CARBOHYDRATE POLYMERS
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2023
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IF 11.2
Hua Wei,Shengkai Yu,Yansheng Zhang,Hua Zhang,Yuxi Ma,Mengjia Xu,Peng An,Yang Zhou,Sami Halila,Yen Wei,Jing Chen
Delayed or chronic wound healing is one of severe clinical issues. Developing scaffold materials capable of supporting cells and inducing tissue regeneration remains a challenge. Here, a polysaccharide-based hydrogel is constructed for promoting full-thickness skin wound healing in mouse model. The engineering hydrogel consists of a dynamic crosslinking network formed by the Schiff base reaction between aldehyde-containing xyloglucan and methacrylated chitosan. Its reversible gel-sol-gel transition upon shearing force is highly beneficial to completely cover and fill irregular wound shape. The second covalent cross-linking network achieved by photo-initiated polymerization offers a feasible way to tune the mechanical property of hydrogel after injection, with an ideal mechanical adaptivity for clinical application. Remarkably, both in vitro and in vivo evaluations demonstrate that the hydrogel with endogenously bioactive galactoside units can promote cell spheroid formation and accelerate wound healing by expediting re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles.
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CHEMICAL ENGINEERING JOURNAL
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2023
·
IF 15.1
Ke Liu,Juan Yang,Jiale Liu,Qin Shuai,Yusuke Yamauchi,Minsu Han,Lijin Huang
Covalent organic framework (COF) aerogels have attracted significant interest due to their broad range of potential applications. However, synthesizing COF aerogels with tailored structures and robust mechanical stability remains a formidable challenge. In this work, we present a double-cross-linking strategy to prepare a series of compressible COF/chitosan (COF/CS) aerogels under mild conditions. By harnessing chemical cross-linking and physical interactions, such as electrostatic and hydrogen bonding, ionic COF powders containing sulfonic acid groups ( i.e. , TpPa-SO 3 H) are immobilized and connected with CS, forming a three-dimensional interconnected network. Impressively, the ratio of COF to CS and the size of the COF/CS aerogels can be easily controlled by adjusting the processing parameters. The resulting COF/CS aerogels possess a highly porous structure and low density, enabling the aerogels to self-float and facilitating practical applications and recycling. Due to these remarkable characteristics, TpPa-SO 3 H/CS aerogel demonstrates excellent adsorption capacity, effectively removing sulfamerazine from aqueous solutions with an adsorption capacity of 102.5 mg·g −1 . Moreover, the aerogel can be reused in three adsorption–desorption cycles without significant capacity loss. This proposed method offers a facile, eco-friendly, and scalable approach for producing highly compressive COF-based aerogels, thereby accelerating the practical utilization of COFs and contributing to environmental remediation.
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Fengjiao Zhang,Sufeng Zhang,Shuyuan Cui,Xiaokai Jing,Yao Feng,Sergiu Coseri
In this study, the quaternized carboxymethyl chitosan (QCMCS), oxidized hyaluronic acid (OHA), 3,3′-dithiobis-(propionohydrazide) (DTP) were used as raw materials for the synthesis of hydrogels with excellent properties as carriers for drug release. The hydrogels were prepared by a simple “one-pot” method without external stimuli on the basis of interactions between formed dynamic covalent bonds (imine bonds, acylhydrazone bonds, disulfide bonds) and hydrogen bonds . The hydrogels had rapid self-healing properties, with a self-healing rate of 96 % after 30 min, as well as good pH responsiveness and excellent cytocompatibility (up to 98 % cell survival). The compressive stress of the hydrogels reached 423 kPa. Moreover, a representative drug (acetylsalicylic acid) demonstrated sustained release in the hydrogels (>72 h). The drug release behaviour was shown to be consistent with the Fick diffusion mechanism by kinetic modelling. Collectively, the findings demonstrate that the QCMCS + OHA + DTP injectable self-healing hydrogels are a potential material for the construction of pH-controlled drug delivery platforms.
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BIOMACROMOLECULES
·
2023
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IF 6.2
Xiaokang Na,Bowen Zou,Xiaohan Zheng,Ming Du,Beiwei Zhu,Chao Wu
Innovation in green, convenient, and sustainable antimicrobial packaging materials for food is an inevitable trend to address global food waste challenges caused by microbial contamination. In this study, we developed a biogenic, hydrophobic, and antimicrobial protein network coating for food packaging. Experimental results show that disulfide bond breakage can induce the self-assembly of bovine albumin (BSA) into protein networks driven by hydrophobic interactions, and chitosan oligosaccharide (COS) with antimicrobial activity can be stably bound in this network by electrostatic interactions. The inherent antimicrobial activity of COS and the numerous hydrophobic regions on the surface of the BSA-network give the BSA@COS-network significant in vitro antimicrobial ability. More importantly, the BSA@COS-network coating can prolong the onset of spoilage of strawberries in various packaging materials by nearly 3-fold in storage. This study shows how surface functionalization via protein self-assembly is integrated with the biological functioning of natural antibacterial activity for advanced food packaging applications.
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ACS Sustainable Chemistry & Engineering
·
2023
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IF 8.4
Jingxian Yang,Gangwen Chen,Jianhong Chen,Yong Liu,Ziying Yang,Xugang Shu,Fan Luo
The development of biobased antibacterial nanomaterials for normal-temperature food preservation is important to prevent foodborne pathogenic infections and achieve low-carbon life. Herein, we developed a biodegradable self-assembling polymer-based nanocomposite with efficient antibacterial activity through the copolymerization of chitosan units with Astragalus polysaccharides and functional dihydromyricetin. The as-prepared irregular spherical-type nanocomposite exhibited multidimensional antibacterial action such as cell membrane devastation, cellular leakages, and respiratory disturbance (ATP pathway), thereby achieving an efficient inhibition in vitro against Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus). After the natural deposition of the designed nanocomposite onto a commercial fiber paper (FP), the resulting modified FP was found to possess remarkable pathogen eradication, enhanced UV shielding, and improved water vapor barrier properties. As a proof-of-concept demonstration, the shelf life of salt-baked chicken (processed food) packaged in the modified FP was extended to 5 days in a room-temperature environment. Therefore, the simple design and validation of polymer-based nanocomposite in this work will provide a good reference for room-temperature food preservation technology.
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Polymers
·
2023
·Vol. 15
·期 24
·4632
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IF 5
Huimei Wu,Yishan Lou,Zhonghui Li,Xiaopeng Zhai,Fei Gao
To meet the escalating demand for oil and gas exploration in microporous reservoirs, it has become increasingly crucial to develop high-performance plugging materials. Through free radical grafting polymerization technology, a carboxymethyl chitosan grafted poly (oligoethylene glycol) methyl ether methyl methacrylate acrylic acid copolymer (CCMMA) was successfully synthesized. The resulting CCMMA exhibited thermoresponsive self-assembling behavior. When the temperature was above its lower critical solution temperature (LCST), the nanomicelles began to aggregate, forming mesoporous aggregated structures. Additionally, the electrostatic repulsion of AA chains increased the value of LCST. By precisely adjusting the content of AA, the LCST of CCMMA could be raised from 84.7 to 122.9 °C. The rheology and filtration experiments revealed that when the temperature surpassed the switching point, CCMMA exhibited a noteworthy plugging effect on low-permeability cores. Furthermore, it could be partially released as the temperature decreased, exhibiting temperature-switchable and self-adaptive plugging properties. Meanwhile, CCMMA aggregates retained their reversibility, along with thermal thickening behavior in the pores. However, more detailed experiments and analysis are needed to validate these claims, such as a comprehensive study of the CCMMA copolymer’s physical properties, its interaction with the reservoir environment, and its performance under various conditions. Additionally, further studies are required to optimize its synthesis process and improve its efficiency as a plugging material for oil and gas recovery in microporous reservoirs.Keywords:temperature-switchable;intelligent fluid;adaptive;rheological properties;filtration loss
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EUROPEAN POLYMER JOURNAL
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2023
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IF 6
Jun Wang,Fei Qi,Huiying Feng,Anqi Xu,Dao-Qiang Lu,Junru Liang,Ziwen Zhang,Jie Li,Dahai Liu,Bin Zhang,Yanling Hu
Chitosan-based hydrogels crosslinked through covalent bonds have been extensively researched for their remarkable wound healing properties. However, their practical application has been limited due to the complexity of the preparation process and weak tissue-adhesive strength. In this study, we present a straightforward method for producing tissue-adhesive carboxymethyl chitosan hydrogels consisting of a single component, without the need for an initiator, catalyst, or external crosslinking agent. We synthesized o -nitrobenzyl alcohol-conjugated carboxymethyl chitosan and utilized 365 nm LED light irradiation to self-crosslink the hydrogels through photo-triggered o -nitrobenzyl alcohol and primary amine cyclization. The resulting o -nitrosobenzaldehyde groups not only covalently crosslinked carboxymethyl chitosan chains but also formed robust covalent bonds with the amino groups from the tissue surface, resulting in enhanced adhesion. Furthermore, the hydrogels demonstrated favorable biocompatibility. In vivo studies using a mice full-thickness defect model demonstrated that the hydrogel significantly accelerated wound healing, indicating their potential as a wound repair dressing.
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LANGMUIR
·
2023
·
IF 3.9
Ruizhi Tang,Lei Pan,Quan Bai,Cong Li,Shujuan Ma,Junjie Ou,Yehua Shen
High-performance reusable materials from renewable resources are rare and urgently required in bioseparation. Herein, a series of tannic acid-chitosan composite membranes for the enrichment of phosphopeptides were fabricated by the freeze casting method. First, a tannic acid-chitosan composite membrane was acquired via the multiple hydrogen bonds between tannic acid and chitosan, which had a long-range aligned three-dimensional microstructure. Second, a covalent–hydrogen bond hybrid composite was also fabricated, with stable and aligned honeycomb-like microstructures that formed by the synergy of covalence and hydrogen bonding. Besides, a ternary composite membrane was “one-pot” synthesized by the copolymerization of tannic acid, chitosan, and Ti4+ ions, indicating the feasibility of involving metal ions in the composition of the polymer skeleton in place of additional modification steps. The as-prepared chitosan composite membranes exhibited excellent performance in the enrichment of phosphopeptides from β-casein tryptic digest and human serum. Benefitting from the long-range aligned honeycomb-like structure coordinated by hydrogen bonds and covalent bonds, and a large number of pyrogallol functional groups provided by tannic acid, the covalent–hydrogen bond hybrid membrane showed excellent reusability and could be reused up to 16 times in phosphopeptide enrichment, as far as we know, which is the best reported result to date.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Xiaoxia Chen,Yixi Li,Yu-Long Qiu,Gong-Liang Zhang,Hongshun Hao,Hong-Man Hou,Jingran Bi
To develop food packaging with good antibacterial activity and mechanical performance, four amino carboxymethyl chitosan (ACC)//dialdehyde starch (DAS) /polyvinyl alcohol (PVA) films were prepared by Schiff base and hydrogen bond interactions for efficient loading and release of ε-polylysine (ε-PL). The effects of the Schiff base reaction on the physicochemical properties of the films were explored based on the different aldehyde group contents in DAS. The ACC//DAS 4 /PVA film exhibited a tensile strength of 62.5 MPa, and the water vapor and oxygen permeability was 8.77 × 10 -3 ·g·mm/m 2 ·d·kPa and 0.15 × 10 3 ·cm 3 ·mm/m 2 ·d, respectively. By leveraging the Schiff base reaction, the film swelling properties were improved by adjusting the cross-link density, mesh size, and molecular mass between the cross-links. The ACC//DAS 4 /PVA film could efficiently load ε-PL with a value of 98.44% and long-term release in a food simulant of 10% ethanol at 25 °C for 120 min. Moreover, the ACC-ε-PL//DAS 4 /PVA film was successfully used for salmon preservation.
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BIOMACROMOLECULES
·
2023
·
IF 6.2
Cunguo Chen,Murong Hu,Yunyun Cao,Binbin Zhu,Jiashe Chen,Yashi Li,Junyi Shao,Sen Zhou,Pengfei Shan,Chen Zheng,Zhongyu Li,Zhiming Li
Cyclic dinucleotides (CDNs) are a promising class of immune agonists that trigger the stimulator of interferon genes (STING) to activate both innate and acquired immunity. However, the efficacy of CDNs is limited by drug delivery barriers. Therefore, we developed a combined immunotherapy strategy based on injectable reactive oxygen species (ROS)-responsive hydrogels, which sustainably release 5,6-dimethylxanthenone-4-acetic acid (DMXAA) as known as a STING agonist and indocyanine green (ICG) by utilizing a high level of ROS in the tumor microenvironment (TME). The STING agonist combined with photothermal therapy (PTT) can improve the biological efficacy of DMXAA, transform the immunosuppressive TME into an immunogenic and tumoricidal microenvironment, and completely kill tumor cells. In addition, this bioreactive gel can effectively leverage local ROS to facilitate the release of immunotherapy drugs, thereby enhancing the efficacy of combination therapy, improving the TME, inhibiting tumor growth, inducing memory immunity, and protecting against tumor rechallenge.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2023
·
IF 4.5
Haibo Chen,Chengqi Zhao,Yu Li,Junyao Li,Wenrong Cai,Yong Kong,Zheng-Zhi Yin
Au nanoparticles (AuNPs) is first combined with d -methionine ( d -Met) through Au–S bond, and the obtained Au- d -Met was self-assembled with chitosan (CS) via electrostatic driving. Both d -Met and CS are important chiral sources, and therefore the resultant Au- d -Met/CS displays distinct chirality. Interestingly, the chirality of the Au- d -Met/CS can be reversed depending on the ratio of d -Met to CS, as revealed by circular dichroism spectra. Due to the high electrical conductivity of AuNPs as well as the intrinsic chirality of d -Met and CS, the resultant Au- d -Met/CS is used as the electrochemical chiral sensing platform for the discrimination of tryptophan (Trp) enantiomers. Although the Trp enantiomers can be successfully discriminated by the developed chiral sensing platform, the electrochemical signals of l -Trp and d -Trp can be reversed on the differential pulse voltammograms (DPVs) when different ratios of d -Met to CS are used, which can be ascribed to the reversible chirality of the Au- d -Met/CS complexes prepared by different ratios of d -Met to CS.
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LANGMUIR
·
2023
·
IF 3.9
Yaozong Li,Yingying Peng,Yang Hu,Jian Liu,Teng Yuan,Wuyi Zhou,Xianming Dong,Chaoyang Wang,Bernard P. Binks,Zhuohong Yang
Poly(ε-caprolactone) (PCL)-incorporated lignin-chitosan biomass-based nanocomposite porous scaffolds have been effectively prepared by templating oil-in-water Pickering high internal phase emulsions (HIPEs). PCL is dissolved in oil and chitosan and lignin nanoparticles originate in water. The continuous phase of the emulsions is gelled by cross-linking of chitosan with genipin and then freeze-dried to obtain porous scaffolds. The resulting scaffolds display interconnected and tunable pore structures. An increase in PCL content increases the mechanical strength and greatly reduces the water absorption capacity of the scaffolds. Scaffolds loaded with the anti-bacterial drug enrofloxacin show a slow drug release profile, adjustable release rate, and favorable long-term anti-bacterial activity. Moreover, Pickering emulsion templates with suitable viscosity are used as 3D printing inks to construct porous scaffolds with personalized geometry. The results imply that the simplicity and versatility of the technique of combining freeze-drying with Pickering HIPE templates is a promising approach to fabricate hydrophobic biopolymer-incorporated biomass-based nanocomposite porous scaffolds for biomedical applications.
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