CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
·
2022
·
IF 1.193
Kun WANG,Er-Fei DONG,Min FANG,Ting CHEN,Wei-Ju ZHU,Cun LI
A new ratio fluorescence sensor based on mercaptamine capped cadmium telluride quantum dots (Mea-CdTe) and benzocoumarin-3-carboxylic acid (BTA) were constructed. The ratio fluorescence sensor (BTA@Mea-CdTe) was synthesized by amidation reaction between the amino groups on the surface of Mea-CdTe quantum dots and the carboxyl groups of BTA. It is found that Hg 2+ ions react with the amino groups on the surface of the quantum dots in the BTA@Mea-CdTe sensor to quench the fluorescence, but it has no effect on the fluorescence of grafted BTA. The sensor has good selectivity and high sensitivity for Hg 2+ ions detection. The detection linear range is 0.4–1.2 µM, and the detection limit is 0.03 µM. This ratio fluorescence sensor can be used for Hg 2+ visual recognition in water sample detection with obvious color change.
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npj Science of Food
·
2022
·Vol. 6
·期 1
·1-8
·
IF 7
Chen Yu-Hong,Zhang Yan-Hong,Chen Gen-Sheng,Yin Jun-Feng,Chen Jian-Xin,Wang Fang,Xu Yong-Quan
Phenolic acids are important taste components in green tea. The aim of this study was to analyze the taste characteristics of phenolic acids and their influence on the bitterness and astringency of green tea by sensory evaluation and chemical determination. The major tea phenolic acids and quercetin-3- O -rutinoside (Que-rut) were significantly positively correlated with the bitterness ( r = 0.757, p < 0.01; r = 0.605, p < 0.05) and astringency ( r = 0.870, p < 0.01; r = 0.576, p < 0.05) of green tea infusion. The phenolic acids have a sour and astringent taste, whereas Que-rut has a mild astringent taste. Phenolic acids and Que-rut can increase the bitterness of epigallocatechin gallate (EGCG). However, these components behaved differently for astringency on EGCG. Gallic acid (GA) enhances the astringency throughout all the concentrations in this study. While it seemed to be double effects of caffeic acid (CA), chlorogenic acid (CGA), and Que-rut on that, i.e., the inhibition at lower concentrations (CA: 0–0.2 mM; CGA: 0–0.2 mM; Que-rut: 0–0.05 mM) but enhancement at higher ones. The phenolic acids and Que-rut interacted synergistically with tea infusion and as their concentration increased, the synergistic enhancement of the bitterness and astringency of tea infusion increased. These findings help provide a theoretical basis for improving the taste of middle and green tea.
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ELECTROCHIMICA ACTA
·
2022
·
IF 7.336
Wenting Wei,Jiaxuan Li,Huiqin Yao,Hongyun Liu
Herein, by a one-step synthetization method, a viologen derivative diallyl viologen (DAV) was first polymerized with methacryloylglycine (MAG) into P(MAG-DAV) polymer films on the surface of ITO electrodes. DAV component in the P(MAG-DAV) films was used not only as a cross-linker and immobilized in the film phase for repetitive usages, but also demonstrated reversibly electrochromic and luminescent properties. When the electrode voltage was switched between −0.7 and −0.5 V (vs SCE), DAV could transfer from its purple reduction state (DAV •+ ) to colorless oxidation state (DAV 2+ ) through the electrode reactions , accompanied with the fluorescence signal switching between non-fluorescence (DAV •+ ) and green fluorescence (DAV 2+ ) states. The addition of KMnO 4 in the solution could oxidize DAV •+ to its DAV 2+ form in the films to generate electrocatalytic signals and change the optical signals at the same time. Based on various reversible stimulus-responsive behaviors of P(MAG-DAV) film electrodes, a logic system of 3-input/3-output was established using potential, KMnO 4 and ultraviolet excitation light as inputs, and cyclic voltammetry (CV), fluorescence (FL) and UV−vis signals as outputs. Including an encoder and a decoder, a unique resettable and reprogrammable keypad lock was built with 3 different outputs. The system used a single immobilized molecule as the core of computing, and applied only 3 stimuli as inputs to construct an integrated logic computing system with 3 different output signals, which greatly improved the complexity and diversity of the molecular computing system. This might provide a new idea for the subsequent development of multifunctional integrated logic devices.
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Cell Metabolism
·
2023
·
IF 29
Qingqing Zhang,Qing Zhao,Tao Li,Longya Lu,Fei Wang,Hong Zhang,Zhi Liu,Huihui Ma,Qihui Zhu,Jingjing Wang,Xuemei Zhang,Yang Pei,Qisha Liu,Yuyu Xu,Jinlong Qie,Xiaoting Luan,Zhibin Hu,Xingyin Liu
Previous studies have shown that Lactobacillus species play a role in ameliorating colorectal cancer (CRC) in a mouse model. However, the underlying mechanisms remain largely unknown. Here, we found that administration of a probiotic strain, Lactobacillus plantarum L168 and its metabolite, indole-3-lactic acid, ameliorated intestinal inflammation, tumor growth, and gut dysbiosis. Mechanistically, we indicated that indole-3-lactic acid accelerated IL12a production in dendritic cells by enhancing H3K27ac binding at the enhancer regions of IL12a that contributed to priming CD8+ T cell immunity against tumor growth. Furthermore, indole-3-lactic acid was found to transcriptionally inhibit Saa3 expression related to cholesterol metabolism of CD8+ T cells through changing chromatin accessibility and subsequent enhancing function of tumor-infiltrating CD8+ T cells. Together, our findings provide new insights into the epigenetic regulation of probiotics-mediated anti-tumor immunity and suggest the potential of L. plantarum L168 and indole-3-lactic acid to develop therapeutic strategies for patients with CRC.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Fan Xiao,Ming Cao,Rongrong Chu,Xiaoyu Hu,Wenxiong Shi,Yingbo Chen
A new type of composite membrane was prepared through the vacuum filtration self-assembly, in which, graphene oxide (GO) was the basic material, and the horizontal insertion material is product of perylene-3, 4, 9, 10-tetracarboxylic dianhydride (PTCDA) and UiO-66-NH 2 (PTCDA-UiO-66-NH 2 ). The leading role of Π-Π conjugate, auxiliary effect of hydrogen bonding during membrane preparation have been confirmed through Fourier transform infrared spectroscopy (FTIR), UV–visible spectrophotometer, Raman spectroscopy, and X-ray diffraction (XRD). The prepared GO@PTCDA-UiO-66-NH 2 membrane had new nodular structure compared to GO membrane by scanning electron microscopy (SEM) and atomic force microscopy (AFM), which promoted the water transport. In addition, the insertion of PTCDA-UiO-66-NH 2 narrowed the actual filtration spacing between GO sheets, and PTCDA-UiO-66-NH 2 could also adsorbed dye laterally. Experiments showed that the permeance of GO@PTCDA-UiO-66-NH 2 membrane was 1.7 times of GO membrane, and the removal of methyl blue, congo red, crystal violet and disperse black 9 was close to 100%. Under extreme pH, high salt concentration and multiple recycling, its separation ability was still excellent. The GO@PTCDA-UiO-66-NH 2 membrane constituted a unique synergistic structure of vertical-screening and horizontal-adsorption, which successfully overcame the trade-off effect and obtained excellent stability of structure and performance. Therefore, GO@PTCDA-UiO-66-NH 2 membrane had great potential in practical applications.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Jialu Huang,Chengwei Deng,Yue Liu,Tingting Han,Feng Ji,Yuehua Zhang,Hongbin Lu,Ping Hua,Bowei Zhang,Tao Qian,Xiaolei Yuan,Yaoyue Yang,Yong Yao
Palladium (Pd) is supposed to be one of the most promising catalytic metals towards ethanol (C 2 H 5 OH) oxidation reaction (EOR). However, Pd electrocatalysts easily suffer from the poisoning of the intermediates (especially CO), resulting in the quick decay of EOR catalysis. Herein, inspired by the Brønsted-Lowry acid-base theory, a “attraction–repulsion” concept is proposed to guide the surface structure engineering toward EOR catalysts. Specifically, we induce Bi(OH) 3 species as Brønsted base onto PdBi nanoplates to effectively repel the adsorption of CO intermediates. The PdBi-Bi(OH) 3 nanoplates show an impressive mass activity of 4.46 A mg Pd -1 during the EOR catalysis and keep excellent stability. Both the stability and enhanced performance are attributed by the interfacial Brønsted base Bi(OH) 3 which can selectively attract and repel reactants and intermediates, as evidenced from in situ measurements and theoretical views.
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JOURNAL OF MOLECULAR LIQUIDS
·
2021
·
IF 6.165
Mingcan Mei,Xutao Hu,Zhen Song,Lifang Chen,Liyuan Deng,Zhiwen Qi
Although chemisorptive ionic liquids (ILs) are widely expected as promising CO 2 absorbents, rigorous thermodynamic analyses for such systems remain challenging due to the inevitable co-existence of chemisorption and physisorption. In this work, an experimental approach combining quantitative NMR (qNMR) spectroscopy and mass balance is proposed to straightforwardly quantify the chemisorption and physisorption of CO 2 in chemisorptive absorbent, and 1-ethyl-3-methylimidazolium acetate ([Emim][OAc]) is selected for an exemplary study. The total CO 2 solubility in [Emim][OAc] is measured by the pressure drop method, of which the chemisorption part is quantified by qNMR and the physisorption part is then determined by mass balance. Correspondingly, a large set of CO 2 solubilities at four temperatures (298.15 K, 313.15 K, 323.15 K, and 348.15 K) covering the low pressure range below 100 kPa are determined, where the chemisorption and physisorption contribution are distinguished quantitatively. Following that, thermodynamic analyses for the CO 2 absorption by [Emim][OAc] are made from chemisorption and physisorption point of view, respectively.
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Chemical Science
·
2021
·Vol. 12
·期 15
·5631-5637
·
IF 9.825
Qiujian Xie,Yumin Yang,Weijie Zhang,Zhu Gao,Xiaofeng Li,Juntao Tang,Chunyue Pan,Guipeng Yu
Conjugated microporous polymers (CMPs) are cost-effective photocatalysts in organic transformations, while they are usually limited by the insufficient separation of photogenerated charges. Here we report a polarization strategy through molecular geometry optimization to promote the charge separation of CMPs. Three CMP photocatalysts with an alternative donor–acceptor skeleton and tunable symmetry were synthesized by the oxidative coupling of bis-carbazoles with electron-deficient bridges (benzene/pyridine/pyrimidine). Simply regulating the polarization of the starting monomers leads to tailorable porosity, photoelectric properties, and photocatalytic activity of the CMPs. They exhibited high efficiency in C-3 selenocyanation of indoles under visible-light and at room temperature, and pyridine-based CMPs with the largest dipole moment gave a yield of up to 94%, superior to their state-of-the-art photocatalyst counterparts. Photo-physical experiments combined with theoretical calculations further supported that the incorporation of the polarized linker introduced an internal electric field, benefitting efficient charge separation. This offered new insight into developing high-performance photocatalysts.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2020
·
IF 5.573
Mengdi Zhang,Zhaoxin Wang,Siyu Hao,Lei Hao,Xinying Zhang,Peng Yu,Hua Sun
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and important risk factor for cardiac diseases, diabetes and extrahepatic cancers. Natural 3′-geranylchalconaringenin (GC) and desmethylxanthohumol (DX) from hop were synthesized using a regio-selective iodination and the Suzuki coupling reaction as key steps. GC and DX, along with their aglycone naringenin chalcone (NC) were investigated their decreasing the accumulation of cellular lipids . GC reduced lipid content and activated the AMP-activated protein kinase (AMPK) pathway in HepG2 and 3T3-L1 cells. In addition, GC had an obvious therapeutic effect on alleviating NAFLD and metabolic syndrome by activating the AMPK pathway in vivo . In conclusion, GC may be potentially used as a candidate drug and functional food for treating NAFLD and metabolic syndrome.
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JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Mengyuan Liu,Jing Li,Jiali Li,Bingsheng Zhou,Paul K.S. Lam,Chenyan Hu,Lianguo Chen
The application of 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) as an antifouling biocide causes high toxicity to non-target marine organisms. To examine the developmental cardiotoxicity and mechanisms of DCOIT, we concurrently performed sub-chronic exposure and life-cycle exposure experiments using marine medaka embryos. After sub-chronic exposure to DCOIT at 1, 3, 10, and 33 μg/L, cardiac defects were caused by upregulation of cardiac gene transcriptions, decreasing heart size, and accelerating heartbeat. Hyperthyroidism in medaka larvae was identified as the cause of developmental cardiotoxicity of DCOIT sub-chronic exposure. In addition, parental life-cycle exposure to 1, 3, and 10 μg/L DCOIT led to transgenerational impairment of cardiogenesis in offspring medaka. A crossbreeding strategy discriminated a concentration-dependent mechanism of transgenerational cardiotoxicity. At 1 μg/L, the DCOIT-exposed female parent transferred a significantly higher amount of triiodothyronine (T3) hormone to offspring, corresponding to an accelerated heart rate. However, DCOIT at higher exposure concentrations modified the methylome imprinting in larval offspring, which was associated with cardiac dysfunction. Overall, the findings provide novel insights into the developmental cardiotoxicity of DCOIT. The high risks of DCOIT—even at environmentally realistic concentrations—raise concerns about its applicability as an antifoulant in a marine environment.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Fuchun Si,Xiaojing Cui,Yaping Zhang,Yifan Li,Huaixia Yang,Yanju Liu
Down-regulator of transcription 1 (DR1) is a crucial biomarker closely related to Hashimoto's Thyroiditis (HT). In this study, a highly selective electrochemical biosensor for ultrasensitive detection of DR1 was prepared by combining nanomaterials CMK-3 @AuNPs and atom transfer radical polymerization (ATRP) signal amplification strategy for the first time. Based on the specific recognition of antigen and antibody, the sensor has strong selectivity. CMK-3 @AuNPs can not only increase the conductivity of the electrode, but also provide more active sites for biological molecules, so as to effectively amplify the output signal. The FMMA monomers were polymerized on the electrode surface through ATRP reaction, which made the electrochemical signal increased significantly. Under optimal conditions, the fabricated electrochemical biosensor showed a wide detection range of 5 × 10 -4 ng/mL ∼ 5 × 10 2 ng/mL with a detection limit as low as 0.159 pg/mL. In addition, the electrochemical biosensor has good stability and anti-interference ability. Therefore, the sensor has broad prospects in the detection of biomarkers.
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CARBON
·
2023
·
IF 10.9
Bin Wang,Shizhen Dong,Xiaojuan Wu,Yanling Yu,Nuoxin Wang,Jinyang Li,Zuowan Zhou
Poly (3-aminophenylboronic acid) is an important boronic acid-based functional polymer, but its synthesis is difficult owing to the boronic acid group in 3-aminophenylboronic acid (ABA) has a strong electron-withdrawing effect. A topologically defective carbon-based catalyst with nanotubular morphology is developed by ammonia-assisted atomic imprinting and applied to facilitate the polymerization of ABA. Catalytic experiments show that the catalyst can greatly increase the polymerization rate of ABA and also significantly improve the quality of the polymer. The study of catalytic mechanism reveals the interaction between ABA (and its derivatives) and various structures of the catalyst, including electron-transfer-based interactions between ABA and topological defects as well as spatial confinement effects between ABA and nanospace structures. Under the combined influence of the above effects, ABA achieves efficient polymerization centered on topological defects. Consequently, this study demonstrates a carbon-based catalytic system that can efficiently promote the chemical oxidative polymerization of ABA.
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