INORGANIC CHEMISTRY COMMUNICATIONS
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2026
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IF 5.9
Yi Li,Jing Zhang,Jing Shao
Antibiotics are widely used in the treatment of various diseases in humans and animals, and the detection of metabolic residual antibiotics has become an important research task. Flexible surface-enhanced Raman scattering (SERS) substrates are in great demand for sensitivity and specificity detection of antibiotics. Herein, we constructed a surface-enhanced Raman scattering-molecular imprinting polymer sensor (SERS-MIP) consisting of polyvinyl chloride (PVC) membrane loaded with silver nanoparticles and molecular imprinting layer. The surface of PVC was aminated by nucleophilic substitution reaction as a carrier for the formation of silver nanoparticle. The molecular imprinting method of atom transfer-electron transfer radical polymerization was used to realize the controlled growth of polymer for constructing SERS-MIP sensor, and its detection capability for ciprofloxacin reached 10 −9 M. Simultaneously, the stability, uniformity, reusability, and selectivity of the sensor all showed good performance. The characteristic peaks of ciprofloxacin were still visible in the mixed solution with other interferents. The results indicated that SERS-MIP sensor could realize sensitivity and specificity detection in complex environment.
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 4
·223
·
IF 5.4
Wang Tingyu,Xu Zefan,Wu Lei,Zhang Yu,Liu Hang,Wang Zuyao,Zong Shenfei,Yang Kuo,Wang Hong,Wang Zhuyuan
Exosomes hold considerable promise for early cancer diagnosis. However, their low abundance during early tumor progression and inefficient receptor binding remain obstacles to their broad application. Here, we present the surface acoustic wave (SAW)-SERS Exosome Capture Analysis Chip (SEC-chip), which enriches exosomes within 5 min and quantifies HER2 using only 5 µL of serum. The device features a reusable acoustic transducer coupled with a disposable, CD63 aptamer functionalized capture base. Acoustic microstreaming concentrates vesicles into the detection zone, enabling a detection limit of 5 particles/5 µL, representing a 100-fold improvement over static assays. This hybrid design eliminates cross-contamination and reduces costs. Validated on 12 clinical samples, the SEC-chip accurately stratified HER2-positive breast cancer patients. Integrating rapid processing with ultrasensitivity, the platform offers a robust liquid biopsy tool for tumor diagnosis and future point-of-care screening.
Section
Graphical
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VACUUM
·
2026
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IF 4.3
Qiang Wang,Gen Li,Zhaoyang Wang,Rongyue Zhang,Yinghao Zhao,Xiaojuan Cao,Yuankun Zhang,Xiaojing Xue,Fei Chen,Lixue Yang,Chao Feng
Surface-enhanced Raman scattering (SERS) is a powerful analytical technique for ultrasensitive detection; however, its practical application is often limited by poor substrate stability and insufficient signal reproducibility. In this work, a robust three-dimensional (3D) SERS substrate based on macroporous polymer microspheres decorated with silver nanoparticles (AgNP@PM) was developed for trace-level analysis. The substrate was fabricated via atom transfer radical polymerization combined with a solution-phase deposition method, enabling Ag nanoparticle loading within a confined polymer framework. The resulting 3D architecture generated a high density of electromagnetic hotspots and facilitated analyte enrichment through surface functional groups, leading to enhanced and reproducible SERS signals. Under optimized conditions, the AgNP@PM substrate exhibited an enhancement factor of 1.2 × 10 11 and an ultralow detection limit of 5.0 × 10 −13 M for Rhodamine 6G. Excellent signal reproducibility and long-term stability were achieved, with a relative standard deviation of 8.97% after 180 days of storage. Importantly, the analytical applicability of the proposed substrate was demonstrated by the direct, label-free detection of β-estradiol and testosterone in serum samples at nanomolar concentrations (5.0 × 10 −9 M). These results indicate that the AgNP@PM substrate provides a reliable and sensitive SERS platform for hormone analysis in complex biological matrices, showing potential for practical applications in bioanalysis and food safety.
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ANALYST
·
2026
·
IF 3.6
Huiqi Zhu,Ying Chen,Weiqing Yang,Zunxiang Zeng,Yuling Hu,Ji Zhang
The inherently weak Raman signals from molecules with small scattering cross-sections pose a significant challenge for surface-enhanced Raman scattering (SERS), a technique that is further limited by its reliance on costly precious metal substrates and exogenous labeling strategies. To address these limitations, this study constructs a Ti3C2–CoFe2O4 heterostructure by anchoring oxidase (OXD)-like CoFe2O4 nanoparticles (NPs) on two-dimensional (2D) conductive Ti3C2 MXene nanosheets. The resulting interface forms a Mott–Schottky junction, which facilitates rapid charge transfer and synergistically enhances both catalytic and SERS performance. Structurally, the 2D Ti3C2 framework provides abundant anchoring sites for the uniform dispersion of CoFe2O4 NPs. This effectively prevents particle aggregation and maximizes the exposure of catalytic active sites, thereby enhancing both stability and catalytic activity. Additionally, the Ti3C2–CoFe2O4 heterojunction effectively suppresses the recombination of charge carriers and promotes the separation of photogenerated charges, generating abundant superoxide anion radicals that oxidize 3,3′,5,5′-tetramethylbenzidine (TMB) for catalytic signal amplification. Therefore, the ingenious combination of nanozymes and SERS technology enables the generation of SERS-active reporters via nanozyme-catalyzed reactions, thus avoiding the need for external labeling modifications. The strategy simultaneously enhances Raman signals through the synergistic effect of photoinduced charge transfer and localized surface plasmon resonance. This Ti3C2–CoFe2O4 heterojunction exhibits integrated OXD-like activity and SERS enhancement, enabling sensitive glutathione (GSH) detection in human serum samples. Through catalytic oxidation of TMB to oxidized TMB, a distinct Raman peak emerges at 1615 cm−1, with its intensity reduction quantitatively correlating with GSH concentration via competitive reactive oxygen species scavenging. Quantitative analysis demonstrates a linear response range of 0.50–200 μmol L−1 and a detection limit of 0.073 μmol L−1, with serum sample recoveries ranging from 94.7%–115%. This study provides a paradigm for designing non-precious metal nanozyme materials with integrated catalytic and SERS capabilities, demonstrating significant potential for practical applications in clinical diagnostics and biosensing.
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ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Zhaoyan Yang,Gujie Pei,Jinlin Zhang,Bing Chen,Yeming Qing,Kuo Yang,Dan Zhu,Bingxiang Li,Zhuyuan Wang
Background Nanoplastics are progressively recognized as a significant global pollutant and a severe threat to human health. Owing to their tiny particle size and low environmental concentrations, nanoplastics detection currently relies on sophisticated laboratory instrumentation. Colorimetric assays represent a rapid, user-friendly strategy, as the testing results can be readily identified by the naked eye. However, this technique is generally limited by unsatisfactory detection sensitivity. Surface-enhanced Raman scattering (SERS) technique allows for the highly sensitive analysis of samples in aqueous solutions without direct contact. Nevertheless, the complicated preparation of high-performance SERS substrates greatly hinders their practical application in nanoplastics detection. Results Herein, a novel colorimetric/SERS dual-mode sensing strategy was developed via Nile Red labeling for rapid and sensitive detection of nanoplastics (≥100 nm). Nanoplastics labeled with Nile Red (referred to as NPs@NR) demonstrated a visually discernible coloration to the naked eye, as well as an obvious SERS signal under a portable Raman spectrometer. Moreover, the SERS signal of NPs@NR was collected from a straightforward SERS substrate with an RSD of 9.93% that fabricated by transferring Ag nanoparticles film (ANF) onto the end of a hydrophilic polyvinylidene fluoride (PVDF) strip in one step. Colorimetric assays were capable of qualitative identification and quantitative detection of NPs@NR at a concentration of 10 μg/mL and higher. Furthermore, the ANF-based SERS substrate achieved a low limit of detection (LOD) of 0.01 μg/mL toward NPs@NR. More importantly, the proposed colorimetric/SERS dual-mode strategy presented excellent feasibility for the detection of nanoplastics spiked in real environmental samples. Significance Given integrating the advantages of facile detection through colorimetric analysis and highly sensitive trace assays using SERS, the proposed dual-mode method demonstrates potential for on-site monitoring of nanoplastics in aquatic environments.
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Surfaces and Interfaces
·
2026
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IF 6
Tianran Yao,Lingfei Ji,Zhenyuan Lin,Weigao Sun,Ming Guan,Liang Qu,Bohao Zhou
Realizing Au-based SERS substrates via laser-driven confined interfacial coalescence. • Achieving high sensitivity (detectable concentration ≤ 10 −18 M) for the SERS test. • Revealing specific vibrational modes of aromatic ring functioning in SERS detection. In this study, a picosecond laser-driven interfacial coalescence method is developed for realizing highly sensitive and uniform Au-based surface-enhanced Raman scattering (SERS) substrates via enhancement of aromatic ring vibrational modes, achieving an ultralow detection limit of 10 −18 M toward aromatic-ring-containing dyes and an exceptional enhancement factor of 1.83×10 12 . The confined environment restricts liquid Au flow, generating interfacial vortices within ∼100 nm region and leading to the formation of high-density nanoparticles with excellent SERS performance. The enhancement mechanism is found to strongly correlate to the concentration, particularly at low concentration (<10 −8 M), the selective single-molecule-level enhancement of aromatic ring vibrational modes under sub-monolayer adsorption allows highly sensitive detection of five specific dyes and pigments with aromatic-ring (Rhodamine 6 G, Malachite Green, Alizarin Red, Carmine Red, and Indigo), confirming its broad applicability for trace molecular detection. The Au-based SERS substrate exhibits remarkable uniformity with a relative standard deviation of 5.74% and retains stable SERS activity for over 1 year under ambient conditions. This work establishes a scalable, cost-effective laser-based manufacturing paradigm for high-performance SERS sensors, offering exceptional sensitivity, reproducibility, and stability. The method enables ultralow-concentration detection of aromatic molecules via enhancement of aromatic ring vibrational modes, demonstrating versatility across cultural heritage preservation, environmental monitoring, and biomedical diagnostics. A laser-induced confined interfacial coalescence strategy is developed to fabricate high-density, uniform Au nanoparticles for SERS substrates, allowing precise control of nanoparticle size, shape, and distribution. This enables selective adsorption and ultrahigh sensitivity, providing a versatile and scalable platform capable of cultural heritage analysis while also applicable to environmental, food, and biomedical molecular detection. Download: Download high-res image (220KB) Download: Download full-size image
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Bence Gao,Dongxu Zhang,Wenjun Jiang,Anxin Jiao,Teng Li,Xiaoning Wang,Chuanzhao Li,Yong Liu,Ming Chen,Xiaoguang Ma
A recyclable Au/Cu 2 O SERS platform with lattice oxygen stabilization was prepared. • Au/Cu 2 O achieves ultra-low LODs (10 −12 –10 −13 M) for CV, MB and R6G in lake water. • The heterostructures enable the simultaneous detection of mixed organic pollutants in lake water. • Cyclic reuse enabled by photocatalytic degradation, retaining ∼89% SERS activity over four cycles. The increasing presence of organic pollutants in aquatic environments poses significant risks, and their detection and removal at trace levels in complex water systems remain challenging due to matrix interference. Herein, Au nanoparticle-decorated octahedral Cu 2 O heterostructures were fabricated via an in-situ reduction strategy as a recyclable SERS platform. The heterostructures enable ultrasensitive detection of crystal violet (CV), methylene blue (MB), and rhodamine 6G (R6G) in lake water, with detection limits of 10 −12 –10 −13 M and a maximum enhancement factor of 3.82 × 10 11 . The SERS platform exhibits good reproducibility, stability, and anti-interference capability, and allows simultaneous detection of mixed pollutants. In addition, the Cu 2 O component provides photocatalytic activity for pollutant degradation, enabling partial recovery of SERS performance over multiple cycles, with ∼89% activity retained after four cycles. Therefore, it is believed that the developed recyclable Au/Cu 2 O SERS platform holds great potential for ultrasensitive and reusable monitoring of organic pollutants in complex aqueous environments. Download: Download high-res image (193KB) Download: Download full-size image
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Lixia Li,Minglong He,Yurui Huang,Jiabin Zhao,Yufang Liu
Developed a deep learning-assisted dual-modal SPR/digital SERS optical fiber sensor. • Enabled highly selective measurement of mercury ions. • Adopted a silver (Ag)/Ti 3 C 2 T x MXene/gold nanoparticle (AuNP) hybrid composite structure. • Achieved Hg 2+ detection limits as low as 10 pM. A deep learning-assisted dual-mode optical fiber sensor integrating surface plasmon resonance (SPR) and digital surface-enhanced Raman scattering (SERS) is developed for ultra-trace Hg 2+ detection. The sensor employs a silver (Ag)/Ti 3 C 2 T x MXene/Gold nanoparticle (AuNP) hybrid interface, where synergistic LSPR–SPR coupling amplifies electromagnetic fields for sensitive sensing. Upon Hg 2+ exposure, thymine (T)-rich DNA immobilized on the sensing surface and 4-mercaptopyridine-functionalized gold nanoparticle (AuNP@4-MPY) can selectively bind Hg 2+ , forming stable T–Hg 2+ –4-MPY complexes. This process anchors AuNP@4-MPY onto the sensing surface to form AuNP dimers, inducing a distinct SPR redshift and a prominent digital SERS enhancement. The sensor achieves detection limits of 10 pM (SPR) and 1 pM (digital SERS). The 18-layer Residual Network-Squeeze-and-Excitation (ResNet18-SE) regression model is utilized in this study to precisely predict Hg 2+ concentrations, yielding coefficient of determination ( R 2 ) values of 0.9997 and 0.9991 for SPR and digital SERS modes, respectively. Spike-and-recovery experiments performed in tap water and river water produced recoveries in the range of 95.4%–106.4% for both detection modes. This work provides an effective strategy for ultra-trace Hg 2+ detection and offers new perspectives on dual-mode optical sensing. Download: Download high-res image (269KB) Download: Download full-size image
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Yanying Rao,Binggui Wang,Hong Li,Xiaoying Ding,Kaiguo Liu,Xiaojuan Wang,Yue Li
Integrating β-CD-AgNPs and AuNSs arrays enables rapid, quantitative SERS sensing of antibiotic residues. • The system detects AMP, CIP, ENR, NFX individually and in mixtures with high sensitivity. • The combined substrate enabled accurate, applicable antibiotic detection in real waters. β-Cyclodextrin-functionalized Ag nanoparticles (β-CD-AgNPs) were synthesized via a one-step method and integrated with ordered Au nanoshells (AuNSs) arrays to construct a highly sensitive surface-enhanced Raman scattering (SERS) sensor for antibiotic detection. The specific dimensions of the β-CD-AgNPs enable selective binding, drawing antibiotic molecules into close proximity with the AgNPs surface. This proximity generates plasmonic hot spots, significantly amplifying the Raman signals. In this design, the β-CD-AgNPs serve a dual role as both the primary SERS substrate and an internal standard. A strong linear relationship was established between the concentration of antibiotics and the intensity ratio of the characteristic antibiotic peak to the β-CD-AgNPs peak. Based on this principle, we achieved sensitive detection of both individual antibiotics and their mixtures, and validated the method through spike-and-recovery experiments in environmental water samples. The calibration plots were established by linearly fitting the intensity ratio (antibiotic characteristic peak/internal standard peak) against the concentration of Ampicillin (AMP), Ciprofloxacin (CIP), Enrofloxacin (ENR), and Norfloxacin (NFX) solutions, all exhibiting excellent linearity (R 2 > 0.99), as well as for binary mixtures of CIP and AMP, with R 2 values of 0.9942 and 0.9953, respectively. The limits of detection (LODs) for these antibiotics ranged from 0.0827 to 0.3365 μmol·L −1 , and the limits of quantification (LOQs) ranged from 0.27 to 1.11 μmol·L −1 . The linear working ranges were 0.61–5.00, 0.55–12.00, 0.48–12.00, and 1.11–12.00 μmol·L −1 for AMP, CIP, ENR, and NFX, respectively. In environmental water samples, apparent recovery rates of individual antibiotics ranged from 98.84% (±0.03%) to 100.02% (±0.01%), with relative standard deviations (RSDs) between 1.32% and 4.92%. For CIP and AMP mixtures in similar samples, recoveries ranged from 98.53% (±0.01%) to 111.29% (±0.04%), with RSDs between 1.15% and 5.71%. These results demonstrate that the proposed SERS sensor enables efficient and accurate antibiotic detection, offering a viable approach for the rapid and highly sensitive monitoring of antibiotic contaminants in the environment. Download: Download high-res image (188KB) Download: Download full-size image
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Analytical Methods
·
2025
·
IF 2.6
Jia Chen,Longtao Jin,Xinyan Zhang,Qiaoqiao Shi
As an essential trace nutrient, vitamin B 12 (VB 12 ) plays a crucial role in maintaining normal metabolic processes and physiological functions in the human body, particularly in neurological development, overall growth, and energy metabolism in children. Therefore, the accurate and sensitive determination of VB 12 levels in blood is of great significance for monitoring and evaluating children's growth and developmental status. In this study, a surface-enhanced Raman scattering (SERS) aptasensor was designed for ultrasensitive detection of VB 12 in blood samples. The VB 12 aptamer was modified on the surface of Fe 3 O 4 @Au nanoparticles (Fe 3 O 4 @Au NPs) to serve as the capture probe. Meanwhile, complementary DNA (cDNA) was immobilized on the surface of gold nanoparticles (Au NPs) functionalized with the Raman reporter molecule 5,5'-dithiobis (2-nitrobenzoic acid) (DTNB), serving as the signal probe. In this sensor, the VB 12 aptamer hybridizes with the cDNA, forming a dual-layer core-satellite plasmonic nanostructure (Fe 3 O 4 @Au NPs-Apt/ Au NPs-DTNB-cDNA). Quantitative detection was achieved by measuring the SERS signal intensity of DTNB at 1033 cm -1 . Based on this design, the developed aptasensor exhibits high sensitivity toward VB 12 with a detection limit as low as 0.73 pg/mL. Furthermore, the SERS aptasensor demonstrates excellent specificity and stability when applied to the detection of VB 12 in blood samples.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Xiongchao Liu,Xinyu Li,Xifeng Li,Mingli Wang,Yaru Zhang,Na Xie,Yuangang Li,Tifeng Jiao
In this research, Langmuir-Blodgett (LB) composite films were fabricated by integrating phthalocyanine (Pc) with derivatives of perylene diimide (PDI) and naphthalene diimide (NDI). The potential applications of these films in chemical gas sensing and surface-enhanced Raman spectroscopy (SERS) were investigated. The LB technique enables precise regulation of molecular arrangements within films, rendering them highly effective for applications as sensitive sensors. Upon exposure to NH₃ and HCl gases, the composite films exhibited good sensitivity, demonstrating their potential in chemical sensing applications. By employing R6G as a probe molecule, the films demonstrated remarkable SERS performance, distinguished by their uniformity, reproducibility, and amplified signal intensity, achieving an enhancement factor (EF) of 1.76 × 10⁵. This work demonstrates rapid colorimetric response to NH₃/HCl and achieves a high SERS enhancement factor of 1.76 × 10⁵, confirming the significant potential of these LB films for real-world sensing applications.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
·
IF 9.7
Jie Zhou,Xiaoyan Ma,Xiaozhe Zhang,Yaxian Chen,Ling Zhang,Yuan Gao,Qian Zhang,Lixin Xia
A reusable and self-calibrating Surface-Enhanced Raman Spectroscopy (SERS) substrate was developed for reliable detection and degradation of organic pollutants in complex environments. The substrate was fabricated by synthesizing Prussian blue (PB)-functionalized cotton (Cotton/PB), followed by Ag + ion exchange with Fe 3+ in the surface-bound PB and in situ reduction to form silver nanoparticles (Ag NPs). PB serves as an internal standard (IS) to correct SERS signal fluctuations and enables self-cleaning via photo-Fenton catalysis. The substrate exhibited high sensitivity, with detection limits for crystal violet (CV), rhodamine 6G (R6G), and malachite green (MG) of 4.6 × 10 −11 M, 9.2 × 10 −12 M, and 4.7 × 10 −11 M, respectively. IS calibration significantly improved quantitative precision, reducing the substrate uniformity relative standard deviation (RSD) from 13.59 % to 4.15 % and reproducibility RSD from 15.17 % to 3.33 %. Additionally, the substrate exhibited outstanding photo-Fenton degradation performance for R6G, achieving a 99 % removal rate within 120 min. The in situ growth of Ag NPs on the PB surface enhanced the photo-Fenton activity, increasing the rate constant of the Cotton/PB-Ag substrate by 2.1 times compared to Cotton/PB. Importantly, the platform maintained remarkable performance with a low RSD of 2.45 % after seven reuse cycles. This work offers a promising strategy for the consistent and precise detection of organic contaminants in environmental monitoring applications.
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