EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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2024
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IF 6
Yanping Li,Haoran Liu,Ronghao Fang,Jiamin Jin,Feng Yang,Jian Chen,Juzheng Zhang
Metal-based drugs have been used in the clinical treatment of tumors for over 30 years. However, no metal-based drugs have been clinically approved to treat glioma. Although metal complexes have excellent cytotoxicity, their most critical problem is crossing the blood–brain barrier. Therefore, to enable metal complexes to cross blood–brain barrier and target glioma therapy, herein, we propose to rationally used the basic structure of diazepam (5-chlorobenzophenone) and thiosemicarbazide to synthesize gold (Au) complexes C1, C2 and C3 with antiglioma activity. The C3 complex with two methyl groups attached to the N3 of thiosemicarbazone exhibited excellent cytotoxicity to glioma cells through its multiaction mechanism against glioma, inducing apoptosis, autophagy death, and deoxyribonucleic acid damage. In addition, the synthesized C3 complex can effectively cross the blood–brain barrier and accumulate in glioma, considerably decreasing the untoward reaction in vivo . Our findings provide a novel strategy for designing metal-based complexes for the treatment of glioma.
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Materials Today Bio
·
2024
·
IF 8.7
Diyu Wang,Subin Lin,Tuanwei Li,Xiaohu Yang,Xiang Zhong,Qian Chen,Guoqin Jiang,Chunyan Li
ABSTRACT Radiotherapy plays a critical role in the clinical treatment of breast cancer. However, the efficacy of traditional X-ray radiotherapy is greatly limited by its low tumor specificity and treatment tolerance mediated by the tumor microenvironment. Herein, we proposed a novel nano-radiotherapy sensitization strategy to design and construct a cancer cell membrane-coated siRNA-decorated Au/MnO 2 nanosensitizer (R&F@Au/MnO 2 -CM) to synergistically enhance radio-immunotherapy for breast cancer. In the integrated nanosensitizer, the cancer cell membrane (CM) derived from 4T1 breast cancer cells is utilized for targeted functionality, while Au/MnO 2 is designed to improve X-ray absorption and alleviate tumor hypoxia. Additionally, PD-L1 siRNA (R) is used to downregulate PD-L1 expression in tumor cells. In an in situ mouse model of 4T1 breast cancer, R&F@Au/MnO 2 -CM demonstrated accurate tumor identification via CM-mediated homologous targeting after intravenous injection, which was monitored in real-time through NIR-II fluorescence imaging of NIR-935 (F). Subsequently, the radiotherapy sensitivity was achieved due to the strong radiation absorption properties and oxygen generation through catalysis of Au/MnO 2 upon X-ray irradiation. Furthermore, the immunosuppressive microenvironment of the tumor is improved by downregulating PD-L1, enhancing synergistic anti-tumor effect. Our findings demonstrate a promising approach for tumor treatment by combining targeted enhanced radiotherapy with immune activation.
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FOOD CHEMISTRY
·
2024
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IF 8.5
Rui Tan,Mei Zeng,Qiuwen Huang,Na Zhou,Mengjiang Deng,Yuanyuan Li,Xiaojun Luo
The presence of nitrite in food products has generated significant public concern. A simple and rapid dual-mode surface-enhanced Raman spectroscopy (SERS)/colorimetric detection of nitrite is proposed based on a diazo reaction and multifunctional gold nanoparticle-doped covalent organic framework (Au@COF) composite. Under acidic conditions, the reaction between toluidine blue and nitrite yielded a colorless diazo salt, simultaneously attenuating its characteristic absorption peak and Raman signal. The multifunctional Au@COF materials enhanced the Raman signal and ensured good reproducibility. Additionally, the reaction rates improved, and the sensitivity was enhanced due to the excellent adsorption capacity of the COF. The proposed method demonstrated high sensitivity and excellent recovery rates for nitrite detection in food samples. This approach shows potential for precisely detecting nitrite content in real-world food samples by integrating the simplicity of colorimetric analysis with the enhanced sensitivity of SERS.
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ACS Applied Materials & Interfaces
·
2024
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IF 8.3
Hai Jiang,Jiabo Zhang,Zhiwei Weng,Longyan Chen,Yichuan Wu,Xuan Weng
Flexible strain sensors have been widely used in wearable electronics. However, the fabrication of flexible strain sensors with a large strain detection range, high sensitivity, and negligible hysteresis remains a formidable challenge, even after enormous advancements in the field. Herein, a flexible microfluidic strain sensor was fabricated by filling poly(3,4-ethylenedioxythiophene):polystyrenesulfonate–MXene–gold (PEDOT:PSS–MXene–Au) nanocomposites into microchannels in an elastic matrix. Owing to the unique properties of the nanofiller and Ecoflex elastomer microchannel, the microfluidic strain sensor detected a strain of 0%–500% with low hysteresis (2.4%), high sensitivity (guage factor = 25.4), short response times (∼86 ms), and good durability. Moreover, the flexible microfluidic sensor was used to detect various physiological signals and human activities, control a mechanical hand, and capture hand motions in real time. As demonstrated by its good performance, the proposed flexible microfluidic sensor holds great potential in applications such as wearable electronics, physiological signal monitoring and human–machine interactions.
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Progress in Natural Science-Materials International
·
2025
·
IF 7.1
Jie Li,Zhangyue Zheng,Yuehong Huang,Liu He,Hongying Guo,Chunzheng Wu,Wei Liu,Weiwei Huan
The serious problems caused by water contamination call for efficient treatment. The catalytic reduction of 4-nitrophenol (4-NP) by NaBH 4 in solution is a convenient way to convert 4-NP to 4-aminophenol (4-AP), which is a precious intermediate for manufacturing of important materials such as pharmaceuticals. In the present study, the Co modified MoS 2 supported Au nanoparticles (Au/Co-MoS 2 ) is proved to be an efficient catalyst for the reduction of 4-NP. With the introduction of cobalt, the catalytic activity is improved obviously compared to Au/MoS 2 . When Co:Mo is 2:8 (mol), the Au/CoMoS 2 (2/8) catalyst exhibits the highest activity. The kinetics of the catalytic reactions were studied by the plot of ln(C t /C 0 ) against reaction time and the k app for Au/CoMoS 2 (2/8) is 1.063 min −1 . The characterization of the catalysts shows that the addition of cobalt can create more crystal defects, promote the exposure of active edge sites, facilitate the surface of catalysts to be more reactive.
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BIOELECTROCHEMISTRY
·
2024
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IF 4.8
Xiaoying Cui,Lina Lv,Ke Zhao,Panpan Tian,Xipeng Chao,Ying Li,Baozhong Zhang
Overuse of enrofloxacin (ENR) has posed a potential threat to ecosystems and public health, so it is critical to sensitive and accurate determination of ENR residues. In this work, a novel ultra-sensitive and specific electrochemical aptasensor was fabricated based on the cobalt diselenide loaded gold and platinum nanoflowers (Au@Pt NFs/ CoSe 2 ) and Exonuclease III (Exo III)-assisted cycle amplification strategy for the detection of ENR. Au@Pt NFs/ CoSe 2 nanosheets as the substrate material, with large surface area, accelerate electron transfer and attach more DNA probes on the electrode substrate, have effectively enhanced the electrochemical performance of the electrode. With the existence of Enrofloxacin (ENR), the aptamer recognizes and binds to ENR, thus the signal probe cDNA was released and immobilized onto the electrode surface to hybridized with methylene blue (MB) labelled DNA (MB-DNA), thereby triggering the Exo III-assisted cycle for further signal amplification. As expected, the prepared aptasensor demonstrated excellent sensitivity and selectivity, with a wide linear range from 5.0 × 10 −6 ng/mL to 1.0 × 10 −2 ng/mL for ENR, a low detection limit of 1.59 × 10 −6 ng/mL. Consequently, this strategy provided a promising avenue for ultrasensitive and accurate detection of ENR in milk samples.
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IEEE Transactions on Components Packaging and Manufacturing Technology
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2024
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IF 2.3
Yi Zhong,Zhongliang Liu,Binbin Jiang,Dongxiao Yang,Weidong Zhong,Penghui Wu,Tengteng He
Fine-pitch flip-chip Au bumps play a critical role in interconnecting and packaging advanced optoelectronics, historically known for their good corrosion resistance and high reliability. However, this study reveals the susceptibility of Au bumps to corrosion and cracking during 85°C/85%RH high temperature and humidity (THT) reliability testing. Cracks were observed at the under-bump metallization (UBM) interfaces, originating at the bump undercut and propagating towards the bump center. This leads to a dramatic 26.7% reduction in mechanical shear strength, significantly compromising the reliability. The failure mechanism of Au bump was analyzed through the combination of characterization and simulation, which identifies a stress-induced and halogen-enhanced galvanic cell corrosion at the UBM interfaces as the root cause. Furthermore, a protective surface coating strategy involving self-assembled monolayer notably improves bump corrosion resistance, as demonstrated by the absence of strength degradation and interfacial delamination after 500-hour accelerated THT test. These insights are pivotal for advancing reliable, high-performance optoelectronic packaging.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2025
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IF 6.6
Qi Sun,Miaomiao Ma,Zhijuan Li,Xiang Chen,Jian Zeng,Meiqi Huang,Yuting Yin,Xueyan Ran,Jianmei Li,Tao Le
Zearalenone (ZEN) poses significant threats to food safety and human health due to its widespread contamination in cereals. Current detection methods face limitations in cost, complexity, and field applicability. To address this, we developed a novel colorimetric aptasensor leveraging the peroxidase-like activity of Au/CoOOH nanozymes for rapid and sensitive ZEN detection. Systematic characterization of cobalt-based nanomaterials (β-Co(OH) 2 , Co 3 O 4 , CoOOH, and Au/CoOOH) revealed that Au/CoOOH exhibited the highest catalytic efficiency, achieving a 3.5-fold enhancement over CoOOH due to synergistic interactions with Au nanoparticles. The aptasensor employed a competitive displacement strategy: ZEN binding to aptamer-functionalized magnetic beads released cDNA-conjugated Au/CoOOH, reducing 3,3′,5,5′-tetramethylbenzidine oxidation signals. Optimized parameters enabled a linear detection range of 0.3–500 ng/mL with a detection limit of 0.23 ng/mL. Specificity tests confirmed minimal cross-reactivity with other mycotoxins. The sensor demonstrated exceptional sensitivity, specificity, and practicality, validated by recovery rates of 90.65–105.63 % in spiked matrices, positioning it as a reliable tool for safeguarding food safety through rapid, precise mycotoxin monitoring.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2024
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IF 8.1
Guoping Yu,Binglin Tang,Qingcheng Luo,Huanyu Chen,Zhe Yin,Zhichao Zhang,Ziwen Wang,Bo Lv,Shaoyun Shan
Powdered titanium dioxide (TiO 2 ) photocatalysts are widely used in the photodecomposition of water for H 2 production due to their low cost, and high stabilizing activity under UV light . However, it has encountered great challenges in photocatalytic reactions, such as easy aggregation and being difficult to recycle. To solve these problems, we proposed a hydrogel (HY) composite material. The material Au@TiO 2 /HY was created by mixing HY with TiO 2 supported co-catalyst Au nanoparticles (NPs). The results show that Au@TiO 2 /HY is difficult to spread owing to its block shape in the photocatalytic reaction, the H 2 evolution rate is only 4.59 mmol/g/h. Therefore, on account of the fact that hydrogel microspheres (HYM) can enhance performance, Au@TiO 2 /HYM was self-assembled by mechanical methods on the synthesis scheme of Au@TiO 2 /HY, which improves the Ultraviolet and visible (UV–vis) light absorption range. The H 2 evolution rate of Au@TiO 2 /HYM is 17.08 mmol/g/h, which is ∼3.7-fold higher than that of Au@TiO 2 /HY (4.59 mmol/g/h), according to the data. The mechanism studies demonstrate that the HYM improve the UV–vis light absorption range and promote the separation of photogenerated electron-hole pairs in Au@TiO 2 /HYM during photocatalysis compared to typical bulk HY, thus improving the photocatalytic H 2 evolution activity. The results provide a reference for the preparation of recyclable HYM for photocatalytic H 2 production.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Chang Liu,Qinghan Wang,Peng Chen,Kaige Sun,Jianbo Li,Luis A. Cisternas,Shaoxian Song,Feifei Jia
MoS 2 materials performed well as adsorbent for Au(S 2 O 3 ) 2 3- recovery, but the effect of its crystal facets on recovery behavior and mechanism remained unclear. In this study, flower-shaped MoS 2 with exposed (110) facet and flake-shaped MoS 2 with (002) exposed facet have been synthesized through a simple hydrothermal method, and their recovery performance and mechanism for gold from Au(S 2 O 3 ) 2 3- solution were explored. The results indicated that MoS 2 materials could recover Au(S 2 O 3 ) 2 3- via adsorption and photocatalytic reduction. Importantly, MoS 2 materials with different exposed facets displayed crystal anisotropy, which greatly affected the recovery behavior of Au(S 2 O 3 ) 2 3- . Flake-shaped MoS 2 showed better dispersibility because of stronger surface electronegativity, and flower-shaped MoS 2 displayed better photocatalysis property thanks to more activated edge sites. The better dispersibility made flake-shaped MoS 2 have higher contact probability to Au(S 2 O 3 ) 2 3- molecules, resulting in faster recovery rate as well as higher recovery for Au(S 2 O 3 ) 2 3- with low concentration. Meanwhile, flower-shaped MoS 2 with better photocatalysis property could release more photogenerated electrons, so that achieving more excellent recovery for Au(S 2 O 3 ) 2 3- with high concentration. The finding in this study enhanced the understanding about the effect of MoS 2 facets on Au(S 2 O 3 ) 2 3- recovery, which had great significance for the design of MoS 2 structure and green production of gold in the future.
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Journal of Materials Chemistry C
·
2024
·Vol. 12
·期 26
·9652-9661
·
IF 5.7
Ling Zhang,Jie Yang,Junchao Yang,Jianan Wei,Chuan Zhou,Jiang Zhao,Qibin Huang
The fabrication of gas-sensing devices with high sensitivity and low limit of detection (LOD) for monitoring chemical warfare agents and their simulants is of great importance. Metal oxide-based semiconducting nanomaterials and their heterojunctions hold great promise in chemiresistive gas sensing. However, the demands of high working temperature, integration on interdigitated electrodes (IDEs) and requirement of additional heaters impede their popularity. This work demonstrates in situ laser-assisted preparation of Au-decorated laser-induced graphene (LIG/Au) hetero-material as a flexible and effective near-room-temperature 2-chloroethyl ethyl sulfide (2-CEES) sensor. The structure of the sensor was simplified via omitting the IDE and an additional heating module. After optimizing the concentration of the HAuCl4 precursor solution and power of secondary scribing, the LIG/Au-0.1 M gas sensor exhibited an enhanced response of 7.85‰ to 1.0 ppm 2-CEES, which is twice that of pure LIG. Furthermore, its LOD was as low as 5.8 ppb. The sensing mechanism analysis revealed that the decoration of Au nanoparticles enriched the active sites of LIG/Au-0.1 M and provided catalytic and sensitization effects. The present study not only provides an appealing 2-CEES gas sensor but also demonstrates an effective method for large-scale fabrication of other high-performance sensing devices.
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ANALYTICA CHIMICA ACTA
·
2025
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IF 6
Xing Zhong,Hezheng Zhan,Xiao Wang,Min Zhang,Shoushan Wang,Meili Zhang,Faliang Cheng,Peng Liu
Background Surface-enhanced Raman spectroscopy (SERS) substrates have undergone extensive development over the years, yet the challenge of significantly enhancing their sensitivity persists. Most existing substrates face considerable difficulties in obtaining the strongest electromagnetic coupling to maximize SERS signal intensity, i.e., it is hard to achieve optimal structural parameters such as the gap width and particle size, and to fabricate surfaces that are free from contamination such as surfactants. Therefore, there is a pressing need for a substrate optimization approach that allows for in-situ monitoring and real-time dynamic adjustments to precisely achieve the ideal substrate characteristics for superior performance. Results In this study, a highly sensitive porous copper-gold (Cu–Au) SERS substrate was fabricated using the galvanic replacement reaction (GRR), coupled with in-situ SERS monitoring to optimize substrate preparation. The Cu–Au nanoparticles formed and grew on sacrificial templates while noble metal ions were reduced by the sacrificial metal during GRR. The substrate preparation process revealed that the optimal preparation time was 200 ± 20 s. The SERS performance with crystal violet (CV) as a probe molecule demonstrated the substrate's remarkable sensitivity with detecting concentrations as low as 10 −16 M, which surpasses most literature reports. The optimized SERS substrate was further tested for detecting malachite green (MG), yielding an ultra-high enhancement factor (EF) of 8.96 × 10 14 . The entire optimization process did not involve the addition of aggregation or surfactant agents, ensuring a clean substrate surface. Significance and novelty This study is a further proof of the significance of the in-situ optimization of SERS substrates via GRR which allows real-time adjustment of nanoparticle size and gap width to enhance sensitivity. This approach has enabled us to develop substrates with exceptional sensitivity and reproducibility. These significant contributions may open up new avenues for the facile fabrication of ultrasensitive SERS substrates.
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