JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
Wen Teng,Haipei Xu,Shun Wen,Xiang Yu,Yanrong Yang,Jing Zhang
Organophosphorus pesticides (OPPs) seriously threaten human health and ecosystems due to their environmental persistence, creating an urgent demand for highly efficient and sensitive detection technologies in environmental monitoring. UL-AuAgMSs@β-CD composite substrate was fabricated through the integration of urchin-like Au-Ag microspheres (UL-AuAgMSs) with β-cyclodextrin (β-CD) to overcome three persistent challenges in surface-enhanced Raman scattering (SERS) detection, i.e., low molecular selectivity, substrate instability, and complex matrix interference. Optimizing the three-dimensional branched structure of UL-AuAgMSs through controlled silver nitrate (AgNO 3 ) addition, a dual enhancement becomes available from both electromagnetic effects (nanotip-localized hotspots) and chemical effects (β-CD's molecular recognition capabilities). The composite substrate presented superior performances, a detection limit of 10⁻ 13 M for crystal violet (CV), excellent reproducibility (RSD = 9.10%, n = 13), and long-term stability (73.35% signal retention after 21 days), surpassing conventional single-metal substrates. Its versatility is further demonstrated in detecting methylene blue (MB), methyl orange (MO), the OPP chlorpyrifos (CPF), and the pesticide intermediate 4-aminothiophenol (4-ATP). This study proposes a synergistic strategy combining morphological engineering and molecular recognition. It offers a stable and adaptable SERS platform for rapid trace pollutant monitoring in food safety and complex environments.
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ANALYTICAL CHEMISTRY
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2025
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IF 6.7
Yanan Wu,Yuqing Yang,Rui Wang,Haifeng Yang,Xinling Liu
Surface-enhanced Raman scattering (SERS), despite its high sensitivity in molecular fingerprint detection, typically lacks chiral specificity. Chiral metal nanoclusters (CMNCs) with sub-3 nm cores hold promise for chiral molecular sensing, yet their application in SERS-based chiral recognition remains largely unexplored. In this study, two-dimensional self-assembly of Au nanoparticles (NPs, 30 ∼ 50 nm) functionalized with D- or L-penicillamine (Pen) stabilized sub-3 nm Au nanoclusters (NCs) were constructed as SERS-active substrates. On these substrates, distinct SERS signals were observed for L- versus D-phenylalanine (Phe) enantiomers, with a signal intensity difference of approximately 5-fold at a low concentration of 10–6 mol/L, suggesting a good enantiomeric discrimination effect and detection sensitivity. Similar chiral discrimination phenomena were also found by using propranolol enantiomers or chiral Cu NCs. These findings demonstrate the significant potential of the integration of CMNCs into plasmonic SERS substrates for developing sensitive chiral sensing strategies based on nonchiral vibrational Raman spectroscopy and advancing the fundamental studies of metal nanocluster-molecule chiral interactions.
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TALANTA
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2024
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IF 5.6
Bin Yang,Jia Liu,Xin Liu,Shiyue Niu,Fengming Zhang,Yuting Wang,Daqian Song,Shuyun Bi
The high efficient surface-enhanced Raman scatterring (SERS) methods to detect thiacloprid and imidacloprid were established using ZIF-8-wrapped Ag nanoparticles (AgNPs) modified with β -cyclodextrin ( β -CD). The substrate of ZIF-8/ β -CD@AgNPs was characterized by ultraviolet visible spectra (UV–vis), thermogravimetric analysis (TGA), X-ray diffraction (XRD), transmission electron microscopy (TEM) and scanning transmission electron microscopy (STEM). The interaction between the substrate and thiacloprid/imidacloprid was also explored. The optimum measurement conditions were obtained by response surface model based on single-factor experiments. Enhancement factors (EFs) of thiacloprid and imidacloprid were respectively 2.29 × 10 6 and 2.60 × 10 6 . A good linearity between the scattering intensity and the concentration of thiacloprid/imidacloprid within 3–1000 nmol L −1 /6–400 nmol L −1 was established. The interference experiments indicated that the methods had good selectivity . The SERS methods were successfully applied to detect thiacloprid and imidacloprid in several vegetables samples. The recoveries ranged from 95.5 % to 105 % (n = 5). The detection limits (LODs) (S/N = 3) for thiacloprid and imidacloprid were 1.50 and 0.83 nmol L −1 , respectively.
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ANALYTICA CHIMICA ACTA
·
2024
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IF 5.7
Tao Gai,Jiaolai Jiang,Shaofei Wang,Yiming Ren,Shanli Yang,Zhen Qin,Lang Shao,Qian Wu,Jun Zhang,Junsheng Liao
Background In the fields of environmental monitoring and nuclear emergency, in order to obtain the relevant information of uranyl-induced environmental pollution and nuclear accident, it is necessary to establish a rapid quantitative analytical technique for uranyl ions. As a new promising technique, surface-enhanced Raman scattering (SERS) is hopeful to achieve this goal. However, uranyl ions are easily desorbed from SERS substrates under acidic conditions, and the structures of SERS substrates will be destroyed in the strong acidic aqueous solutions. Besides, the quantitative detection ability of SERS for uranyl ions needs to be promoted. Hence, it is necessary to develop new SERS substrates for accurate quantitative detection of trace uranyl in environmental water samples, especially in acidic solutions. Results In this work, we prepared silver ions/sodium alginate supramolecular hydrogel membrane (Ag + /SA SMH membrane), and the Ag + ions from the membrane were transformed into Ag/Ag 2 O complex nanoparticles under laser irradiation. The Raman signal of uranyl was strongly enhanced under the synergistic interaction of electromagnetic enhancement derived from the Ag nanoparticles and charge transfer enhancement between uranyl and Ag 2 O. Utilizing the peak of SA (550 cm −1 ) as an internal standard, a quantitative detection with a LOD of 6.7 × 10 −9 mol L −1 was achieved due to a good linear relation of uranyl concentrations from 1.0 × 10 −8 mol L −1 to 2 × 10 −6 mol L −1 . Furthermore, foreign metal ions hardly affected the SERS detection of uranyl, and the substrate could determine trace uranyl in natural water samples. Particularly, the acidity had no obvious effect on SERS signals of uranyl ions. Therefore, in addition to the detection of uranyl ions in natural water samples, the proposed strategy could also detect uranyl ions in strong acidic solutions. Significance and novelty A simple one-step method was used to prepare an Ag + /SA SMH membrane for rapid quantitative detection of uranyl ions for the first time. The proposed substrate successfully detected uranyl ions under acidic conditions by immobilizing uranyl ion in hydrogel structure. In comparison with the previous studies, a more accurate quantitative analysis for uranyl ions was achieved by using an internal standard, and the proposed strategy could determine trace uranyl in either natural water samples or strong acidic solutions.
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Tianyue Zhang,Xueting Li,Dongmei Liu,Jiyu An,Maofeng Zhang,Jian hua Li,Changlong Jiang
In-situ detection of analytes on curved surfaces is a persistent and great challenge in the application of SERS technique. A hydrogel-based flexible SERS substrate demonstrates a unique charm for providing close contact to the real-sample surface but limited by its weak enhancement capability in the quantitative analysis. Herein, we report a reinforced hydrogel by reduction of plasmonic silver nanoparticles (AgNPs) on a PNIPAM membrane with the aid of polyvinylpyrrolidone (PVP) surfactant. The modification of AgNPs on PNIPAM endows the AgNPs/PNIPAM composite hydrogel with good mechanical properties and reinforced swelling property. Moreover, the AgNPs/PNIPAM hydrogel-based SERS sensor exhibits an enhanced SERS sensitivity as well as improved signal uniformity (RSD ＜10 %), and the detection concentration for pesticide molecules can be down to 10 -9 M. Due to the fingerprint feature of SERS, multicomponent detection of pesticide mixtures was readily realized. In addition, the flexible AgNPs/PNIPAM hydrogel was successfully applied to the curved apple surface for SERS detection. Notably, it is capable of achieving qualitative and quantitative analyses of different pesticides, which has lower analytical concentrations than European Union (EU) standards, indicating the potential applications in rapid in-situ pesticide analysis.
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MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Fang Wang,Yi-Mei Li,Jing Zhao,Jing Ye,Yuan-Ting Li
This study presents a dual-mode colorimetric and surface enhanced Raman scattering (SERS) platform for the highly sensitive and selective assay of N-nitrosodiethylamine (NDEA) in antihypertensive drugs. A polydopamine embedded molecularly-imprinted agarose hydrogel (MIAG) chip was developed, serving as a multifunctional sensing substrate. Upon exposure to NDEA, the chip facilitates specific target adsorption and enrichment, simultaneously triggering a Griess reaction that yields a deep-red azo compound. This reaction provides the basis for both colorimetric readout and generates a strong Raman signal through azo-enhanced scattering for quantification. This design allows the MIAG chip to function not only as a naked-eye indicator but also as a platform for smartphone-based colorimetric analysis by directly translating color responses into digital barcodes. Furthermore, the in-situ synthesized gold nanoparticles (AuNPs) within the hydrogel matrix generate enhanced SERS activity, leveraging the porous network to create abundant hotspots for ultra-sensitive detection, achieving a limit of detection as low as 2.3 × 10 −14 M. The synergistic combination of dual-mode output offers robust and cross-verification results, significantly improving detection reliability. This integrated smartphone-compatible platform holds great promise for point-of-care testing of drug safety, making accurate screening accessible from regulatory laboratories to the public
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2025
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IF 4.6
Shijie Liu,Qian Ding,Lijun Zhao,Yueyv Bai,Miaoyun Li,Jong-Hoon Lee,Yaodi Zhu,Yijing Ding,Lingxia Sun,Yanxia Liu,Yangyang Ma,Dong Liang
In order to realize rapid identification of different species of lactic acid bacteria and rapid quantitative detection of mixed lactic acid bacteria. In this study, L. plantarum Y1 and P. pentosaceus Z1 were used as research subjects, and AuNPs@4-MBA was prepared as the SERS substrate material for the acquisition of SERS spectra of different species of lactic acid bacteria and the construction of taxonomic identification models and SERS digitized quantitative equations. The results showed that the enhancement factor of AuNPs to 4-MBA was 3.08 × 10 2 , and the reproducibility was excellent ( RSD < 10 %). With AuNPs@4-MBA as the base material, the differences of SERS peaks between L. plantarum Y1 and P. pentosaceus Z1 could be clearly distinguished. Principal component analysis (PCA) and cluster analysis (LDA) could completely visually classify and identify different species of lactic acid bacteria. The SERS quantitative equation y = 7509.32×-5942.69, R 2 = 0.99 and the detection limit lower than 10 CFU/mL was determined by the construction of SERS detection and quantitative model for different ratios and concentrations of mixed lactic acid bacteria. In the complex environment matrix, the detection accuracy of mixed lactic acid bacteria by this method reached 96.34 % to 103.54 %. It provides a promising technical strategy for rapid qualitative and real-time quantitative monitoring of mixed lactic acid bacteria.
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APPLIED SURFACE SCIENCE
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2022
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IF 7.392
Chang Wang,Shihao Zhou,Yue Tian,Anxin Jiao,Hui Ma,Mengya Zhang,Linqi Zheng,Xiangdong Liu,Qingqiang Cui,Shuang Li,Ming Chen
The powerful surface-enhanced Raman scattering spectroscopy (SERS) practical technique is not only related to signal enhancement but also heavily dependent on spatial uniformity. Different from the routine hydrophobic substrates, an extraordinary super-hydrophilic SERS sensor is established by loading plasmonic Au nanoparticles (NPs) on two-dimensional (2D) hexagonal boron nitride (h-BN) then the hybrids uniformly are grafted into 3D bacterial nanocelluloses (BNCs). The Au NPs@h-BN/BNCs exhibit a remarkably high SERS activity with a limit of detection (LOD) of dyes at 0.1 femtomole (fM) level (∼10 -16 M). It is attributed to the strong synergistic coupling effect between highly dense Au NPs and modified h-BN as well as multiple light-scattering effects in 3D porous supports. More importantly, the distinctive advantage is further highlighted by the exceptional 3D spatial SERS uniformity with relative standard deviation (RSD) less than 3.4% along both horizontal and vertical directions. The unique feature is due to the 3D homogeneous distribution of the injected colloidal analytes via ultra-rapid liquid diffusion throughout the entire body with superior wettability . Besides, the flexible SERS substrates with excellent easy-tailorable mechanical properties can be robust enough to withstand the portable operations in real-world scenarios. These competitive merits are particularly beneficial for reliable SERS quantitative surveillance.
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ANALYTICA CHIMICA ACTA
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2024
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IF 5.7
Jianhui Xie,Shuying Mao,Yanglan Zhao,Guimin Zhang,Jingchun Yao,Yongxia Guan,Jizhong Yan,Hui Zhang
Natural products-based screening of active ingredients and their interactions with target proteins is an important ways to discover new drugs. Assessing the binding capacity of target proteins, particularly when multiple components are involved, presents a significant challenge for sensors. As far as we know, there is currently no sensor that can accomplish high-throughput quantitative analysis of natural product-target protein binding capacity based on Raman spectroscopy. In this study, a novel sensor model has been developed for the quantitative analysis of binding capacity based on Surface-Enhanced Raman Spectroscopy (SERS) and Photocrosslinked Molecular Probe (PCMP) technology. This sensor, named SERS-PCMP, leverages the high throughput of molecular probe technology to investigate the active ingredients in natural products, along with the application of SERS labelling technology for target proteins. Thus it significantly improves the efficiency and accuracy of target protein identification. Based on the novel strategy, quantitative analysis of the binding capacity of 20 components from Shenqi Jiangtang Granules (SJG) to α-Glucosidase were completed. Ultimately, the binding capacity of these active ingredients was ranked based on the detected Raman Intensity. The compounds with higher binding capacity were Astragaloside IV (Intensity, 138.17), Ginsenoside Rh2 (Intensity, 87.46), Ginsenoside Rg3 (Intensity, 73.92) and Ginsenoside Rh1 (Intensity, 64.37), which all exceeded the binding capacity of the positive drug Acarbose (Intensity, 28.75). Furthermore, this strategy also performed a high detection sensitivity. The limit of detection for the enzyme using 0.1 mg of molecular probe magnetic nanoparticles (MP MNPs) was determined to be no less than 0.375 μg/mL. SERS-PCMP sensor integrating SERS labeling and photocrosslinked molecular probes which offers a fresh perspective for future drug discovery studies. Such as high-throughput drug screening and the exploration of small molecule-target protein interactions in vitro.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Xinru Ding,Jiaxue Chen,Renyan Zhang,Ling Huang,Hui Xu
Liquid-liquid interfacial co-assembly yields uniform and large-area nanofilms. • Urchin-like GNPs provide tip-enhanced hotspots for superior SERS sensitivity. • CNT-g-P4VP hybrid offers robust mechanical support and molecular enrichment capability. • The nanofilm achieves 10⁻¹ ² M detection limit with excellent signal reproducibility. • The nanofilm enables sensitive, quantitative detection of diverse antibiotics. The sensitive and reliable detection of antibiotic residues is important for food safety, environmental monitoring, and public health. In this work, a robust surface-enhanced Raman scattering (SERS) platform was developed through the liqud-liquid interfacial co-assembly of poly(4-vinylpyridine)-grafted carbon nanotubes (CNT- g -P4VP) and sea urchin-like gold nanoparticles (SUGNPs). Unlike previously reported antibiotic-oriented SERS systems that mainly emphasize either ultralow detection limits, matrix-specific analysis, or mechanical reinforcement, the present design integrates morphology-amplified plasmonic hotspots with a transferable and mechanically reinforced nanofilm in a single assembly process. The key advance is that tip-rich SUGNPs are incorporated into the CNT- g -P4VP scaffold without sacrificing film continuity, thereby producing substantially stronger SERS signals than an identically assembled spherical-AuNP control. The sharp SUGNP tips and interparticle junctions provide intense electromagnetic enhancement, while the CNT- g -P4VP network anchors the particles, maintains film integrity, and may assist analyte association near the plasmonic regions. Using 4-mercaptobenzoic acid as a probe, the substrate achieved a detection limit of 10 −12 M and a relative standard deviation of 4.3%. Clearly identifiable SERS signals were retained after 100 bending cycles and after 3 months of ambient storage. Sulfacetamide and cephalexin were detected down to 10 −8 M with RSD values of 5.72% and 7.97%, respectively, and their molecular fingerprints remained recognizable in pretreated lake water. Thus, this work advances the field by demonstrating a morphology-engineered, transferable SERS film that balances sensitivity, reproducibility, mechanical durability, and matrix applicability rather than improving only a single analytical metric. Download: Download high-res image (246KB) Download: Download full-size image
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MATERIALS CHARACTERIZATION
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2026
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IF 6.2
Zhuxu Xu,Zhenhua Dan,Fengxiang Qin
Diffusion couples of Ag/Al stacking foils with layered structures as good precursors. • Rose-thorn-shaped nanoporous Ag inherits Ag 2 Al phase. • Flexibility of SERS substrates is from unreacted Ag layer and nanoporous Ag layer. • SERS limit of detection of 1 × 10 −16 mol·L −1 . • High Raman scattering is arisen from surface rose-thorn-shaped nanoporous Ag. Establishing highly accurate and sensitive surface enhanced Raman scattering (SERS) substrate is of critical importance for trace-level detection of probe molecules. An ultrasensitive and flexible Ag SERS substrate for rhodamine 6G (R6G) and crystal violet (CV) is rationally designed and successfully fabricated via the way of “geometric coupling design of thermal-diffusion induced phase growth” and “nanoporous structure inheritance”. The formation of rose-thorn-shaped nanoporous Ag and hierarchical nanoporous architecture with pore size distribution is governed by microstructural inheritance from tip diffusion growth Ag 2 Al intermetallic phase of Ag/Al thermal diffusion couples. Consequently, SERS substrate achieves ultralow detection limits of 10 −16 mol·L −1 for both R6G and CV, outperforming previously reported nanoporous Ag-based SERS substrates. The excellent mechanical flexibility originates from the synergistic integration of undiffused Ag layer as a structural backbone and nanoporous top-layer that undergoes controlled deformation for effective energy absorption. There rose-thorn-shaped nanoporous Ag collectively generate pronounced localized electromagnetic hot spots and stronger localized surface plasmon resonance, one of them yielding a local enhancement factor of approximately 10 5 . The superior SERS performance arises from enhanced surface scattering from rose-thorn-shaped nanostructure and strong electromagnetic coupling within the ultra-narrow nanopores with average pore size of 11 nm.
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Surfaces and Interfaces
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2026
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IF 6
Xueying Zhang,Wei Lai,Mengdi Guo
Quality assessment of herbal medicines is complicated by their complex matrices and variability in chemical composition. In this study, a three-dimensional surface-enhanced Raman scattering (SERS) substrate was constructed for the analysis of Astragalus membranaceus extracts. The substrate consists of carboxylated carbon nanotubes (HOOC CNTs) integrated with Ti 3 C 2 T x MXene and decorated with in situ-grown silver nanoparticles (AgNPs), forming an interconnected porous network. This hierarchical architecture provides accessible plasmonic sites, while the CNT–MXene framework improves material dispersion and limits MXene restacking in aqueous media. The AgNP/HOOC CNT/Ti 3 C 2 T x substrate exhibited a measured SERS enhancement factor of 1.82 × 10 6 , together with improved signal uniformity and stability under the tested conditions. Quantitative calibration models were established for astragalosides, polysaccharides, and calycosin in A. membranaceus extracts with limited sample pretreatment, and the analytical results were compared with those obtained using reference methods. The measured chemical profiles also enabled preliminary discrimination among the investigated samples from different geographical origins and assessment of batch-to-batch variation. Among the samples included in this study, those collected from Jilin showed relatively high levels of the target constituents. These results indicate that the proposed SERS substrate has potential as a rapid analytical platform for compositional assessment and comparative quality evaluation of A. membranaceus . Further validation using larger and more geographically representative sample sets is required before the method can be applied to routine origin authentication and quality grading. Download: Download high-res image (370KB) Download: Download full-size image
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危险品化学品经营许可证（带存储）