Journal of Magnesium and Alloys
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2025
·
IF 13.8
Shixuan He,Dongdong Li,Xingqing Duan,Jinting Chen,Bogu Liu,Yawei Li,Haixiang Huang,Haoyuan Zheng,XinHua Wang,Ying Wu
Catalysis is an effective means to improve the slow kinetics of hydrogen absorption and desorption, as well as the poor cycle life of the 2LiBH 4 +MgH 2 composite system. In this study, The TiVC MXene was obtained by etching TiVAlC and introduced into 2LiH + MgB 2 by ball milling. Products obtained were heated and hydrogenated to prepare the 2LiBH 4 + MgH 2 (LMBH) system, which exhibits distinguished kinetic performance and capacity retention rate. In the LMBH + 6 wt% TiVC, a 9.3 wt% hydrogen is released within 35 min at 400 °C as well as hydrogenation is completed within 30 min at 350 °C, 9 MPa. Moreover, the capacity retention rate was up to 96 % after the 15 th cycle. During the heating and hydrogenation process, the TiH and V 8 C 7 are generated in-situ as active products, and stably exist in the subsequent process to catalyze the hydrogen absorption-desorption reactions of the composite. The presence of TiH/LiH/V 8 C 7 /MgB 2 interface improves the kinetic performance of the system. Reversibility is improved by inhibiting the generation of polyborane and the aggregation during the hydrogen absorption-desorption process. The interface structure-activity relationship is first elucidated that between bimetallic MXene and 2LiBH 4 + MgH 2 composite system during hydrogen absorption-desorption processes, providing a novel viewpoint and optimization path for the modification research of 2LiBH 4 + MgH 2 composites.
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Journal of Energy Storage
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2025
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IF 9.8
Xin-Ying Ren,Min-Peng Li,Wen-Jie Shi,Wei-Hai Yi,Hong-Yan Li,Cai-Xia Zheng,Xiao-Rui Wang,Mao-Cheng Liu,Yu-Xia Hu
Zinc metal is recognized as a highly promising anode material for aqueous zinc-ion batteries due to its high theoretical capacity and favorable oxidation-reduction potential. Nevertheless, uncontrolled zinc dendrite growth and side reactions pose critical challenges to their practical applications. Herein, the amide groups are introduced into microporous polymers (PIM-CONH 2 , denoted PC) via amine functionalization and applied as a surface engineering coating for zinc anodes. The functionalization of amide groups enhances the zincophilicity of the polymer coating through coordination interactions with Zn 2+ , while also forming hydrogen bonds with water molecules to reduce solvation and prevent side reactions. Additionally, the microporous structure of PIM-CONH 2 facilitates the uniform distribution of Zn 2+ , promoting more even ion flow, enhancing dendrite-free zinc deposition, and improving electrochemical stability. Consequently, the PC@Zn||PC@Zn symmetric battery achieves prolonged cycle stability over 1250 h at 0.5 mA cm −2 /0.5 mAh cm −2 . The PC@Zn||Cu asymmetric battery exhibits stable zinc plating/stripping over 2200 cycles at 2.0 mA cm −2 /1.0 mAh cm −2 and achieves an average CE of 99.8 %, which exhibits exceptional Zn plating/stripping reversibility. The PC@Zn||NVO full battery demonstrates outstanding cycling performance, retaining 72 % specific capacity retention after 2000 cycles at 10 A g −1 . This work establishes a generalizable strategy for high-performance zinc metal anodes through rational design of functional microporous polymer interfaces, opening new avenues for sustainable energy storage systems.
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Small Methods
·
2025
·Vol. 9
·期 12
·e01743
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IF 9.1
Yi Xie,Hao Zhang,Xinran Li,Jian Luo,Xiong Qian,Yong Zheng,Chuanlin Hu,Ivan P. Parkin,Lee Li,Zhi Chen,Xiujian Zhao
The development of robust transparent superamphiphobic (SAP) and superhydrophobic (SH) coatings remains challenging due to the inherent trade-offs between surface micro-nano architecture, optical clarity, liquid repellency, and mechanical resistance. Herein, a balancing strategy that combines femtosecond laser-etched V-groove microstructures on glass with functionalized SiO 2 nanoparticles is presented. This approach results in transparent and mechanically robust coatings with water and oil contact angles of 173.6° and 170.4°, respectively, while the average spectral transmittance, ranging from 380 to 1100 nm can be enhanced from 80.4% in the uncoated laser-etched glass to 82.1% in the SAP-coated etched glass. The etched V-groove architecture serves as a structural confinement framework, enhancing nanoparticle adhesion and providing mechanical robustness, thereby maintaining stable SH performance even after 50 abrasion cycles. As a sharp comparison, the SAP-coated non-etched sample loses its liquid repellency after 2 friction cycles. Furthermore, the SAP-coated sample demonstrates excellent chemical and environmental stability, retaining superwetting properties under acidic, neutral, salt environments, and prolonged UV illumination. The proposed method not only addresses the challenge of balancing optical transparency with superwetting performance and mechanical robustness but also offers a practical route for fabricating multifunctional coatings with self-cleaning and anti-icing, suitable for applications in architectural glazing and photovoltaics.
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MOLECULES
·
2024
·Vol. 29
·期 6
·1335
·
IF 4.2
Zongyi Su,Wei Chen,Shanshan Liang,Hao Fang,Minglu Zhang,Meng Wang,Lingna Zheng,Bing Wang,Yi Bi,Weiyue Feng
Understanding the final fate of nanomaterials (NMs) in the liver is crucial for their safer application. As a representative two-dimensional (2D) soft nanomaterial, graphene oxide (GO) has shown to have high potential for applications in the biomedical field, including in biosensing, drug delivery, tissue engineering, therapeutics, etc. GO has been shown to accumulate in the liver after entering the body, and thus, understanding the GO–liver interaction will facilitate the development of safer bio-applications. In this study, the hepatic clearance of two types of PEGylated GOs with different lateral sizes (s-GOs: ~70 nm andl-GOs: ~300 nm) was carefully investigated. We found that GO sheets across the hepatic sinusoidal endothelium, which then may be taken up by the hepatocytes via the Disse space. The hepatocytes may degrade GO into dot-like particles, which may be excreted via the hepatobiliary route. In combination with ICP-MS, LA-ICP-MS, and synchrotron radiation FTIR techniques, we found that mores-GO sheets in the liver were prone to be cleared via hepatobiliary excretion thanl-GO sheets. A Raman imaging analysis of ID/IGratios further indicated that boths-GO andl-GO generated more defects in the liver. The liver microsomes may contribute to GO biotransformation into O-containing functional groups, which plays an important role in GO degradation and excretion. In particular, more small-sized GO sheets in the liver were more likely to be cleared via hepatobiliary excretion thanl-GO sheets, and a greater clearance ofs-GO will mitigate their hepatotoxicity. These results provide a better understanding of the hepatic clearance of soft NMs, which is important in the safer-by-design of GO.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2024
·
IF 8.1
Guanhua Zhang,Shengjie Xia,Huimin Li,Hao Du,Tiantian Li,Yongyong Cao,Yue Meng,Juan Wang,Chenglin Zhong,Woon-Ming Lau
The synergistic treatment of pollutants in water by radical and non-radical pathways based on photo-like Fenton-activated peroxydisulfate (PDS) has received much attention from researchers. However, clarifying the structure–activity relationship between the photocatalyst structure and the dual-pathway degradation mechanism is difficult. Herein, the flower-like nickel–iron layered double hydroxide containing oxygen vacancy (NiFe-LDH-V O ) was constructed by dual-hydrothermal method. The NiFe-LDH-V O /PDS/light system exhibited excellent degradation performance (93.1%) for norfloxacin (NOR). Notably, the apparent rate constant exceeded pristine NiFe-LDH by 2.6 times. The results of experiments, characterization and DFT calculations indicated that the enhanced degradation activity was attributed to the dual-pathway of radical and non-radical induced by V O on the catalyst surface. V O can not only improve the migration and separation efficiency of photogenerated carriers, which ensures the energy base of PDS activation, but also act as the active site of both radical pathway and non-radical pathway. In particular, V O can change the adsorption conformation of PDS, which enhances the adsorption of PDS on the catalyst and significantly reduces the energy barriers of the two activation pathways of PDS. The reasonable pathways for NOR degradation were proposed based on HPLC-MS and DFT calculations. In addition, the toxicity analysis of intermediates indicated lower developmental toxicity and mutagenicity compared to NOR. The present work provides innovative insights into the study of photocatalysts with dual degradation pathways and their mechanistic elaboration.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Jiahong Chen,Yunzhu Qian,Heng Li,Wei Zuo,Wentao Sun,Danlei Xing,Xuefeng Zhou
Guided bone regeneration (GBR) technology has been widely used for the regeneration of periodontal bone defects. However, the limited mechanical properties and bone regeneration potential of the currently available GBR membranes often limit their repair effectiveness. In this paper, serum-derived growth factor lysophosphatidic acid (LPA) nanoparticles and dopamine-decorative nanohydroxyapatite (pDA/nHA) particles were double-loaded into polylactic-glycolic acid/polycaprolactone (PLGA/PCL) scaffolds as an organic/inorganic biphase delivery system, namely, PP-pDA/nHA-LPA scaffolds. Physicochemical properties and osteogenic ability in vitro and in vivo were performed. Scanning electron microscopy and mechanical tests showed that the PP-pDA/nHA-LPA scaffolds had a 3D bionic scaffold structure with improved mechanical properties. In vitro cell experiments demonstrated that the PP-pDA/nHA-LPA scaffolds could significantly enhance the attachment, proliferation, osteogenic differentiation, and mineralization of MC3T3-E1 cells. In vivo, the PP-pDA/nHA-LPA scaffolds exhibited great cytocompatibility and cell recruitment ability in 2- and 4-week subcutaneous implantation experiments and significantly promoted bone regeneration in the periodontal defect scaffold implantation experiment. Moreover, LPA-loaded scaffolds were confirmed to enhance osteogenic activities by upregulating the expression of β-catenin and further activating the Wnt/β-catenin pathway. These results demonstrate that the biphase PP-pDA/nHA-LPA delivery system is a promising material for the GBR.
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ACS Biomaterials Science & Engineering
·
2024
·
IF 5.4
Hui Zhang,Yujun Bao,Guanghao Li,Siqi Li,Xiong Zhang,Changhong Guo,Xiaodan Wu,Yingxue Jin
Cancer metastasis and invasion are closely related to tumor cell immunosuppression and intracellular hypoxia. Activation of immunogenicity and intracellular oxygenation are effective strategies for cancer treatment. In this study, multifunctional nanomicelle hyaluronic acid and cinnamaldehyde is self-assembled into nanomicelles (HPCNPs) were constructed for immunotherapy and tumor cell oxygenation. The Schiff base was constructed of HPCNPs with pyropheophorbide a–Cu (PPa–Cu). HPCNPs are concentrated in tumor sites under the guidance of CD44 proteins, and under the stimulation of tumor environment (weakly acidic), the Schiff base is destroyed to release free PPa. HPCNPs with photodynamic therapeutic functions and chemokinetic therapeutic functions produce a large number of reactive oxygen species (1O2 and •OH) under exogenous (laser) and endogenous (H2O2) stimulations, causing cell damage, and then inducing immunogenic cell death (ICD). ICD markers (CRT and ATP) and immunoactivity markers (IL-2 and CD8) were characterized by immunofluorescence. Downregulation of Arg1 protein proved that the tumor microenvironment changed from immunosuppressive type (M2) to antitumor type (M1). The oxidation of glutathione by HPCNP cascades to amplify the concentration of reactive oxygen species. In situ oxygenation by HPCNPs based on a Fenton-like reaction improves the intracellular oxygen level. In vitro and in vivo experiments demonstrated that HPCNPs combined with an immune checkpoint blocker (α-PD-L1) effectively ablated primary tumors, effectively inhibited the growth of distal tumors, and increased the oxygen level in tumor cells.
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ADVANCED FUNCTIONAL MATERIALS
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2024
·
IF 18.5
Ruyi Lin,Jia Yan,Bokai Gong,Fan Tong,Yujun Song,Xue Xia,Haili Hu,Yufan Wang,Yang Zhou,Tao Gong,Maxim Shevtsov,Huile Gao
Homogeneous distribution and adequate accumulation of photosensitizer in tumor are essential for effective photodynamic therapy (PDT). However, the intricate tumor microenvironment (TME) often poses great challenges to the deep penetration and retention of therapeutic agents in tumor. Moreover, the important effect of PDT to induce specific antitumor immune response is impeded by multiple immunosuppressive mechanisms within TME. Confronting these issues, here a rationally designed nanosystem (SUN-NPA) with acid-responsive sphere-to-fiber transformation ability by leveraging the characters of drug molecules is proposed to achieve self-delivery of photosensitizer Chlorin e6 (Ce6) and two small-molecule immunomodulators, metformin (MET) and sunitinib (SUN). The spatiotemporal controlled transformation enables homogeneous distribution and high accumulation of drugs to achieve enduring PDT and complete tumor elimination. Meanwhile, the co-delivered MET and SUN alleviate tumor immunosuppression from multiple aspects, effectively synergizing with PDT to ignite potent host immune response and long-lasting immunological memory against tumor cells. The artful integration of enhanced PDT and activated antitumor immunity realized by SUN-NPA leads to the significant inhibition of tumor growth and metastasis, exhibiting great potential for oncotherapy.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Xin-yang Pan,Zi-han Wang,Xiao-qing Wu,Chang-rong Guo,Lin-xing Yang,Hui-ru Liu,Yuan-hao Wang,Wen-juan Chen,Jing-jie Wang,Kai-hui Nan,Ling-li Li
Reactive oxygen species (ROS) scavenging is a viable approach to promote corneal epithelium wound healing. This study created a single-component hydrogel (HA Gel) with a novel dual-functionalized hyaluronic acid derivative (HA-GA-PBA) containing gallol and phenylboronic acid (PBA) moieties. Both of these moieties were dual-functional. Specifically, they not only functioned as structural building blocks for hydrogel formation, but also served as bioactive ingredients for therapeutic purpose. Dynamic covalent complexation between gallol and PBA moieties led to the self-crosslinked HA Gel, which was antioxidative and tissue-adhesive. It was demonstrated that the hydrogel enhanced the proliferation rate of human corneal epithelial cells by over 2.5 folds. When treating the mouse corneal alkali burn model with HA Gel, the corneal epithelial healing percentages reached 69.19 ± 9.41 % and 84.12 ± 6.09 % on day 3 and 5, respectively, which were significantly higher than the placebo group (51.14 ± 9.63 % and 67.32 ± 10.54 % on day 3 and 5, respectively). Meanwhile, reduced scar formation and inflammation was observed. These findings indicated HA Gel could find applications in various of ocular diseases for improved corneal epithelial wound healing.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Zhaoyu Wu,Xiaoyu Wu,Xiangtian Meng,Jiahao Lei,Chenlin Zeng,Hongji Pu,Yijun Liu,Zhijue Xu,Xiaodong Wu,Sheng Huang,Jinbao Qin,Jianqiang Liu,Xinwu Lu,Bo Li
Abdominal aortic aneurysm (AAA) is a chronic inflammation-driven disease characterized by aortic wall destruction and expansion, leading to high morbidity and mortality. However, previous drug treatments for its common risk factors have not achieved favorable results, and the early prevention and treatment is still the main clinical dilemma. Anti-inflammation therapy is a promising therapeutical method targeting its pathogenesis mechanism, but it has not been explored in depth. Herein, interleukin-1 receptor antagonist-loaded manganese-doped mesoporous silica nanoparticles (IL-1Ra@MMSN) were designed and synthesized to target macrophage-mediated chronic aortic inflammation for AAA treatment. IL-1Ra@MMSN showed high IL-1Ra-loading efficiency, great stability and pH-responsive drug-releasing property. IL-1Ra@MMSN specially phagocytosed by macrophages can protect against oxidative stress injury and promoted the M2 polarization via transforming growth factor-β (TGF-β) signaling in vitro . Furthermore, IL-1Ra@MMSN exhibited good lesion targeting ability, hemocompatibility and biocompatibility in angiotensin II-induced murine AAA model. In vivo experiments also confirmed the excellent treatment efficacy in reducing AAA formation and progression via protecting aortic wall integrity and promoting anti-inflammatory microenvironment. Taken together, the current study demonstrated that IL-1Ra@MMSN is a promising nanoplatform for early intervention of AAA, which provides a novel treatment strategy based on anti-inflammatory immune regulation.
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Analytical Methods
·
2024
·
IF 2.7
Qian Zhang,Xiaoqi Wang,Lili Yuan,Lina Yu,Congying Shao,Hongxing Jia,Shun Lu
Sunset Yellow (SY) is a widely used food coloring in the food industry. However, exceeding the allowable limit of this dye poses a significant threat to human health. To address this issue, we developed Lycium ruthenicum-derived nitrogen-doped carbon dots (N-CDs) with a stable blue fluorescence through hydrothermal treatment for SY determination. The quantum yield (QY) of these N-CDs was found to be up to 10.63%. Physical characterization of N-CDs was performed using various spectroscopic techniques to confirm their excellent photostability and non-toxic properties. Furthermore, the presence of SY had a substantial quenching effect on the fluorescence intensity (F0/F) of the N-CDs. Leveraging this observation, we developed a fluorescent sensor for the determination of SY in the concentration range of 0.05 to 35.0 μM, with a limit of detection (LOD, 3σ/K) of 17 nM. The excellent fluorescent sensor also showed satisfactory results in the practical drink samples. Moreover, the stability and cytotoxicity of N-CDs as a fluorescent probe were studied. Finally, the N-CDs were applied to cell imaging using A549 cells.
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Acta Biomaterialia
·
2024
·
IF 9.4
Yingying Zhang,Yujuan Xing,Hong Zhou,Enhui Ma,Wenbei Xu,Xinran Zhang,Canran Jiang,Shuo Ye,Yanjia Deng,Hong Wang,Jingjing Li,Shaohui Zheng
Nanoparticle-based photo-immunotherapy has become an attractive strategy to eliminate tumors and activate host immune responses. However, the therapeutic efficacy is heavily restricted by low tumoral penetration and immunosuppressive tumor microenvironment (TME). Herein, near infrared laser (NIR)-propelled Janus nanomotors were presented for deep tumoral penetration, photothermal tumor ablation and photothermal-triggered augmented immunotherapy. The Janus nanomotors (AuNR/PMO@CPG) were constructed with gold nanorods (AuNR) and periodic mesoporous organo-silica nanospheres (PMO), followed by loading of immune adjuvant (CPG ODNs). Under NIR irradiation, the nanomotors exhibited superior photothermal effect, which produced active motion with a speed of 19.3 µm/s for deep tumor penetration and accumulation in vivo . Moreover, the good photothermal heating also benefited effective photothermal ablation to trigger immunogenic cell death (ICD). Subsequently, the ICD effect promoted the release of tumor-associated antigens (TAAs) and damage associated molecular patterns (DAMPs), and further generated abundant tumor vaccines in situ for reprograming the immunosuppressive TME in combination with CPG ODNs to inhibit tumor growth. As a result, a notable in vivo synergistic therapeutic effect was realized on CT26-bearing mice by combining photothermal therapy-induced ICD with modulation of immunosuppressive TME. Thus, we believe that the synthesized nanomotors can provide a new inspect to boost photothermal therapy-induced ICD in tumor immunotherapy. Statement of Significance Nanoparticle-based synergistic photo-immunotherapy has become a popular strategy to eliminate tumors and activate host immune responses. However, the therapeutic efficacy is heavily restricted by low tumoral penetration and immunosuppressive tumor microenvironment (TME). In this work, near infrared laser (NIR)-propelled Janus nanomotors were presented for deep tumoral penetration, photothermal tumor ablation and photothermal-triggered augmented immunotherapy. Under NIR irradiation, the nanomotors exhibited a superior photothermal effect, which produced active motion for deep tumor penetration and accumulation in vivo . Moreover, good photothermal heating also facilitated effective photothermal ablation to trigger immunogenic cell death (ICD), which promoted the release of tumor-associated antigens and damage-associated molecular patterns (DAMPs), and further generated abundant tumor vaccines in situ for reprograming the immunosuppressive TME to inhibit tumor growth.
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