Nature Communications
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2019
·Vol. 10
·期 1
·1-11
·
IF 11.878
Yang Lu,Ma Zaijun,Wang Han,Niu Kongyan,Cao Ye,Sun Le,Geng Yang,Yang Bo,Gao Feng,Chen Zuolong,Wu Zhen,Li Qingqing,Shen Yong,Zhang Xumin,Jiang Hong,Chen Yelin,Liu Rui,Liu Nan,Zhang Yaoyang
The long-lived proteome constitutes a pool of exceptionally stable proteins with limited turnover. Previous studies on ubiquitin-mediated protein degradation primarily focused on relatively short-lived proteins; how ubiquitylation modifies the long-lived proteome and its regulatory effect on adult lifespan is unclear. Here we profile the age-dependent dynamics of long-lived proteomes in Drosophila by mass spectrometry using stable isotope switching coupled with antibody-enriched ubiquitylome analysis. Our data describe landscapes of long-lived proteins in somatic and reproductive tissues of Drosophila during adult lifespan, and reveal a preferential ubiquitylation of older long-lived proteins. We identify an age-modulated increase of ubiquitylation on long-lived histone 2A protein in Drosophila , which is evolutionarily conserved in mouse, monkey, and human. A reduction of ubiquitylated histone 2A in mutant flies is associated with longevity and healthy lifespan. Together, our data reveal an evolutionarily conserved biomarker of aging that links epigenetic modulation of the long-lived histone protein to lifespan.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
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2019
·Vol. 54
·期 11
·8247-8261
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IF 3.442
Wang Shuzhan,Zhou Shaofeng,Huang Jin,Zhao Guizhe,Liu Yaqing
ZrO 2 nanoparticles were electrostatic self-assembled on the surface of graphene oxide (GO) for enhancing the mechanical and tribological properties of phenolic resin. Zeta potential analysis and structural characterization confirmed that ZrO 2 nanoparticles had been successfully adhered onto the surface of GO, and the as-prepared ZrO 2 @GO nanohybrid possessed good dispersity. The results showed that filling 1.5 wt% ZrO 2 @GO nanohybrid could improve the flexural strength, flexural modulus and impact strength of phenolic resin (PF) by 38.6%, 10.7% and 8.3%, respectively. When 0.5 wt% ZrO 2 @GO was added, the initial decomposition temperature and the residual content at 800 °C of PF increased by 20.0% and 16.9%, respectively. The ZrO 2 @GO nanohybrid also exhibited synergistic effect for improving the tribological performance of PF effectively, that when adding 0.5 wt% ZrO 2 @GO nanohybrid, the average friction coefficient and wear rate of the composites reduced by 21.8% and 30.6%, respectively. SEM observation and 3D non-contact surface topography analysis showed the wear surface of ZrO 2 @GO nanohybrid filling PF composite was smooth, low spalling and shallowly grooved with the typical characteristic of abrasive wear. It was explained that the ZrO 2 @GO nanohybrid could play the role of rolling bearings, form stable and smooth friction transfer film and enhance the interfacial interaction, thus indicated the synergistic wear-resisting performance for PF matrix. It provides a green, convenient and fast method for preparing ZrO 2 nanoparticles-attached GO nanohybrid that can enhance the mechanical and tribological performance of resin-based materials effectively.
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Scientific Reports
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2019
·Vol. 9
·期 1
·1-11
·
IF 4.011
Chandrashekar Bananakere Nanjegowda,Smitha Ankanahalli Shankaregowda,Wu Yingchun,Cai Nianduo,Li Yunlong,Huang Ziyu,Wang Weijun,Shi Run,Wang Jingwei,Liu Shiyuan,Krishnaveni S.,Wang Fei,Cheng Chun
Transfer method of chemically vapor deposition graphene is an appealing issue to realize its application as flexible and transparent electrodes. A universal stamping method to transfer as grown graphene from copper onto different flexible and transparent polymers (FTPs) reported here ensures simple, robust, rapid, clean and low-cost. This method relies on coating ethylene vinyl acetate (EVA) onto the as grown graphene, binding EVA coated graphene/Cu with FTPs and delamination by hydrogen bubbling process, which is analogous to the method used by stamping process where ink carries the imprint of the object onto any materials. The fate of the stamping method depends on how strongly the adhesion of EVA coated graphene/Cu with target FTPs. Interestingly, we have found that the thin film of EVA/graphene/Cu can only bind strongly with the FTPs of less than 25 µm in thickness and lower glass transition temperature value to the EVA while wide range of other FTPs are considered upon surface engineering to enhance the binding strength between FTPs and EVA. What’s more, the electrical performance was investigated with a demonstration of triboelectric nanogenerators which confirmed the reliability of graphene transfer onto the FTPs and prospect for the development of flexible and transparent electronics.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2019
·Vol. 411
·期 12
·2577-2585
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IF 3.286
Qi Fenglian,Yan Chunxiao,Meng Zihui,Li Shuguang,Xu Jiayu,Hu Xiaochun,Xue Min
G-series nerve agents, such as sarin, tabun, and soman, would cause tremendous harm in military and terrorist attacks, so it is necessary to develop a simple method for the rapid and efficient detection of these hazardous substances. We have developed a tunable acetylcholinesterase (AChE)-functionalized two-dimensional photonic crystal (2D PhC) for the detection of a real nerve agent, sarin. In accordance with the 2D PhC previously prepared by our group, the AChE-functionalized 2D PhC was optimized by adjustment of the amount of monomer in the hydrogel, which not only increased the sensitivity of the 2D PhC, with the detection limit decreasing by two orders of magnitude, but also ensured the structural color spanned the whole visible region in the detection range. A linear relationship between the logarithm of the sarin concentration and the particle spacing of the AChE-functionalized 2D PhC was observed from 7.1 × 10 -17 to 7.1 × 10 -4 mol/L. The AChE-functionalized 2D PhC also responded to mimics of G-series nerve agents, including dimethyl methylphosphonate, diisopropyl methylphosphonate, and isodipropyl methylphosphonate, to various degrees. The proposed 2D-PhC hydrogel has potential for low-cost, trace-level, and on-site monitoring of other G-series nerve agents.
Graphical abstract
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2019
·Vol. 30
·期 7
·6954-6962
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IF 2.195
Jiang Nan,Du Yi,Du Minxing,Feng Yibing,Liu Yang
TiO 2 nanobelts with different synthesis methods have been actively pursued for a long time, however, a systematic study corresponding to the fabrication of TiO 2 nanobelts by alkali-hydrothermal method has not been worked out by any research. Here, we systematically study the conditions such as the source of Ti and hydrothermal parameters with the assistance of X-ray diffraction (XRD), scanning electron microscope (SEM), N 2 -sorption measurement and photochemical tests. The XRD and SEM measurements show that the TiO 2 nanobelts exhibit excellent belt-like structures and high crystalline intensity when using tetrabutyl titanate (Ti(OBu) 4 ) as the source of Ti, the volume of 10 mol/L NaOH is 15 mL, the hydrothermal reaction is conducted at 180 °C for 20 h and the heat treatment system is 800 °C for 2 h. The length–diameter ratio of the final obtained sample is about 130 and the specific surface area is 50.4 m 2 /g.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2019
·Vol. 411
·期 23
·6049-6056
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IF 3.286
Zhang Cong,Hu Fangxin,Zhang Han,Chen Shihong,Yuan Ruo
As an important glycoprotein of the lectin family, soybean agglutinin (SBA) is an anti-nutritional factor with considerable toxic and side effects and plays a significant role in tumor analysis. In order to achieve the sensitive detection of SBA, a sandwich-structured electrochemiluminescence (ECL) biosensor was constructed using carboxylated carbon nitride (C-g-C 3 N 4 ) as luminophore and D-galactosamine (galM) as a recognition element. A glassy carbon electrode (GCE) was modified with Au nanoparticles (Au NPs) for capturing the galM via Au-N bond, and further capturing the target SBA by specific recognition between galM and SBA. In the presence of SBA, the composite C-g-C 3 N 4 -galM was immobilized onto the electrode. With the increase in the concentration of SBA, the ECL signal from C-g-C 3 N 4 increased, thus achieving a signal-on detection of SBA. The linear range of the biosensor was 1.0 ng/mL~10 μg/mL and detection limit for SBA was as low as 0.33 ng/mL. In this construction strategy, C-g-C 3 N 4 not only acted as an excellent signal probe, but also as an immobilization matrix to easily achieve a high loading of the small molecule recognition element galM. This strategy provides a simple alternative SBA detection platform.
Graphical abstract
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2019
·Vol. 411
·期 20
·5175-5186
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IF 3.286
Wei Lu,Zhang Yanhui,Eziz Nurguzal,Yang Yaru,Li Guixin,Guan Ming
An ultrasensitive electrochemiluminescence (ECL) immunosensor for alpha-fetoprotein (AFP) detection based on a poly(aniline-luminol)/graphene oxide nanocomposite was developed. The nanocomposite, which was prepared using a fast and simple chemical oxidation strategy for the first time, showed excellent ECL performance. This outstanding ECL performance is due to the formation of poly(aniline-luminol) on the graphene oxide (GO) surface and the excellent electron-transfer properties of GO. Moreover, the poly(aniline-luminol)/graphene oxide nanocomposite has abundant amino groups at its surface, making it a good platform for biomacromolecule labeling. Using the nanocomposite, a novel ECL immunosensor for the determination of AFP was successfully developed. Anti-AFP was immobilized on the surface of a poly(aniline-luminol)/graphene oxide nanocomposite-modified electrode using a glutaraldehyde crosslinking method to form the ECL immunosensor. The AFP was then captured at the modified electrode surface through an antigen–antibody immunoreaction. When the AFP was captured by its antibody, the ECL intensity decreased. This ECL immunosensor for the detection of AFP exhibited a linear range of 1.7 × 10 −12 to 1.7 × 10 −8 mg mL −1 and a detection limit of 5 × 10 −13 mg mL −1 , indicating high sensitivity and linearity across a wide concentration range. Furthermore, the immunosensor was successfully applied to determine AFP in a real-world human serum sample.
A new poly(aniline-luminol)/graphene oxide nanocomposite was prepared using a fast and simple strategy for the first time, and an ultrasensitive electrochemiluminescence (ECL) immunosensor for alpha-fetoprotein (AFP) detection based on this nanocomposite was developed
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Advanced Composites and Hybrid Materials
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2019
·Vol. 2
·期 2
·279-288
·
IF 0
Li Shihua,Yang Chunying,Sarwar Shatila,Nautiyal Amit,Zhang Pengfei,Du Haishun,Liu Na,Yin Jialin,Deng Kuilin,Zhang Xinyu
As one of the most investigated conducting polymers, polyaniline (PANI) is considered to be of practical use in many applications. In this study, two new ionic liquids, 1-methylimidazolium hydrogen sulfate ([Hmim]HSO 4 ) and 1-methyl-3- n -butylimidazopersulfate ([C 4 mim] 2 S 2 O 8 ), which were synthesized from 1-methylimidazole ([Hmim]), were used as solvent and dopant, oxidizer, respectively, for in situ polymerization of aniline. Because of the application of the unique structure of ionic liquid, we obtained the ionic liquid–doped polyaniline (IL-PANI) with high solubility (25 mg mL −1 in dimethyl sulfoxide (DMSO)). And by adjusting the ratio of [C 4 mim] 2 S 2 O 8 to aniline monomer, the preferred PANI nanofibers could be controlled to form a three-dimensional porous structure. It was found that the ion/electron transport channels could be formed inside the 3D structure. Thus, the redox reactions could occur both at the surface and inside the PANI electrode. Electrochemical characterization showed that the fabricated PANI electrode exhibited a specific capacitance of 489 F g −1 at a current density of 0.5 A g −1 . Also, the capacity retention rate reached up to 81% after 4000 cycles investigated at 2 A g −1 . In addition, a high-energy density of 80.2 Wh kg −1 was measured when [Hmim]HSO 4 was used as an electrolyte. Thus, the present work suggested a new strategy for fabricating high-performance PANI electrode for supercapacitor applications.
Ionic-liquid templated assembly of conducting polymer nanostructures for energy applications.
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CELLULOSE
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2019
·Vol. 26
·期 8
·5065-5074
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IF 3.917
Hou Ting,Guo Kechun,Wang Zhongguo,Zhang Xiong-Fei,Feng Yi,He Ming,Yao Jianfeng
Self-standing and flexible regenerated cellulose membranes were fabricated by using a facile ZnCl 2 /CaCl 2 /cellulose dissolution system. The filtration experiments of the membranes were conducted by using methyl orange and Congo red as water contaminations. To improve the selectivity and stability, the crosslinkers of glutaraldehyde and polyvinyl alcohol were introduced to the membrane network. The best performance was observed over glutaraldehyde and polyvinyl alcohol crosslinked cellulose (P-G-RC) membrane with a Congo red rejection rate of 99.9% and a methyl orange rejection rate of 93.5%. The suitable pore radius (0.67 nm), low root-mean-square roughness (2.9 nm) and abundant hydroxyl groups were considered as the primary reasons contributed to the separation behavior. Furthermore, the P-G-RC membrane displayed excellent stability and reusability during the filtration tests.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2019
·Vol. 30
·期 11
·10516-10523
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IF 2.195
Zhao Xiaoli,Qi Shuhua,Liu Jianjun,Han Xiao,Zhang Fan
Known as a new kind of two dimensional materials, Mxene has attracted much attention in applications in polymer based composites because of their unique mechanical, thermal, and electrical properties. In this work, we report on the synergistic enhancement of Ti 3 C 2 T x Mxene nanosheets coated on carbon fiber (CF/Mxene) to epoxy resin. Ti 3 C 2 T x Mxene nanosheets were synthesized by HF etching and sonicating and used as surface sizing agent to modify NH 2 -CF by electrostatic self-assembly. NH 2 -CF/Mxene reinforced epoxy resin (NH 2 -CF/Mxene/EP) composites were prepared using a solution blending method. Their structure, morphology and performance were investigated. It is observed that Mxene possesses nanosheet structure and functional groups which are responsible for improving interfacial adhesion between NH 2 -CF and EP resin. The structural characterization showed that Mxene nanosheets are successfully attached to the NH 2 -CF surfaces. Importantly, the tensile strength, flexural strength, shear strength, and impact strength of NH2-CF/Mxene/EP composites have respectively increased by 40.8, 45.9, 38.5, and 74.4% compared to those of pristine CF/EP composites, suggesting that Ti 3 C 2 T x Mxene nanosheets use is a promising approach for improving the mechanical properties of EP-based composites.
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RARE METALS
·
2019
·
IF 1.785
Jiao Can,Sun Hao-Bo,Zhang Li,Zhao Shang-Qian,Pang Guo-Yao,Zhao Chun-Rong,Lu Shi-Gang
Abstract Lithium (Li) metal is the most promising electrode for next-generation rechargeable batteries. In order to push the commercialization of the lithium metal batteries, a kind of nitrogen(N)-doped composite graphene (NCG) adopted as the Li plating host was prepared to regulate Li metal nucleation and suppress dendrite growth. Furthermore, a new kind of sandwich-type composite lithium metal (STCL) electrode was developed to improve its application. The STCL electrode can be used as convenient as a piece of Li foil but no dendrite growth. In a symmetric battery, the STCL electrode cycled for more than 4500 h with the overpotential of less than 40 mV. And due to the creative design, the STCL promises the Li–S battery with a prolonged cycling lifespan. Graphical Abstract
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Journal of Inorganic and Organometallic Polymers and Materials
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2019
·Vol. 29
·期 6
·2012-2023
·
IF 1.637
Gao Peng,Du Linlin,Luo Haiqiang,Rao Wenhui,Deng Weixing,Liu Yuanli,Wei Chun,Yu Chuanbai
A novel organic–inorganic hybrid particle (JF633-SBA-15A) was successfully prepared by solution blending method using hybrid hyperbranched polyether polyol (JF633) and surface-modified mesoporous (SBA-15). Further, JF633-SBA-15A/EP composites were fabricated by melt-blending method. The structure and morphology of JF633-SBA-15A were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetry analysis, nitrogen adsorption–desorption, and scanning electron microscopy. The mechanical and dynamic mechanical properties of JF633-SBA-15A/EP were also studied. The results demonstrated that the prepared JF633-SBA-15A hybrid particles had excellent thermal stability and unique mesoporous structural characteristics. Compared with pure EP, the maximum degradation temperature of the composites decreased and the thermal stability increased at high temperature. Notably, the JF633-SBA-15A/EP composite had better comprehensive performance. The impact strength and temperature of the glass transition (T g ) of JF633-SBA-15A/EP composites with 1.0 wt% JF633-SBA-15A increased by 32% and 23 °C, respectively. SEM images of the cross-section of the composite which reinforced with hybrid particles exhibited a rough surface and multiple dimples, indicating a ductile fracture.
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