ACS Applied Polymer Materials
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2026
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IF 4.7
Shuang Chen,Ang Gao,Ke Liu,Ru Xiao
To enhance the flame retardancy of polyamide 6 (PA 6) while retaining its processability and mechanical properties, we developed a synergistic strategy that combines reactive copolymerization with additive incorporation. A rationally designed, lactam-based phosphonamide comonomer (DCL) ensured compatibility and reactivity during the ring-opening polymerization of caprolactam and was copolymerized in the presence of melamine cyanurate (MCA). The resulting PA 6-DCL/MCA composites exhibited outstanding fire performance: PA 6 with 5 wt % DCL alone achieved an LOI of 29.5%, whereas the hybrid composite containing 3 wt % DCL and 2 wt % MCA reached a UL94 V-0 rating with nonflaming melt dripping. The flame-retardant mechanisms were systematically investigated using techniques including cone calorimetry, with a focus on the pyrolysis process and charring behavior. The flame suppression is attributed to a synergistic effect involving dominant gas-phase inhibition combined with condensed-phase action, the latter comprising heat dissipation through controlled melt flow and the formation of a slightly reinforced char barrier. This design provides a scalable, halogen-free route to high-performance PA 6, where the flame-retardant efficacy arises from the interplay of molecular structure and additive synergy.
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Advanced Science
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2026
·
IF 14.1
Haote Ding,Ling Jiang,Yijia Song,Zhongji Pu,Lirong Yang,Haoran Yu
(2 R ,3 R )-butanediol dehydrogenases (BDHs) are promising catalysts for the production of α -hydroxy ketones, which are highly valuable compounds in the synthesis of fine chemicals and pharmaceuticals. However, (2 R ,3 R )-BDHs display limited stereoselectivity, thus restricting wider applications. In this study, we engineered a (2 R ,3 R )-BDH from Bacillus subtilis ( Bs BDH) to enhance and invert its stereoselectivity toward 1,2-cyclohexanediol (1,2-CHD) for the production of chiral 2-hydroxycyclohexanone. The hot spots 115, 118, 293 of Bs BDH were initially identified using the protein language model ESM-1v. Subsequently, to obtain a stable scaffold to engineer stereoselectivity, we devised a strategy of position analysis and source search, achieving a true-positive rate of 88.2% in designing thermostable single variants. Furthermore, iterative saturation mutagenesis was applied to the hot spots of the thermostable variant 6M2, and obtained a trans -CHD preference variant LTF ( ee > 99%) and a cis -CHD preference variant 10M ( ee > 99%). Several high-activity variants were also obtained, including 6M2/F115C/L118F and 6M2/F115L/L118M, which demonstrated the activity improvements toward 25 substrates, with the highest enhancement reaching 5183.1-fold. Additionally, molecular dynamics (MD) simulations and the incorporation of non-canonical amino acids (ncAAs) were utilized to elucidate the mechanisms underlying the variants. The engineered Bs BDH variants exhibit promising potential for the biocatalytic production of α -hydroxyketones.
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ANTIOXIDANTS & REDOX SIGNALING
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2026
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IF 6.1
Zhenyu Wang,Jinda Wang,Xuemin Li,Yu Wan,Jing Tao
Aims:Cataracts are the leading cause of blindness worldwide, and the mechanism underlying cataract formation is linked to the oxidative damage and the apoptosis of lens epithelial cells. Retinoic acid Receptor‐related orphan receptor α (RORα), a transcription factor, prevents oxidative stress and cell apoptosis. RORα is decreased in the lens from patients with cataract, but it remains unclear whether decreases in RORα are attributed to cataract formation.Results:Here, rat models of selenite-induced cataracts were used for in vivo experiments. In vitro, human lens epithelial cells (SRA01-04) were treated with selenite. RORα was downregulated in the lens from rat models of selenite-induced cataracts. The RORα agonist SR1078 significantly mitigated the degree of lens opacity. SR1078 reduced oxidative stress, cell apoptosis, and mitochondrial dysfunction and promoted the peroxisome proliferative activated receptor gamma coactivator (PGC-1α) and the nuclear factor erythroid 2-related factor 2 (Nrf2)-heme oxygenase-1 pathways in the lens from rat models of selenite-induced cataracts and lens epithelial cells upon selenite stimulation. RORα overexpression showed a similar protective effect on lens epithelial cells in vitro. Nerve growth factor (NGF) expression was up-regulated by RORα overexpression. Although RORα overexpression prevented selenite-induced damage to lens epithelial cells, the damage recurred following NGF knockdown.Conclusion:RORα protects against selenite-induced oxidative stress and cellular apoptosis. In the context of cataractogenesis, NGF is newly identified as a transcriptional target of RORα, and its reduction is related to mitochondrial dysfunction in lens epithelial cells. Our study highlights the translational potential of RORα activation as a nonsurgical cataract intervention. Antioxid. Redox Signal. 00, 000–000.
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高影响因子
FOOD CHEMISTRY
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2026
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IF 9.8
Baozhu Shi,Yueran Ma,Dong Li,Zisheng Luo
Corosolic acid (CA) is a potent α-glucosidase inhibitor, but its application is limited by poor aqueous solubility and low bioaccessibility. In this study, a CA-stabilized water-in-oil (W/O) Pickering emulsion was proposed as a self-assembled delivery strategy to overcome these limitations. The emulsion markedly improved the gastrointestinal performance of CA, leading to a substantially higher bioaccessibility (28.54%) compared with crystalline CA (6.48%). Enzyme kinetic analysis for CA emulsion showed an apparent non-competitive inhibition mode and enhanced α-glucosidase inhibition with a reduced K i and IC 50 . Molecular dynamics simulations supported stable binding interactions consistent with an allosteric inhibition mechanism. Overall, this work demonstrates that structuring CA into a W/O Pickering emulsion can simultaneously improve its bioaccessibility and inhibitory efficiency, providing a conceptual framework for enhancing the functionality of poorly soluble triterpenoids.
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高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2022
·Vol. 47
·期 47
·20561-20571
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IF 7.139
Tianyu Ai,Jing Li,Shuai Nie,Yansheng Yin,Jinlin Lu,Shuo Bao,Ling Yan
Transition elements doping metal oxide is of great significance for developing gas sensors with high performance. To achieve this goal, α-Fe 2 O 3 rod and Mn-doped α-Fe 2 O 3 polyhedrons are successfully synthesized by a facile N, N-dimethylformamide assisted hydrothermal method and characterized by several physical techniques. The morphology of α-Fe 2 O 3 is evolved by introducing Mn elements. The performance of the α-Fe 2 O 3 rod and Mn-doped α-Fe 2 O 3 polyhedrons as H 2 gas sensors are studied and compared. The Mn/α-Fe 2 O 3 -5 polyhedrons sensor exhibit the best performance at optimum operating temperature of 300 °C. The response and recovery times are 10 s/24 s for H 2 with a concentration of 200 ppm, which is much faster in contrast to those recently reported H 2 gas sensors. Furthermore, α-Fe 2 O 3 rod and Mn-doped α-Fe 2 O 3 polyhedrons show abnormal n-p transition sensing behavior with the change of operating temperature. This work provides a facile method for synthesizing α-Fe 2 O 3 based sensing materials for various sensors applications.
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BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
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2013
·Vol. 17
·期 6
·1128-1134
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IF 1.277
Li Bin,Wang Lei,Su Lingqia,Chen Sheng,Li Zhaofeng,Chen Jian,Wu Jing
OmpA signal peptide mediated cgt gene from Paenibacillus macerans JFB05-01 was cloned and expressed in E. coli BL21 (DE3). The effects of glycine and Triton X-100 on extracellular production of α-cyclodextrin glycosyltransferase (α-CGTase) were investigated. When supplemented with Gly or Triton X-100 to the culture media individually, the secreted extracellular enzyme reached 32 or 33 U/mL at 48 h of cultivation, respectively. When supplemented with Gly and Triton X-100 together, the extracellular α-CGTase activity reached 48 U/mL after 48 h cultivation, which was 20-fold of the control group without any additives. Analysis of membrane permeability demonstrated that addition of glycine and Triton X-100 enhanced the permeability of both outer and inner membrane. The potential mechanism of the enhanced protein secretion was discussed.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9
Beibei Liu,Zhigang Wang,Xiaoyao Tan
Compared to organic nanofiltration (NF) membranes, ceramic NF membranes exhibit higher stability under harsh conditions such as extreme pH and elevated temperatures. γ-Al 2 O 3 is commonly employed as an interlayer in multilayer ceramic NF membranes, but it is restricted to relatively mild conditions. In this study, on a macroporous alumina hollow fiber support, a boehmite sol coating is transformed from γ-Al 2 O 3 to α-Al 2 O 3 at a reduced phase-transformation temperature under the induction of TiO 2 , forming a uniform ultrafiltration interlayer for the fabrication of SiO 2 -ZrO 2 separation layer in a single step. By dual regulating the TiO 2 doping content in boehmite sol and sintering temperatures, the resulting SiO 2 -ZrO 2 /α-Al 2 O 3 NF membrane with a pore size of 1.4 nm demonstrates extended stability across a wide pH range of 1–13 under elevated temperatures. During the long-term dynamic textile wastewater treatment test, it maintains stable permeance and selectivity for over 24 h at pH 2/12 under 60 °C, significantly outperforming γ-Al 2 O 3 -supported SiO 2 -ZrO 2 membranes. Meanwhile, it displays a permeance of up to 18 LMH/bar and superior dye desalination performance (CR: 99.23%, NaCl <12%). This optimization strategy not only enhances the stability of SiO 2 -ZrO 2 NF membranes with the aid of an α-Al 2 O 3 interlayer but also provides a simplified route for their fabrication.
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Energy Materials
·
2026
·Vol. 6
·期 8
·N
·
IF 11.9
Dongxue Chu\u003Csup\u003E1,2\u003C\u002Fsup\u003E,Rui Gao\u003Csup\u003E3,\u003C\u002Fsup\u003E,Linglong Hu\u003Csup\u003E1\u003C\u002Fsup\u003E,Hongji Xu\u003Csup\u003E1\u003C\u002Fsup\u003E,Daming Yang\u003Csup\u003E1\u003C\u002Fsup\u003E,Zhongjun Chen\u003Csup\u003E4\u003C\u002Fsup\u003E,Ze Gao\u003Csup\u003E1\u003C\u002Fsup\u003E,Wanxia Huang\u003Csup\u003E4\u003C\u002Fsup\u003E,Ming Feng\u003Csup\u003E1,5,\u003C\u002Fsup\u003E
Developing low-cost and renewable quasi-solid-state electrolytes (QSSEs) is critical for advancing energy storage technologies. Cellulose-based QSSEs have attracted considerable attention for their inherent renewability and cost advantages. However, discontinuous Li+ conduction pathways within cellulose frameworks severely limit their development as advanced electrolyte materials. Herein, an “ion-bridge” strategy is proposed, in which zeolitic imidazolate framework-67 (ZIF-67) serves as a bridge to connect α-Li2TiO3 and bacterial cellulose (BC), forming a BC/ZIF-67@Li2TiO3 hybrid electrolyte. This strategy effectively constructs interconnected long-range Li+ transport channels within the electrolyte, achieving a high ionic conductivity of 2.3 × 10-3 S cm-1 and a lithium-ion transference number of 0.81. Notably, α-Li2TiO3 serves as a highly favorable filler with excellent Li+ conductivity. Moreover, it provides an “active defense” mechanism against lithium dendrites through a tip-shielding effect, thereby reducing the risk of dendrite penetration. The Li|BC/ZIF-67@Li2TiO3|LiFePO4 (LFP) full cell demonstrates exceptional cycling stability, retaining 89% of its initial capacity after 900 cycles at 1 C. This work provides a robust strategy for developing QSSEs that balance electrochemical performance and sustainability.
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CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 12.5
Cunchun Dai,Quanying Li,Guiyu Zhou,Yunjie Liu,Xirui You,Binghu Fang
A novel nanoparticle (WSLM) encapsulating α-mangostin and Lycium barbarum polysaccharide for oral co-delivery. • WSLM effectively eradicates intracellular methicillin-resistant Staphylococcus aureus . • WSLM suppresses pro-inflammatory cytokines to alleviate the inflammatory response. • WSLM combats intestinal infection via integrated antibacterial and anti-inflammatory. Methicillin-resistant Staphylococcus aureus (MRSA) is a globally prevalent pathogen responsible for severe and often refractory gastrointestinal infections. Current therapeutic strategies predicated on bactericidal activity overlook the critical pathological consequence of bacterial lysis, which involves the release of cell components that trigger excessive host inflammatory responses and exacerbate intestinal injury. Inspired by the need for integrated host-pathogen modulation, we developed an oral co-delivery nanoparticle system (WSLM) based on chitosan and whey protein isolate, which encapsulates α-mangostin and Lycium barbarum polysaccharide, to enable coordinated antibacterial and anti-inflammatory intervention within the gastrointestinal tract. WSLM effectively inhibited MRSA biofilm formation and bacterial colonization while significantly attenuating infection-associated inflammation, reducing TNF-α and IL-6 levels by approximately 76.1% and 59.3%, respectively. In a mouse model of MRSA intestinal infection, oral administration of WSLM significantly alleviated intestinal pathology, restored colon length, and decreased bacterial load by approximately three orders of magnitude. Mechanistically, WSLM promoted epithelial barrier repair through the upregulation of tight junction proteins. Furthermore, microbiome analysis revealed that WSLM showed enrichment of beneficial commensal families, including Lachnospiraceae and Oscillospiraceae . Overall, this study has established a multifunctional nano-delivery system targeting bacterial infection and hyperinflammation simultaneously, providing an experimental paradigm for the treatment of bacterial intestinal infections. Download: Download high-res image (119KB) Download: Download full-size image
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JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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2026
·
IF 2.5
Qiwen Shi,Haiping Xiang,Ying Fan,Chunyan Wu,Shengqiang Tong
Dual high-resolution profiling integrated α-glucosidase and DPPH assays. • Twelve bioactive constituents were identified from Lygodium japonicum roots. • Two new compounds were isolated and structurally characterized. • Multi-technique studies revealed their interactions with α-glucosidase. This study aimed to isolate and characterize α-glucosidase inhibitory and antioxidant compounds from the roots of Lygodium japonicum and to investigate their interactions with α-glucosidase. Dual high-resolution α-glucosidase inhibition and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging profiling was employed, which led to the identification of 12 constituents associated with α-glucosidase inhibitory and/or antioxidant activities from L. japonicum roots, including two new compounds, 6-hydroxy-7-(hydroxymethyl)-2-isopropyl-1,4-naphthoquinone ( 7 ) and 1,1′-dimer of 2,3-dihydroxy-4-methoxydibenzofuran ( 10 ). Several isolated compounds showed notable bioactivities, with compounds 7 , 8 , and 10 exhibiting measurable α-glucosidase inhibitory activity (IC 50 < 11 μM) and compounds 1 , 2 , 4 , 5/6 , and 10 displaying robust DPPH radical scavenging activity (IC 50 < 20 μM). Enzyme inhibition kinetics, fluorescence spectroscopy, circular dichroism spectroscopy, and molecular docking were employed to characterize three of the most potent α-glucosidase inhibitors and to reveal their potential binding interactions with the enzyme. Overall, this study highlights the utility of dual high-resolution bioactivity profiling for identifying chemically defined constituents that contribute to the in vitro α-glucosidase inhibitory and antioxidant activities of L. japonicum roots. Download: Download high-res image (160KB) Download: Download full-size image
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PHYTOMEDICINE
·
2026
·
IF 11.3
Benlu Chen,Hongduo Lu,Jiayu Gan,Yunhao Hu,Zhiwen Chen,Changbo Cheng,Yang Liu,Yangwenxiang Wei,Yuehui Zhou,Yuxuan Xue,Yuhao Liu,Chi Zhou,Yinuo Fan,Zhenqiu Chen
CSA ameliorates estrogen-deficient osteoporosis without hepatotoxicity or nephrotoxicity. • CSA bidirectionally inhibits osteoclastogenesis and promotes osteogenesis. • CSA directly targets TNF-α to restore bone coupling balance. • CSA upregulates MIRO1 and promotes mitochondrial transfer from osteoblasts to osteoclasts. Background Oestrogen-deficient osteoporosis features an imbalanced bone formation–resorption coupling with excessive osteoclast activation and impaired osteoblast function. Compounds that bidirectionally regulate bone metabolism remain rare among natural small molecules. Cajaninstilbene acid (CSA) from Cajanus cajan leaves exerts regulatory effects on bone metabolism and anti-inflammatory activity, but its mechanism in restoring bone homeostasis via intercellular mitochondrial transfer remains unclear. Purpose To investigate the therapeutic effect of CSA on oestrogen-deficient osteoporosis and reveal its molecular mechanism by targeting TNF-α-mediated mitochondrial transfer to rebalance osteogenesis and osteoclastogenesis. Materials Ovariectomised (OVX) mice were used as the estrogen-deficient osteoporosis model and treated with Cajaninstilbene Acid (CSA) for 6 weeks. Bone microstructure and metabolism were evaluated by micro-computed tomography (micro-CT), histological staining and immunohistochemistry (IHC). Primary bone marrow macrophages (BMMs) and bone marrow mesenchymal stem cells (BMSCs) were cultured for osteoclastic and osteogenic differentiation. Differentiation was assessed by tartrate-resistant acid phosphatase (TRAcP), alkaline phosphatase (ALP) and alizarin red staining (ARS). Key targets were screened by transcriptomic analysis and validated by molecular docking and surface plasmon resonance (SPR). Mitochondrial transfer and activity were observed by co-culture, fluorescence labelling and JC-1 staining. Protein and gene expression were determined by Western blot (WB) and quantitative real-time polymerase chain reaction (qPCR). Results CSA significantly increased bone mineral density and improved trabecular microarchitecture in OVX mice without obvious hepatorenal toxicity. In vitro, CSA dose-dependently suppressed RANKL-induced osteoclastogenesis by downregulating NFATc1 and CTSK, while enhancing osteoblast differentiation by upregulating RUNX2, OCN and OPG. Mechanistically, CSA directly bound and inhibited TNF-α, upregulated the mitochondrial transporter MIRO1, and restored mitochondrial transfer from osteoblasts to osteoclasts, reversing the disrupted bone coupling balance. Conclusion CSA bidirectionally inhibits bone resorption and promotes bone formation by blocking TNF-α signalling and restoring MIRO1-mediated mitochondrial transfer, effectively ameliorating oestrogen-deficient osteoporosis. This study provides pharmacological support and novel mechanistic insights for CSA as a promising natural candidate for osteoporosis treatment. Download: Download high-res image (189KB) Download: Download full-size image
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Haoyuan Zheng,Hua Ning,Chen Jin,Shuzhong Wang,Yadong Wang,Shixuan He,Haizhen Liu,Rui Tang,Xinhua Wang
α -phase AlH 3 , as a high-capacity hydrogen storage material (10.01 wt%), is often used in the hydrogen fuel cell industry. However, its high dehydrogenation temperature remains difficult to match with the operating temperature of proton exchange membranes. Designing efficient catalysts can effectively improve the dehydrogenation performance of AlH 3 , enabling low-temperature dehydrogenation by destabilizing it. In this work, a two-dimensional transition metal carbide V 4 C 3 with a layered structure was designed. Using V 4 AlC 3 as a precursor, two-dimensional V 4 C 3 was prepared via hydrofluoric acid etching. The AlH 3 –V 4 C 3 composite material was constructed by combining V 4 C 3 with AlH 3 through mild ball milling, which significantly enhanced the dehydrogenation performance of AlH 3 . With an optimal additive ratio (+3 wt% V 4 C 3 ), AlH 3 began to release hydrogen at temperatures as low as 47°C, exhibited a dehydrogenation peak temperature of only 110.2°C, and achieved a final hydrogen release capacity of 8.37 wt%. In isothermal dehydrogenation kinetic tests, the dehydrogenation capacity of V 4 C 3 -modified AlH 3 within 60 min at 120°C was significantly increased from 2.11 wt% to 7.50 wt%, and the activation energy for dehydrogenation was reduced from 88.5 kJ/mol to 35.7 kJ/mol, demonstrating remarkable improvement in isothermal dehydrogenation performance. The mechanism behind the improved dehydrogenation of AlH 3 by V 4 C 3 was investigated through a combination of characterization techniques and density functional theory (DFT) calculations. The results indicate that V 4 C 3 effectively weakens the Al-H bonds in AlH 3 , facilitates hydrogen dissociation, and alters the nucleation and growth mechanism of AlH 3 during dehydrogenation. Throughout the entire dehydrogenation process, V 4 C 3 remains chemically stable and enhances the dehydrogenation kinetics of AlH 3 via interfacial catalysis. The aforementioned approach effectively improves the overall dehydrogenation performance of AlH 3 , providing a novel paradigm for enhancing light-metal high-capacity hydrides.
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