ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 16
·48389-48400
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IF 5.8
Zhao Huanxin,Chen Wenkai,Wu Dan,Liu Xinyue,Hu Wanjie,Zhang Xuejun
Although heterogeneous cobalt-based catalysts have been widely studied and used in SO 4 •− based advanced oxidation processes, the efficiencies were still not high enough due to the limiting step of Co(III)/Co(II) cycle in the system. In this study, a bimetallic oxide composed of Co and Mo was designed and used for enhancing the performance of peroxymonosulfate activation on organic pollutants removal. The CoMoO 4 nanorods exhibited superior catalytic activity for methylene blue (MB) degradation than Co 3 O 4 , MoO 3 , and their mechanical mixture, which was attributed to the synergetic effect between Co and Mo. CoMoO 4 nanorods were able to efficiently degrade MB under a wide pH range of 3–11 and could maintain high efficiency in 5 cycles with less leakage of metal ions. Moreover, CoMoO 4 nanorods displayed broad spectrum applicability to the different water matrix and a variety of pollutants such as phenol and Congo red. The Co(II) was proved to be the main active site of the catalyst, while Mo played an important role in promoting the Co(III)/Co(II) cycle. Surface free radicals are the main active species in the degradation process. This work provides new insights into the design of cobalt-based bimetallic catalyst and the improvement on PMS activation.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2023
·Vol. 332
·期 4
·1047-1054
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IF 1.6
Hu Yichen,Ma Jiaju,Liu Tonghuan,Zhang Yongjie,Yu Yuhong,Sun Zhiyu,Fang Fang,Dong Tianhao,Zhao Yanhong,Zhou Gen
In this paper, three polymeric bases (styrene, vinyl toluene, methyl methacrylate (MMA)) plastic scintillators were synthesized by thermal and UV irradiation polymerization. The influences of the concentrations of the primary fluorescent agent 2.5-diphenyloxazole (PPO) and wave-shift agent 1,4-bis-2(5-phenyloxazoyl)benzene (POPOP) on plastic scintillators characterization were investigated. The results suggest that the maximum emission wavelength of synthesized plastic scintillators with different polymeric base are all around 423 nm matching with maximum response wavelength of general photoelectric devices, and its decay time with several nanoseconds has reached the same level as the EJ-200. The maximum light yield of the plastic scintillator was achieved when the mass ratio of PPO/POPOP is 1.0%/0.02% for the styrene plastic scintillators.
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Journal of Food Measurement and Characterization
·
2022
·Vol. 17
·期 3
·2301-2312
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IF 3.006
Gao Dan,Helikh Anna,Duan Zhenhua,Xie Qingli
In this study, the thermal, structural, and emulsifying properties of pumpkin seed protein isolates (PSPI) subjected to pH-shifting were investigated. PSPI subjected to different pH values (pH 2, 4, 6, 8, 10, and 12), were named PSPI 2, PSPI 4, PSPI 6, PSPI 8, PSPI 10, and PSPI 12, respectively. According to the differential scanning calorimetry analysis, the control PSPI exhibited denaturation temperatures of 87.67 and 104.11 °C, and their corresponding enthalpies were 1.66 and 0.37 J/g, respectively. Among the PSPI samples, only PSPI 2 showed no significant difference in denaturation temperatures and enthalpies as compared to the control PSPI. The emulsifying activity indexes of PSPI 2, PSPI 4, and PSPI 12 increased ( p > 0.05) by 205.84, 298.98, and 288.69%, respectively, and the emulsion stability indexes of these three samples increased by 42.32, 67.58, and 40.87%, respectively. The disulfide bond contents of PSPI 2, PSPI 4, and PSPI 12 increased by 7.46, 9.28, and 5.01%, respectively, and the free sulfhydryl group contents of these three samples decreased by 36.69, 44.39, and 29.11%, respectively, which indicated that the improved emulsifying properties of PSPI 2, PSPI 4, and PSPI 12 might be correlated to the increased disulfide bond contents and decreased free sulfhydryl group contents. However, the emulsifying properties of PSPI samples had no obvious correlation with their surface hydrophobicity and particle sizes.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 30
·期 13
·38174-38184
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IF 5.19
Zhang Ziang,Ma Yan,Li Aimin,Pan Yang,Yao Qianqian,Jia Xiaorui,Zhou Qing
The hydrophilic substances in natural organic matter (NOM) are the main precursor of disinfection by-products (DBPs) formed during disinfection processes. The fractionation of the components in NOM based on hydrophilicity contributes to elaborating the behavior of NOM during disinfection. However, the traditional NOM fractionation method using two hydrophobic resins of DAX-8 and XAD-4 lays emphasis on the separation of hydrophobic substances, limiting the thorough study of the hydrophilic components in NOM. In this work, the amphiphilic resin NDAM was employed as a replacement of XAD-4 to realize more thorough separation of the hydrophilic substances. Compared with the divinylbenzene (DVB) structure of XAD-4, the NDAM possesses a more hydrophilic skeleton of N-vinylpyrrolidone (NVP) and DVB which favors the adsorption of hydrophilic components in NOM. The two fractionation methods of DAX-8 + XAD-4 and DAX-8 + NDAM were applied to fractionate NOM, and the obtained fractions were characterized via fluorescence spectra, UV spectra, acid–base titration, the partition coefficients of aqueous two-phase systems(ATPs), and 1H nuclear magnetic resonance (1H-NMR). The results showed that the transphilic fractions separated by XAD-4 accounted for 11.09% of NOM, while the proportion increased to 20.33% with the method of NDAM fractionation. Besides, the hydrophilic components enriched by NDAM not only have more π-conjugated systems and more aromatic structure but also contain more oxygen-containing and nitrogen-containing functional groups. In addition, the hydrophilic fractions separated by NDAM contained more DBP precursors. The NDAM separates more NOM which can produce bromine-containing DBPs into HPIA, and the DBP productivity of HPIN is significantly higher than that of XAD-4. In general, the NOM fractionation method proposed in this study utilizing NDAM resin could fractionate the hydrophilic fractions in NOM more thoroughly, showing application potential in the analysis and control of DBPs formed from NOM.
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MEDICINAL CHEMISTRY RESEARCH
·
2022
·Vol. 32
·期 2
·288-313
·
IF 2.351
Zhang Yuanwen,Zheng Yueming,Wu Qingqing,Tian Fuyun,Ma Chuanjun,Xu Haiyan,Zhan Li,Gao Zhaobing,Zhao Guilong,Ti Huihui
A clinical therapy for chronic neuropathic pain is urgently needed, and the voltage-gated calcium channel (VGCC) α2δ subunit is among the most promising therapeutic targets. To intensively explore the structure-activity relationship (SAR) of the lipophilic moiety in VGCC α2δ subunit ligands (gabapentinoids), we designed and synthesized 11 bicyclic and monocyclic derivatives based on mirogabalin, a third-generation VGCC α2δ subunit ligand. The competitive binding of the synthesized compounds to the human VGCC α2δ-1 subunit was measured in vitro, and the results demonstrated that the lipophilic moiety size was strictly limited in gabapentinoids, in which conformationally rigid bicylo[3.2.0]heptane/heptene with a cis -fusion was the most preferred structure. In contrast, monocyclic cyclobutane was associated with a markedly decreased binding affinity except in 4 (IC 50 = 15.2 nM), in which the substituents could mimic the rigid conformation of bicylo[3.2.0]heptane/heptene; heteroatoms in the lipophilic moiety were detrimental to the binding affinity ( 2 , IC 50 > 729 nM). The SAR findings obtained in the present study will be valuable for designing novel gabapentinoid drugs to treat chronic neuropathic pain in the future. Graphical abstract
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JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2023
·Vol. 37
·期 6
·1271-1278
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IF 1.6
Luo Zhang,Gong Chaihong,Mao Xiaowei,Wang Zhe,Liu Zhifan,Ben Yali,Zhang Weiying
Keratinocytes and fibroblasts, derived from hiPSCs, were used to construct the human epidermal model by a culture patch made by monolayer poly-(lactic-co-glycolic acid) (PLGA) nanofibers and a human skin-on-a-chip device. Unlike the conventional culture dish method, two different epidermal cells are successfully adhered to the front and back sides of the patch, which produces a three-dimensional nanofibrous scaffold similar to a natural extracellular matrix before the patch was cultured in the skin-on-a-chip device to mimic the physiological conditions of human skin. As expected, the differentiated hiPSCs show the expression of keratinocyte- and fibroblast- specific proteins on the patch, and the layering is found between these two kinds of cells, indicating that this approach creates a powerful in vitro system for modeling skin development and diseases.
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JOURNAL OF MOLECULAR MODELING
·
2023
·Vol. 29
·期 2
·1-13
·
IF 2.2
Zhu Guodian,Shang Jingqi,Wen Weihong,Li Yuanyuan,Yin Guoqiang
Context Lignin has an immense potential for the production of lignin-based functional materials. In this work, effect of 2-chloro-ethyltrimethyl ammonium chloride (AC)-grafted alkali lignin (AL) on the morphologies in water was investigated by dissipative particle dynamics (DPD) simulations. The results showed that AL molecules formed spherical micelles, but the corresponding phenylpropane units of AL were randomly distributed in spherical micelles. However, AC-grafted modification of phenolic hydroxyl groups in AL led to the formation of multilamellar spherical micelles. The formation of multilamellar spherical micelles of AL mainly went through four stages: small clusters, larger aggregates with a core-shell structure, trilaminar, and multilamellar spherical micelles. AL molecules resulted in dimethomorph molecules being randomly distributed in the spherical micelle, while the dimethomorph molecules were perfectly entrapped into the spherical micelles of AC-grafted AL. Various molecular weights of AL had no effect on the formation and size of multilamellar spherical micelles. With increasing the content of AC-grafted AL, small clusters, multilamellar spherical micelles, tube-like, and lamellar aggregates were observed successively. This work highlights the potential of lignin to prepare monodispersed lignin-based functional colloidal spheres. Methods Coarse-grained beads were performed energy minimization, geometric optimization, NPT ensemble (298 K and 1.0 bar), and NVT ensemble (298 K) calculations. DPD simulations were carried out at 300,000 steps in a 30×30×30 Rc 3 cubic box with Materials Studio 7.0 program.
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Science China-Life Sciences
·
2022
·Vol. 66
·期 7
·1569-1588
·
IF 10.372
Ma Ning,Guo Pingting,Chen Jingyu,Qi Zengkai,Liu Chunchen,Shen Jiakun,Sun Yiwei,Chen Xiyue,Chen Guo-Qiang,Ma Xi
Maintainance of sulfomucin is a key end point in the treatment of diarrhea and inflammatory bowel disease (IBD). However, the mechanisms underlying the microbial sense to sulfomucin are poorly understood, and to date, there are no therapies targeting the secretion and maturation of sulfomucin in IBD. Herein, we biosynthesized poly-β-hydroxybutyrate (PHB) and found that PHB could alleviate inflammation caused by diarrhea and colitis by enhancing the differentiation of sulfomucin. Microbiota transplantation and clearance together demonstrate that PHB promoting sulfomucin is mediated by Lactobacillus johnsonii ( L. johnsonii ). Further studies revealed that PHB provides a favorable niche for L. johnsonii biofilm formation to resist disturbance and support its growth. L. johnsonii -biofilm alleviates colitis by regulating fucose residues to promote goblet cell differentiation and subsequent sulfomucin maturation. Importantly, PHB alleviates colitis by enhancing sulfomucin secretion and maturation in a L. johnsonii -dependent manner. PHB represents a class of guardians, acting as a safe probiotic-biofilm delivery system that significantly promotes probiotic proliferation. Altogether, this study adds weight to the possible role of probiotics and functional materials in the treatment of intestinal inflammation. The application of PHB and biofilm self-coating L. johnsonii carries high translational potential and may be of clinical relevance.
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Nano Research
·
2022
·Vol. 16
·期 6
·8385-8393
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IF 10.269
Zheng Qingyi,Fan Xiaoxiang,Liu Guoqing,Hou Qing,Fan Jingmin,Zheng Mingsen,Dong Quanfeng
Lithium-sulfur batteries are regarded as promising next-generation energy storage batteries for their ultra-high theoretical energy density. However, the complex sulfur electrode process with sluggish sulfur conversion reactions is a critical issue for lithium-sulfur batteries, in which catalytic interfacial reactions and accelerated lithium-ion diffusion are the key factors. Our previous work has shown that implanting functional molecules with multiple redox properties in the electrode can break through the conventional diffusion layer constraints and achieve forced convection. In this work, a functionalized complex molecule, methylene blue anthraquinone-2-sulfonate (MB-AQ), with multiple redox activities as well as abundant active sites, was synthesized and introduced into the sulfur cathode. In addition to accelerating the transport of lithium ions by reversible inhaling and exhaling lithium ions, the MB-AQ can combine polysulfides by its active sites to accelerate sulfur conversion reactions. Benefiting from two functions of accelerating ion diffusion and catalyzing interfacial reactions, MB-AQ/reduced graphene oxide (rGO)/S cathode can achieve high initial capacities of 884 and 674 mAh·g −1 with stable cycling of 700 and 1,000 times at 1 and 4 C, respectively. It is worth mentioning that the capacity of 462 mAh·g -1 can be achieved even at a high current density of 6 C. This work provides a new approach to enhancing the sulfur cathode process.
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Cell Death & Disease
·
2023
·Vol. 14
·期 2
·1-17
·
IF 9
Chen Yulian,Jiang Huanguo,Zhan Zhikun,Lu Jindi,Gu Tanwei,Yu Ping,Liang Weimin,Zhang Xi,Liu Shuwen,Bi Huichang,Zhong Shilong,Tang Lan
Converting lipid disturbances in response to energy oversupply into healthy lipid homeostasis is a promising therapy to alleviate hepatosteatosis. Our clinical studies found that a further elevation of triglyceride (TG) in obese patients with the body mass index (BMI) greater than 28 was accompanied by a further reduction of phosphatidylethanolamine (PE). Shorter survival and poor prognosis were shown for the patients with high TG and low PE levels. Liver X receptor alpha ( LXRα ) knockout mice aggravated high-fat diet (HFD)-induced obesity and lipid disorders, making the TG enrichment and the PE decrease more pronounced according to the liver lipidomics analysis. The RNA-seq from mice liver exhibited that these metabolism disorders were attributed to the decline of Atgl (encoding the TG metabolism enzyme ATGL) and Ept1 (encoding the PE synthesis enzyme EPT1) expression. Mechanistic studies uncovered that LXRα activated the ATGL and EPT1 gene via direct binding to a LXR response element (LXRE) in the promoter. Moreover, both the supplement of PE in statin or fibrate therapy, and the LXRα inducer (oridonin) ameliorated cellular lipid deposition and lipotoxicity. Altogether, restoration of lipid homeostasis of TG and PE via the LXRα-ATGL/EPT1 axis may be a potential approach for the management of hepatosteatosis and metabolic syndrome.
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BMC GASTROENTEROLOGY
·
2023
·Vol. 23
·期 1
·1-10
·
IF 2.4
Xiang Ping,Ge Tingrui,Zhou Jingyi,Zhang Yonggang
Background Increasing research indicates that circular RNAs (circRNAs) play critical roles in the development of ulcerative colitis (UC). This study aimed to determine the role of circRNA CCND1 in UC bio-progression, which has been shown to be downregulated in UC tissues. Methods Reverse transcription quantitative polymerase chain reaction was used to determine the levels of circRNA CCND1 , miR-142-5p, and nuclear receptor coactivator-3 ( NCOA3 ) in UC tissues and in lipopolysaccharide (LPS)-induced Caco-2 cells. Target sites of circRNA CCND1 and miR-142-5p were predicted using StarBase, and TargetScan to forecast potential linkage points of NCOA3 and miR-142-5p, which were confirmed by a double luciferase reporter-gene assay. Cell Counting Kit 8 and flow cytometry assays were performed to assess Caco-2 cell viability and apoptosis. TNF-α, IL-1β, IL-6, and IL-8 were detected using Enzyme-Linked Immunosorbent Assay kits. Results CircRNA CCND1 was downregulated in UC clinical samples and LPS-induced Caco-2 cells. In addition, circRNA CCND1 overexpression suppressed LPS-induced apoptosis and inflammatory responses in Caco-2 cells. Dual-luciferase reporter-gene assays showed that miR-142-5p could be linked to circRNA CCND1 . Moreover, miR-142-5p was found to be highly expressed in UC, and its silencing inhibited LPS-stimulated Caco-2 cell apoptosis and inflammatory responses. Importantly, NCOA3 was found downstream of miR-142-5p. Overexpression of miR-142-5p reversed the inhibitory effect of circRNA CCND1 -plasmid on LPS-stimulated Caco-2 cells, and the effects of miR-142-5p inhibitor were reversed by si- NCOA3 . Conclusion CircRNA CCND1 is involved in UC development by dampening miR-142-5p function, and may represent a novel approach for treating UC patients.
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International Journal of Environmental Science and Technology
·
2023
·Vol. 20
·期 11
·11865-11876
·
IF 3.1
Xin X.,Liu H.,Sun J.,Gao K.,Jia R.
The composite material based on N- , S- , and Fe-doped TiO 2 (NSFe-TiO 2 ) synthesized by wet impregnation was used as a photocatalyst to rapidly degrade sulfadiazine. The photocatalytic degradation behavior and mechanism of sulfadiazine on NSFe-TiO 2 were investigated for revealing the role of degradation under ultraviolet light. The results showed that compared with TiO 2 , NSFe-TiO 2 markedly improved the efficiency in photocatalytic degradation of sulfadiazine: more than 90% of sulfadiazine could be removed within 120 min by NSFe-TiO 2 dosage of 20 mg L −1 . The process conformed to first-order reaction kinetics model. The parameters such as loaded amount of NSFe-TiO 2 , solution pH value, humic acid concentration and recycle numbers on removal efficiency were also studied. Compared to neutral and alkaline conditions, acidic condition was not conducive to the photocatalysis. HA, Ca 2+ , Cu 2+ and Zn 2+ in the actual water body had mild inhibition on sulfadiazine degradation in UV/NSFe-TiO 2 system. Fragments screened by high-resolution mass spectrometry were conducted to explore the oxidation mechanism and pathways of sulfadiazine degradation. On the whole, UV/NSFe-TiO 2 photocatalysis has a good effect on sulfadiazine removal.
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