Nature Communications
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2026
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IF 18.1
Zhong Rui,Fu Yanjie,Jiang Shubao,Wang Shan,Yue Liang,Tan Weihong
Multistable systems, ideally, could stabilize at any desired, switchable state within a continuous spectrum. However, conventional systems, constrained by signal-mediated mutual activation or inhibition, are limited to a finite set of discrete steady states. Here, we propose a rational framework for achieving continuously tunable multistability through reversible displacement reaction-mediated competition between positive autoregulatory DNA polymerization/nicking modules. This framework harnesses the chemical energy of dNTP hydrolysis to suppress spontaneous interconversion between modules for stabilizing at any target state along a continuous compositional gradient. With unparalleled tunability, the framework enables continuous, orthogonal state transitions and concentration-adaptive molecular memory in response to transient stimuli. Moreover, the single-stranded DNAs generated by polymerization/nicking reactions can be customized with predefined structures and functions, enabling continuously multistable control over downstream processes, e.g., biocatalysis and RNA transcription, while maintaining multistability. This framework establishes a versatile and robust platform for developing chemical and material systems with continuously tunable multistability.
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Microbial Cell Factories
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2026
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IF 4.9
Ma Jinglin,Zhuang Yan,Guan Huiting,Zhang Zhenjun,Zhu Ning,Han Changze,Wang Yonggang,Chen Jixiang
Cytochrome P450 monooxygenases (CYPs) constitute a versatile family of biocatalysts capable of regio- and stereoselective hydroxylation, offering significant potential for pharmaceutical synthesis and the environmental remediation of endocrine-disrupting steroids. Although their synthetic utility is widely recognized, the mechanistic basis of their activity, particularly in bacteria, remains insufficiently explored. Building on prior discovery of steroid-degrading activity in Rhodococcus erythropolis KB1, in this study, we functionally characterized three putative P450 enzymes (CYP125ARh1, CYP125ARh2, and CYP153ARh3) identified from its genome. Substrate-binding assays demonstrated strong affinity toward progesterone and testosterone, but negligible affinity for 11β-hydroxysteroids, including cortisol and corticosterone. In vitro conversion assays revealed that all three enzymes specifically catalyze 16α-hydroxylation of progesterone and testosterone, although with varying catalytic efficiencies. Among them, CYP125ARh2 was identified as the most efficient enzyme, achieving near-quantitative conversion of progesterone (88%) and testosterone (62%). Kinetic analysis further underscored the superior catalytic properties of CYP125ARh2, which displayed lower Michaelis constants (K m = 16.41 ± 1.97 µM for progesterone and 24.50 ± 2.60 µM for testosterone) and higher turnover rates (V max = 6.05 ± 0.16 µM/min and 5.09 ± 0.13 µM/min, respectively). The superior catalytic efficiency of CYP125ARh2 originates from its unique active site architecture, which integrates a pre‑organized, synergistic residue network with pronounced induced‑fit plasticity. This structural synergy enables precise substrate positioning and optimal reaction geometry, thereby rationalizing its high 16α‑hydroxylation activity toward both progesterone and testosterone. These findings highlight CYP125ARh2 as a promising template for engineering high-performance biocatalysts. Overall, this work provides foundational insights into the role of the P450 enzymes in steroid chemistry and the biodegradation of steroidal pollutants.
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International Journal of Minerals Metallurgy and Materials
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2026
·Vol. 33
·期 2
·727-736
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IF 8.8
Li Yuting,Wang Jie,Tang Fu,Gao Junheng,Li Lidong
Coal cinder is an abundant byproduct of the extensive consumption of coal in industrial production and daily life. Making full use of the cinder is conducive to a low-carbon economy. In this study, inspired by the burning of coal, a new method for constructing a silica-based composite porous material (SiO 2 -CPM) was developed by combusting a siloxane-modified anthracite coal gel (CSiO 2 gel). During this process, the combustion product was directly converted into a porous material, and the calorific value of the coal remained nearly unchanged (∼98% of the original calorific value was retained), demonstrating the viability of this method for energy-efficient applications. The SiO 2 -CPM exhibited an ultra-low thermal conductivity (0.036 W/(m·K) at room temperature), outperforming conventional insulation materials (e.g., cotton ∼0.05 W/(m·K)). Additionally, it showed enhanced mechanical strength (fracture stress of 41.8 kPa) compared to the powder state of the coal cinder. Experimental results indicate that the amount of siloxane, structure-directing agent, and an acidic environment were critical for mechanical enhancement. The SiO 2 -CPM showed good dimensional stability against thermal expansion and exhibited excellent thermal insulation and fire resistance even at 900°C. Meanwhile, the SiO 2 -CPM with complex geometry could be easily fabricated using this method owing to the excellent shaping ability of the CSiO 2 gel. Compared to conventional methods such as sol–gel synthesis or freeze-drying, this approach for fabricating SiO 2 -CPM is simpler and cost-effective and allows the direct utilization of coal cinder post-combustion.
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WATER AIR AND SOIL POLLUTION
·
2026
·Vol. 237
·期 8
·496
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IF 3.5
Tang Chuiyun,Yao Jun,Liu Xingyu,Lv Ying,Liu Jianli,Masakorala K.
Blast furnace slag (BFS) is an industrial by-product that generates large volumes of waste and poses potential environmental risks, necessitating its safe utilization. In this study, iron (hydr)oxide modified blast furnace slag (FBFS) was prepared by loading iron (hydro)oxides onto BFS for the remediate of lead (Pb) and cadmium (Cd) from aqueous solutions and soil. This adsorbent not only provides a novel approach for valorizing BFS but also prevents the agglomeration of iron (hydr)oxide particles, resulting in more surface functional groups (such as Fe–O and –OH) and an increased specific surface area. The results showed that the adsorption process of Pb fit the PSO and Langmuir models, and that of Cd followed the Elovich and Langmuir models. The maximum adsorption capacities of Pb and Cd by FBFS2 and FBFS6 in single-component system were 352.93, 395.15, and 112.34, 119.04 mg·g −1 , respectively. In binary system, Pb exhibited a stronger inhibitory effect on Cd adsorption. The underlying mechanisms, including ion exchange, complexation, precipitation, and flocculation. In addition, FBFS significantly reduced the bioavailability of Pb, Cd and Zn in the soil, decreased by 20.03%, 45.86% and 58.75%, respectively. This study suggests that FBFS is a promising candidate for the simultaneous remediation of heavy metals in both aqueous solution and contained soil.
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Nature Communications
·
2026
·
IF 15.7
Wang Shenglong,Deng Weili,Huang Haichao,Yan Zhuocheng,Wang Yongbin,Zhou Tingting,Ao Yong,Wang Zihan,Zhang Jiabin,Tian Guo,Lan Boling,Sun Yue,Xu Tianpei,Yang Tao,Huang Longchao,Jin Long,Lu Jun,Yang Weiqing
Titanium carbide MXene flakes hold great promise for system-level MXene-based electronics (MXetronics) due to their outstanding electrical conductivity and diverse functional properties. However, the weak MXene interlayer bonding often causes film fracturing under mechanical strain, ultimately leading to device failure, manifested as unstable operation, inaccurate data transmission, and potential electrical disconnection. Here, we present strain-invariant, omnidirectionally stretchable MXetronics (sos-MXetronics) through hierarchical stiffness microgrid engineering. This strategy synergistically integrates patterned elastiff regions and modulus-buffered interconnects, effectively preventing performance shifts in sos-MXetronics. This circular sos-MXetronics with a radius of 3.3 cm integrates a near-field communication (NFC) antenna, eight micro-supercapacitors (MSCs), three resistive sensors, and interconnected conductive networks, demonstrating exceptional strain invariance with 95–98% performance retention even under 40% strain. With the capability to minimize motion-induced artifacts, the system ensures accurate blood pressure (BP) monitoring without electrical disconnection, even during wrist deformations. This breakthrough not only marks a significant step toward the practical application of MXene in omnidirectional stretchable MXetronics, but also paves the way for reliable, high-performance electronics based on two-dimensional materials for next-generation healthcare monitoring systems that seamlessly integrate with the human body under real-world conditions.
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CHEMICAL PAPERS
·
2026
·
IF 2.5
Wang Pan,Zhang Mengxue,Cai Jun,Chen Zhixuan
A series of polypyrrole oligomers (PPOs)—MPMH, MPEH, MPTH, and MPCH—were synthesized via solution polycondensation of N-methylpyrrole and para-substituted benzaldehydes to systematically explore substituent effects on their structural, optical, and electrochemical properties. MPTH showed enhanced crystallinity via π–π stacking, while MPCH formed a honeycomb-like porous structure. Optically, MPCH exhibited red-shifted excitation and emission (394/513 nm) due to a push–pull effect. The oligomers emitted violet (MPMH, MPEH), blue (MPTH), and green (MPCH) fluorescence, respectively. Electrochemically, substituents fine-tuned HOMO levels, giving band gaps of 2.0–2.4 eV suitable for visible-light emission. This study clarifies the role of substituents in modulating optoelectronic behavior, supporting the design of functional polymers for electronics and sensing. Graphical abstract
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Silicon
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2026
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IF 3.3
Idowu Peter Babatunde,Wang Xiaohui,Ma Shuhua,Oduye Temitope Gabriel
A new process for the controlled-synthesis of large surface area mesoporous silica nanoparticles (MSNs) from the unique (NH 4 ) 2 SiF 6 -NH 4 F solution produced from coal fly ash was developed using template assisted rapid chemical precipitation method. This work achieved the synthesis of MSNs with specific surface area (SSA) (~ 500 m 2 /g—1064 m 2 /g), small particle size (~ 90 nm- 133 nm) with narrow pore size distribution ranging between (7.56 nm- 20.11 nm) and reduced agglomeration condition by proposing a unique reactant’s feeding pattern and studying other parameters aiding the controlled synthesis process. The effect of high concentration fluoride ion on cationic cetyltrimethylammonium bromide (CTAB) template was also investigated. A novel CTAB removal method from the highly porous cavities of the silica nanoparticles under mild conditions was proposed. At 50 °C and atmospheric pressure, the foam fractionation technique showed 61% efficiency of CTAB removal while maintaining the porous structure and surface silanol of the particles compared with the traditional calcination method, providing green, economic and sustainable method for surfactant removal in MSNs.
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MOLECULAR DIVERSITY
·
2026
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IF 3.8
Chai Meng-Yan,Dang Yu-Li,Qin He,Xie Li-Xia,Zheng Xin,Liu Lijie,Liu Guoxing,Xiang Yu-Qiang,Niu Cao-Yuan,Guo Sheng-Qiang
Biomedical imaging has become an essential tool in the field of early cancer diagnosis and treatment. It is of great significance to develop a method that can monitor tumor hypoxia in real time and maintain a good photodynamic therapy (PDT) effect under hypoxic conditions. To achieve this goal, here we designed and synthesized a novel water-soluble porphyrin derivative, PtTSPP. The photophysical properties of PtTSPP were comprehensively characterized by UV–Vis absorption spectroscopy and fluorescence emission. This porphyrin has an extremely large Stokes shift and red emission (λ em = 690 nm), which can effectively reduce the interference of background fluorescence and is used for the fluorescence imaging of HeLa cells. PtTSPP has good water solubility, is not prone to aggregation, and has a high singlet oxygen quantum yield. It also exhibits low dark toxicity and excellent photocytotoxicity. These properties make PtTSPP a promising candidate reagent for biomedical imaging and photodynamic therapy.
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Nature Communications
·
2026
·
IF 15.7
Gan He,Liu Dongjie,Zhang Ying,Han Cuiping,Cheng Hui-Ming
Controlling the morphology of Zinc (Zn) deposits is an effective strategy to produce stable Zn-metal batteries. However, the degradation of Zn negative electrodes and changes in their morphology remain poorly understood. Here, we show that the Zn plating process has two distinct stages. The first being the formation of relatively dense, lumpy Zn, while the second involves the formation of porous mossy Zn on its protrusions, which changes into electrochemically inactive dead Zn during stripping. Based on this, we propose a strategy involving a combination of cationic and anionic reagents to revive the dead Zn. The cations create a positively charged inert region on the negative electrode surface for Zn-ion dispersion that inhibits mossy Zn formation, while the anions act as a redox mediator to revive the dead Zn. Consequently, the Zn negative electrode shows a Coulombic efficiency (CE) of 99.7% and stable Zn plating/stripping over 1400 h (10 mA cm −2 and 10 mAh cm −2 ). An Ah-scale pouch cell retains 96.2% capacity after 800 cycles. This work provides key insights into mossy Zn formation and proposes a promising approach for stable Zn-metal batteries.
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Nature Communications
·
2026
·
IF 15.7
Pan Tingting,Xu Weiwei,Deng Hua,Zhao Heng,Xiong Yujie,Chen Zhangxing
Photothermal dry reforming of methane, a promising approach to producing syngas, typically uses oxide materials and is mediated by lattice oxygen. However, it is limited by the balance of the oxygen-releasing/replenishing loop. Here, we present a methane activation pathway free of lattice oxygen on a N-Ni/NiCo@C catalyst. Direct involvement of reactive oxygen species (O*/OH*) released from CO 2 promotes effective CH 4 activation and eliminates coke deposition on oxophilic NiCo sites. Control experiments and density functional theory calculations show that forming a C-N-Ni structure is essential for improving catalytic performance. This is achieved by strengtheni ng the electronic interaction between the NiCo nanoparticles and the carbon layer, thereby boosting the elemental steps of CH 4 dehydrogenation and CH* oxidation and preventing metal oxidation. The optimal catalyst exhibits a high light-to-chemical energy efficiency of 52%, maintaining stability during 200 hours of continuous operation at a mild temperature of 540 °C. This work demonstrates that highly efficient and stable photothermal dry reforming of methane can be achieved by bypassing lattice oxygen.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2026
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IF 1.6
Li Tingting,Xia Liangshu,Wang Fang
The efficient recovery of uranium from acidic wastewater is a critical challenge in nuclear environmental management. Herein, We developed a novel potassium manganese ferricyanide/sodium alginate (KMnFC/SA) membrane for uranium recovery from acidic effluents. Fabricated via a simple, low-cost method, the membrane exhibits high performance with a maximum static capacity of 377.7 mg g −1 and excellent reusability over eight cycles, demonstrating its reliability. This work presents the KMnFC/SA membrane as a robust, efficient, and reusable adsorbent with significant potential for practical uranium remediation from acidic effluents.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2026
·
IF 1.6
Mao Yiyin,Zhou Peng,Jiang Juntao,Liu Yaling,Wang Hongyong,Han Guoqing,Wu Jun,Zou Pei,Lu Chunxiong
Programmed death-ligand 1 (PD-L1) represents a pivotal target for immune checkpoint blockade therapy. This study developed a novel PD-L1-targeting SPECT probe [ 99m Tc]Tc-G 3 C-2CBM based on dimeric 2-bromo-3-biphenyl (CBM) scaffold design. The probe was designed to enable bivalent interactions through dual CBM domains, exhibiting > 98% radiochemical yield and excellent in vitro stability. Cellular uptake studies revealed significantly higher accumulation in PD-L1-overexpressing A375-hPD-L1 cells compared to A375 cells (14.15 ± 2.11% vs. 5.89 ± 0.55% at 4 h; uptake ratio = 3.20). The probe displayed favorable binding affinity (K D = 36.54 ± 7.28 nM) and inhibitory potency (IC 50 = 69.62 ± 5.15 nM). In vivo SPECT imaging confirmed tumor-specific accumulation, though accompanied by notable hepatic uptake. These results demonstrate that CBM dimerization is a feasible approach for retaining PD-L1 binding and may provide a basis for the future development of multivalent radiotracers.
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