductivity, thereby realizing additional signal amplification. Hollow polyaniline (PANI) microtubules decorated with Pd NPs were used as the sensing platform (PANI/Pd NPs). The hollow microtubules provided abundant active sites and considerably improved the electron-transfer rate. Under optimal conditions, a linear range and remarkably low detection limit of 100 fg mL −1 –10 ng mL −1 and 42.23 fg mL −1 , respectively, were achieved. These experimental results indicate that the strategy reported herein can be adopted as a novel approach for the convenient and rapid detection of GDF-15. Graphical abstract
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Biomass Conversion and Biorefinery
·
2023
·
IF 4
Chen Xiaoqiang,Yang Shihan,Yang Hong,Zhang Jinshan,Huang Yuyuan,Zhang Ying
Response surface methodology was used to optimize the ultrasonic-assisted extraction (UAE) of total flavonoids (TF) and total phenols (TP) from Berberis kongboensis fruit. Single-factor experiments were conducted with the ultrasonication power, liquid–solid ratio, ethanol concentration, extraction temperature, and extraction time. A Plackett–Burman design was used to identify the main factors affecting the extraction rates of TF and TP. A Box–Behnken design was used to further optimize the ethanol concentration, solvent/sample ratio, and extraction temperature. Under the optimum conditions, the ethanol concentration of 34.67%, solvent/sample ratio of 38.44 mL/g, and extraction temperature of 46.53 °C, the yields of TF and TP were 107.92 mg rutin equivalents/g and 4.86 mg gallic acid equivalents/g, respectively. The extract from UAE had a better yield and higher antioxidant activities in vitro than that obtained by conventional solvent extraction. The B. kongboensis fruit is rich in flavonoids and phenolics, and it has potential application value in the food industry.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2022
·Vol. 20
·期 1
·1-24
·
IF 9.429
Yang Xiao-Yan,Zhang Jin-Guo,Zhou Qiao-Mei,Yu Jie-Ni,Lu Yuan-Fei,Wang Xiao-Jie,Zhou Jia-Ping,Ding Xin-Fa,Du Yong-Zhong,Yu Ri-Sheng
Background Excessive extracellular matrix (ECM) deposition in pancreatic ductal adenocarcinoma (PDAC) severely limits therapeutic drug penetration into tumors and is associated with poor prognosis. Collagen is the most abundant matrix protein in the tumor ECM, which is the main obstacle that severely hinders the diffusion of chemotherapeutic drugs or nanomedicines. Methods We designed a collagenase-functionalized biomimetic drug-loaded Au nanoplatform that combined ECM degradation, active targeting, immune evasion, near-infrared (NIR) light-triggered drug release, and synergistic antitumor therapy and diagnosis into one nanoplatform. PDAC tumor cell membranes were extracted and coated onto doxorubicin (Dox)-loaded Au nanocages, and then collagenase was added to functionalize the cell membrane through lipid insertion. We evaluated the physicochemical properties, in vitro and in vivo targeting, penetration and therapeutic efficacy of the nanoplatform. Results Upon intravenous injection, this nanoplatform efficiently targeted the tumor through the homologous targeting properties of the coated cell membrane. During penetration into the tumor tissue, the dense ECM in the PDAC tissues was gradually degraded by collagenase, leading to a looser ECM structure and deep penetration within the tumor parenchyma. Under NIR irradiation, both photothermal and photodynamic effects were produced and the encapsulated chemotherapeutic drugs were released effectively, exerting a strong synergistic antitumor effect. Moreover, this nanoplatform has X-ray attenuation properties that could serve to guide and monitor treatment by CT imaging. Conclusion This work presented a unique and facile yet effective strategy to modulate ECM components in PDAC, enhance tumor penetration and tumor-killing effects and provide therapeutic guidance and monitoring. Graphical Abstract
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Scientific Reports
·
2022
·Vol. 12
·期 1
·1-12
·
IF 4.996
El-Sayed Fatma Mohamed,E.A.Ali Mohamed,Isawi Heba,Abo Aly M. M.,Abo El-Fadl M. M. S.
In this study, the main motivation of this work is desalination of water for irrigation arid area such as Sidri- Baba basins- south Sinai, Egypt. Also, the novelty of this work is modification of TFC surface membrane by mix of HA, DA and GO to get high performance of FO technique. Interfacial polymerization was employed to modify a thin-film composite (TFC) membrane for forward osmosis (FO) applications; moreover, graphene oxide (GO) nanosheets (GONs), a dopamine solution (DA), and naturally accessible humic acid (HA) were modified on a polyethersulfone (PES) substrate. The effects of the different quantities of GO, HA, and DA on the membrane surfaces, as well as their various cross-sectional morphologies and FO-desalination capabilities, were investigated. The integrated TFC membrane containing appropriate GO, HA, and DA blends outperformed the control membrane, obtaining high water flux, and high salt rejection. Furthermore,.
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JOURNAL OF ELECTRONIC MATERIALS
·
2022
·Vol. 52
·期 2
·907-916
·
IF 2.047
Shao Mengyao,Hu Bin,Ge Shengyan,Zhou Xingfu
Ti/TiO 2 / SnO 2 -Sb-Ir/SnO 2 -Sb-Ni electrodes modified with three kinds of TiO 2 interlayer materials were fabricated. TiO 2 macroporous membrane (MAc) substrate was prepared by direct calcination, and TiO 2 nanotubes (NTs) and TiO 2 mesoporous membrane (MEs) substrate were fabricated by anodic oxidation under different conditions. The study shows that the TiO 2 -nanotube-based anode reduces crack morphology and provides a larger surface area for loading the electrochemically active materials. TiO 2 -NTs as the optimized interlayer improve the oxygen evolution potential (OEP) from 1.49 to 1.85 V and increase the current density of the oxidation peak from 0.28 to 0.55 mA cm −2 , which enhances the oxidative degradation ability of the electrode. In addition, the service life of the Ti/TiO 2 -NTs/SnO 2 -Sb-Ir/SnO 2 -Sb-Ni electrodes is 3.18 times longer than that of the Ti/SnO 2 -Sb-Ir/SnO 2 -Sb-Ni electrodes according to accelerated life tests. The degradation rate of methylene blue (MB) wastewater with an initial concentration of 20 mg L −1 reaches 99.14% under 5.0 V within 5 min by using Ti/TiO 2 -NTs/SnO 2 -Sb-Ir/SnO 2 -Sb-Ni electrodes, which is 1.67 times more than that of the Ti/SnO 2 -Sb-Ir/SnO 2 -Sb-Ni electrodes. Graphical Abstract
Ti/SnO 2 -Sb-Ir/SnO 2 -Sb-Ni electrodes modified with three kinds of TiO 2 interlayer have been
fabricated. The service life of the optimized Ti/TiO 2 -NTs/SnO 2 -Sb-IrO 2 /SnO 2 -Sb-Ni electrode is
3.18 times longer than that of the Ti/SnO 2 -Sb-Ir/SnO 2 -Sb-Ni electrodes. The degradation rate of
the optimized electrode reaches 99.1 % within 5 min, which is 1.67 times more than that of the
Ti/SnO 2 -Sb-Ir/SnO 2 -Sb-Ni electrodes.
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NEUROCHEMICAL RESEARCH
·
2022
·Vol. 48
·期 5
·1305-1319
·
IF 4.414
Cheng Shen,Chen Chen,Wang Liling
Given that the role of Gelsemine in neuroinflammation has been demonstrated, this research aimed to investigate the effect of Gelsemine on neonatal hypoxic-ischemic (HI) brain injury. An in vivo HI brain injury neonatal mouse model and an in vitro oxygen–glucose deprivation (OGD) cell model were established and pretreated with Gelsemine. The brain infarct volume, neuronal loss and apoptosis, as well as spatial learning and memory were examined by TTC staining, Nissl’s staining, TUNEL staining and Morris water maze test. Immunohistochemical staining was applied to detect the microglia cells and astrocytes in the mouse brain tissue. The cell viability was analyzed by CCK-8 assay. The levels of malondialdehyde (MDA), superoxide dismutase (SOD), TNF-α, IL-1β, and IL-6 were determined via ELISA. The lactate dehydrogenase (LDH) release and reactive oxygen species (ROS) level in OGD-treated cells were detected by colorimetry and DCFH-DA staining. Nrf2, HO-1, and inflammation-related factors were analyzed by immunofluorescence, qRT-PCR, or western blot. Gelsemine reduced the infarct volume and neuronal loss and apoptosis, yet improved spatial learning and memory impairment of HI-injured mice. Gelsemine inhibited the elevated MDA, TNF-α, IL-1β, IL-6, LDH and ROS levels, promoted the reduced SOD level and viability, and strengthened the up-regulation of HO-1 and Nrf2 in brain tissues and OGD-treated cells. However, Nrf2 silencing reversed the effects of Gelsemine on the Nrf2/HO-1 pathway, inflammation, and oxidative stress in OGD-treated cells. Gelsemine produces neuroprotective effects on neonatal mice with HI brain injury by suppressing inflammation and oxidative stress via Nrf2/HO-1 pathway.
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CELLULOSE
·
2022
·Vol. 30
·期 2
·1225-1244
·
IF 6.123
Liu Huan,Quan Jingran,Wang Junyao,Hou Qi,Wang Rui,Cui Bowen,Lang Tianhong,Chen Yansong,Pan Hongxu,Xu Jianxin,Yang Hanbo,Li Lixiang,Liu Yahao
Paper-based sensors have good application prospects due to their flexibility and environmental protection. However, paper-based materials are difficult to balance both conductivity and flexibility. This paper mainly reports a high porosity conductive paper based on bamboo wood mixed fiber materials through the wet-manufacture method. The crucial material properties, and long-chain structure of PEDOT:PSS, play an important role in conductivity and flexibility. The relevant experiments show that conductive paper has excellent physical properties and electrical signal transmission capacity. Among them, the conductivity of paper-based electrodes is up to 18.52 S/cm, and there is a low delay in the transmission of the electric signal, when the signal frequency is 300 kHz, the phase frequency angle changes by only 4.9°, not only that, as an electrode, the human pulse signal measured in the capacitive sensor is normal. Under the action of other composite materials, the manufactured electronic paper has a certain mechanical strength, and the thickness is about 90 μm, lower than ordinary paper products. The research shows that the paper-based electrode has the advantages of high conductivity, low hysteresis, light, and thinness, which provides the possibility to be used as a flexible electrode. Graphical abstract
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-16
·
IF 17.694
Meng Yun,Chen Lijie,Chen Yang,Shi Jieyun,Zhang Zheng,Wang Yiwen,Wu Fan,Jiang Xingwu,Yang Wei,Zhang Li,Wang Chaochao,Meng Xianfu,Wu Yelin,Bu Wenbo
Bacteria and excessive inflammation are two main factors causing non-healing wounds. However, current studies have mainly focused on the inhibition of bacteria survival for wound healing while ignoring the excessive inflammation induced by dead bacteria-released lipopolysaccharide (LPS) or peptidoglycan (PGN). Herein, a boron-trapping strategy has been proposed to prevent both infection and excessive inflammation by synthesizing a class of reactive metal boride nanoparticles (MB NPs). Our results show that the MB NPs are gradually hydrolyzed to generate boron dihydroxy groups and metal cations while generating a local alkaline microenvironment. This microenvironment greatly enhances boron dihydroxy groups to trap LPS or PGN through an esterification reaction, which not only enhances metal cation-induced bacterial death but also inhibits dead bacteria-induced excessive inflammation both in vitro and in vivo, finally accelerating wound healing. Taken together, this boron-trapping strategy provides an approach to the treatment of bacterial infection and the accompanying inflammation.
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