CARBOHYDRATE POLYMERS
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2023
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IF 11.2
Yong Zhang,Bingyu Mei,Binhao Shen,Lingyi Jia,Jun Liao,Wenkun Zhu
A novel chitosan-based composite with rich active sites was synthesized by uniformly dispersing biochar into the cross-linked network structure formed by chitosan and polyethyleneimine . Due to the synergistic effect of biochar (minerals) and chitosan-polyethyleneimine interpenetrating network (amino and hydroxyl), the chitosan-based composite possessed an excellent adsorption performance for uranium(VI). It could rapidly (<60 min) achieve a high adsorption efficiency (96.7 %) for uranium(VI) from water and a high static saturated adsorption capacity (633.4 mg/g), which was far superior to other chitosan-based adsorbents. Moreover, the separation for uranium(VI) on the chitosan-based composite was suitable for a variety of actual water environments and the adsorption efficiencies all exceeded 70 % in different water bodies. The soluble uranium(VI) could be completely removed by the chitosan-based composite in the continuous adsorption process, which could meet the permissible limits of the World Health Organization. In sum, the novel chitosan-based composite could overcome the bottleneck of current chitosan-based adsorption materials and become a potential adsorbent for the remediation of actual uranium(VI) contaminated wastewater.
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Catalysis Science & Technology
·
2023
·Vol. 13
·期 4
·1128-1139
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IF 5
Peijing Guo,Shaoyu Yuan,Bingrong Guo,Siwei Li,Yongjun Gao
A CoO–CdS heterostructured photocatalyst CC-2-300 loaded with carbon derived from the biomass material chitosan was synthesized. Under visible-light irradiation, the photocatalytic hydrogen evolution rate can reach up to 10.60 mmol gcat−1 h−1, which is 7.21 times higher than that of pure CdS under the same conditions, with good cycle stability and high apparent quantum efficiency. The control experiments and characterization results prove that the chitosan-derived carbon supported CoO nanorods and CdS nanoparticles are cross-distributed to form a direct Z-scheme heterojunction, which improves the migration efficiency of photogenerated carriers and effectively slows down the recombination rate of photogenerated charges and holes on CdS that is susceptible to photocorrosion, thus improving the efficiency of photocatalytic hydrogen evolution.
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PROGRESS IN ORGANIC COATINGS
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2019
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IF 3.42
Bingyang Lu,Dan Luo,Ansha Zhao,Haohao Wang,Yuancong Zhao,Manfred F. Maitz,Ping Yang,Nan Huang
Environmentally responsive polymer films have received much attention, but the stability of such films and the sensitivity of the response still have to be improved. The preparation of responsive films for low pH changes still faces challenges. In this study, catechol groups were used to functionalize chitosan and hyaluronic acid for mussel-inspired, catechol based adhesion. The modified chitosan and the modified hyaluronic acid were deposited in a layer-by-layer manner. The chemical properties of the compounds and surface properties of the coatings were characterized by UV, IR, scanning electron microscopy and water contact angles. The assembly and stability of the film were investigated in situ using quartz crystal microbalance (QCM-D). The film had improved stability compared to the native polymers and it showed reversible pH-dependent swelling and shrinkage. The film was loaded with a drug and placed in PBS solutions of different pH for several days, and the amount of drug released by the drug-loaded film was different under different pH environments. This provides ideas for the intelligent application in materials science and biology, and has broad prospects in drug delivery systems and tissue engineering.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2019
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IF 4.784
Jibo Dou,Defu Gan,Qiang Huang,Meiying Liu,Junyu Chen,Fengjie Deng,Xiaoli Zhu,Yuanqing Wen,Xiaoyong Zhang,Yen Wei
In this work, we reported a novel “one-pot” strategy for preparation of chitosan-coated carbon nanotubes (CNTs) composites via a combination of Diels-Alder (DA) reaction and mercaptoacetic acid locking imine (MALI) reaction for the first time. To evaluate the adsorption characteristics, the as-prepared samples were applied to remove copper ions (Cu 2+ ) from aqueous solution. The effects of contact time, solution pH, temperature and initial Cu 2+ concentration on the adsorption of Cu 2+ onto the as-prepared samples were investigated. The chitosan modified CNTs composites showed high affinity and fast kinetics for the adsorption of Cu 2+ ions, and adsorption capacity of the composites was found to be 2 times that of pristine CNTs. Adsorption kinetics and thermodynamic indicated a spontaneous and endothermic nature of the adsorption of Cu 2+ on the surface of chitosan-coated CNTs composites, kinetically obeyed the pseudo-second-order model. Equilibrium data could be best described by the Langmuir isotherm model, with a maximum monolayer adsorption capacity of 115.84 mg/g. In view of the extensive applicability of DA chemistry and MALI reaction, different carbon nanomaterials based composites with various functional groups could be fabricated and applicable to different fields such as environmental catalysis and biomedicine .
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Journal of Nanomaterials
·
2019
·
IF 2.233
Xiaojuan Zhang,Wenbin Cai,Lingyun Hao,Wei Zhang
This study synthesized poly(vinyl alcohol)/carboxymethyl chitosan/cyanidin (PVA/CMCS/CY) hydrogel films. First, PVA and CMCS were used to synthesize hydrogel films by ultraviolet irradiation. Meanwhile, CY was in situ combined into the hydrogel films through the electrostatic attraction between CMCS and CY. Next, the products were analyzed using Fourier-transform infrared spectroscopy, scanning electron microscopy, contact angle test, swelling analysis, and mechanical property test. The results revealed that compared with PVA/CMCS hydrogel films, the PVA/CMCS/CY hydrogel films had an interporous structure and good swelling and mechanical properties. Moreover, the drug release experiments demonstrated that the PVA/CMCS/CY hydrogel films had a CY encapsulation efficiency of 33.5% with a sustained CY release of up to 60 h. Furthermore, the examined antibacterial activities against Staphylococcus aureus and Escherichia coli showed that the porous PVA/CMCS/CY hydrogel films exhibited a certain inhibition. Cell viability experiments demonstrated that the PVA/CMCS/CY films displayed no obvious cytotoxicity to human umbilical vein endothelial cells.
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CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Hu Tu,Guomin Wu,Yang Yi,Mengtian Huang,Rong Liu,Xiaowen Shi,Hongbing Deng
Novel antimicrobials with well biocompatibility are urgently needed for human public health protecting. Here, the silk fibroin (SF) nanofibrous mats coated with carboxymethyl chitosan (CMC), both extracted from natural polymers, were fabricated by combining electrospinning and electrostatic layer-by-layer (LBL) self-assembly techniques. The amphoteric CMC could be easily adsorbed on the surface of SF nanofibers due to the electrostatic interaction, which were a highly efficient and “green” route for the surface modification of SF mats. The mats after LBL procedure exhibited better hydrophilicity and stronger mechanical properties. The experimental results demonstrated that the LBL modified mats not only kept well biocompatibility but also obtained extremely enhanced antibacterial activity. More importantly, the mats displayed better bacterial inhibition with the increased CMC layers. LBL 10 and LBL 10.5 owned the antibacterial activity of more than 67% at the bacterial concentrations of 10 6 cfu ml −1 after 24 h cultivation, which implied that these novel natural polymer-based materials could be utilized as wound dressings for clinical skin and tissue regeneration, especially for infected wounds.
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Clinical Implant Dentistry and Related Research
·
2019
·Vol. 21
·期 2
·324-335
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IF 3.212
Xiaoxiao Cao,Xinjie Cai,Ruiying Chen,Huimei Zhang,Tao Jiang,Yining Wang
Background Mechanical and biological complications associated with implant systems happen frequently in the clinic. Purpose To develop a chitosan (CS)-based thermosensitive hydrogel for sealing and lubricating purposes in dental implant system. Materials and Methods In this study, a thermosensitive hydrogel made up of CS, β-glycerophosphate pentahydrate (β-GP), and povidone-iodine (PVP-I), called CS/β-GP/PVP-I thermosensitive hydrogel, was fabricated. Three experimental groups with different volume ratios of CS to β-GP were prepared, namely 16/4, 13/7, and 10/10 groups. The surface topography of the different groups and their physicochemical characteristics were examined by SEM, FTIR, and X-ray diffraction analysis. The cytotoxicity of the hydrogel was examined by CCK-8 test. In vitro antibacterial efficiency was analyzed by the spread plate method. Sealing ability was detected by incubating two-piece implants in Escherichia coli suspension. Lubricating ability of the hydrogel was evaluated by the removal torque test with a calibrated digital torque meter. Results The CS/β-GP/PVP-I thermosensitive hydrogel was fabricated and showed a highly porous structure under SEM. An in vitro cytotoxicity test demonstrated that 13/7 group displayed no cytotoxicity. Furthermore, all three groups showed obviously antibacterial effects. In the sealing ability test, 16/4 group showed the best sealing ability. The removal torque of 16/4 group and 13/7 group was significantly greater than control group. Conclusions Based on our findings, it could be concluded that the thermosensitive and antibacterial CS/β-GP/PVP-I hydrogel with sealing and lubricating ability was successfully prepared. The hydrogel had better sealing and lubricating effects when the volume ratio of CS to β-GP was 16/4.
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CHEMICAL ENGINEERING SCIENCE
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2019
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IF 3.372
Haiyan Zhang,Chunjie Liu,Liang Chen,Bin Dai
We presented an improved preparation method to generate cryogels with controllable pore size. It included 5 stages: pre-cooling, pre-crystallization, crystal growth, freezing, and thawing (PPCFT); crystal growth was the key step. Chitosan (CS) cryogels with uniform and honeycomb-like structures were prepared with the method, and then the properties of these cryogels were studied. The results demonstrated that the mean pore diameters of CS cryogels were successfully controlled in a wide range (approximately 60–240 μm, by scanning electron microscope) by simply varying the temperature and time of crystal growth. The crystal growth law of this process was described by an empirical equation based on the classical theory for Ostwald ripening by Lifshitz, Slyozov, and Wagner (LSW). Furthermore, the hydrodynamics performance (permeability and column efficiency) of CS cryogel columns clearly varied with crystal growth conditions, while both the accessible porosity and water absorption ratio remained at a high level.
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
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2019
·Vol. 35
·期 3
·504-508
·
IF 1.071
Cao Jing,Wang Miao,Chen Weihua,She Yongxin,Wang Jing,Wang Fengzhong,Lao Shuibing
A novel artificial esterase based on chitosan and amino acids was synthesized in the present study. The Fmoc-His and Glu were linked to chitosan by active ester method(AEM). The hydroxide radical in chitosan, imidazole group of Fmoc-His and carboxyl from Glu formed a catalytic center of natural esterase. Gel microspheres were coated with a protective layer and a supporting layer by self-assembly construction function in carboxymethylcellulose sodium(CMCS) solution. As for catalytic activity, chitosan-His-Glu was found to be more efficient than chitosan- His and chitosan-Glu in mimicking the core catalytic sites of natural esterase, and the best ratio(mass ratio) of chitosan-His-Glu:CMCS was 1:3. Furthermore, metal ions, such as Ca 2+ , Mg 2+ , Fe 2+ , etc., were able to improve the catalytic efficiency of artificial esterase. And the Lineweaver-Burk plot indicated that the catalytic kinetics of artificial esterase conformed to Michaelis-Menten equation.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Lili Chen,Yuanyuan Zheng,Longbao Feng,Zonghua Liu,Rui Guo,Yuanming Zhang
The aim of this work was to examine the formation and properties of a novel polyelectrolyte complex of drug carrier system for the delivery of doxorubicin (DOX), which consists of hyaluronic acid (HA) coated hydrophobically modified chitosan (CS). Various batches of polyelectrolyte complexes with the molar ratio of deoxycholic acid (DCA) and chitosan (CS) of 0.1, 0.2, 0.3 were prepared, and were termed as CS-DCA 10 , CS-DCA 20 , and CS-DCA 30 respectively. The samples were characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), Transmission electron microscopy (TEM), nuclear magnetic resonance hydrogen spectrum ( 1 H NMR) and dynamic light scattering (DLS). Particle sizes of synthesized polyelectrolyte complex nanoparticles (PCNs) were found to be in the range of 280–310 nm, larger than those of uncoated nanoparticles (~150 nm). The PCNs have large zeta potentials (about 26 mV) which make them stable and no sizes' change was determined. DOX could be easily incorporated into the PCNs with encapsulation efficiency (56%) and kept a sustained release manner without burst effect when exposed to PBS (pH 7.4) at 37 °C. Overall, these findings confirmed the potential of these PCNs for drug carrier and prolonged and sustained delivery in the bloodstream.
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FOOD AND CHEMICAL TOXICOLOGY
·
2019
·
IF 3.775
Mingjing Zheng,Suzhen Lei,Hongqiang Wu,Baodong Zheng,Yi Zhang,Hongliang Zeng
The effect of chitosan (CS) on the in vitro digestibility and molecular structural properties of lotus seed starch (LS), and the correlation matrix was studied. The addition of CS could delay the hydrolysis of LS due to a increased level of slowly digestible starch (SDS). LS-CS blends exhibited lower pasting viscosity, greater amylose content and higher ordered structure than LS alone. A significant correlation was found between the digestibility and molecular structural properties of LS-CS blends. Rapidly digestible starch content was positively correlated with viscosity and full width at half-maximum height (FWHH) at 480 cm −1 ; whereas, SDS content was negatively correlated with setback and FWHH. Moreover, CS concentration was positively related to absorbances at 1047 and 1035 cm −1 and amylose content. The results indicated that the addition of CS could be beneficial to the formation of an ordered molecular structure in LS-CS blends and decreased digestibility in vitro .
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Shuting Li,Liefeng Hu,Dapeng Li,Xin Wang,Panpan Zhang,Jun Wang,Guoqing Yan,Rupei Tang
This work described the preparation of two type nanogels based on the crosslinking between carboxymethyl chitosan (CMCS) and two different crosslink agents, an acid-labile cyclic ortho ester compound with dual epoxy end groups (OEDe) or corresponding non-sensitive ethyleneglycol diglycidyl ether (EGDE). The particle size, zeta potential, and micromorphology were characterized by dynamic light scattering and electron microscopy, respectively. Nanogels' stability was also investigated at physiological environments. Doxorubicin hydrochloride as a therapeutic drug model was efficiently embedded into nanogels. The pH-triggered size changing, degradation and drug release were then investigated at three different pH values. Cellular uptake and cytotoxicity evaluation demonstrated that NG1/DOX could be successfully degraded and efficiently release DOX in acid cell organelles, leading to higher cytotoxicity than NG2/DOX. The accumulation and penetration of these DOX-loaded nanogel were then investigated by tumor-like multicellular spheroids (MCTS). The results indicated that the acid-degradable nanogels can deliver more DOX into the inner of MCTS by the hydrolysis of ortho ester bonds, thus efficiently inhibit the growth of MCTS. All results suggested that the acid-degradable nanogels could be degraded in mildly acidic conditions and remain stable at physiological environment, which indicated that the acid-degradable nanogels would be potentially useful as drug carriers.
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