Food Analytical Methods
·
2026
·Vol. 19
·期 8
·236
·
IF 3
Neng Jing,Yu Jimei,Guo Qian,Wang Yazhi,Wang Yan,Zhang Yilong,Chen Peng,Yang Kai
A molecularly imprinted polymer (MIP) coating for surface-enhanced Raman spectroscopy (SERS) was developed for the detection of sibutramine. Using sibutramine as the template, methyl methacrylate as the functional monomer, 1,4-butanediol dimethacrylate as the cross-linker, and phenylsilane as the initiator, MIPs were synthesized via molecular imprinting on silver nanorod–coated copper rods. The coating specifically recognizes sibutramine in complex matrices such as milk tea. The characteristic peak intensity is proportional to concentration over a linear range of 5–500 ng/mL, with a detection limit of 2 ng/mL. Recoveries for spiked samples ranged from 96.60 to 99.08% with a relative standard deviation of 2.64–8.67%, consistent with HPLC results. The coating exhibits dual functionality: It specifically recognizes and adsorbs sibutramine, and it is reusable. This work presents a novel SERS method for detecting sibutramine in diet foods, offering an accurate, low-cost, and highly selective approach for analyzing complex food systems.
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高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Yang Chen,Ning Ma,Xiaolian Liu,Zihao Liu,Shengyu Ling,Can Li,Yinyan Gong,Lengyuan Niu
The development of semiconductor-based surface-enhanced Raman scattering (SERS) substrates is often hindered by their limited sensitivity. Crystal facet engineering has been recognized as an effective strategy to improve the SERS performance of semiconductors. However, the underlying mechanism by which different exposed facets influence SERS activity in bimetallic oxide systems remains unexplored. In this study, we successfully synthesized NiCo 2 O 4 and ZnCo 2 O 4 bimetallic oxides with distinct exposed facets by regulating the alkali source. When evaluated using 4-Nitrothiophenol (4-NBT) as a probe molecule, the {110} facet demonstrated the highest SERS activity in both oxide systems. The enhancement factors (EF) reached 5.56 × 10 4 for NiCo 2 O 4 and 7.41 × 10 4 for ZnCo 2 O 4 . The limit of detection (LOD) was as low as 10 −7 M and 10 −8 M, respectively, as well as the excellent repeatability and stability. Energy level structure reveals that the superior SERS properties on the {110} facet can attributed to their higher VB maxima, which enhances the thermodynamic driving force and kinetic efficiency of the interfacial charge transfer (CT) process. Moreover, first-principles calculations further illustrate that the CT efficiency on the {110} facet can be effectively improved. This work provides a clear new direction for designing high-performance semiconductor SERS substrates through precise facet control.
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ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Jingwen Xu,Xu Hu,Zongyan Li,Junhan Li,Zhida Gao,Zhi-Yong Wu,Yan-Yan Song
Accurate identification of mercury species in aqueous environments is essential for assessing ecological and human health risks, given the distinct toxicity and bioaccumulation potential of different mercury forms. Herein, we present a paper-based analytical device that uses electrophoresis and surface-enhanced Raman scattering (SERS) for rapid and in situ detection of inorganic mercury (Hg2+) and methylmercury (CH3Hg+) in aqueous samples. Using a dumbbell-shaped paper microchannel and applying voltage to both ends of the channel, quickly separate Hg2+ and CH3Hg+ due to their differential migration behaviors. The two mercury species were subsequently identified using AuNPs@β-cyclodextrin@4-mercaptophenylboronic acid (AuNPs@β-CD@4-MPBA) SERS tags, which enable distinct chemical recognition: electrophilic substitution by Hg2+ and Au–Hg amalgam formation with CH3Hg+. The platform achieves sub μg L–1 detection limits, completes the full workflow─from sample loading, mercury species separation, to spectra readout─in 5 min, and shows high specificity against common metal-ion interferents. Validation of mercury species in the seawater sample confirmed the robustness of the platform in complex matrices. This electrophoresis-assisted SERS platform provides a new strategy for online separation and identification of multiform toxic species.
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高影响因子
ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Yunshan Wang,Nan Lu,Peiyao Wu,Yue Chu,Yonghao Xing,Jing Wang,Xinfeng Zhao
The development of conventional orthosteric drugs targeting G protein-coupled receptors (GPCRs) is often hindered by off-target effects and low subtype selectivity. Allosteric ligands enable precise control of receptor signaling through selective conformational changes, highlighting their critical importance as a promising therapeutic strategy and as a key frontier in modern drug discovery. To enhance GPCR ligand screening efficacy, surface-enhanced Raman spectroscopy (SERS), with sensitivity and narrow spectral peaks, was employed to outline a methodology based on allosteric aptamer binding and stabilizing conformations of the β2 adrenergic receptor (β2AR) for identifying GPCR ligands by fabricating a sandwich-type SERS sensor. The method involved immobilization of β2AR on magnetic plasmonic nanoparticles by label-free click chemistry, probing and stabilization of the allosteric conformational changes by RNA aptamer, and amplification and detection of the signal by SERS-active nanoparticles. The success of the allosteric β2AR assay was confirmed through multiple analytical techniques, including SERS, SEM, UV–vis spectroscopy, and particle size analysis. This methodology demonstrates broad applicability, characterized by rapid response, high sensitivity, and excellent selectivity. BI167107 could be detected within a range of 10–9–10–6 M, with a detection limit of 49 pM. Such a sandwich biosensor successfully identified the agonist, antagonist, and allosteric inhibitor of β2AR from the ligand complex in both aqueous solution and serum. This method is expected to become an alternative for high-throughput and multiplexed drug screening when it comes to a compound library.
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高影响因子
ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Xuehua Zhang,Hansheng Li,Hao Si,Xianling Yang,Ziyuan Kang,Yifei Chen,Ziyu Wang,Shi Pu,Junhui Guo,Qichang Li,Zhishu Shen,Hao Xie,Jingxing Guo
Surface-enhanced Raman spectroscopy (SERS) represents unique advantages for on-site analysis due to its high sensitivity, high specificity, and applicability to gaseous, liquid, and solid samples. However, the complex and unknown components in matrices, as well as competitive adsorptions between targets, will cause signal fluctuation and spectral overlap, which make it challenging to detect multiple targets in untreated real samples. Herein, we designed a deep learning model named the multicomponent simultaneous identification network (MSINet) for analyzing the SERS spectra of untreated samples and output qualitative and content evaluation results of multiple inside targets. The hierarchical feature extraction and multiple feature integration made MSINet robust to signal fluctuations and spectral overlaps while requiring only a small amount of training to quantify target contents in any samples due to its threshold judgment rule. Using the MSINet-assisted SERS detection scheme, the presence and content levels of multiple UV absorbers in seawater, food additives in ready-to-drink cocktails, and biomarkers in human serum could all be determined with ≥0.90 accuracy when facing testing databases. But in contrast, the accuracy in evaluating the target contents in the above untreated samples by the standard curve method was as low as 0.05. The powerful ability to process spectral data, an easy-to-use graphical user interface, and “zero” extra cost make MSINet a universal tool to assist arbitrary SERS sensors in performing high-throughput detection of real samples, leading to great potential in on-site analysis.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
·
IF 3.8
Xu Miaowen,Zhang Dong,Li Tianran,Zhuang Yanwen,Wang Zixun,Zhang Xudong,Zhang Zhaohan,Chen Lepeng,Xu Qiong,Qian Yayun,Li Limao
This study developed a nanozyme-SERS dual-function sensor that exhibits both highly efficient peroxidase (POD)-like activity and superior surface-enhanced Raman spectroscopy (SERS) enhancement, designed for detecting homocysteine (Hcy) in serum from colorectal cancer (CRC) patients. Bimetallic Au@Pt nanoparticles (Au@Pt NPs) exhibited exceptional nanozyme catalysis and SERS performance, enabling the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to oxidized TMB (oxTMB) with a pronounced SERS signal generation. Au@Pt NPs were assembled into aminated capillaries via electrostatic adsorption and subsequently modified with Hcy aptamers to create the nanozyme-SERS dual-function sensor. When Hcy was present, the reducing thiol groups (-SH) consumed the hydroxyl radicals (·OH) produced by the decomposition of H 2 O 2 . This inhibited the oxidation of TMB, resulting in a weaker SERS signal. The SERS sensor demonstrated a remarkably low detection limit (LOD) for Hcy, reaching as low as 0.14 × 10⁻ 12 mol/L. Furthermore, within the concentration range of 10⁻ 12 to 10⁻ 4 mol/L, there was a linear relationship between the logarithm of Hcy concentration and the SERS signal intensity. Serum samples from both healthy individuals and CRC patients were tested with the SERS sensor. The results demonstrated a high degree of concordance with those obtained by the enzyme-linked immunosorbent assay (ELISA), showing significantly higher Hcy levels in CRC patient serum compared to healthy controls. Unlike traditional methods such as colorimetric assays, fluorescence analysis, and the SERS “sandwich” strategy, which often involve complex procedures and have low sensitivity, this approach offers a simple, highly sensitive, and specific method for detecting Hcy. It holds promise as an effective tool for early CRC diagnosis.
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高影响因子
MEASUREMENT
·
2026
·
IF 6.1
Jiaxuan Li,Zeyu He,Liwen Su,Lijiao Zu,Shi Qiu,Wa Jin,Yanjun Zhang,Xinghu Fu
A high-sensitivity and high-stability fiber-optic surface-enhanced Raman scattering (SERS) probe based on a square microcavity structure is proposed. The probe is fabricated by femtosecond laser processing technology to precisely prepare a square microcavity with dimensions of 13 × 13 × 60 μm on the core of a multimode optical fiber. Silver nanoparticles with an average particle size of approximately 44 nm were uniformly deposited on the inner surface of the microcavity using a sol self-assembly method to functionalize the structure. Experimental results indicate that the SERS probe exhibits optimal enhancement performance when the self-assembly time is 40 min at a the same experimental conditions. Using Methylene Blue as the probe molecule, the probe achieves a detection limit of 10 −10 M. The relative standard deviation of the characteristic peak intensity is less than 5%, demonstrating good reproducibility. The calculated analytical enhancement factor is as high as 1.19 × 10 9 . In the simulated blood test, the probe achieved a detection limit of 1 μg/mL for the antiepileptic drug 10-monohydroxy derivative (MHD), with a linear correlation coefficient R 2 of 0.9895 for gradient concentrations. Therefore, the probe exhibits excellent in-situ detection capability and operational stability, providing a new and reliable means for the application of SERS technology in trace substance detection and in-situ analysis.
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Laser & Photonics Reviews
·
2026
·
IF 9.7
Yangdong Xie,Songtao Hu,Jiling Xu,Bingshuai Zhou,Yaqi Cui,Zhifang Wang,Yunyang Li,Lin Xu,Jiao Sun,Biao Dong
Surface-enhanced Raman scattering (SERS) faces limitations in its spatial detection range (the “SERS skin depth”) and a trade-off between performance and fabrication simplicity. Here, we propose an opal photonic crystal (OPC)-guided spatial-range SERS detection strategy. This approach synergistically integrates the electromagnetic enhancement of plasmonic nanostructures with the wide-range localized field regulation capability of an OPC to construct a novel hybrid substrate (OPC@Ag NL). The substrate is fabricated by depositing an adjustable silver nanolayer (Ag NL) onto a water-stable, self-assembled OPC template with a tunable PBG. This design synergizes plasmonic enhancement with the OPC's ability to modulate excitation laser, generating an expanded localized field that suppresses electric field decay. Consequently, significant SERS enhancement is maintained up to 300 nm from the surface, enabling 3D Raman imaging of macrophages. The substrate demonstrates high sensitivity (detection limit: 10 − 1 1 m for 4-MBA, EF: 1.7 × 10 7 ) and uniformity (RSD < 5.8%), achieving bacterial detection limits of 10 CFU/mL (labeled) and 10 2 CFU/mL (label-free). This work marks a paradigm shift from hotspot engineering to macroscopic field modulation for overcoming SERS spatial constraints.
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高影响因子
SENSORS
·
2026
·Vol. 26
·期 6
·1891
·
IF 4
Zheyu Shen,Qiang Chen,Xia Gao,Yan Liu,Jiamin Wang,Pei Liang
Organotin compounds (OTCs) are toxic pollutants threatening ecosystems and human health, among which dioctyltin (DOCT), widely used in skin-contact textiles, can induce immune dysfunction and metabolic disorders. Although DOCT levels in textiles are strictly regulated by international standards, traditional GC-MS suffers from cumbersome derivatization, unsatisfactory repeatability, and lengthy analysis, highlighting the urgent demand for a rapid and sensitive detection approach. Herein, we developed a fast SERS-based strategy for DOCT determination using size-optimized Au@Ag core–shell nanoparticles as the substrate, which offers simple pretreatment, high efficiency, good uniformity, and excellent reproducibility. The SERS spectra and functional group vibration modes of DOCT were elucidated by density functional theory (DFT) calculations combined with experimental validation, and the peak at 301 cm −1 was identified as the characteristic peak for quantitative analysis. After extractant optimization, the method achieved a low LOD of 0.1 μg/L in real textile samples, with recoveries ranging from 86% to 108% and good linearity from 0.1 to 1000 μg/L ( R 2 = 0.9804). This approach provides a reliable, high-sensitivity alternative for rapid monitoring of DOCT residues in textiles.
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高影响因子
Surfaces and Interfaces
·
2026
·
IF 6
Anh-Tuan Pham,Dang Thi Hanh Trang,Ngo Thi Loan,Nguyen Thai Huy,Nguyen Ha Anh,Ta Ngoc Bach,Quan-Doan Mai,Anh-Tuan Le
Styrene is one of the most important volatile organic compounds (VOCs) used extensively in polymer and composite manufacturing, where occupational exposure occurs predominantly through inhalation of its vapor. Although surface-enhanced Raman spectroscpoy (SERS) offers exceptional sensitivity for molecular analysis, its application to vapor-phase detection remains challenging because volatile molecules are difficult to efficiently accumulate at plasmonically active sites. Consequently, conventional styrene vapor analysis generally relies on multistep workflows involving vapor sampling and analyte desorption prior to analysis. Herein, we report a flexible Cellulose/ZIF-8/Ag SERS chip combined with a simple attach-and-capture strategy for direct solvent-free detection of styrene vapor. By attaching the SERS sensing chip to the inner surface of a vial cap, vapor sampling and SERS detection were integrated into a single workflow without additional sample pretreatment. The developed SERS platform achieved a detection limit of 240 mg/m 3 , below current occupational exposure limits for styrene, together with excellent analytical reliability (RSDs of 1.89% within a single chip and 5.29% between independently fabricated chips), good selectivity for styrene, stable performance under high relative humidity, robust SERS activity after repeated mechanical deformation, and outstanding post-sampling signal stability. By separating passive vapor accumulation from subsequent spectroscopic analysis, the attach-and-capture configuration enables the chip to be deployed in advance and retrieved for rapid on-demand SERS readout, offering operational flexibility beyond conventional multistep sampling workflows. These findings establish the proposed attach-and-capture strategy as a practical analytical workflow for integrating vapor sampling and SERS detection into a single solvent-free operation for rapid occupational monitoring of styrene vapor. Download: Download high-res image (171KB) Download: Download full-size image
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高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 10
·700
·
IF 5.4
Zhao Xinyuan,Xu Bingxin,Zhang Wei,Wei Haiyan,Zhang Yu,Chen Wenwen,Shang Ming,Wang Cuijuan
A portable ozone detection strategy is reported based on derivatization-assisted surface-enhanced Raman spectroscopy (SERS). The strategy integrates active sampling, chemical derivatization, and signal enhancement using high-index gold trisoctahedrons embedded in a porous hydrogel (Au TOHs/hydrogel), assembled into a 48-well microdevice. Ozone is selectively captured by eugenol and converted to formaldehyde, which reacts with 3-methyl-2-benzothiazolinone hydrazone (MBTH) to form a Raman-active azo compound, enabling sensitive detection. The SERS signal at 1270 cm − 1 exhibited a strong linear correlation with the logarithm of analyte concentration (R 2 = 0.996). The limit of detection under simulated air conditions is 5.80 × 10 − 6 mg/m 3 . The SERS sensor demonstrated high stability, spatial uniformity, and reproducibility (RSD < 10%), along with good selectivity against common volatile organic compounds. Validation with air samples and comparison with ultraviolet-visible UV-vis spectrophotometry further supports its applicability. This cost-effective and user-friendly platform shows potential for point-of-use detection of trace ozone. Graphical abstract
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高影响因子
FOOD CHEMISTRY
·
2026
·
IF 10.4
Haoxiang Liu,Zhenjiong Wang,Lihua Zhou,Weiwei Cheng,Peng Li,Di Wu,Linghan Meng,Yan Zhang,Xiaozhi Tang
A novel and eco-friendly ZEN phase transfer method was developed using CD-MOF. • Amphiphilic character of CD-MOF promotes transfer of ZEN from oil to aqueous phase. • CTAB micelles on Au NRs facilitated adsorption of hydrophobic ZEN to its hotspot. • Rapid SERS sensing of ZEN was achieved based on this novel pretreatment method. An eco-friendly phase-transfer method based on cyclodextrin-metal-organic framework (CD-MOF) was developed to extract zearalenone (ZEN) from edible oil into aqueous phase. Leveraging this green pretreatment approach, a rapid surface-enhanced Raman spectroscopy (SERS) sensing platform was established for ZEN detection. CD-MOF possesses an amphiphilic structure, whose hydrophobic cavities can encapsulate ZEN to form host-guest complexes. The gradual structural collapse of CD-MOF leads to the release of ZEN into the aqueous phase, achieving efficient oil-to-water transfer with an extraction efficiency of 80–90%. Following this extraction method, SERS detection was achieved using cetyltrimethylammonium bromide (CTAB)-capped gold nanorods (Au NRs). The CTAB bilayer on the Au NR surface facilitates the adsorption of hydrophobic ZEN toward the plasmonic hotspots, significantly enhancing the Raman signal. Benefiting from the synergistic effect of CD-MOF extraction and Au NRs-based SERS enhancement, rapid detection of ZEN in corn oil was achieved with performance comparable to that of conventional high-performance liquid chromatography (HPLC). Download: Download high-res image (110KB) Download: Download full-size image
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危险品化学品经营许可证（带存储）