EUROPEAN JOURNAL OF PHARMACOLOGY
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2022
·
IF 5.195
Fangfang Xu,Jun Wang,Pan Wang,Tao Hou,Han Zhou,Yaopeng Zhao,Jixia Wang,Yanfang Liu,Xinmiao Liang
Ursodeoxycholic acid (UDCA) is a safe bile acid effective in reducing hepatic steatosis in non-alcoholic fatty liver disease (NAFLD). However, the mechanism of action linked to this effect is poorly defined. In the present study, we identified that UDCA acted as a free fatty acid receptor 4 (FFA4) agonist with EC 50 of 10.4 ± 0.7 μM, and its activity was determined by dynamic mass redistribution, fluorometric imaging plate reader, inositol monophosphate and bioluminescence resonance energy transfer assays. Moreover, UDCA showed FFA4 selectivity over eleven other G protein-coupled receptors. Real-Time PCR and immunocytochemistry analyses showed that FFA4 was abundantly expressed in human hepatocytes HuH-7 cells. In an in vitro model of NAFLD induced by oleic acid (OA), UDCA downregulated lipid accumulation in HuH-7 cells and suppressed sterol-regulatory element binding protein-1c (SREBP-1c) mRNA expression. This suppression of SREBP-1c was restored when FFA4 expression was knocked down in siRNA assay. In a mouse model of hepatic steatosis, db/db mice were exposed to a high-fat diet (HFD), and treatment of UDCA or docosahexaenoic acid (DHA, an endogenous FFA4 agonist) effectively prevented body weight gain and hepatic fat deposition and reduced triglyceride (TG) levels in serum and liver. This study not only identified a new skeleton of FFA4 agonists, but also demonstrated that FFA4 signal was accounting for the protective effects of UDCA in the NAFLD treatment.
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Petroleum Science
·
2022
·
IF 4.757
Xiao-Yi Liu,Xiu-Ping Li,Rong-Xiang Zhao
Ce 2 (MoO 4 ) 3 was synthesized by a simple reflux method using cerium nitrate hexahydrate and ammonium molybdate as reactants. The as-prepared Ce 2 (MoO 4 ) 3 was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Scanning electron microscope (SEM), and X-ray photoelectron spectroscopy (XPS). The removal of dibenzothiophene (DBT) in model oil was studied using Ce 2 (MoO 4 ) 3 as catalyst and oxygen as oxidant. The reaction factors such as reaction temperature, amount of catalyst, and sulfide type on sulfur removal were researched. The results prove that both Ce 3+ and MoO 4 2- play significant role in the conversion from DBT to DBTO 2 . The Ce 2 (MoO 4 ) 3 catalyst has an excellent performance for the sulfur removal of DBT. Under the optimum reaction conditions, sulfur removal of 99.6% was obtained. After recycling five times, no significant loss in catalyst activity of Ce 2 (MoO 4 ) 3 . Mechanism of aerobic oxidative desulfurization was proposed based on the experiment of free radical capture and infrared characterization.
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ELECTROPHORESIS
·
2022
·
IF 3.595
Yulan Liu,Ling Xia,Xiaohua Xiao,Gongke Li
Microfluidic CE (MCE) is an effective solution for rapid and sensitive determination of multiple analytes. Herein, a dynamic coated cyclic olefin copolymer microchip was developed having an on-chip micropump for fluid velocity adjusting in electrophoretic separations. This micropump was fabricated by constructing a polyacrylamide gel membrane at one channel terminal. Once applying electric field across the membrane, a pressure-driven flow generated automatically to balance the electroosmotic flow (EOF) mismatch at the channel-membrane interface. The influence of gel precursor concentration and operating voltages on the fluid velocity was carefully evaluated. Moreover, the highly integration of injection, separation, and pumping units of the MCE system minimized the dead volume and provides satisfied column efficiency. Experiments showed that by adjusting of pumping voltage reduced the fluid velocity by a factor of 6, resulting six- and threefold resolving power enhancements of rhodamine dye mixture and amino acid mixture, respectively. Furthermore, the developed MCE method was applied for rhodamines and amino acids quantitation in food and cosmetics, with standard addition recoveries of 87.3–106.9% and 89.9–117.4%, respectively. These results were also confirmed by standard HPLC method, revealing the application potential in fast and onsite analysis of complex samples.
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Nanoscale
·
2022
·Vol. 14
·期 13
·4957-4964
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IF 8.307
Tingshi Zhang,Chengkai Yang,Borong Li,Yuanming Zhang,Zanyong Zhuang,Yan Yu
Preparation of high-density and atomically-dispersed clusters is of great importance yet remains a formidable challenge, which precludes rational design of high-performance, ultrasmall heterogeneous catalysts for alleviating the energy and environmental crises. In this study, we demonstrated an appealing non-equilibrium growth model to give sub-2 nm CuO clusters not from the growth of nuclei but from the top-down growth of metastable bulk crystals. These CuO clusters have high density and intriguingly uniform orientation, and are atomically scattered on an inactive ultrathin AlOOH substrate, which has been driven by the lattice matching between the CuO clusters and the utlrathin AlOOH substrate. The catalytic activity of CuO clusters, with the hydrogenation of 4-nitrophenol as a model reaction, proved to be extremely efficient and showed a rate constant of 130.0 s−1 g−1, outperforming the commercial Pd/C catalysts and reported state-of-the-art noble-metal catalysts (1.89–117.2 s−1 g−1). These clusters have abundant interfacial oxygen vacancies (OVs) whose concentration can be regulated, and the OVs are found to be essential, according to density functional theory (DFT) calculations, in reducing the energy barrier of catalytic reduction and significantly boosting the catalytic reaction. These findings could add to the library of crystals downsized to the atomic level and demonstrate how engineering point defects on the sub-nanometer materials help design high-efficient catalysts.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
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IF 5.518
Yun Xue,Jiaqi Chen,Peng Liu,Jianzhang Gao,Yunyang Gui,Wanting Cheng,Fuqiu Ma,Yongde Yan
In order to satisfy the increasing needs for sustainable development of the nuclear energy industry, it is critical to vigorously develop efficient materials for uranium separation and recovery from wastewater. In this work, novel amidoxime-functionalized membranes (PAO membranes) were successfully synthesized via a facile one-step non-solvent induce phase separation rather than as-reported synthesized approaches that needed complicated additives or harsh reaction conditions. The pore channels provided large specific surface areas and massive binding sites, and the bulk-shape membrane was convenient for collection. Removal of uranium as a function of initial pH, reaction time, initial concentrations of U(VI), and temperature was studied. The maximum adsorption capacity of the PAO membranes toward U(VI) calculated from the Langmuir model was up to 641.72 mg·g −1 at pH 5 and 298 K. Thermodynamic studies indicated that the enrichment of U(VI) was a spontaneous and endothermic process. The removal percentage of uranium reached 86.50% in simulated wastewater in the case of multiple coexisting metal ions . In addition, the scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) results confirmed that the abundant adsorption sites of the PAO membranes were responsible for the efficient immobilization of uranium by forming chelating species, especially amidoxime groups and carboxyl groups. This work presents a novel strategy for mass production of a new generation of high-efficiency adsorbents for uranium-containing wastewater treatment in the future.
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CRYSTENGCOMM
·
2022
·Vol. 24
·期 11
·2100-2106
·
IF 3.756
Song-Tao Dong,Zhuang Fu,Miaocheng Yu,Jia-Ling Jiang,Xiaoyun Jin,Yu-Hang Guo,Lei Wang,Ya-Mei Zhang
Self-powered photoelectric devices as a new type of sensor without an external power source have a great potential advantage in the next generation of portable and wearable personal devices. The design of those devices is normally based on three kinds of strategies: a p–n junction, the Schottky junction and ferroelectric polarization. Here, a novel solution based on ion migration induced self-powered photodetectors was explored. In this work, high quality halide perovskite FAPbBr3 crystals were grown by an inverse temperature crystallization (ITC) method. An irreversible ion migration was intentionally created using a symmetrically structured Au/FAPbBr3/Au device. The resulting built-in electric field and energy band bending were proved using electrical measurements in the dark and under light. Finally, the response of the ion migration induced self-powered FAPbBr3 detector was investigated with the values of R (∼0.18 mA W−1) and EQE (∼0.055%) under light with a power density of 1 mW cm−2 and a wavelength of 397 nm. Our investigation demonstrates that ion migration, which is normally deemed a detrimental factor for device stability, can be intentionally used for self-powered photoelectric devices.
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INTERNATIONAL JOURNAL OF ENERGY RESEARCH
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2022
·Vol. 46
·期 7
·8949-8961
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IF 4.672
Xinfei Fan,Haichao Mu,Yuanlu Xu,Chengwen Song,Yanming Liu
Summary Solar-driven interfacial evaporation is an emerging environmentally-friendly technology to produce freshwater, but the current interface evaporators are restricted by their high cost, complex fabrication processes, and low resistance to environmental conditions. Here, a low-cost and high-efficient evaporator was prepared simply by modifying natural wax gourd with polydopamine (PDA) and silver nanoparticles (AgNPs). The prepared AgNPs-PDA-wax gourd exhibited excellent light absorption (>94%) in the whole solar spectrum (300-2500 nm). Under 1 sun illumination, the prepared evaporator achieved an extraordinary evaporation rate of 1.70 kg m −2 h −1 (efficiency of 83.21%), which was 3.78 and 1.21 times higher than the rates of natural wax gourd and PDA-wax gourd, respectively. Such excellent performance was mainly attributed to the synergic light-to-heat conversion capability between localized surface plasmon resonance effect from AgNPs and enhanced light-adsorption ability from PDA. Due to the presence of AgNPs, the final evaporator also displayed a fascinating antibacterial behavior for both E. coli and S. aureus even during evaporating actual lake water. Meanwhile, the AgNPs-PDA-wax gourd presented good durability during 10-cycled experiments, seawater desalination, dye water purification and some extreme conditions (acid, alkaline and freezing). These results suggested the great potential for future practical applications of such biomass solar evaporators.
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Journal of Materials Chemistry C
·
2022
·Vol. 10
·期 13
·5147-5154
·
IF 8.067
Yanbin Chen,Hewei Yang,Jian Song,Bao Zhang
Doping metal ions into a perovskite lattice is an effective strategy for tailoring the intrinsic properties of perovskite nanocrystals (NCs). Herein, strong red-emitting and highly ambient and light stable Fe2+-doped CsPbBrI2 NCs with a maximum photoluminescence quantum yield (PLQY) of 92.1% were obtained. Systematic investigation of Fe2+ doping on the stability and the luminescence performance of CsPbBrI2 NCs was performed. Owing to the smaller ionic size compared to Pb2+, Fe2+ induced the lattice contraction and shortened the bond length of Pb–X, which suppressed the distortion of [PbX6]4− octahedra, thus improving the stability of CsPbBrI2 NCs. The champion sample could maintain up to 86% emission under the ambient conditions for 5 weeks. Besides, the incorporation of Fe2+ suppressed the formation of halide vacancies and optimized the relaxation process of CsPbBrI2, thereby contributing to the enhancement of PLQY. This facile Fe2+ doping method provides an effective strategy to synthesize stable and highly photoluminescent red perovskite materials.
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Metals
·
2022
·Vol. 12
·期 4
·579
·
IF 2.695
Wanyi Zeng,Lei Xu,Qiongling Wang,Chen Chen,Minglai Fu
Considering environmental friendliness and economic factors, the separation and extraction of indium under acidic conditions are of great significance. In this research, metal-organic frameworks (MOFs) of UiO-66 were successfully prepared and used for the separation and adsorption of indium. The properties of UiO-66 were structurally characterized using powder X-ray diffraction (XRD), Fourier-Transform Infrared Spectroscopy (FTIR), Brunauer-Emmett-Teller surface area analyzer (BET), thermogravimetric analysers (TGA) and Scanning Electron Microscope (SEM). The results show that UiO-66 can resist acid and keep its structure unchanged, even at a strong acidity of pH 1. The adsorption performance of UiO-66 to indium (III) was also evaluated. The results show that the adsorption process of indium ions was by the Langmuir adsorption isotherm, with a maximum adsorption capacity of 11.75 mg·g−1being recorded. The adsorption kinetics experiment preferably fits the second-order kinetic model. A possible mechanism for the adsorption of In(III) by UiO-66 was explored through X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared analysis(FT-IR). It was concluded that the C=O of free –COOH of UiO-66 was involved in the adsorption of In(III) by cation exchange. This study indicates, for the first time, that UiO-66 can be applied as an acid-resistant adsorbent to recover indium (III).Keywords:UiO-66;MOFs;Adsorption;Indium recovery
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Materials
·
2022
·Vol. 15
·期 5
·1719
·
IF 3.748
Jingjing Wang,Junjie Ren,Qinglin Tang,Xinzhi Wang,Yao Wang,Yanxin Wang,Zhonglin Du,Wei Wang,Linjun Huang,Laurence A. Belfiore,Jianguo Tang
Copper (II) complexes containing mixed ligands were synthesized in dimethyl formamide (DMF). The intense cyan emission at an ambient temperature is observed for solid copper (II) complexes with salicylic acid and a 12% quantum yield with a fluorescent lifetime of approximately 10 ms. Hence, copper (II) complexes with salicylic acid are excellent candidates for photoactive materials. Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) reveal that the divalent copper metal centers coordinate with the nitrogen and oxygen lone pairs of conjugate ligands. XPS binding energy trends for core electrons in lower-lying orbitals are similar for all three copper (II) complexes: nitrogen 1s and oxygen 1s binding energies increase relative to those for undiluted ligands, and copper 2p3/2binding energies decrease relative to that for CuCl2. The thermal behavior of these copper complexes reveals that the thermal stability is characterized by the following pattern: Cu(1,10-phenanthroline)(salicylic acid) > Cu(1,10-phenanthroline)(2,2’-bipyridine) > Cu(1,10-phenanthroline)(1-benzylimidazole)2.Keywords:copper (II) complex;luminescent materials;benzylimidazole;bipyridine;salicylic acid;spectroscopy
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Acta Metallurgica Sinica-English Letters
·
2022
·Vol. 35
·期 10
·1653-1664
·
IF 3.024
Xie Shenghui,Liao Xiang,Zeng Xierong,Yang Haipeng,He Liang
High-entropy alloys (HEAs) have attracted widespread attention due to their excellent mechanical properties. However, their functional properties arising from the supersaturated solid solution state can be improved. Advanced oxidation processes (AOPs) are considered to be an effective method for decomposing organic pollutants, and HEAs are proposed as effective candidates for AOP catalysts. Currently, several HEAs used for organic pollutant degradation are prepared through mechanical alloying. In this work, FeAlCoNi and FeAlCoNiB Fenton-like catalysts were prepared by single roll melt spinning and subsequent ball milling techniques. We found that the FeAlCoNiB HEA exhibits highly efficient degradation for p -nitrophenol ( p -NP). The degradation efficiency of FeAlCoNiB is 120 times higher than that of FeAlCoNi, which confirms that boron functions effectively during the degradation process. FeAlCoNiB has a better degradation efficiency than pure iron powder and a degradation efficiency comparable to that of the amorphous Fe 78 Si 11 B 11 alloy. Additionally, the degradation efficiency of FeAlCoNiB X increases ( k values from 0.13 to 0.55 min −1 ) when the boron content increases from an X value of 0.25 to 1.25. We speculate that Fe 2 B favors the degradation process and promotes zero-valent iron to decompose organic pollutants through a galvanic cell effect. Possible p -NP degradation pathways are proposed after LC–MS analysis. This study provides a new series of HEA Fenton-like catalysts, which have the potential to be prepared into bulk devices for industrial applications.
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Journal of Materials Chemistry B
·
2022
·Vol. 10
·期 21
·4012-4019
·
IF 7.571
Zhen Zhao,Hua Zhang,Hongda Chen,Yuanhong Xu,Lina Ma,Zhenxin Wang
In this work, the polyacrylamide/phytic acid/polydopamine (termed as PAAM/PA/PDA) hydrogel is used as a drug loading matrix and photothermal conversion reagent, which is prepared by copolymerization of dopamine with acrylamide through a phytic acid crosslinker. Due to the porous structure of PAAM and strong near-infrared light (NIR)-absorption of PDA, the PAAM/PA/PDA hydrogel exhibits a high doxorubicin (DOX)-loading capacity (170 mg g−1) and efficient photothermal transduction efficiency (47.4%) even under low power density 808 nm NIR laser (0.75 W cm−2) irradiation, which is superior to those of most conventional photothermal conversion agents reported in the literature. With NIR laser irradiation, the PAAM/PA/PDA hydrogel loaded with DOX (termed as PAAM/PA/PDA/DOX) shows excellent synergistic interaction between photothermal therapy (PTT) and enhanced chemotherapy, resulting in the completely suppressed growth of mouse-bearing SW620 tumors. Furthermore, the PAAM/PA/PDA hydrogel shows good physicochemical stability, negligible cytotoxicity and low toxicity in vivo. All these characteristics render the as-prepared PAAM/PA/PDA hydrogel promising for biomedical applications.
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危险品化学品经营许可证（带存储）