JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.7
Weixiang Chen,Yuxiong Wang,Yaoyu Zhang,Yue Liu,Zhongbiao Wu
Ammonia (NH 3 ) has emerged as a promising zero‑carbon energy source for energy and transportation. However, its utilization leads to the emission of NH 3 , which contributes to PM 2.5 formation and disrupts the global nitrogen cycle. Selective catalytic oxidation (SCO) represents a mainstream technology for NH 3 treatment, yet achieving both sufficient activity and high N 2 selectivity across a broad temperature window remains challenging. Here, a core-shell Pt@Cu-ZSM-5 catalyst was employed for NH 3 catalytic abatement by encapsulating metallic Pt clusters (Pt 0 ) inside the channels of Cu ion-exchanged ZSM-5. The optimal sample achieved a complete NH 3 conversion below 250 °C and maintained over 92% N 2 selectivity from 250 to 500 °C due to the synergism between the Pt Cu dual sites. Mechanistic studies revealed that NH 3 oxidation preferentially occurred on Pt 0 sites with excellent redox capacity to produce N 2 O and NO x at relatively low and high temperatures, respectively. And the presence of Cu ions (Cu δ+ ) could efficiently both inhibit the formation of N 2 O on Pt 0 sites and reduce NO x emission, thereby improving the N 2 selectivity. At relatively low temperatures, NH 3 -solvated Cu + (NH 3 ) 2 could migrate to the adjacent Pt sites and reduce the adsorbed NO* species from NH 3 oxidation, damping the formation of N 2 O. At high temperatures, the NO and NO 2 emitted from Pt 0 sites could be reduced on Cu δ+ sites via a typical selective catalytic reduction. This study provides new insights into the rational design of bifunctional SCO catalysts and offers a comprehensive understanding of the synergistic effects in Pt Cu dual-site systems.
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高影响因子
SYNTHETIC METALS
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2016
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IF 2.299
Qiang Zhao,Junhua Chen,Fubin Luo,Lu Shen,Ying Wang,Kun Wu,Mangeng Lu
Nanostructure of ordered polyaniline-graphene (PANI-rGO PMAS ) hybrid nanomaterials is assembled based on poly(2-methoxyaniline-5-sulfonic acid) (PMAS) functionalized reduced graphene oxide (rGO PMAS ) nanosheets. The presence of PMAS not only improves dispersibility of reduced graphene oxide nanosheets, but also plays a key role for heterogeneous nucleation of polyaniline (PANI) nanorods . The formation mechanism of ordered PANI-rGO PMAS hybrid nanomaterials was studied in details by using field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM) and ultraviolet-visible spectrophotometry (UV–vis). The conductivity of PANI-rGO PMAS hybrid with 17 wt% rGO PMAS is as high as 4480 S/m, compared with 2.93 S/m for pure PANI. The cyclic voltammetry tests indicate that, PANI-rGO PMAS containing 2 wt% rGO PMAS possesses fast response to redox reactions and excellent reversible stability. It has a high specific capacitance of 385 F g −1 at the scan rate of 10 mV s −1 with potential ranges from −0.2 to 0.8 V. This ordered polyaniline-graphene hybrid has potential applications for flexible supercapacitors, sensors, batteries, electromagnetic materials and thermoelectric materials, etc.
研究领域:
材料科学
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纳米科技
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高分子化学
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电化学
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能源材料
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SENSORS AND ACTUATORS B-CHEMICAL
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2012
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IF 3.898
Wei Sun,Li Xu,Xiuzhen Wang,Jun Liu,Guangjiu Li,Zhenfan Sun
A graphene, chitosan and 1-ethyl-3-methylimidazolium tetrafluoroborate composite was prepared and modified on the surface of a carbon molecular wire electrode. The fabricated electrode was characterized by different methods such as scanning electron microscopy, cyclic voltammetry and electrochemical impedance spectroscopy . Electrochemical behaviors of guanosine-5′-triphosphate (GTP) were carefully studied on the modified electrode . The electrochemical parameters such as the charge transfer coefficient ( α ) and the electrode reaction standard rate constant ( k s ) were calculated with the results as 0.57 and 1.56 × 10 −4 s −1 . Under the optimized conditions, the oxidation peak current was proportion to the GTP concentration in the range from 0.007 to 70.0 μmol/L with the detection limit of 0.232 nmol/L (S/N = 3). Moreover, the proposed method showed good selectivity to the GTP detection without the interference of coexisting substances, and was further applied to the artificial samples determination with satisfactory results.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2026
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IF 3.9
Yongyue Bai,Lei Ye,Yunxing Bai,Peng Zhou,Yongrui Wang,Ying Ouyang,Weixin Huang,Jichang Liu,Xingtian Shu,Wenjie Yang,Youhao Xu
Coconversion of hydrocarbons offers a sustainable and efficient route to high-value products while lowering the cost and energy demand for pure feedstock preparation. Here, we propose a cocracking process for alkanes and alkenes, and systematically investigate their interactions under mixed feed conditions through experiments and simulations. Introducing 0–40% alkanes into the alkene feed enhances conversion and maintains high selectivity for light olefins while suppressing methane and aromatics. At 20% alkane, the combined selectivity of ethylene and propylene reaches 69.8%, with an ethylene/methane ratio of 11.94. Validation experiments using cocracking of pentadiene and n-pentane with in situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) show that dienes improve the product profile of alkane cracking and strengthen n-pentane adsorption on acidic zeolites, which favors alkene formation and suppresses methane and aromatics. Density functional theory (DFT) calculations further support that interactions between pentadiene and n-pentane facilitate a shift in the cracking pathway from a pentacoordinate to a tricoordinate carbocation mechanism, lowering the energy barrier. This work demonstrates a feasible strategy for the production of light olefins via hydrocarbon coconversion and advances mechanistic understanding of alkane–alkene cocracking.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
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IF 6.7
Di Zhang,Kunpeng Yang,Yuting Fan,Ding Jia,Dejun Ma,Yu-Cheng Gu,Han Xu,Zhen Xi
The development of 1-deoxy-d-xylulose-5-phosphate synthase (DXPS) inhibitors still needs an innovative extension with novel chemotypes to avoid herbicide resistance. Herein, a series of 2,4-diphenylquinoline derivatives were designed, synthesized, and structurally optimized from lead compound 24 via stepwise A/B/C-ring modification. Greenhouse assays identified a-3 (3-CF3 A-ring) as the most potent analogue, exhibiting the higher herbicidal activity (71.4% inhibition on DESSO at 375 g a.i./ha) and dosage tolerance than 24. The mechanism of compound a-3 targeting DXPS proteins has been also identified using surface plasmon resonance binding assay, physiological biomarker measurement, substrate accumulation, and molecular docking. The key active motifs between a-3 and DXPS have been further defined based on the structure–activity relationships. This work will further expand the structural diversity of DXPS inhibitors with higher bioactivity.
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高影响因子
Frontiers in Plant Science
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2026
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IF 5.9
Xiaohao Guo,Siyu Lin,Chuan Dong,Xinyu Huang,Hailian Hu,Baohai Li,Yuanyuan Tan,Qingyao Shu
IntroductionSerotonin and melatonin are plant signaling molecules involved in growth, stress responses, and redox balance. While animals produce serotonin via 5‑hydroxytryptophan (5‑HTP), plants are thought to use the tryptamine pathway. Although 5‑HTP exists in plants, its conversion to serotonin lacks a genetically defined enzyme.MethodsWe performed phylogenetic and structural analyses of Arabidopsis aromatic aldehyde synthase (AtAAS), expressed recombinant AtAAS, and examined its 5-HTP decarboxylase activity in vitro. Enzyme kinetic parameters were determined, and endogenous 5-HTP levels in Arabidopsis were quantified. A T-DNA insertion mutant of AtAAS was further used to assess serotonin accumulation following 5-HTP feeding and to determine endogenous levels of serotonin, N-acetylserotonin, and melatonin under normal growth conditions.ResultsAtAAS showed phylogenetic and structural similarities to animal aromatic amino acid decarboxylases and efficiently converted 5-HTP to serotonin in vitro (optimal pH 7.5, 55°C; Km = 1.806 mM, Vmax = 3.089 nmol/min/mg). Endogenous 5-HTP was detectable in Arabidopsis. Compared with wild-type plants, the AtAAS T-DNA insertion mutant exhibited reduced serotonin accumulation following 5-HTP feeding and decreased endogenous levels of downstream N-acetylserotonin and melatonin under normal growth conditions.Discussionhis discovery unveils enzymatic plasticity in plant serotonin biosynthesis and provides evidence for a previously unrecognized 5-HTP-dependent route in Arabidopsis.
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BIORESOURCE TECHNOLOGY
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2026
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IF 8.2
Junyu Wang,Qianqian Chen,Yuan Wang,Long Su,Zuotao Tan,Dong Liu,Shaohong You,Hongli Wu,Fei Cao
Multi-enzyme cascade valorizes starch-rich TCHRs into 5KGA; • NADP + regeneration built via Ga5DH-SBFA-CAT coupling; • Reverse activity suppressed, enabling efficient GA-to-5KGA conversion; • Fed-batch production of 5KGA reached 203 g/L with TTN of 9.5 × 10 4 . Herbal residues (HRs) are emerging as an important and sustainable biomass resource, driven by the diversification of global health concepts and the rapid growth in related consumption. Herein, we established a valorization route from starch-rich traditional Chinese herb residues (TCHRs) to high-value 5‑keto‑D‑gluconic acid (5KGA) via a multi-enzymatic cascade. Starch-rich TCHRs were first converted to gluconic acid (GA) through enzymatic hydrolysis and oxidation (>80% conversion). Subsequently, an oxidized cofactor regeneration system was established to efficiently convert GA into 5KGA by coupling gluconate-5-dehydrogenase (Ga5DH) with a synthetic bridged-flavin analogue (SBFA), thereby mitigating constraints arising from Ga5DH’s high reductive activity. This system catalyzed the irreversible dehydrogenation of GA to 5KGA, achieving complete conversion of 100 mM GA within 4 h (total turnover number, TTN = 1.0 × 10 4 ). Furthermore, upon scaling up in a 1-L bioreactor with continuous operation for 48 h, 203.3 g/L (950 mM) of 5KGA was produced with a TTN of 9.5 × 10 4 . This value-upgrading strategy provides an efficient and economically viable biotransformation pathway for starch-based non-edible biomass feedstocks. Download: Download high-res image (112KB) Download: Download full-size image
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Journal of Physical Chemistry Letters
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2026
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IF 4.5
Liyuan Wang,Zhishun Feng,Shiji Li,Hongsheng Liu,Yanying Ren,Junfeng Gao,Lei Li
Silver nanoparticles hold great promise in biomedical and environmental applications, yet small and uniform Ag nanoclusters are hindered by easy aggregation, uncontrollable growth, and difficult recovery. Here we report a rapid and controllable ultrasmall (1–4.5 nm) Ag nanocluster by uniformly dispersed encapsulation in ZSM-5 channels using a microwave-assisted one-pot synthesis strategy. The ZSM-5 containing 1.21 wt % Ag nanoclusters exhibits a high Ag atomic utilization rate of 81.2%. The unique confinement structure effectively prevents Ag nanocluster overgrowth while conferring exceptional recyclability, maintaining over 99.9% bactericidal efficacy against Escherichia coli after three cycles. Performance testing reveals the material exhibits remarkable peroxidase-like activity (3.73 U/mg) and catalytic capability (methylene blue reduction rate constant of 0.167 min–1). This study offers a size-controllable approach for preparing high-performance, easily recoverable, and scalable Ag-based nanomaterials.
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高影响因子
PLoS One
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2026
·Vol. 21
·期 6
·e0351846
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IF 2.8
Ming Liu,Xiaomei Liao,Fangchao Wang,Pengqing Jiao,Zhongkai Wang
Acquired drug resistance is a major cause of failure in gastric cancer treatment. The protein tyrosine phosphatase receptor type E (PTPRE) plays an oncogenic role in certain tumours; however, its function in chemotherapy-resistant gastric cancer remains unclear. Therefore, we analysed PTPRE expression in gastric cancer using The Cancer Genome Atlas. In vitro experiments were then conducted to investigate the effects of PTPRE on the resistance of cancer cells to 5-fluorouracil (5-FU) and its potential mechanisms. The results were further validated in vitro using xenograft studies. We found that PTPRE is upregulated in gastric cancer tissues and participates in the induction of 5-FU resistance. Mechanistic studies revealed that PTPRE suppressed ferroptosis in gastric cancer cells and promoted 5-FU resistance by activating the Src/FAK pathway to upregulate TRIB3 expression. In summary, PTPRE suppresses ferroptosis in gastric cancer cells via the Src/FAK/TRIB3 signalling pathway, thereby inducing 5-FU resistance. Intervention with PTPRE and its downstream targets may represent a potential approach for the clinical treatment of 5-FU-resistant gastric cancer.
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EBioMedicine
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2026
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IF 11.2
Lei Zhang,Xiaotong Han,Xinran Gao,Hangyu Chen,Chunliang Shang,Long Chen,Jian Lin,Hongyan Guo
Background Adenomyosis diagnosis and classification relies primarily on magnetic resonance imaging or pathological examination. Liquid biopsy has been widely applied in oncology but remains underexplored for adenomyosis. We aimed to identify liquid-biopsy-derived 5hmC biomarkers to aid adenomyosis diagnosis and molecular subtyping. Methods Genome-wide 5hmC profiles were obtained by 5hmC-Seal from plasma cfDNA (adenomyosis: n = 51; controls: n = 46) and tissue DNA (adenomyosis: n = 26; controls: n = 21). A paired-tissue-driven splitting strategy was used: the training set comprised 26 adenomyosis plasmas with matched tissues plus 23 controls, and the validation set comprised remaining samples. A 5hmC-based logistic regression model was developed and validated. The identified marker amyloid precursor protein ( APP ) was functionally characterised in cellular and mouse models. Findings Ten 5hmC markers were identified by machine learning. The model showed a sensitivity of 0.88 and a specificity of 0.87 (AUC = 0.91) in the validation set, with better performance than CA125 and CA199. 5hmC signatures could distinguish intrinsic from extrinsic adenomyosis subtypes. APP was related to epithelial cell migration and fibrosis in experimental models, which indicated its potential involvement in adenomyosis pathophysiology. Interpretation Plasma cfDNA 5hmC markers show promise for adenomyosis diagnosis and molecular classification. The APP-HOXD9 axis represents a potential therapeutic target warranting further validation. These findings require prospective, multi-centre confirmation before clinical implementation. Funding This work was supported by grant 82274034 from the National Natural Science Foundation of China, grant 2022YFB3604700 from the National Key Research and Development Program of China, and project BYESS2022031 from the Beijing Association for Science and Technology–Young Elite Scientist Sponsorship Program (BAST-YESS).
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ACS Sustainable Chemistry & Engineering
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2026
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IF 7.6
Qiuyang Wu,Yimeng Wang,Shuming Jin,Dong Lu,Luo Liu,Fang Wang,Li Deng,Kaili Nie
Abstract HMFO enables O2-dependent conversion of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) without soluble cofactor regeneration, but prolonged operation is limited by HMF substrate inhibition, pH drift, and enzyme deactivation. Here, these limitations were addressed through a combination of kinetic analysis, enzyme stabilization, and process optimization. High HMF and FDCA concentrations reduced apparent HMFO activity; pH control relieved the FDCA-related acidification effect, whereas HMF caused direct substrate inhibition, favoring controlled feeding over high initial loading. 8B×HMFO was therefore stabilized by computation-guided mutagenesis and disulfide engineering. 8B×HMFO-5M increased apparent melting temperature by 17 °C and extended the 30 °C half-life from 29.1 to 98.5 h while retaining similar apparent kinetic behavior. E. coli resting cells expressing 8B×HMFO-5M served as a simplified catalyst format, and CAT–HMFO fusion improved FDCA formation. Kinetic feeding incorporating HMF substrate inhibition, catalyst deactivation, and a whole-cell effectiveness factor converted 231.5 mM cumulative HMF input to 214.8 mM FDCA in a 3 L stirred-tank reactor over 72 h, giving a 92.8% molar yield. An E-factor of 4.47 kg·kg−1 including crude FDCA isolation demonstrated the material efficiency of this HMFO-based route.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Yunfan Gui,Wenzhi Li,Chenchen Gui,Ajibola T. Ogunbiyi,Lida Wang,Guoshun Liu
A reactive benzyl alcohol/5-SSA system enabled efficient corn stover component fractionation. • The fractionation removed 86.52% lignin and 90.51% hemicellulose while retaining 88.45% cellulose. • Low-condensation lignin was recovered through benzyl alcohol-mediated structural protection. • HSQC and DFT revealed that benzyl alcohol suppressed lignin condensation via reactive grafting. • Pretreated residue is converted into high-surface-area porous biochar. Efficient fractionation of lignocellulosic biomass under mild conditions while preserving lignin structural integrity remains a major challenge for biomass valorization. In this work, we developed a binary pretreatment system composed of benzyl alcohol and 5-sulfosalicylic acid (5-SSA) for the mild fractionation and component utilization of corn stover. The results showed that under the optimal conditions (100 °C, 60 min, and 4 wt% 5-SSA), 86.52% of lignin and 90.51% of hemicellulose were removed, while 88.45% of cellulose was retained. The recovered lignin showed high purity, a light color, a low condensation degree, and a relatively uniform molecular-weight distribution. 2D-HSQC NMR combined with DFT calculations suggested that benzyl alcohol may suppress lignin condensation through stabilization of benzylic intermediates and interaction with reactive nucleophilic sites on lignin aromatic rings. In addition, benzyl glycosides were identified as important hemicellulose-derived products in the aqueous phase, suggesting a solvent participated alcoholysis/glycosylation pathway. The cellulose-rich solid residue was upgraded into porous biochar with a specific surface area of up to 1388.13 m 2 g −1 via KHCO 3 -assisted pyrolysis. This work provides an effective strategy for the mild fractionation of corn stover, recovery of high-quality lignin, and integrated valorization of biomass components. Download: Download high-res image (114KB) Download: Download full-size image
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