JOURNAL OF CHROMATOGRAPHY A
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2026
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IF 4
Xuanyu Liu,Birong Jia,Xuehai Jiang,Yihan Zhao,Lei Sui,Na Zhou,Yi Bi,Lingxin Chen,Zhihua Song
F-ILs-CDs-SiO 2 stationary phases were modified with fluorinated ILs and CDs. • Superior selectivity of F-ILs and versatile interactions of CDs were combined. • Exhibiting mixed-mode retention mechanism including RPLC and HILIC. • Demonstrating remarkable separation performance toward highly polar analytes. • Performances of F-ILs-CDs-SiO 2 were superior to some commercial stationary phases. Multifunctional stationary phases are highly desirable for high-performance liquid chromatographic separations. Stationary phases functionalized with fluorine (F), ionic liquids (ILs), and carbon dots (CDs) have exhibited remarkable separation performance toward highly polar analytes. Herein, a silica stationary phase co-modified with fluorinated ILs and CDs (denoted F-ILs-CDs-SiO 2 ) was synthesized, comprehensively characterized, and systematically evaluated for polar analytes separation. This composite material integrates the superior selectivity of fluorinated ILs, versatile intermolecular interactions endowed by CDs, and fast mass transfer kinetics inherent to silica microspheres, enabling efficient separation of polar compounds. The chromatographic retention performance of the F-ILs-CDs-SiO 2 packed column was benchmarked against reference columns including F-ILs-SiO 2 , commercial amino-bonded silica, diol-bonded silica, C18 silica, and pentafluorophenyl (PFP) silica. The F-ILs-CDs-SiO 2 column delivered outstanding resolution and high column efficiency for multiple target analytes, namely nucleosides, ginsenosides, organofluorine pesticides, and sulfonamides. A Tanaka test and mobile phase optimization experiments were subsequently performed, verifying that F-ILs-CDs-SiO 2 operates via a mixed-mode retention mechanism combining reversed-phase liquid chromatography (RPLC) and hydrophilic interaction liquid chromatography (HILIC). The as-prepared F-ILs-CDs-SiO 2 column possesses acceptable run-to-run repeatability, long-term stability, and batch-to-batch reproducibility. Then, the F-ILs-CDs-SiO 2 column was successfully applied to the separation and quantitative analysis of ginsenoside Rg1 in rat plasma, demonstrating promising practical applicability. Collectively, the experimental results confirm that the synergistic F-ILs-CDs composite modification substantially enhances the overall separation capacity of silica substrates. This straightforward fabrication strategy and systematic performance assessment of the F-ILs-CDs-SiO 2 stationary phase offer a promising avenue for the combined utilization of fluorinated ILs and CDs as advanced chromatographic separation media. Download: Download high-res image (200KB) Download: Download full-size image
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高影响因子
POLYMER
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2026
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IF 5.1
Siran Qiu,Fei Jin,Shenghua Zhou,Qiong Wu,Hongliang Ge,Ying Wang
Ionic liquids regulate the hydrogen-bonding structure of WPU hard segments. • The fabricated film and fiber temperature sensors exhibit −2.25%/°C and −2.21%/°C. • Ion-migration conduction makes the sensor pressure-insensitive. • The sensors are practical for breath monitoring, thermal-tactile, and body temperature. Flexible temperature sensors with high sensitivity and good mechanical stability are of great significance in wearable medical and human-computer interaction fields. However, traditional thermistors are usually limited by the strong cross-sensitivity between temperature and mechanical strain. To solve this problem, this paper proposes a molecular engineering strategy based on ionic liquid-modified water-based polyurethane (WPU). By introducing ionic liquids as a structural regulator between the WPU chain segments, this strategy purposefully inhibits the excessive aggregation of the hard segments. The resulting material not only exhibits a resistance temperature coefficient (TCR) as high as −2.25% °C −1 , corresponding to a temperature resolution of 0.2 °C, while also possessing excellent anti-mechanical load pressure sensitivity due to the ionic migration−based conductive mechanism. Moreover, by directly coating the thermosensitive layer onto natural silk fibers, a fiber temperature sensor was successfully constructed, with a TCR remaining stable at −2.21% °C −1 , significantly enhancing the wearable and system integration capabilities. This temperature-sensitive material demonstrates outstanding practical value in various application scenarios such as respiratory monitoring, thermal stimulus recognition, touch-based human-computer interaction, and body temperature monitoring. This schematic systematically illustrates the molecular design, device fabrication, and temperature-sensing application logic of ionic-liquid-modified waterborne polyurethane ionogels. The enlarged left panel shows the polymer network with abundant hydrogen-bonding interactions. Based on this material, flexible film sensors can be fabricated, and they can be further extended to fiber sensors via a coating process. The resistance-temperature response curves in the upper right part demonstrate that both types of devices exhibit excellent negative temperature coefficient (NTC) characteristics. The film and fiber sensors achieve TCR values of −2.25% °C −1 and −2.21% °C −1 , respectively. The inset simultaneously verifies their high temperature resolution and robust resistance to pressure interference. The lower right part illustrates that the flexible film/fiber temperature sensors can conformally attach to human skin for real-time body temperature monitoring, highlighting their promising potential in wearable thermosensing applications. Download: Download high-res image (268KB) Download: Download full-size image
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高影响因子
LANGMUIR
·
2025
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IF 3.9
Chun Zhao,Gangqiang Tang,Shilong Liu,Xin Zhao,Dong Mei,Yanjie Wang
Ionic polymer sensors (IPS) can replicate the topological structures of human skin based on the ion migration mechanism, which has great application potential in the fields of medical monitoring and electronic skins. The existing piezoelectric IPS are usually prepared through chemical methods and utilize cations and water as the electrolyte, which has two challenges: a slow preparation process and solvent volatilization. In this article, we proposed a fast method to prepare piezoelectric IPS by integrating spraying and electrodepositing Au processes. Meanwhile, the method of heating in ionic liquid solution was adopted to effectively enhance the long-term stability of IPS. Compared with the traditional IPS based on Na+, the sensitivity of the prepared IPS to humidity was decreased by 1531%, increasing the environmental stability. Besides, the signal amplitude of the prepared IPS showed no decay caused by the volatilization of the electrolyte during 12 days of exposure, exhibiting excellent long-time stability. Moreover, the prepared IPS was integrated into a wearable sensing glove, which realized the functions of gesture recognition, pulse measurement, and grip force monitoring and showed good application potential in the field of wearable sensing.
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PubMed
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
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2025
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IF 3.7
Mi Wang,Tianqi Liu,Hao Wang,Zhenyuan Wang,Jiaheng Zhang
Graphical This study presents a sustainable supramolecular system composed of naturally derived ingredients: PE, AHP8, and a bioactive ionic liquid from betaine and MA, which offers multiple anti-aging benefits while promoting skin permeability. The growing demand for safe and sustainable cosmetics has led to a marked inclination toward natural extracts and peptides as raw materials. In this study, we developed a sustainable system with multiple antiaging effects by combining peony extract (PE) and acetyl hexapeptide-8 (AHP8) to simultaneously treat static and dynamic wrinkles, as well as skin dullness. As the poor skin permeability of AHP8 limited its efficacy, we used a bioactive ionic liquid derived from betaine and malic acid (MA) ([Bet][MA]) as a permeation enhancer. In vitro and in vivo zebrafish experiments indicated that [Bet][MA] not only significantly enhances transdermal and cellular penetration, but also exerts synergistic anti-aging effects. While being biosafe, [Bet][MA] significantly increased the transdermal permeation, skin retention, and cellular uptake of AHP8. Theoretical calculations revealed that [Bet][MA] improved the anti-wrinkle and whitening efficacies of AHP8 and PE through supramolecular interactions; it modulated their electron cloud distribution and molecular polarity and thus intensified their affinity to target proteins. The supramolecular PE/AHP8/[Bet][MA] system demonstrated excellent radical- and reactive oxygen species-scavenging capability, collagen production, and tissue repair capability while concurrently inhibiting tyrosinase activity, motion signaling, and inflammation. The study findings pave the way for sustainable and multifunctional skincare solutions.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Yingyao He,Jianqiang Wang,Jie Gao,Waifen Yong,Shenghua Zhou,Haibo Lin,Qiu Han,Fu Liu
Hard water softening by removing multivalent cations such as calcium (Ca 2+ ) and magnesium (Mg 2+ ) remain challenging for nanofiltration (NF) membranes due to the trade-off between membrane permeability and selectivity. In this study, chelation ionic liquid ([NH 4 ] [P204]) was synthesized to modify the polyamide selective layer of thin film composite (TFC) NF membranes. This modification enhanced ion rejection of membranes through synergistic effects of size sieving and electrostatic interactions without much compromising the water flux. The optimal membrane NF-ILs-2.0 wt% achieved rejection rates of 95.1 % and 92.5 % for Mg 2+ and Ca 2+ , respectively, alongside a stable water flux of 36.0 LMH. Density functional theory (DFT) calculations and molecular dynamics (MD) simulations revealed the effectiveness of the membranes in removal hardness and strong coordination interactions between [NH 4 ] [P204] and the cations. The novel ionic liquid functions as a promising modifier for-developing advanced NF membranes with enhanced simplicity, efficiency and durability for water treatments.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Xiaojun Li,Tingting Wang,Jingyu Shang,Lei Dong,Junjie Wu,Tuo Ji,Jiahua Zhu,Lilong Zhang,Liwen Mu,Xiaohua Lu,Han Lin
Graphene oxide (GO) lamellar membranes hold significant promise for gas separation but suffer from structural instability, particularly under high temperature, which deteriorates their separation performance. To address this, we developed a composite membrane by incorporating exfoliated boron nitride (BN) nanosheets into a GO matrix, followed by ionic liquid (IL) intercalation. Liquid nitrogen (LN 2 )-exfoliated BN nanosheets, characterized by uniformity and rigidity, were integrated to construct stable interlayer nanochannels. The resulting GO/BN-LN 2 membrane achieved a H 2 /CO 2 selectivity of 15.5 with a H 2 permeance of 505 GPU (gas permeation unit). More importantly, the intercalation of ILs (e.g., [Bmim][TF 2 N]) into the GO/BN interlayers yielded a synergistic enhancement. The ILs functioned as a selective CO 2 -absorbing layer and a “thermal buffer”, significantly improving the membrane's thermal stability. Consequently, the optimized GO/BN@IL composite membrane (d-spacing is 7.9 Å, and membrane thickness is 0.88 μm) maintained excellent performance at 363 K, exhibiting a markedly enhanced H 2 /CO 2 selectivity of 23.26 and a high H 2 permeance of 1020 GPU. This work demonstrates a facile strategy to simultaneously boost the selectivity, permeance, and thermal resilience of 2D lamellar membranes, showcasing their great potential for high-temperature H 2 purification applications.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Shaoping Ma,Changyong Cai,Zhijian Tan
The extraction of ingredients from complex extracts and separation of structurally similar compounds remains significantly challenging. In this study, double-layered Janus microgel particles based on poly(ionic liquids) were prepared, which consisted of a hydrophobic organic-solvent-gel core and a hydrophilic hydrogel shell, poly( N -isopropylacrylamide. The double-layered structure was confirmed using various characterization methods, and subsequent experiments confirmed the enhanced separation and enrichment of tanshinone homologs from the extract. A maximum adsorption capacity of 30 mg/g and adsorption selectivity of 31.56 were obtained under the optimal conditions. Molecular dynamics simulations revealed the potential mechanisms for the separation of different compounds through the unique structure of the microgel particles. The adsorption of flavonoids demonstrates that this double-layered structure has a universal enrichment effect. In conclusion, this double-layered microgel structure exhibited enhanced performance in the extraction and separation of tanshinone homologs, and has great potential for the separation of other active compounds.
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高影响因子
GREEN CHEMISTRY
·
2022
·Vol. 25
·期 4
·1597-1610
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IF 11.034
Xiaoyu Wang,Wenqiu Zheng,Zongwei Guo,Haq Nawaz,Tingting You,Xin Li,Feng Xu
The preparation of regenerated cellulose (RC) materials with high performance via dissolution processing is dependent on the properties of the cellulose solution and the conditions of the coagulation bath. Herein, a novel sustainable superbase-derived ionic liquid (SIL, [DBUH][CH3CH2OCH2COO]) with excellent solubility (14.83 wt% at 80 °C) for dissolving wood pulp (DWP; DP = 526) is demonstrated. The rheological characteristics of DWP/[DBUH][CH3CH2OCH2COO] solutions and the regeneration process of cellulose were first systematically investigated. The results indicated that the DWP concentration significantly affected the apparent viscosity (η), structural viscosity index (Δη), overlap concentration (c*), entanglement concentration (ce), storage modulus (G′), and loss modulus (G′′). Notably, a 12 wt% DWP solution possessed favourable temperature-sensitive properties with an activation energy (Eη) of 55.428 kJ mol−1 and a gel–sol transition temperature of 59.5 °C, presenting superior viscoelasticity to that of imidazolium-based ILs/cellulose in fibre spinning. Moreover, these properties of DWP solutions offered essential advantages for the subsequent preparation of RC films. Comparing the properties of RC films prepared in various coagulation baths, cellulose films regenerated from ethanol exhibited high transparency (up to 90% at 800 nm) and outstanding mechanical properties (tensile strength: 120 MPa; elongation at break: 12%). In this regard, it was inferred that the diffusion rates between [DBUH][CH3CH2OCH2COO] and ethanol contributed to the construction of RC films with high crystallinity and a dense morphology. Hence, [DBUH][CH3CH2OCH2COO] as a solvent and ethanol as a coagulation bath can be a promising processing platform for manufacturing high-performance cellulose materials.
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高影响因子
Journal of Environmental Chemical Engineering
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2022
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IF 7.968
Yuehan Wang,Yujie Zhang,Ning Cai,Juanqin Xue
Recently, capacitance deionization (CDI) has attracted much attention as an energy-saving and high-efficiency wastewater treatment technology , in which electrode materials play a significant role. In this work, ionic liquid (1-ethyl-3-methylimidazole tetrafluoroborate)-doped composite electrode materials (PPy- IL /CS/CNT) were prepared by electrochemical deposition and applied in the heavy metal ions wastewater adsorption. Compared with PPy/CS/CNT, PPy -IL /CS/CNT has improved the specific capacitance (358.76 F/g) and specific surface (79.99 m 2 /g) because of the doping of IL, which substantially improves the agglomeration phenomenon in the morphology. After 1000 cycles of CV, the specific capacitance decay is only 13.51%, which shows that the prepared material has excellent cycling stability. The adsorption of PPy -IL /CS/CNT can reach 35.84 mg/g for 100 mg/L Cu 2+ solution, which is nearly 2 times as much as PPy/CS/CNT, in addition, the adsorption of Ag + (26.43 mg/g) and Fe 3+ (37.82 mg/g) by PPy -IL /CS/CNT is also pretty impressive. Therefore, this study presents an effective basis and new sight into the industrialization of CDI technology for the treatment of heavy metal ion wastewater.
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高影响因子
Catalysis Science & Technology
·
2022
·Vol. 12
·期 21
·6405-6415
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IF 6.177
Zou Bin,Feng Ting,Yan Yan,Liu Feng,Onyinye Adesanya Idowu,Suo Hongbo
A lipase from Candida rugosa (CRL) is an efficient enzyme for phytosterol esterification. However, its poor stability limits its application. A novel cross-linked enzyme aggregate of CRL (CRL-FIL-CLEAs@Fe3O4) was designed by lipase surface modification with a functional ionic liquid (FIL) and immobilization with magnetic Fe3O4 nanoparticles as carriers simultaneously. The loading of CRL was 0.16 mg protein per mg CRL-FIL-CLEAs@Fe3O4. The hydrolysis expressed activity of CRL-FIL-CLEAs@Fe3O4 was 1.36 ± 0.04 U per mg CRL-FIL-CLEAs@Fe3O4. The hydrolysis specific activity of CRL-FIL-CLEAs@Fe3O4 (8.48 ± 0.25 U per mg protein) was significantly higher than that of conventional CRL-CLEAs (2.86 ± 0.26 U per mg protein). After 15 days of storage at room temperature, CRL-FIL-CLEAs@Fe3O4 exhibited 2.6 times higher activity (73.31%) than free lipases (28.52%). After eleven times of reuse, CRL-FIL-CLEAs@Fe3O4 still retained a high hydrolysis activity (83.42%). CRL-FIL-CLEAs@Fe3O4 was further applied in the solvent-free esterification reaction of phytosterol with oleic acid, and the conversion rate of phytosterol was up to 93.24% after 22 hours (the reaction temperature was 48 °C, the substrate molar ratio of oleic acids to phytosterols was 10 : 1, and the amount of biocatalysts and substrate phytosterol was 5 mg and 0.1 mmol, respectively). It was expected that a good reference could be provided for the more efficient and green production of food-grade phytosterol esters.
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高影响因子
Journal of CO2 Utilization
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2022
·
IF 8.321
Haolin Du,Yifei Ye,Ping Xu,Jianmin Sun
The development of novel and efficient catalysts for the cycloaddition of CO 2 -epoxide has attracted the interest of researchers. In this work, a series of dicationic vinyl-functionalized imidazolium ionic liquids (ILs) were prepared, then polymerized and further copolymerized with 1,4-divinylbenzene (DVB) by free radical reaction. The synthesized PIL-DVB-IV catalyst presented 93% yield and 99% selectivity to the product of propylene carbonate under the optimized reaction conditions of 110 °C, 2.0 MPa for 6 h. Besides, the PIL-DVB-IV catalyst exhibited excellent recyclability and generality to various epoxides. The potential energy surface of the catalytic reaction was given by the computation of Density Functional Theory (DFT), which further revealed the proton migration catalytic mechanism of PIL-DVB-IV catalyst. The kinetic process of the catalyst was illustrated through the study of catalytic reaction kinetics and the calculation of DFT.
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高影响因子
MOLECULES
·
2022
·Vol. 27
·期 24
·9028
·
IF 4.927
Ling Zhang,Zhenkuan Ma,Yun Fan,Songlin Jiao,Zhan Yu,Xuwei Chen
In this work, ionic liquid (IL) of 1-propyl-3-methyl imidazolium chloride-functionalized silica-mesostructured cellular foam (MCF) was prepared. The obtained MCF-IL was used to construct the Fe(CN)63−-confined electrode (MCF-IL-Fe(CN)63−/PVA) and H2O2electrochemical behavior on the electrode was investigated. It was found that H2O2was oxidized on the freshly prepared electrode while catalytically electro-reduced on the acid pretreated one. Cyclic voltametric results revealed that the real catalyst for catalytic reduction of H2O2was Prussian blue (PB) rather than Fe(CN)63−. The electrocatalytic ability of the acid-pretreated MCF-IL-Fe(CN)63−/PVA electrode offered a wide linear range for H2O2detection. The present study on H2O2electrochemical behavior on an MCF-IL-Fe(CN)63−/PVA electrode might provide useful information for further developing integrated Fe(CN)63−-mediated biosensors as H2O2is extensively involved in the classic reaction containing oxidase enzymes.Keywords:silica mesostructured cellular foam;hydrogen peroxide;ferricyanide;reduction;Prussian blue;ionic liquid
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PubMed
高影响因子
危险品化学品经营许可证（带存储）