CHEMPHYSCHEM
·
2022
·Vol. 23
·期 6
·e202200002
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IF 3.52
Jingfang Zhou,Rukang Li
Graphical Ba 3 Sc 2 (BO 3 ) 4 displays a beneficial layered structure in which BO 3 units are parallelly arranged by the modulation of ScO 6 octahedra and BaO n (n=9, 12) polyhedrons. The parallel arrangement of planar BO 3 units generates a large basic birefringence of 0.096, further enhanced by distorted ScO 6 octahedra up to Δn=0.149@550 nm, which is similar to the values reported in TiO 2 , LiNbO 3 , BaTi(BO 3 ) 2 . Transition metal ions with d 0 electronic states (Ti 4+ , Zr 4+ , Nb 5+ and Ta 5+ ) are widely investigated as functional materials. This work first illustrates that Sc 3+ ion, long-time ignored, displays a second-order Jahn-Teller (SOJT) effect similar to asymmetric oxide-coordinated transition metal ions, thus providing a new ground to seek for asymmetric functional materials with enhanced performances. In Ba 3 Sc 2 (BO 3 ) 4 , BO 3 groups are parallelly arranged, satisfying the ideal arrangement to produce large birefringence. Importantly, distorted octahedral ScO 6 with Sc 3+ ion in its d 0 electronic state enlarges birefringence unexpectedly up to 0.149 @ 550 nm, which is larger than previously reported borates containing solely BO 3 , even to B 3 O 6 units. Subsequently, the SOJT influence of distorted ScO 6 octahedra on birefringence is verified by a comparison between experimental data and theoretical calculations. In addition, Ba 3 Sc 2 (BO 3 ) 4 also displays a high transmittance in the range of 230 nm–3.5 μm with a UV cut-off wavelength at 198 nm and a large laser induced damage threshold (2.7 GW/cm 2 ), comparable to α-BaB 2 O 4 . Above characteristics imply that the title compound may be a promising birefringent material.
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FOOD CONTROL
·
2023
·
IF 6
Lingling Yu,Xingxing Wang,Yingying Wei,Shu Jiang,Jianfen Ye,Yi Chen,Feng Xu,Hongfei Wang,Xingfeng Shao
Terpinen-4-ol has potent antifungal activity and controls decay in postharvest strawberry fruit. In order to overcome the unstable and volatile characteristics of terpinen-4-ol, a γ-cyclodextrin (γ-CD) metal-organic framework (MOF) with high porosity and large specific surface area was synthesized by vapor diffusion and ultrasonic mixing. Terpinen-4-ol-loaded γ-CD-MOF (γ-CD-MOF/Ter) was then prepared using physical adsorption. Scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy analysis, and nitrogen adsorption-desorption showed that terpinen-4-ol was successfully loaded into the center of the γ-CD-MOF structure, and that encapsulation efficiency and drug loading reached 53.61% and 9.31%, respectively. γ-CD-MOF/Ter reduced the release rate of terpinene-4-ol, and exhibited the higher antifungal effect against B. cinerea in vitro test. Meanwhile, it was effective in controlling gray mold and maintaining the quality of strawberry fruit. We conclude that γ-CD-MOF loads terpinen-4-ol and reduces its volatilization and has potential application in the preservation of strawberry fruit.
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INORGANIC CHEMISTRY
·
2023
·
IF 4.6
Jingfang Zhou,Pifu Gong,Mingjun Xia,Aimin Ji,Lifang Zhang,Huiqiang Wu,Qian Wu
Replacing alkali metals (K, Na atoms) by an alkaline-earth metal (Ba atom), α-Ba3Sc2(BO3)4 (high-temperature phase) is successfully obtained by a molten salt method, taking Ba2K1.6Na0.4Sc2(BO3)4 as the parent template. Although both of them exhibit similar layered structures composed of ScO6 and BO3 units, α-Ba3Sc2(BO3)4 shows largely distorted ScO6 octahedra (Δd = 0.56) forced by the uniform tension of a larger space effect from BaO12 polyhedrons, rather than regular ScO6 octahedra like in Ba2K1.6Na0.4Sc2(BO3)4. Experimental measurements and calculated analyses elucidate that distorted ScO6 octahedra in α-Ba3Sc2(BO3)4, displaying a second-order Jahn–Teller (SOJT) effect, enlarge the experimental birefringence up to 0.14@550 nm, while Ba2K1.6Na0.4Sc2(BO3)4 with regular ScO6 octahedra only shows Δn = 0.11 under the same condition. In addition, other optical and thermal properties of the two title compounds were characterized. The experimental results indicate that Ba2K1.6Na0.4Sc2(BO3)4 and α-Ba3Sc2(BO3)4 are promising birefringent materials.
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JOURNAL OF ORGANIC CHEMISTRY
·
2023
·
IF 3.6
Haiyun Peng,Yangyi Zhang,Guisheng Deng
Silver(I)-catalyzed tandem reaction of enynones with 4-alkenyl isoxazoles provides access to 2-(furan-2-yl)-1,2-dihydropyridines. No competitive cyclopropanation of alkenes and O–H insertion via (2-furyl)carbene complexes were observed. The cascade reaction proceeds via the formation of (2-furyl)metal carbene intermediate, the N–O bond cleavage of 4-alkenyl isoxazoles/rearrangement, subsequent 6π electrocyclic reaction, and [1,5] H-shift. The successive construction of both 1,2-dihydropyridine skeleton and furan frame has been achieved in the one-pot reaction. A broad range of readily available enynones and 4-alkenyl isoxazoles are suitable to this protocol; however, when R3 is the alkyl group such as n-Bu and Me, a complicated mixture was generated without the desired products. In addition, in the case of R4 = bulky group such as R3′SiOCH2, the reaction gave an in situ oxo-product of (2-furyl)silver carbene. An atom-economic strategy for the synthesis of 2-(furan-2-yl)-1,2-dihydropyridines has been established.
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高影响因子
Current Medical Science
·
2023
·Vol. 43
·期 2
·223-231
·
IF 2.4
Zhang Qing,Pan Rong-rong,Wu Yu-tao,Wei Yu-miao
Objective Vascular smooth muscle cell (VSMC) differentiation from stem cells is one source of the increasing number of VSMCs that are involved in vascular remodeling-related diseases such as hypertension, atherosclerosis, and restenosis. MicroRNA-146a (miR-146a) has been proven to be involved in cell proliferation, migration, and tumor metabolism. However, little is known about the functional role of miR-146a in VSMC differentiation from embryonic stem cells (ESCs). This study aimed to determine the role of miR-146a in VSMC differentiation from ESCs. Methods Mouse ESCs were differentiated into VSMCs, and the cell extracts were analyzed by Western blotting and RT-qPCR. In addition, luciferase reporter assays using ESCs transfected with miR-146a/mimic and plasmids were performed. Finally, C57BL/6J female mice were injected with mimic or miR-146a-overexpressing ESCs, and immunohistochemistry, Western blotting, and RT-qPCR assays were carried out on tissue samples from these mice. Results miR-146a was significantly upregulated during VSMC differentiation, accompanied with the VSMC-specific marker genes smooth muscle-alpha-actin (SMαA), smooth muscle 22 (SM22), smooth muscle myosin heavy chain (SMMHC), and h1-calponin. Furthermore, overexpression of miR-146a enhanced the differentiation process in vitro and in vivo . Concurrently, the expression of Kruppel-like factor 4 (KLF4), predicted as one of the top targets of miR-146a, was sharply decreased in miR-146a-overexpressing ESCs. Importantly, inhibiting KLF4 expression enhanced the VSMC-specific gene expression induced by miR-146a overexpression in differentiating ESCs. In addition, miR-146a upregulated the mRNA expression levels and transcriptional activity of VSMC differentiation-related transcription factors, including serum response factor (SRF) and myocyte enhancer factor 2c (MEF-2c). Conclusion Our data support that miR-146a promotes ESC-VSMC differentiation through regulating KLF4 and modulating the transcription factor activity of VSMCs.
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2021
·Vol. 37
·期 6
·1296-1300
·
IF 1.307
Rong Xin,Lu Xiuli,Lu Tongbu
T he fabrication of highly active and easily recyclable Pd-based catalyst is meaningful for their practical application. Herein, a Pd-based dip-catalyst(Pd@Pyr-GDY) is fabricated on graphdiyne(Pyr-GDY) grown on copper foam, and applied in the reduction of nitroarenes. Specially, the as-formed Pd@Pyr-GDY shows good catalytic performance toward the reduction of 4-nitrophenol(4-NP) to 4-aminophenol(4-AP) by NaBH 4 with a rate constant k value of 3.84 min −1 , which is 12-fold higher than that of the commercial Pd/C. More importantly, Pd@Pyr-GDY could be easily and rapidly recovery from the reaction medium and no distinct inactivation was found after six cycles of the reaction. This work presents an easy way to design an efficient and easily recyclable Pd-based catalyst for practical use.
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JOURNAL OF MOLECULAR LIQUIDS
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2017
·
IF 3.648
Chen Yang,Qi Li,Yong Wu
Data on corresponding solid-liquid equilibrium of 4-methylbenzoic acid in different solvents are essential for a preliminary study of industrial applications. In this paper, the solid-liquid equilibrium of 4-methylbenzoic acid in methanol, ethanol, isopropanol, 1-butanol, acetone and acetonitrile pure solvents and (acetone + acetonitrile) mixture solvents were explored in the temperatures (from 278.15 to 323.15 K) under atmosphere pressure. For the temperature range investigated, the solubility of 4-methylbenzoic acid in the solvents increased with increasing temperature. The modified Apelblat model, the Buchowski-Ksiazaczak λh model, and the ideal model were adopted to describe and predict the change tendency of solubility. Computational results showed that the modified Apelblat model had more advantages than the other two models. The solubility data were fitted using a modified Apelblat equation, a variant of the combined nearly ideal binary solvent/Redich-Kister (CNIBS/R-K) model, Jouyban-Acree model and Ma model in (acetone + acetonitrile) binary solvent mixture. In addition, the calculated thermodynamic parameters indicated that in each studied solvents the dissolution of 4-methylbenzoic acid is endothermic and entropy-driven process.
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ACS Applied Nano Materials
·
2023
·
IF 5.9
Xiaoqiu Yao,Ming Jin,Jiang Du,Decheng Wan
In the jigsaw puzzle of quality gold nanoclusters (AuNCs), those protected by weak ligands or coligands are still rarely available. Here, we provide an example in the case of supported AuNCs. Branched polyethylenimine (PEI, diameter of 1.86 nm) is introduced as discrete molecular patches onto the support of mesoporous polymer beads. Each patch is derived into polyaminophosphine with 2-(diphenylphosphino) benzaldehyde (dppb). The molecular patch is of nanoscale and uniform size. The polymer beads after PEI loading bear unimodal pores (3.9 nm), and the specific surface area is of 390 m2 g–1. AuNCs are obtained by mildly heating the mixture of the functionalized beads and aqueous chloroauric acids. Uniform AuNCs with a diameter of 1.2 ± 0.2 nm (∼53 Au atoms) are obtained when each PEI patch bears 17 dppb ligands, smaller than that of 3.5 nm in the absence of any dppb, suggesting that dppb enhances the nucleation of AuNCs. The heteroleptic AuNCs show ultrahigh catalytic performance (TOF = 391 h–1) for the reduction of 4-nitrophenol, where the dppb ligands hardly suppress the catalytic activity. The catalyst is well recoverable and durable for the reduction of 4-nitrophenol.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2015
·
IF 3.447
Feifei Li,Guoli Wu,Huixia Zheng,Li Wang,Zhengbao Zhao
A glycoside prodrug of 4-aminosalicylic acid (4-ASA) with d -glucose was synthesized for targeted drug delivery to inflammatory bowel. The in vitro assessment of 4-aminosalicylic acid-β-O-glucoside (4-ASA-Glu) as a colon-specific prodrug was studied using colitis rat with the healthy one as control. The stability studies in aqueous buffers (pH 1.2, 6.8 and 7.4) indicated that 4-ASA-Glu was stable over a period of 12 h. The incubation of 4-ASA-Glu with cecal or colonic contents of healthy rats at 37 °C released 4-ASA in 77 or 80% of the dose in 12 h, respectively. The amount of 4-ASA liberated from the incubation of 4-ASA-Glu in cecal or colonic contents of colitis rats at 37 °C was 69 or 79% in 12 h respectively, while less than 9% 4-ASA was detected from the incubation of 4-ASA-Glu with the homogenates of stomach or small intestine . The curative effect of 4-ASA-Glu was evaluated in 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) induced experimental colitis model in male Sprague–Dawley (SD) rats. It was found that 4-ASA-Glu possess significantly ameliorate effect than sulfasalazine , oral 4- and 5-aminosalicylic acid.
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JOURNAL OF LUMINESCENCE
·
2023
·
IF 3.6
Ruiqi Yang,Ju Li,Xinjing Xie,Jingjing Lian,Chaoyue Wang,Changlin Li,Haoran Su,Zhequan Zou,Shouan Xie,Ruijin Yu
In this study, a series of innovative red-emitting Sm 3+ -doped K 5 La(MoO 4 ) 4 phosphors were synthesized using the solid-state reaction method. The X-ray powder diffraction patterns and Rietveld refinement confirmed the single-phase structure of the synthesized K 5 La(MoO 4 ) 4 :Sm 3+ samples with trigonal system (space group R 3 ‾ m (#166)). The phosphors demonstrated a strong red emission at 644 nm, corresponding to the electric dipole transition 4 G 5/2 → 6 H 9/2 of Sm 3+ ions. The optimal doping concentration for K 5 La (1- x ) ( MoO 4 ) 4 : x Sm 3+ was found to be approximately 5 mol%. The temperature-dependent emission of phosphors was examined and found that the luminescence intensity remained at 86 % even at 480 K, showing the exceptional thermal stability of this material. K 5 La (1- x ) ( MoO 4 ) 4 : x Sm 3+ phosphors displayed remarkable color stability with chromaticity coordinates falling within the red region in 1931 CIE diagram. K 5 La(MoO 4 ) 4 :5 mol%Sm 3+ exhibited a high color purity of 99.9 % and internal quantum efficiency (IQE) was measured as 66.8 %. Light-emitting diodes (LEDs) were constructed using InGaN chips and the synthesized red phosphors. The chromaticity coordinates of the fabricated w-LED (white light-emitting diode) were (0.330, 0.351), closely resembling the typical white point of the National Television System Committee (NTSC) at (0.333, 0.333). The color rendering index (CRI, R a ) and correlated color temperature (CCT) of w-LED were 87 and 5627 K. These findings strongly suggest the potential use of K 5 La(MoO 4 ) 4 :Sm 3+ phosphors as red phosphors in LEDs.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2023
·
IF 6.7
Cong Chen,Bing Zhang,Jiaojiao Tu,Yanfen Peng,Yihuan Zhou,Xinping Yang,Qiming Yu,Xiangduan Tan
Farnesoid X receptor (FXR) plays a key role in bile acid homeostasis , inflammation, fibrosis , lipid and glucose metabolism and is emerging as a promising therapeutic target for nonalcoholic steatohepatitis (NASH). Emerging evidence suggested that intestine-specific FXR antagonists exhibited remarkable metabolic improvements and slowed NASH progression. In this study, we discovered several potent FXR antagonists using a multistage ligand- and structure-based virtual screening approach. Notably, compound V023-9340 , which possesses a 4-aminophenylacetamide scaffold, emerged as the most potent FXR antagonist with an IC 50 value of 4.27 μM. In vivo , V023-9340 demonstrated selective accumulation in the intestine, substantially ameliorating high-fat diet (HFD)-induced NASH in mice by mitigating hepatic steatosis and inflammation. Mechanistic studies revealed that V023-9340 strongly inhibited intestinal FXR while concurrently feedback-activated hepatic FXR. Further structure-activity relationship optimization employing V023-9340 has resulted in the synthesis of a more efficacious compound V02-8 with an IC 50 value of 0.89 μM, which exhibited a 4.8-fold increase in FXR antagonistic activity compared to V023-9340 . In summary, 4-aminophenylacetamide derivative V023-9340 represented a novel intestine-specific FXR antagonist and showed improved effects against HFD-induced NASH in mice, which may serve as a promising lead in discovering potential therapeutic drugs for NASH treatment.
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ORGANIC PROCESS RESEARCH & DEVELOPMENT
·
2023
·
IF 3.4
Junjie Li,Wei Feng,Shichun Weng,Zichao Guo,Wanghua Chen
3,4-bis(4-Aminofurazano-3-yl) furoxan (DATF) is a key precursor for the high-energy explosive 3,4-bis(4-nitrofurazano-3-yl) furoxan (DNTF), and it is also a high-nitrogen content energetic material. In this paper, the synthesis process of DATF was characterized using the HPLC technique, and the effects of four reaction parameters have been thoroughly studied. The thermal risk analysis for DATF synthesis was conducted with a reaction calorimeter (RC1) and an accelerating rate calorimeter. It was found that extracting the intermediate 3-amino-4-oxycyanofurazan from the aqueous to organic phases was an important way to improve the yield of DATF. Therefore, hydrophobic ethyl acetate was selected as one reaction solvent. The higher yield of DTAF obtained was about 60%. In addition, HPLC monitoring and reaction calorimetry results indicated that the rate of diazotization and decomposition of diazonium salt was feeding-controlled, and the cycloaddition reaction was a slow process. Most of the reaction heat has been released by the diazotization and decomposition of diazonium salt, while the heat effect of cycloaddition was not significant. Thermal stability analysis supported the conclusion that the decomposition of the reaction mixture was hardly possible to be triggered by the reaction heat. The thermal risk of DATF synthesis was low.
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