JOURNAL OF MATERIALS SCIENCE
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2025
·
IF 3.9
Uddin Shahab,Ullah Inam,Liu Yiyao,Bai Lu,Duan Jiangong,Yue Zhaorong,Hui Li,Wang Xin,Li Yang,Jingli Zhu,Li Hongyu
Periodontitis is a progressive disease that is difficult to diagnose and treat. This causes pain, chewing difficulty, and ultimately teeth exfoliation, caused by harmful oral biofilms. The need for a rapid method for sample enrichment is essential for accurate diagnosis due to the presence of pathogenic bacteria in saliva at low concentrations. Novel vancomycin-grafted chitosan-coated magnetic nanocarriers (Vm-CS-MNCs) were made in this study. They effectively capture and extract DNA from gram-positive bacteria in saliva for PCR gene-sensing. The purpose of chitosan coating was to enhance biocompatibility and water solubility, while vancomycin acts as a universal probe to selectively target gram-positive bacteria ( Staphylococcus aureus ATCC 29213) . X-ray photoelectron spectroscopy, FTIR, XRD, and energy-dispersive X-ray spectroscopy were used to validate the successful coating of chitosan and grafting of vancomycin onto magnetic nanocarriers. Significantly, Vm-CS-MNCs achieved a capture efficiency of over 95% at bacterial concentration as low as 10^1 CFU/mL within 20 min of enrichment. Finally, when coupled with PCR, Vm-CS-MNCs demonstrated significant pre-concentration ability for S. aureus in saliva, reducing the limit of detection (LOD) to 10 CFU/mL. This signifies a 1,000-times enhancement in diagnostic sensitivity as compared to PCR without pre-concentration. The bacterial capture ability of these nanocarriers enabled a highly sensitive pathogen gene-sensing method. Graphical abstract
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npj Science of Food
·
2025
·Vol. 9
·期 1
·1-13
·
IF 7.8
Liao Yingyi,Xie Xingyu,Lin Zixin,Huang Ning,Wei Guilan,Wu Jiazhen,Li Yucui,Chen Jiannan,Su Ziren,Yu Xiuting,Chen Liping,Liu Yuhong
Visceral adiposity is an important characteristic of metabolic dysfunction-associated steatohepatitis (MASH) that affects its development. Curcumin (Cur) attenuates MASH through microbial biotransformation. However, antibiotics (Abx) do not weaken but rather enhance the resistance to weight gain of Cur on MASH rats. The resistance to weight gain mechanism of Cur is different from its anti-MASH effect, which may relate to alleviate visceral adiposity. Here we investigated the mechanism of Cur against visceral adiposity in high-fat diet-induced MASH rats. The results demonstrated that Cur and Abx reduced body, liver and visceral fat weights of MASH rats. Unlike Abx, which induces resistance to weight gain by reducing appetite, Cur mainly reduced the weight of visceral fat, especially that of perirenal fat. Intriguingly, the reduction in perirenal fat caused by Cur was attributed to its specific inhibition of gastric inhibitory polypeptide (GIP) release. The Cur-induced decrease in intestinal GIP release inhibited the activation of GIP receptors to alleviate adipogenesis and inflammation in perirenal adipose tissue. Moreover, Cur alleviated intestinal epithelium and vascular barrier disruption-mediated hypoxia to inhibit GIP release. In summary, the pharmacological effects of Cur on visceral adiposity were mainly contributed by inhibiting gut barrier disruption-mediated hypoxia to attenuate GIP release.
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JOURNAL OF APPLIED ELECTROCHEMISTRY
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2025
·
IF 3
Liu Hanzhen,Wang Yanjie,Feng Xinyu,Ling Jing,Lin Xuanyu,Lu Zhenhang,Tang Xin
The oxygen evolution reaction (OER) constitutes a pivotal step in numerous energy conversion and storage systems. The strategic advancement of economical, efficient, and resilient catalysts for the anode OER represents one of the pressing bottlenecks hindering their scalable implementation. Experimental results demonstrated that the synergistic effect of Zr doping and the Co 2 Sb 2 O 7 pyrochlore structure increased the oxygen vacancy content and significantly enhanced the catalytic activity. Thus, the appropriate proportion of Zr (only x = 0.1) doped Co 2 Sb 2 O 7 pyrochlore structure exhibited excellent OER performance, reaching 10 mA cm −2 at an overpotential of only 210 mV in 0.5 M H 2 SO 4 and at an overpotential of only 216 mV in 1 M KOH solution. The catalyst operated stably for 60 h at 1 mA cm −2 in 0.5 M H 2 SO 4 and also operated stably for 60 h at 10 mA cm −2 in 1 M KOH. This study offers a promising outlook for reducing the energy consumption of noble metal catalysts used in acidic OER processes in practical electrochemical industries. Graphical abstract
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MEDICAL ONCOLOGY
·
2025
·Vol. 42
·期 7
·1-12
·
IF 3.5
Tang Qing,Huang Kun,Li Mengjie,Zhao Ziqiao,Deng Yuanle,Zuo Yueqi,Wang Ningyu,Zhu Yongxia
Ovarian cancer is a deadly gynecological malignancy often diagnosed at an advanced stage, with few treatment options available. Polyphyllin I (PPI), the primary active ingredient of Paris polyphylla , has shown excellent anti-cancer activity against various cancers. However, studies on PPI use and ovarian cancer are limited, and the potential mechanisms remain unclear. This study explored the effects of anti-ovarian cancer and the potential mechanisms of action of PPI. Methods such as MTT, colony formation, three-dimensional spheroid formation, flow cytometry, and western blotting were employed to assess the anti-proliferative effects of PPI on different ovarian cancer cell lines. RNA sequencing was used to discover potential mechanisms by evaluating the effects of PPI on transcriptional signatures and identifying differences in gene expression patterns. The results indicate that PPI demonstrated dose- and time-dependent anti-proliferative effects on ovarian cancer cell lines. PPI also up-regulated 1518 genes and down-regulated 800 genes. The genes showed enrichment in the “apoptosis” gene sets, while exhibiting negative enrichment in the “cell cycle” and “Myc signaling pathway” gene sets. PPI caused cell cycle arrest at the G0/G1 phase by increasing the expression of p21 and p27 and inhibiting the activity of the CDK2/cyclin E complex. PPI triggered cell apoptosis, which was associated with elevated cellular reactive oxygen species and mitochondrial membrane potential depolarization. Finally, PPI reduced c-Myc protein levels and affected mRNA levels of c-Myc pathway-related genes. PPI effectively suppressed ovarian cancer cell proliferation, indicating its potential as a treatment option for ovarian cancer.
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CELLULAR AND MOLECULAR LIFE SCIENCES
·
2025
·Vol. 82
·期 1
·1-17
·
IF 6.2
Zhong Chong-Chao,Zhang Xu,Pantopoulos Kostas,Song Chang-Chun,Yang Hong,Wei Xiao-Lei,Luo Zhi
Copper (Cu) and zinc (Zn) are essential trace elements for terrestrial animals. Studies suggested that single dietary Cu- or Zn- deficiency lead to liver lipid deposition and cause metabolic dysfunction-associated steatotic liver disease (MASLD). However, the mechanisms by which dietary Cu and Zn co-deficiency promote hepatic lipid deposition and metabolism remain unknown. Our study found that, compared to single Cu- or Zn- deficiency, Cu and Zn co-deficiency significantly increased lipid deposition, induced mitochondrial oxidative stress, disrupted mitochondrial structure and function, and inhibited lipolysis in hepatocytes and whole liver tissue. Mechanistically, Cu and Zn co-deficiency-induced lipotoxicity was mediated by sirtuin 3 (Sirt3). Sirt3 inhibited the acetylation and degradation of forkhead box O3 (Foxo3), preventing its binding to the peroxisome proliferator-activated receptor alpha (PPARα) promoter, which accordingly increased lipid deposition. Overall, for the first time, we elucidated the mechanism by which Cu and Zn co-deficiency aggravates hepatic lipotoxicity and identified the critical regulatory role of the Sirt3/Foxo3/PPARα pathway during this process, with the fish as the model.
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Chinese Medicine
·
2025
·Vol. 20
·期 1
·1-21
·
IF 5.7
Wei Ji-chang,Lin Xiao-yu,Zhao Yi-hang,Tan Xin-ru,Wang Zhi-xia,Li Yuan-yuan,Huang Xue-mei,Wang Peng-long
Background Scutellariae Radix (SR) and Coptidis Rhizoma (CR) are classic drug pairs used in clinical practice for clearing heat and drying dampness, purging fire for removing toxin. By further studying the mechanism of compatibility of SR and CR from the perspective of thermodynamically driven supramolecular phase transition, we could reveal the interaction between its pharmacodynamic components, and provide scientific basis for improving TCM efficacy. Methods The SR-CR and its main components baicalin-berberine (BA-BBR) were taken as the research objects. The morphology of the mechanically mixed samples was characterized by malvern particle size analyzer and scanning electron microscope. UHPLC-Q-Orbitrap HRMS technology was employed to analyze the material basis of each mechanically mixed sample. ITC was used to investigate the effect of temperature on the binding ability between SR and CR. The structural differences of supramolecules in different morphology were explored by molecular dynamics simulation. Finally, in vitro antibacterial models ( E. faecium and B. subtilis , S. aureus ) were used to evaluate the antibacterial activities of the mechanically mixed samples and non-targeted metabolomics was used to explore the differences in antibacterial mechanisms. Results The mechanical mixtures formed nanofibers (NFs), while heating induced a transition to nanospheres (NPs). Molecular dynamics simulations revealed that enhanced hydrogen bonding and tighter molecular packing under thermal conditions drove this morphological shift. In vitro antibacterial assays and non-targeted metabolomics showed NPs exhibited superior inhibition against Staphylococcus aureus by disrupting amino acid biosynthesis and metabolism, whereas NFs suppressed Bacillus subtilis via physical entanglement and interfered with energy metabolism. Conclusion Driven by thermal energy, the existence form of supramolecules changed from NFs to NPs and the morphology of the formed supramolecules was maintained during their interaction with bacteria, further affected the biological activity. Graphical
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Nature Communications
·
2026
·
IF 18.1
Yin Tingting,Yuan Haoyang,Wang Qilin,Shen Zehao,Yin Shuai,Wang Fangmu,Kan Erjun,Jiang Wei,Ouyang Bo,Liu Guigao
Methane dry reforming offers a promising approach for converting CH 4 and CO 2 into valuable syngas, while its application is restricted by catalyst deactivation and carbon deposition. Here, we report a well-designed heterostructured plasmonic photocatalyst consisting of a plasmonically active Ag core and a catalytically active Ir cage selectively grown on the vertices and edges of the Ag core, which preserves strong plasmonic absorption and enables the significant concentration of electromagnetic energy on the Ir cage, as well as the selective dissipation of that energy to generate hot carriers. This heterostructured plasmonic photocatalyst demonstrates long-term stability (300 h), high selectivity (>97%), and much enhanced H 2 and CO production in light-driven methane dry reforming. We demonstrate that light-excited hot carriers, coupled with electron-enriched Ir sites, enhance the activation of CO 2 and CH 4 , and facilitate the conversion of *CH intermediates to *CHO, thereby preventing coke formation and contributing to the high catalytic performance.
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International Journal of Oral Science
·
2026
·Vol. 18
·期 1
·16
·
IF 17.6
Wang Yuqiang,Tang Ying,Huang Qianxiao,An Jiaxin,Zhou Yueli,Yang Hongye,Song Fangfang,Zhang Xianzheng,Huang Cui
The onset and progression of periodontitis are closely associated with subgingival dysbiosis and excessive localized oxidative stress. While some oral probiotics exhibit certain inhibitory effects on periodontitis-related pathogens, they often struggle to effectively colonize and antagonize these pathogens due to the complex oxidative stress at the site of periodontitis. In this study, we engineer Lactobacillus reuteri with a reactive oxygen species (ROS)-responsive adhesive polymer (phenylboric acid-dopamine-hyaluronic acid) (LR@PDH). In the periodontitis microenvironment, this polymer can consume ROS and then expose the phenolic hydroxyl group of dopamine, promoting the selective adhesion and colonization of Lactobacillus reuteri at the site of inflammation to antagonize pathogens. The results show that, compared to conventional probiotic therapy, inflammation-responsive adhesive Lactobacillus reuteri effectively alleviates local oxidative stress, reduces the abundance of pathogenic bacteria in the subgingival microbiome, and inhibits the progression of periodontitis. Additionally, its good biocompatibility and safety highlight its potential as a therapeutic approach for clinical treatment of periodontitis.
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APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2026
·
IF 3.5
Lou Shuqi,Huang Rongkun,Chen Zhen,He Tiantian,Shuai Lan,Chen Sunfei,Duan Shenghan,Wang Hongsheng
In this study, we developed a transdermal tumor vaccine based on total RNA from melanoma cells undergoing immunogenic cell death (ICD). The vaccine employed mannosylated chitosan (MC) modified ethosomes (Eth MC ) as the delivery vehicle, in which the total RNA isolated from tumor cells undergoing celastrol-induced ICD (C-RNA) was electrostatically complexed with protamine (C-RNA-Prt) and subsequently encapsulated. Using electrospray deposition, the C-RNA-Prt loaded Eth MC (C-RNA-Prt@Eth MC ) was immobilized onto a silk fibroin membrane (SFM) to generate a tumor vaccine patch (C-RNA-Prt@Eth MC /SFM). In vitro studies demonstrated that this vaccine effectively targeted and activated dendritic cells (DCs), triggering the secretion of key pro-inflammatory cytokines such as TNF-α, IL-6, and IFN-γ, and promoting T-cell proliferation and differentiation. Animal immunization experiments further confirmed that the vaccine markedly elevated serum levels of pro-inflammatory cytokines, enhanced splenocyte-mediated cytotoxicity against melanoma cells, and exhibited no observable toxicity in major organs. Collectively, this transdermal vaccine patch demonstrated significant immunostimulatory activity, favorable biosafety, and therapeutic potential, providing an effective strategy for the design of personalized transdermal tumor vaccines.
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JOURNAL OF MATERIALS SCIENCE
·
2026
·
IF 4.4
Lu Mengqi,Wang Ruoyu,Miao Xiaoxuan,Tang Tingting,Hu Wenfeng,Jin Xiaoxuan,Wang Haoxiang,He Yuyang,Wang Yang,Xu Dongpo
The increasing consumption of high-protein seafood has heightened the demand for efficient detection of triethylamine (TEA), a key spoilage biomarker. In this study, a novel ternary SnO 2 -Pt/Ti 3 C 2 T x composite was for the first time fabricated via a combined strategy of electrospinning and electrostatic self-assembly for TEA sensing. Characterization confirmed the formation of a well-defined ternary heterostructure with abundant mesopores and a synergistic microstructure. Benefiting from this rational design, gas sensing tests revealed that the composite exhibits a high response, fast response/recovery, excellent cycling/long-term stability, and high selectivity with a low detection limit of 0.05 ppm at an optimal temperature of 122.28°C, alongside stable performance under 30–70% relative humidity. The enhanced performance is attributed to the catalytic effect of Pt, high conductivity of MXene, and synergistic interactions among the components. This work provides new insights for developing high-performance TEA gas sensors with promising practical potential. Graphical abstract
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 4
·318
·
IF 3.2
Su Xiuyuan,Chen Yuan-Bin,Tang Ruxuan
Based on the Na 0.48 La 0.52 MoO 4 ceramic, this study replaced La 3+ ions with Nd 3+ ions through ion substitution, which significantly increased the Q × f of Na 0.48 La 0.52 MoO 4 and reduced the sintering temperature. The good sintering state of this series of ceramics was demonstrated by scanning electron microscopy (SEM) and density tests. X-ray diffraction (XRD) and Raman spectroscopy results revealed the formation of solid solutions without the presence of secondary phases or impurities. The P–V–L theory indicated that the Na/La/Nd–O bond-to-bond ionicity (fi) contribution was dominant, while the Mo–O bond also played a significant role in the lattice energy ( U ), bond energy ( E ), and thermal expansion coefficient ( α ). Among them, the Na 0.48 La 0.48 Nd 0.04 MoO 4 ceramic achieved the best dielectric performance at 900 °C, with ɛ r = 11.027 ± 0.018, Q × f = 113,805 ± 6,358 GHz, and τ f = − 23.36 ppm/℃. Through ion substitution, these materials all have low sintering temperatures and high Q × f values, making them ideal candidates for low-temperature co-fired ceramics (LTCC).
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 3
·131
·
IF 5.4
Jin Meng,Ning Qiong,Zhang Mengping,Wei Haiyan,Meng Xiao,Chen Wenwen,Pan Hui,Xiu Haidi,Liu Lisheng,Wang Cuijuan
A novel surface-enhanced Raman scattering (SERS) based strategy is described for the rapid identification and quantitative determination of deltamethrin and its metabolite 3-phenoxybenzaldehyde in biological samples. A multifunctional sensor was developed using metal-organic framework-801 (MOF-801) and silver nanoflowers (Ag NFs), synthesizing an Ag NFs/MOF-801 composite. This composite is a dual-function material, acting as both a SERS substrate and an adsorbent, which was integrated into a portable 10-well plate. The addition of MOF-801 enhances enrichment selectivity and efficiency, while the abundant tips and rough surfaces of Ag NFs significantly improve SERS sensitivity. The determination of deltamethrin revealed a marked linear relationship between the SERS signal intensity and the logarithmic analyte concentration, with R-values falling within a range 0.959 to 0.972, with detection limits between 0.07 and 0.15 ppb, indicating suitability for clinical applications. This method successfully analyzed a patient sample, showing strong agreement with conventional chromatographic results while ensuring both practicality and accuracy. Notably, the detection process does not necessitate any sample preparation and can be completed within five min, highlighting its potential as an efficient and user-friendly POCD sensor for diagnosing poisoning in emergency settings.
Section
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