LWT-FOOD SCIENCE AND TECHNOLOGY
·
2023
·
IF 6
Wei Zhang,Yang Xiao,Ruijie Deng,Ying Wang,Yong Qiu,Qiyao Sun,Aimin Luo
Chinese Baijiu is a traditional distilled spirit that is consumed abundantly in China and around the world. Aging would dramatically increase the flavor of Baijiu, and famous Baijiu usually needs the long storage time for aging. Therefore, artificial aging that could accelerate the flavor improvement is in high demand. In this study, an electric-field treatment device was developed for the electric-field aging of the liquor. We used three types of strong-flavor crude Baijiu from different manufacturers in Sichuan as samples for electric-field aging. The total acids and esters, volatile flavor components, and sensory evaluation of the Baijiu samples before and after treatment were determined. It was found that the total acids and total esters of the Baijiu samples decreased and increased, respectively, with aging. The composition of volatile components changed after the aging treatment, and the volatile flavor components associated with the changes in the quality of Baijiu were analyzed. Combined with the sensory evaluation results, it was concluded that the quality of the treated Baijiu was significantly improved via electric-field aging. The result showed that electric-field aging can be an effective way to improve the flavor of Baijiu.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2022
·
IF 5.062
Dongzhi Xu,Haihao Wu,Chunguang Zhou
Osteoporosis is a common severe orthopedic disease that can lead to bone fractures and significantly reduce a patient's quality of life. Teriparatide (parathyroid hormone, PTH (1–34)) has been approved for the treatment of osteoporosis. However, PTH (1–34) needs to be injected once daily due to its short half-life of 1 h. To improve the pharmacokinetic and pharmacodynamic profiles of PTH (1–34), a G148-ABD3 (GA3) domain, which can bind to albumin non-covalently, was employed to modify PTH (1–34). The resultant PTH 34 -GA3-GS1 and PTH 34 -GA3-GS3 fusion proteins were constructed by fusing PTH (1–34) to the N-terminus of GA3 via (G 4 S) 1 and (G 4 S) 3 linkers, respectively. The fusion proteins were highly expressed in Escherichia coli . In vitro results showed that both PTH 34 -GA3-GS1 and PTH 34 -GA3-GS3 could bind to human serum albumin (HSA) with high affinity. The fusion proteins significantly increased the proliferation and differentiation of osteoblastic MC3T3-E1 cells, thereby promoting osteogenesis. PTH 34 -GA3-GS3 increased intracellular and serum calcium levels more than PTH 34 -GA3-GS1 did. The half-lives of PTH 34 -GA3-GS1 and PTH 34 -GA3-GS3 were 8.4 h and 9.1 h, respectively, which are significantly longer than that of PTH (1–34). Injection of PTH 34 -GA3-GS3 every three days increased bone mineral density and improved trabecular structure in ovariectomized mice, indicating that PTH 34 -GA3-GS3 has the potential to alleviate osteoporosis in humans. In conclusion, the fusion proteins maintained the biological activity of native PTH (1–34) and were not affected by the GA3 moiety, which extended the half-life of PTH (1–34). Long-acting GA3-fusion PTH (1–34) proteins have therapeutic effects on osteoporosis by improving osteogenesis and by enhancing the proliferation and differentiation of osteoblasts.
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Advanced Materials Technologies
·
2023
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IF 6.8
Shengbin Dai,Jiangqi Zhu,Xingchen Yan,Shun Wu,Yang Liu,Xiang Gao,Hamish Fraser,Peter Hodgson,Yuman Zhu,Martin Heilmaier,Aijun Huang
Oxide dispersion strengthened (ODS) nickel (Ni)-based superalloys are advanced materials known for their outstanding tensile and creep performance at temperatures exceeding 1000 °C. Nevertheless, their conventional synthesis presents a longstanding challenge in cost-effectively producing intricate components for critical applications. In this work, electrostatic self-assembly (ESA) of powders with the laser powder bed fusion (LPBF) process have been successfully combined to produce yttria ODS Inconel 718 (IN718) alloy for the first time. The approach has demonstrated a significant contribution of yttria to the strength of IN718 after the solid solution heat treatment, as evidenced by ≈50% improvement in room temperature yield strength with a 0.5 wt.% yttria addition. The addition of yttria by this process leads to a heterogeneous microstructure. This heterogeneous microstructure comprises two distinct grain areas with varying amounts of yttria nanoparticles and dislocation storage. It has been shown that the yield strength increase can be predicted by the combination of both Y 2 O 3 dispersion strengthening and dislocation strengthening mechanisms. These findings offer an effective approach to tailor heterogeneous microstructures, unlocking new opportunities for cost-effectively producing high-performance ODS Ni-based superalloy products with excellent mechanical properties.
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Bioactive Materials
·
2023
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IF 18.9
Nan Lyu,Daihua Deng,Yuting Xiang,Zeyu Du,Xiaohui Mou,Qing Ma,Nan Huang,Jing Lu,Xin Li,Zhilu Yang,Wentai Zhang
Thrombus formation and tissue embedding significantly impair the clinical efficacy and retrievability of temporary interventional medical devices. Herein, we report an insect sclerotization-inspired antifouling armor for tailoring temporary interventional devices with durable resistance to protein adsorption and the following protein-mediated complications. By mimicking the phenol-polyamine chemistry assisted by phenol oxidases during sclerotization, we develop a facile one-step method to crosslink bovine serum albumin (BSA) with oxidized hydrocaffeic acid (HCA), resulting in a stable and universal BSA@HCA armor. Furthermore, the surface of the BSA@HCA armor, enriched with carboxyl groups, supports the secondary grafting of polyethylene glycol (PEG), further enhancing both its antifouling performance and durability. The synergy of robustly immobilized BSA and covalently grafted PEG provide potent resistance to the adhesion of proteins, platelets, and vascular cells in vitro . In ex vivo blood circulation experiment, the armored surface reduces thrombus formation by 95 %. Moreover, the antifouling armor retained over 60 % of its fouling resistance after 28 days of immersion in PBS. Overall, our armor engineering strategy presents a promising solution for enhancing the antifouling properties and clinical performance of temporary interventional medical devices.
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高影响因子
ACS Sustainable Chemistry & Engineering
·
2023
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IF 8.4
Ningxia Gu,Lixin Song,Pengyun Zhang,Ye Feng,Pingfan Du,Yongjun Zhu,Lei Ning,Zeyuan Sun,Hua Jiang,Jie Xiong
Electron transport layer (ETL)-free perovskite solar cells (PSCs) have garnered significant attention due to their simple manufacturing process. However, containing ETL results in blocking holes and suppressing charge recombination. Herein, the titanium dioxide (TiO2)-doped carbon nanofibers (TiO2/C NFs) via electrospinning were introduced into the perovskite absorber layer. The one-dimensional TiO2/C NFs provided an additional charge transport channel to promote the carrier transfer and suppress nonradiative recombination. Carbon nanofibers with high conductivity could also improve the electrical conductivity of perovskite. Moreover, TiO2/C NFs functioned as the nucleation sites to regulate the preferred orientation of perovskite crystals. Finally, the power conversion efficiency (PCE) of rigid PSCs with TiO2/C NFs was significantly improved from 18.07 to 19.81%, with an enhanced stability of only 11% degradation after exposure to an ambient environment for 300 h. In addition, the TiO2/C NFs-optimized flexible devices exhibited a PCE of 17.61%. Highly flexible TiO2/C NFs incorporating effectively improved the bending stability, wherein the flexible PSCs without and with TiO2/C NFs retained 84.27 and 48.33% of the original PCE after 6000 bending cycles (radius: 3 mm), respectively. This work highlights a significant application of TiO2/C NFs in developing high-efficiency and well-stability minimalist PSCs.
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Journal of Materials Chemistry A
·
2023
·Vol. 11
·期 38
·20665-20675
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IF 11.9
Yuying Kong,Hui Mao,Zihuan Zhang,Junqi Gao,Xiao Han,Wen-Jun Wang,Khak Ho Lim,Xuan Yang
Ionic strength sensing plays a crucial role in numerous fields, and there is an urgent demand for portable and robust sensors with rapid and precise detection ability. This study presents a novel micrometer-diameter nanocellulose composite filament sensor, which can detect ionic strength with high accuracy (R2 > 0.998), using only trace amounts of a liquid sample (20 μL). The preparation of such a filament sensor contains two straightforward steps: (1) raw carbon nanotubes (CNTs) are integrated into a spinning dispersion based on cellulose nanofibrils (CNFs) through a facile co-grinding method; (2) composite filaments are obtained through a wet-spinning process to utilize the assembling structures by these two fibrillar nanoparticles, providing superior mechanical properties and baseline conductivity. Such composite filaments confine capillary swelling in nano-channels for controlled ion diffusion, which enables a precise measuring ability for a wide range of ionic strength from 10−5 to 10−1 M within 1 min. The superior selectivity towards different ions, ability to precisely determine ion content for purified water quality, anti-disturbance capacity, and performance stability under varying environmental conditions are examined. Overall, this study paves the way to utilize carbohydrate and carbon materials at nano- and macro-levels through a simple preparation method. In particular, the control of nanoparticles' assembling into macro-sized materials greatly boosts the potential of nanocomposites for practical sensor applications.
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JOM
·
2023
·Vol. 75
·期 12
·5606-5618
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IF 2.6
Wang Jiuling,He Dandan,Chu Ling,Zhang Yupeng,Zhang Wenbo,Zhang Hong
The massive use of antibiotics has led to contamination of water resources, and concerns have been raised about how to treat antibiotic residues in water. In this study, a novel magnetic attapulgite composite (Fe@APT) was prepared by facile chemical precipitation. The characteristics and properties of Fe@APT were revealed by TEM, XRD, FTIR, XPS, BET, VSM, zeta potential, and batch adsorption experiments. The specific surface area of Fe@APT could reach 246.27 m 2 /g, which was about 1.8 times higher than that of APT. And the adsorption of tetracycline (TC) by the composite was shown by kinetics and isotherms to reveal the mechanisms, such as electrostatic attraction, physical adsorption, hydrogen bonding, π – π interaction, complexation, and electron transfer. The effects of pH and ions coexistence on the removal of TC by Fe@APT were also investigated. Specifically, the pore structure of Fe@APT was ameliorated and abundant active adsorption sites were obtained by the modification. The results showed that the maximum adsorption capacity reached 177.94 mg/g when the pH was 4, and it also exhibited good adsorption capacity under the interference of coexisting ions. Furthermore, the adsorbent displayed excellent recycling performance with easy separation. It has been proved that Fe@APT might have a potential application in antibiotic wastewater.
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Acta Pharmaceutica Sinica B
·
2023
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IF 14.5
Qiujun Qiu,Sunhui Chen,Huining He,Jixiang Chen,Xinyi Ding,Dongdong Wang,Jiangang Yang,Pengcheng Guo,Yang Li,Jisu Kim,Jianyong Sheng,Chao Ga,Bo Yin,Shihao Zheng,Jianxin Wang
Despite exciting achievements with some malignancies, immunotherapy for hypoimmunogenic cancers, especially glioblastoma (GBM), remains a formidable clinical challenge. Poor immunogenicity and deficient immune infiltrates are two major limitations to an effective cancer-specific immune response. Herein, we propose that an injectable signal-amplifying nanocomposite/hydrogel system consisting of granulocyte-macrophage colony-stimulating factor and imiquimod-loaded antigen-capturing nanoparticles can simultaneously amplify the chemotactic signal of antigen-presenting cells and the "danger" signal of GBM. We demonstrated the feasibility of this strategy in two scenarios of GBM. In the first scenario, we showed that this simultaneous amplification system, in conjunction with local chemotherapy, enhanced both the immunogenicity and immune infiltrates in a recurrent GBM model; thus, ultimately making a cold GBM hot and suppressing postoperative relapse. Encouraged by excellent efficacy, we further exploited this signal-amplifying system to improve the efficiency of vaccine lysate in the treatment of refractory multiple GBM, a disease with limited clinical treatment options. In general, this biomaterial-based immune signal amplification system represents a unique approach to restore GBM-specific immunity and may provide a beneficial preliminary treatment for other clinically refractory malignancies.
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2023
·
IF 4.3
Zhiyan Chen,Zhaomei Wu,Lulu Jiang,Tingting Li,Yajun Gao
The control and detection of sunset yellow (SY) are very important due to the high risk of harmful effects on humans caused by excessive intake. In this work, we reported the synthesis of hollow mesoporous carbon spheres (HMCS) and their application in developing a novel electrochemical sensor for SY. Initially, three hollow carbon spheres with different sizes and pore structures were synthesized by adjusting the ratio of TPOS and TEOS using the hard-templating approach. In comparison, HMCS showed the smallest diameter (290 nm), the largest surface area (2229.1 m 2 g −1 ), and a high content of mesoporous structure. This provides a structural basis for high-efficiency pre-concentration of SY on the surface of the HMCS-modified electrode, which effectively improves its electrocatalytic activity . Under optimized conditions, the HMCS/GCE sensor showed a wide linear range varying from 0.0015 − 4 µM, with an ultralow LOD (0.12 nM). Moreover, the HMCS/GCE sensor was deployed for the detection of SY with the advantages of impressive anti-interference ability, satisfactory reproducibility, good repeatability as well as long-term stability. The proposed sensor has been successfully used for the detection of SY in food samples with spiked recoveries of 91.1–103.3%, showing the promising application of the method for the detection of SY in the food matrix.
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International Journal of Electrochemical Science
·
2023
·
IF 1.5
Mingyi Ma,Li He,Xiaoxue Shi,Yanchao Wang,Hong Hai,Xiaoping Wei
This paper presents a novel strategy for ultrasensitive detection of human immunodeficiency virus (HIV) DNA by an electrochemical biosensor. By the shearing cycle of the target DNA (T-DNA), a large amount of complimentary sequence probes (CS probe DNA) are obtained. Then, the Zr 4+ functional probe DNA containing many branched DNAs is captured. Next, the initiator α-bromophenylacetic acid is connected to the branched chains of probe DNA by esterification reaction. Numerous electroactive monomers, namely, ferrocenylmethyl methacrylate (FMMA), are produced at the end of the branched chains by electrochemically mediated atomic transfer radical polymerization reaction. The signal of FMMA is greatly enhanced due to a large number of branched chain-loaded probe clusters containing numerous FMMA. T-DNA can be detected with a linear range of 0.1 fM–10 nM with a detection limit of 0.037 fM. The sensor is highly sensitive and selective. It has been applied to the detection of HIV DNA in human serum samples, and it has potential application prospects in the early clinical diagnosis of AIDS.
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WATER RESEARCH
·
2023
·
IF 12.8
Chaoyun Ying,Chang Liu,Feng Zhang,Lirong Zheng,Xiaoming Wang,Hui Yin,Wenfeng Tan,Xionghan Feng,Bruno Lanson
Manganese (Mn) oxides are extensively used to oxidize As(III) present in ground, drinking, and waste waters to the less toxic and more easily removable As(V). The common presence of multiple other cations in natural waters, and more especially of redox-sensitive ones such as Fe 2+ , may however significantly hamper As(III) oxidation and its subsequent removal. The present work investigates experimentally the influence of Mn(III) chelating agents on As(III) oxidation process in such environmentally relevant complex systems. Specifically, the influence of sodium pyrophosphate (PP), an efficient Mn(III) chelating agent, on As(III) oxidation by birnessite in the presence of Fe(II) was investigated using batch experiments at circum-neutral pH. In the absence of PP, competitive oxidation of Fe(II) and As(III) leads to Mn oxide surface passivation by Fe(III) and Mn(II/III) (oxyhydr)oxides, thus inhibiting As(III) oxidation. Addition of PP to the system highly enhances As(III) oxidation by birnessite even in the presence of Fe(II). PP presence prevents passivation of Mn oxide surfaces keeping As and Fe species in solution while lower valence Mn species are released to solution. In addition, reactive oxygen species (ROS), tentatively identified as hydroxyl radicals (•OH), are generated under aerobic conditions through oxygen activation by Fe(II)–PP complexes, enhancing As(III) oxidation further. The positive influence of Mn(III) chelating agents on As(III) oxidation most likely not only depend on their affinity for Mn(III) but also on their ability to promote formation of these active radical species. Finally, removal of As(V) through sorption to Fe (oxyhydr)oxides is efficient even in the presence of significant concentrations of PP, and addition of such Mn(III) chelating agents thus appears as an efficient way to enhance the oxidizing activity of birnessite in large-scale treatment for arsenic detoxification of groundwaters.
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Nano Energy
·
2023
·
IF 17.6
Meizhen Liao,Wanghuai Xu,Yuxin Song,Zhenghua Pan,Huanxi Zheng,Yuchao Li,Xuezhi Qin,Lili Wang,Jian Lu,Zuankai Wang
Exploiting renewable and high-efficient energy sources is vital in shifting the fossil fuels-dominating energy structure to a green one in the era of intensifying energy crises facing human society. Among various strategies, harvesting energy from inexhaustive solar and water energies has gained increasing attention owing to their ubiquity and eco-friendliness. Although solar panels and droplet-based electricity generators (DEGs) are capable of harnessing solar and water energy, respectively, developing new technologies that collect both energy sources without scarifying their respective performance remains challenging owing to their contrary requirements on weather conditions. Here, we report a hybrid electricity generator with a common-electrode architecture that seamlessly integrates the solar panel and DEG, eliminating the unwanted optical attenuation and imparting ∼10% enhancement on energy conversion efficiency in solar energy harvesting as opposed to existing studies without the utility of the common-electrode design. We envision that the integrating generator featuring the common-electrode architecture design can fundamentally change the energy landscape by synergistically harnessing the apparent advantages inherent in the two weather-dependency techniques.
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危险品化学品经营许可证（带存储）