TALANTA
·
2026
·
IF 6.7
Ruyu Li,Tingting Zhang,Lijie Zhou,Jingjing Feng,Longgang Wang,Haiyan Xiao
Pd 3 Au-LCLP NPs-DOX with anti-protein adsorption properties was prepared. • Pd 3 Au-LCLP NPs-DOX exhibit good enzyme-like activity and photothermal performance. • More DOX was released under the irradiation of 808 nm laser. • Pd 3 Au-LCLP NPs-DOX shows significant anti-tumor effects by multi-therapy. Traditional cancer therapies are limited by severe side effects and therapeutic challenges, while noble metal nanozymes offer promising enzyme-like therapeutic potential but remain constrained by poor aqueous stability. In this work, palladium-gold bimetallic nanoparticles (Pd 3 Au-LCLP NPs) with peroxidase-like activity were constructed using Leonurus cardiaca L. polysaccharide as both a reducing agent and stabilizing template, and further loaded with doxorubicin (DOX) to form Pd 3 Au-LCLP NPs-DOX. The resulting nanoplatform exhibited excellent water dispersibility, structural stability, anti-protein adsorption capability, and enhanced photothermal conversion performance. Under 808 nm laser irradiation, Pd 3 Au-LCLP NPs-DOX achieved a cumulative DOX release of 81% at pH 5.5. In vitro , it showed significant cytotoxicity against A549 and HeLa cells. In vivo , the tumor inhibition rate reached 82.6%. Overall, this combined therapeutic strategy integrating chemodynamic therapy (CDT), photothermal therapy (PTT), and chemotherapy (CT) demonstrated strong synergistic anti-tumor efficacy. Download: Download high-res image (393KB) Download: Download full-size image
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Liu Lin,Huang Kaiyan,Guo Hanjing,He Linping,Wang Xin,Wang Chao,Lin Jianqing,Huang Naihan,Miao Weibing
Internal radiation therapy is an irreplaceable modality for local tumor treatment, offering high-effective radiotherapy while sparing surrounding healthy tissues. However, current clinical non-biodegradable radionuclide implants suffer from permanent retention risks and limited efficacy against distal tumors due to inadequate immune activation. Herein, we engineered a biodegradable radionuclide-labeled oxygen-self-supplying calcium reservoir ( 131 I@CaO 2 ), fabricated through biomimetic mineralization followed by chloramine-T mediated 131 I-radiolabeling, for high-efficiency internal-radioimmunotherapy. 131 I@CaO 2 effectively enhances the internalization of 131 I to improve internal-radiotherapy and exhibits pH-responsive biodegradability, remaining stable under physiological condition while progressively degrading in tumor microenvironment to release H 2 O 2 , O 2 and Ca 2+ . These bioactivators synergistically enhance 131 I-induced internal-radioimmunotherapy through both radiosensitization and immune activation: H 2 O 2 and O 2 boost 131 I-induced ROS generation while Ca 2+ disrupted mitochondrial respiration to reduce oxygen consumption and ATP production (suppressing Ca 2+ pump activity), creating a positive feedback loop of oxygen supply and ion overload, thereby achieving radiosensitization; Concurrently, O 2 alleviates tumor hypoxia to downregulate PD-L1 expression and Ca 2+ overload activates dual pyroptosis pathways, establishing a robust immunogenic microenvironment. As a result, 131 I@CaO 2 effectively eliminates both primary and distant tumors by activating immune cells. This study simultaneously resolves the long-term retention risks of non-biodegradable radionuclide and the dichotomy between local radiotherapy and comprehensive immune modulation.
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Desalination and Water Treatment
·
2026
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IF 3.4
Jin Guo,Xueling Yi,Siqi Liu,Jiangwei Ren,Jiawei Wang,Hui Mao
Chlorophenolic contaminants represented by 2,4-dichlorophenol (2,4-DCP) are ubiquitous persistent and toxic organic pollutants in aqueous environments, posing severe threats to ecological safety and human health. Bimetallic zero-valent iron systems have emerged as promising candidates for the remediation of chlorinated wastewater; nevertheless, their practical application is greatly hindered by inevitable nanoparticle aggregation, poor dispersion, and insufficient exposure of active sites. To overcome these limitations, tannic acid (TA) with abundant phenolic hydroxyl groups was rationally grafted onto three-dimensional porous polyurethane foam (PU) to construct a novel composite support. Benefiting from the strong metal chelation of TA, Fe/Pd bimetallic nanoparticles were uniformly dispersed and firmly immobilized on the TA-PU skeleton, successfully fabricating the stable TA-PU-Fe/Pd catalytic composite. The catalytic performance toward 2,4-DCP degradation was systematically evaluated. Compared with conventional carriers such as activated carbon, zeolite and Al 2 O 3 , the as-prepared TA-PU-Fe/Pd exhibited remarkably enhanced removal activity, achieving a 2,4-DCP removal efficiency of 99.7% at an initial concentration of 20 mg/L. Moreover, the composite possessed outstanding cyclic reusability, retaining a high removal rate of 98.7% even after ten reaction cycles. Satisfactory treatment performance was also realized at a low pollutant level of 2 mg/L, with the removal efficiency reaching 93.0%, demonstrating great application potential for the remediation of actual chlorophenol-contaminated water.
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MOLECULAR PHARMACEUTICS
·
2026
·
IF 4.9
Jiale Wei,Ke Qian,Jingbin Shi,Kexin Chen,Hongyan Zhang,Mancang Gu,Chaofeng Mu,Lifei Chen,Yang Xiong
Abstract Triple-negative breast cancer (TNBC) therapy is limited by the poor efficacy of anti-programmed death-ligand 1 (aPD-L1) monotherapy, with dysregulated lipid metabolism in the tumor microenvironment (TME) driving immunosuppression. Herein, a nanoemulsion co-loaded with berberine (BBR) and rhein (RHE) (BBR-RHE-NE), two lipid-modulating bioactives from Dahuang Huanglian Xiexin Decoction, was fabricated to remodel the immunosuppressive TME and boost aPD-L1 efficacy in TNBC. BBR-RHE-NE was characterized with a small droplet size (185.8 ± 0.44 nm), narrow polydispersity (PDI: 0.12 ± 0.02), and good stability. In orthotopic 4T1Fluc TNBC mouse models, BBR-RHE-NE monotherapy inhibited tumor growth, and its combination with aPD-L1 exerted robust synergistic anti-tumor activity. Flow cytometry revealed that BBR-RHE-NE, as a monotherapy or in combination with aPD-L1, enhanced effector immune cell infiltration and reduced immunosuppressive subsets in both tumor tissues and spleens. Lipidomic analysis, Oil Red O staining, and enzymatic assays confirmed BBR-RHE-NE reduced intratumoral lipid droplet accumulation and downregulated intratumoral triacylglycerols and fatty acids (FAs) levels both in vitro and in vivo. Mechanistically, RNA sequencing and functional validation experiments demonstrated that BBR-RHE-NE potentiated aPD-L1 efficacy via PPARγ/FABP4-mediated lipid metabolic remodeling, a process that promoted dendritic cell maturation and was attenuated by the PPARγ agonist GW1929. Moreover, BBR-RHE-NE exhibited excellent biocompatibility with no detectable organ toxicity. Collectively, these findings demonstrate that BBR-RHE-NE effectively remodels the immunosuppressive TME through lipid metabolic reprogramming, offering a promising nanomedicine-based combinatorial strategy to enhance aPD-L1 immunotherapy for TNBC.
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CELLULAR SIGNALLING
·
2025
·
IF 3.7
Suli Chong,Yang Liu,Ziming Bian,Dongxue Hu,Shiqun Guo,Chenfei Dong,Jiayue Zeng,Sairong Fan,Xiaoming Chen
Despite significant advancements in immunotherapy for cancer treatment, its effectiveness in pancreatic ductal adenocarcinoma (PDAC) remains disappointing, which is greatly due to the unique immunosuppressive microenvironment of PDAC. Here, we focus on the involvement of GALNT6 in immune evasion mechanisms in PDAC. Our results reveal a negative relationship between GALNT6 expression and immune cell infiltration in PDAC. Knockdown of GALNT6 enhances PDAC cells sensitivity to cytotoxic T cells and macrophages. Mechanistically, GALNT6-mediated glycosylation blocks the translocation of STING (stimulator of interferon genes) and accelerates its degradation in a cGAS-independent manner, leading to reduced levels of type I interferon (IFN-β) and CCL5 and CXCL10, thus promoting PDAC immune evasion by inhibiting cytotoxic CD8 + T cell and macrophage infiltration. Furthermore, GALNT6 stabilizes PD-L1 by blocking its ubiquitin-proteasome degradation, thereby promoting tumor immune evasion. Notably, the combination of an O-glycosylation inhibitor with PD-1/PD-L1 inhibitors synergistically enhances the anti-cancer immune response. In summary, these findings highlight GALNT6 as a critical player in immune evasion, and targeting GALNT6 could serve as a valuable approach to boost anti-tumor immunity in PDAC patients.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Rui Yu,Yuli Lan,Guoliang Huang,Congmei Chen,Maofei Ran,Wenjing Sun
The development of high-performance, magnetically recyclable nanocatalysts remains challenging, primarily due to the poor stability and inadequate control over active metal dispersion in conventional magnetic supports. To address these limitations, we designed a Ni@CNTs@PDA–Pd catalyst through innovative interfacial engineering. Carbon nanotube channels effectively encapsulate and protect magnetic nickel nanoparticles, while a polydopamine (PDA) coating enables uniform dispersion of palladium nanoparticles (2.0 ± 0.7 nm). The catalyst exhibits strong superparamagnetism (6.64 emu·g⁻¹), allowing efficient magnetic separation. In Heck reactions, it achieves a turnover frequency (TOF) of 958 h⁻¹ and retains 89.5% conversion after ten cycles, outperforming most reported Pd/CNT and magnetic catalysts. Density functional theory (DFT) calculations reveal that although Ni encapsulation increases the electron density of the CNT surface—which may hinder Pd deposition—the PDA interlayer counteracts this effect via strong coordination bonds, ensuring excellent Pd stabilization. This study provides key insights into electronic metal–support interactions and offers a scalable strategy for designing high-performance magnetically recyclable catalysts. It highlights the active role of the magnetic core in modulating the electronic environment of catalytic sites and underscores the critical synergy between the core, shell, and active metal in rational catalyst design.
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Cancer Communications
·
2026
·
IF 28.4
Chenchen Hu,Feiming Hu,Changjian Shao,Yuanli He,Liping Su,Daimei Shi,Lingying Yu,Yuanjie Sun,Jing Wang,Xiyang Zhang,Hongtao Duan,Junqi Zhang,Yubo Sun,Dongbo Jiang,Xiaolong Yan,Shuya Yang,Kun Yang
Background: Lung cancer remains a major global health burden. RNA-binding proteins (RBPs) play crucial roles in post-transcriptional gene regulation, and their dysregulation is frequently implicated in tumorigenesis. The present study aimed to elucidate the molecular network governed by the highly expressed RBP TIMELESS in lung adenocarcinoma (LUAD) and determine its mechanistic role in LUAD progression. Methods: The Cancer Genome Atlas-LUAD, Gene Expression Omnibus, and single-cell RNA sequencing datasets were analyzed to identify aberrantly expressed RBP genes. The RBP gene TIMELESS exhibited the most significant effect on LUAD cell death and was selected for further study. Photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation sequencing and RNA sequencing were employed to identify ferroptosis-related targets directly bound by TIMELESS. Molecular mechanisms underlying the TIMELESS-mediated regulation of ferroptosis in LUAD were investigated via immunoprecipitation–mass spectrometry, glutathione S -transferase pull-down, immunofluorescence–fluorescence in situ hybridization, RNA immunoprecipitation, poly(A)-tail, and RNA stability assays. In an orthotopic lung cancer mouse model treated with erastin (a ferroptosis inducer) and programmed cell death protein 1 (PD-1) blockade, the role of TIMELESS in therapeutic response was assessed via flow cytometry and multiplex immunofluorescence (mIF). Infiltrating immune cells in LUAD were analyzed by tissue microarrays (TMAs) via mIF. Results: TIMELESS significantly affected LUAD cell proliferation and death, and TIMELESS knockdown significantly enriched RNA-binding and ferroptosis pathways. Transferrin (TF) was identified as a direct TIMELESS target governing ferroptosis. TIMELESS was revealed to bind Ccr4-Not transcription complex subunit 3 (CNOT3) to promote TF mRNA degradation. TIMELESS depletion combined with erastin and PD-1 blockade enhances efficacy, prolongs survival, increases T cell and M1 macrophage infiltration, and reduces M2 macrophage infiltration. Further, high TIMELESS expression was inversely correlated with ferroptosis marker 4-hydroxynonenal but positively correlated with programmed cell death ligand 1 (PD-L1), reduced T cell and M1 macrophage infiltration, and increased M2 macrophage infiltration. Conclusions: TIMELESS recruits CNOT3 to accelerate TF mRNA degradation, thereby suppressing ferroptosis and promoting LUAD growth. These findings suggest that the TIMELESS/TF regulatory axis may be a promising therapeutic target for LUAD.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.1
Qian Chen,Yutang Wang,Yuzhen Cui,Liran Lou,Zihan Yan,Haohua He,Xiangrong Zeng,Yangping Wen,Guixia Tan,Mingfang Li
Ustilaginoidea oryzae, the ascomycete fungus responsible for Rice False Smut (RFS), devastates global rice yields via rice panicles infection, threatening food security. To address the critical need for early pathogen detection, we developed an ultrasensitive electrochemical genosensor utilizing a gold‑palladium bimetallic nanoparticle (Au-PdNPs) decorated violet phosphorene/boron nitride (VP/BN) nanohybrid. The VP/BN support, synthesized via sonication-assisted liquid-phase exfoliation, enabled the uniform anchoring of Au-PdNPs through chemical reduction, creating an enhanced conductive interface. Thiolated DNA probes immobilized on Au-PdNPs via Au S bonds enabled specific recognition of U. oryzae DNA through hybridization. This design achieved exceptional sensitivity with a broad linear range (0.1 μM to 10 pM) and ultralow detection limit (3.67 pM), surpassing some traditional detection methods reported at present in speed and cost-efficiency. The genosensor exhibited high specificity against non-target sequences and delivered 96.6–98 % recovery in spiked rice samples, validating its effectiveness in practical applications. By integrating nanomaterials with electrochemical amplification, this work paves the way for field-deployable portable U. oryzae diagnostics in the future, offering a transformative strategy to mitigate economic and agricultural impacts.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·
IF 3.9
Nuo Xu,Jianghui Miao,Fengquan Li,Yilin Tan,Junli Wang,Suni Hou,Yajuan Wu,Xingchao Dai
The hydrogenation of aliphatic nitriles is an atom-efficient and environmentally benign approach to the synthesis of primary amines. Here, a Pd/Ni/MgO-Al2O3–B catalyst with maximized Pd utilization was successfully designed and fabricated for the selective hydrogenation of aliphatic nitriles to corresponding primary amines, delivering a full conversion of lauronitrile with 99% laurylamine yield under mild conditions (60 °C, 1.5 MPa H2). The remarkable catalytic performance might be attributed to the PdNi synergy facilitating hydrogen adsorption and activation combined with the moderate-strength surface acidity of the MgO-Al2O3 composite support favoring lauronitrile adsorption and laurylamine desorption. Moreover, this catalytic system exhibits remarkable functional group tolerance, excellent recyclability, and exceptional performance for the in situ hydrogenation of aliphatic nitriles into primary amines in industrial wastewater treatment. This work not only provides an effective and practical protocol for the synthesis of primary amines from nitriles but also contributes to sustainable treatment of nitrile-containing wastewater.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Shanqi Liang,Binyu Guo,Lei Zhang,Quanyuan Chen,Lei Li,Pin Gao,Juan Zhou
The growing complexity of water contaminants necessitates a deeper understanding of the interplay between multiple pollutants and catalytic sites. Herein, we explore the simultaneous removal of sulfamethoxazole (SMX) and monoiodoacetic acid (MIAA) via liquid-phase catalytic hydrogenation over Pd nanoparticles supported on diverse carriers (CNT, C₃N₄, Al₂O₃, and SBA-15). Although all catalysts performed well in single-component tests, only Pd/CNT exhibited robust dual-removal capability in mixed systems, achieving complete deiodination of MIAA and 92.4% reduction of SMX within 60 min. Intriguingly, a mutual interference phenomenon was unveiled: MIAA suppressed SMX reduction, while SMX (and other aromatics) unexpectedly accelerated MIAA deiodination. Mechanistic studies identified the pivotal role of hydrogen spillover on Pd/CNT, which possessed a superior H₂ uptake capacity. This facilitated the generation of surface-mobile active H that migrate to the support, enabling a binary active site mechanism. We propose a sequential pathway comprising H₂ dissociative activation, spillover, direct Pd-catalyzed deiodination of MIAA, and CNT-mediated hydrogenation of SMX via spilled-over H species. These findings highlight the exceptional promise of Pd/CNT for the remediation of complex organic contaminants and provide fundamental guidance for designing bifunctional hydrogenation catalysts.
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RSC Advances
·
2023
·Vol. 13
·期 3
·2024-2035
·
IF 3.9
Jiale Wu,Liguo Wang,Shuang Xu,Yan Cao,Ziqiang Han,Huiquan Li
Developing efficient and green catalytic systems is highly desired in the syntheses of alicyclic amines via hydrogenation of nitroaromatics. Herein, we developed Ru–Pd dual active site catalysts in which Ru and Pd species were anchored and highly dispersed on air-exfoliated carbon nitride (Ru–Pd/C3N4-air). As-prepared catalysts were employed in the hydrogenation of nitrobenzene (NB) to cyclohexylamine (CHA). Compared with single Ru or Pd based catalysts, Ru–Pd dual active site catalysts obtained a higher CHA production rate of 26.7 mol CHA mol−1 Ru·Pd h−1 at 80 °C and 3 MPa H2. The activation energy for the hydrogenation of the nitro group and benzene ring was calculated as 26.26 kJ mol−1 and 66.30 kJ mol−1, respectively. Intrinsic kinetic studies demonstrated that Pd was the dominant metal for hydrogenation of nitro group, while Ru was dominant for benzene ring. Thereinto, the corresponding non-dominant metals enhanced activation and dissociation of H2, thereby improving catalytic activity significantly. This excellent performance of Ru–Pd catalysts could be attributed to highly dispersed Ru–Nx and Pd–Nx at a nanoscale distance, which was conducive to metal-assisted hydrogenation. Stability investigation showed that the performance of Ru–Pd catalysts could be essentially maintained at a high level. Additionally, the substrate scope could be successfully extended to hydrogenation of other nitroaromatics with different substituents.
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Materials Today Communications
·
2022
·
IF 3.662
Yingjun Li,Yakun Guo,Zekun Jing,Xingtao Zhao,Yuanlin Zhou,Maobing Shuai
To solve the problems of hydrogen embrittlement and explosion risk generated by the use of hydrogen energy in large-scale applications, organic hydrogen getters have been used to eliminate hydrogen in sealed systems and related fields. However, the hydrogen absorption rate of existing hydrogen getters needs to be further improved. Herein, a three-dimensional (3D) N-doped carbon with interconnected hierarchical pores loaded with a uniform dispersion of palladium particles (6.8 nm) was successfully developed. This material was used as a catalyst for 1,4-bis(phenylethynyl)benzene (DEB) hydrogenation under mild conditions, exhibiting good catalytic performance. The hydrogen uptake performance of this Pd/MFC/DEB getter for the reduction of hydrogen gas was examined at 0 – 1 bar and 25 ℃ with hydrogen consumption evaluated with time. The prepared Pd/MFC/DEB getter demonstrated a hydrogen uptake of 212.2 cm 3 /g after about 20 h, which was significantly higher than that of a typical Pd/AC/DEB pallet getter (162.0 cm 3 /g). This was due to the interactions between the Pd and MFC support, which enhanced the dispersion of Pd, increased the area available for the reaction with DEB, promoted the hydrogen dissociation process, and improved the hydrogen spillover effect. This research offers a highly promising approach for the use of MFC as a catalyst support material in hydrogen getters.
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