CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Xietao Ye,Yeyang Sun,Lin Yang,Chen Chen,Shihao Li,Shuo Dong,Xiaoying Qin,Xiaoqi Li,Congyan Liu,Jiege Huo,Yuping Liu,Yan Chen
The low infiltration and insufficient tumor recognition of cytotoxic-T-lymphocytes (CTLs) are the two primary reasons for the low objective response rate of programmed death-1 protein (PD-1) inhibitors in treating microsatellite-stable colorectal-cancer (MSS-CRC). Ginsenoside Rg1 (Rg1) and atractylenolide-I (Att) can promote CTLs infiltration and recognition of CTLs by facilitating dendritic cells (DCs) maturation and upregulating tumor MHC-I expression, respectively, and the combination of two drugs is expected to improve the efficacy of PD-1 inhibitors. However, due to their poor water solubility and limited tumor targeting, the intratumoral delivery of both drugs faces challenges. Our previously reported a tumor-apoptotic-body-membrane (Ab) modified zeolitic-imidazolate-framework (ZIF) for co-delivering Rg1 and Att (Ab@Rg1/Att-ZIF). It could be transported by monocytes/macrophages into the deep tumor regions, however, partial formulations would be degraded by intracellular lysosomes. To overcome this, we innovatively incorporated inulin into Ab@Rg1/Att-ZIF, constructing an Ab/In@Rg1/Att-ZIF delivery system. By virtue of the Ab and inulin coating on its surface, the system could be specifically phagocytosed by monocytes/macrophages while maintaining stability in the lysosomal. Furthermore, after being transported to CRC tissues, inulin of the Ab/In@Rg1/Att-ZIF is enzymatically degraded by enzymes secreted by intratumoral bacteria, releasing Rg1 and Att to promote DCs maturation and upregulate tumor MHC-I expression, respectively. Ab/In@Rg1/Att-ZIF significantly inhibits tumor growth by enhancing CTLs infiltration and recognition, synergizing with PD-1 inhibitors to achieve a tumor suppression rate of ≈80 %, which is markedly higher than the combined efficacy of Ab@Rg1/Att-ZIF. This study provides new insights for the immunotherapy of MSS-CRC and the intratumoral co-delivery of drugs.
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DESALINATION
·
2025
·
IF 9.8
Yanan Song,Rui Zhang,Baoyuan Dong,Yuan Liu,Mingming Zhang,Xiaoxue Hu,Jiake Li,Jianxian Zeng,Kaipeng Cheng,Lelin Zeng,Jie Shen
To address the persistent challenges of low separation efficiency and severe membrane fouling in water treatment, we engineered multifunctional mixed matrix membranes (MMMs) through a facile one-step phase inversion method by incorporating zeolitic imidazolate framework-8 (ZIF-8) nanoparticles (0.1–1.0 wt%) into a polyethersulfone (PES) matrix. The effects of ZIF-8 loading (0.1–1.0 wt%) on the morphology, hydrophilicity, porosity, pore size, water flux of the MMMs were investigated. The optimal MMMs delivered a water flux of 299.2 L/m 2 ·h, surpassing the pure PES membrane by 65.90 %. Furthermore, the optimized MMMs demonstrated a 516 % increase in permeate flux along with a 113 % increase in bovine serum albumin (BSA) rejection rate simultaneous, indicating their potential to break through the trade-off effect. The improved rejection rate of BSA was attributed to size exclusion and electrostatic repulsion, originating from the introduction of ZIF-8 nanoparticles. In addition, the rejection rate of Congo Red (CR), Rhodamine B (RhB) and tetracycline hydrochloride (TCH) elevated from 40.94 %, 15.40 % and 59.33 % to 95.40 %, 37.40 % and 96.80 %, respectively. This enhancement stems from the incorporated ZIF-8 nanoparticles, which simultaneously modulated the MMMs' structure and imparted specific interactions: Electrostatic attraction and π-π stacking to CR, electrostatic repulsion and π-π stacking to RhB, and π-π stacking to TCH. Furthermore, the MMMs exhibited improved antifouling performance with the increased flux recovery ratio and reduced irreversible fouling ratio. This facile one-step engineering strategy provides a scalable and efficient route to fabricate high permeability, multifunctional MMMs with increased rejection and improved antifouling performance for integrated separation of proteins, dyes, and antibiotics in complex wastewater.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Ying Liu,Guozhu Tong,Jing Li,Yuzhu Jin,Maoli Yin,Xuehong Ren
As living standards continue to rise, the demand for advanced cotton textiles that fulfill enhanced functional requirements has grown significantly. Therefore, the development of multifunctional antibacterial/hydrophobic cotton fabrics holds considerable practical value. In this study, a zeolitic imidazolate framework (ZIF-8) based hybrid material, ZIF/SiO 2 -LDS (Long-chain derivative of silane), was synthesized via a co-precipitation method using silica, zinc nitrate hexahydrate, 3-aminopropyltriethoxysilane (KH-550), 2-methylimidazole and hexadecyltrimethylsilane (HDTMS). The resulting hybrid particles were then applied to cotton fabric through a simple padding process, achieving a loading amount of 2.348 %. This was followed by chlorination treatment with sodium hypochlorite to introduce antibacterial functionality. Hydrophobicity was assessed through contact angle measurements, achieving a maximum contact angle exceeding 145°. Antibacterial efficacy testing revealed complete inactivation of bacteria strains, achieving 100 % effectiveness. Study on the adhesion behavior of Staphylococcus aureus and Escherichia coli showed that HZSi/cot-Cl exhibits outstanding antibacterial adhesion resistance, effectively inhibiting bacterial attachment at concentrations up to 10 6 CFU/mL within one hour. The combined antibacterial and anti-adhesive properties significantly mitigate biofilm formation on the HZSi/cot-Cl surface. Notably, the fabric retained its anti-biofilm functionality even after 50 wash cycles. This research provides valuable insights into the development of advanced antibacterial and anti-adhesive treatments for cotton fabrics.
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CHEMICAL ENGINEERING SCIENCE
·
2025
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IF 4.3
Xiao Yang,Shuting Huang,Dongyun Chen,Shihong Dong,Najun Li,Qingfeng Xu,Hua Li,Jianmei Lu
Microbial fuel cells (MFCs) offer simultaneous wastewater treatment and energy generation, but their performance is limited by sluggish oxygen reduction reaction (ORR) kinetics at the cathode. To address this, we aimed to develop a low-cost, high-performance catalyst as an alternative to noble metals. We hypothesized that a hollow Zn/multi-heteroatom co-doped carbon structure derived from ZIF-8 could enhance ORR activity by improving active site exposure and charge transport. The catalyst was synthesized via template-guided structural transformation and optimized pyrolysis. The resulting Zn/DAFP-800 exhibited a high surface area (748.62 m 2 g −1 ), a Tafel slope of 71.24 mV dec −1 , and achieved a maximum power density of 2535.32 ± 7.64 mW m −2 in MFCs with 93.62 % retention over 30 days. Additionally, it achieved 92 % chemical oxygen demand (COD) removal in simulated industrial wastewater. These findings demonstrate the catalyst’s promise for practical applications in electrocatalysis and sustainable energy conversion systems.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Li Ding,Yiwen Xie,Xinrui Bai,Liang Qiu,Zharykbasov E,Z. Kakimova,Gang Wu,Jianlong Wang,Yuxia Song,Rong Wang
Here, we report a general ultrasound-assisted photodynamic strategy that overcomes this challenge by employing hypocrellin B (HB), originally a narrow-spectrum agent initially effective against Gram-positive bacteria, to eradicate Gram-negative bacteria. By applying exogenous ultrasound (US), we induce interfacial electron movement and leverage the cavitation effect to disrupt the lipid bilayer structure of the outer membrane (OM). Consequently, 200 μg mL −1 of HB@ZIF-8 (ZHB) achieves an almost 7-log reduction in Escherichia coli counts within 20 min, which is sixfold higher compared to the antibacterial activity exhibited by HB alone. Molecular dynamics simulations combined with 1.3-fold increase in fluorescence signals in OM permeability experiments confirm that the synergy of ultrasound and photodynamic treatment promotes OM permeability, facilitating rapid diffusion of ROS and HB into inner membrane and intracellular regions. Furthermore, the ZHB exhibited superior inhibition of bacterial proliferation, remarkably extending Shine Muscat grapes shelf life by up to 15 days. Therefore, the sonodynamic interfacial-assisted photosensitizer ZHB prepared in this work was found effective in enhancing the antimicrobial effect against foodborne pathogens.
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高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 10
·1-14
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IF 5.3
Bi Leyao,Fu Boyan,Lin Jiahui,Wen Junsheng,Fu Jiaxing,Tian Wenyue,Su Ningning,Zou Binglin,Wang Chunjie,Wang Yue
Soda biscuit-like Ag-ZnO@ZIF-8 heterostructures were successfully synthesized using a secondary hydrothermal method for the first time, demonstrating exceptional ethylene glycol sensing performance. The sample (2-Methylimidazol (MeIm) concentration of 0.04 g) exhibits a remarkable response value of 1325.50 to 100 ppm ethylene glycol at 240 °C, along with a rapid response time of merely 7 s. Additionally, it displays outstanding gas selectivity (k = 28.63–696.90), great reproducibility and long-term stability. Further experiments indicate that the enhancement of the composite material’s gas sensing performance can be primarily attributed to the interfacial electron transfer effect, the abundance of oxygen vacancies, and the synergistic interactions within the heterostructures. Overall, this study lays a solid theoretical foundation for the practical detection applications of ethylene glycol and provides new insights into the research on gas sensors based on ZnO-organic frameworks. Graphical
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
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IF 8.1
Ziyi Li,Jia Xiong,Hang Song,Shuchang Liu,Yufei Huang,Yangqiang Huang,Geoffrey I. N. Waterhouse,Ziyun Wang,Yu Mao,Zhiwu Liang,Xiao Luo
To enhance the photocatalytic efficiency of ZIF-67 (Zeolitic Imidazolate Framework-67), we integrated it with Ti 3 C 2 T x MXene through in-situ synthesis and assessed the effects of different MXene concentrations on photocatalytic activity. We identified ZIF-67/Ti 3 C 2 T x MXene as the optimal catalyst (denoted as ZT-450), yielding CO, CH 4 , and H 2 at 62.7, 6.7, and 7.3 μmol g −1 , respectively. The CO productive rate achieved by ZT-450 exhibits a substantial enhancement, outperforming both ZIF-67 and Ti 3 C 2 T x by factors of 16.1 and 4.8, respectively. After introducing Ti 3 C 2 T x in ZIF-67, CO 2 adsorption ability achieves 127.90 μmol g −1 , much higher than those of pure ZIF-67 and Ti 3 C 2 T x . Combining Density Functional Theory (DFT) calculations, we established that introducing Ti 3 C 2 T x in ZIF-67 facilitates rapid electron transfer and improves light absorption, CO 2 activation. In-situ DRIFTS measurements of photocatalytic CO 2 reduction reaction (CO 2 RR) on ZIF-67/Ti 3 C 2 T x MXene composite were employed to reveal the emergence of intermediates such as *COOH, *CHO, *OCH 3 , etc ., and elucidate the mechanism accordingly. This research contributes to the advancement of photocatalytic CO 2 RR, offering insights into applying Ti 3 C 2 Tx MXene in photocatalysis.
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Journal of Physical Chemistry C
·
2025
·
IF 3.2
Wei Zeng,Sili luo,Da Rong,Yanlong Li,Yunying Fei,Meng Zhao,Linsheng Huang
A highly sensitive electrochemical sensor based on a composite of two-dimensional (2D) reduced graphene oxide (rGO) and three-dimensional (3D) zeolitic imidazolate framework-8 (ZIF-8) for detecting the NH4+ ion is reported. The ZIF-8/rGO composite electrode is in situ grown to be anchored on the Si/Ag substrate. Here, the rGO layer has high conductivity, while ZIF-8 has a large specific surface area, which provides a large number of active sites. This structure significantly increases the electrical conductivity and enhances the electrochemical performance. With a differential pulse voltammetry measurement at the pH value of 7.00, the multidimensional composite electrode with the optimal ZIF-8 structure exhibits a sensitivity of 9.30 μA μM–1, and a detection range of 5–50 μM with a low detection limit of 3.00 × 10–9 M, as well as high repeatability, stability, and selectivity. These results might be due to the oxidation reaction of NH4+ with the ZIF-8 framework and the special 2D–3D electron transfer channel formed by the composite.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Hua-Bin Yuan,Lan Wei,Jiapeng Wang,Manman Zhao,Guoqiang Chen,Tieling Xing,Zhong Chen
Textile-based flexible sensors with passive anti-icing, active de-icing capabilities, and information transmission are of significant value, especially in low-temperature environments. This study introduced a hierarchically structured textile (PPTZC) composed of zeolitic imidazolate framework-8 (ZIF-8), tannic acid (TA), polypyrrole, and polydimethylsiloxane (PDMS) modified cotton fabric. The innovative design of introducing ZIF-8, followed by etching it with TA to form a hollow structure, enhanced the wearability (breathability, flexibility, lightness, stability, and UV-blocking performance) of the cotton fabric and improved its sensing sensitivity. PPTZC exhibited excellent superhydrophobicity, self-cleaning, anti-icing, photothermal de-icing, and information transmission capabilities. With a light absorbance of 90–95 %, it can rapidly melt ice through photothermal conversion. In a − 20°C environment, the surface temperature of PPTZC can quickly rise from − 20°C to approximately 25°C under 1 sun of irradiation. Both experimental results and COMSOL simulations demonstrated the remarkable anti-icing performance of PPTZC, with the longest ice delay time of 1291.4 s. Additionally, PPTZC can monitor head movements, finger bending, breathing, and pulse in real time, and be used for underwater information transmission and distress alerts. The multifunctional characteristics of PPTZC make it highly promising for use in low-temperature and underwater protective clothing, making it suitable for exploration and research in cold environments.
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Molecular Catalysis
·
2024
·
IF 3.9
Na Wei,Lin Liu,Jia-Qi Chu,Ting Fang,Zheng-Bo Han,Zhen Zhao
Metal-organic frameworks (MOFs) are widely studied for cycloaddition of CO 2 as a heterogeneous catalyst, because of their potential Lewis acidic sites and adjustable porous structure. However, most of them exhibit good catalytic performance need the assistance of nucleophilic co-catalysts. Herein, a novel MOFs and porous organic polymers (POPs) hybrid catalyst, core-shell ZIF-67@PDB-Br, is constructed by a convenient synthetic strategy, which possesses abundant Lewis acidic sites, imidazole cations and nucleophilic centers and shows robust chemical and thermal stability. This material demonstrates high-efficient catalytic activities and recyclability in the cycloaddition of CO 2 and propylene oxide without co-catalysts, the conversion and selectivity can reach 94.1 % and 99.0 %, respectively (100 °C, 1.0 MPa CO 2 pressure). Furthermore, the effects of the temperature, pressure, amount of catalyst and thickness of POPs shell on the catalytic activity were investigated. This study provides a viable direction for the development of synergistic heterogeneous catalysts for fixation of CO 2 without co-catalysts.
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JOURNAL OF CHROMATOGRAPHY A
·
2024
·
IF 3.8
Yanbo Tian,Abdul Majid,Yuewei Zhang,Liju Tan,Huiru Li,Na Wang,Jiangtao Wang
In this study, molecularly imprinted polymers (MIPs) were prepared for the specific recognition of organophosphorus pesticides and a rapid, efficient and simple method was established for the detection of dimethoate (DIT) in food samples. Fe 3 O 4 magnetic nanoparticles were synthesized by co-precipitation, and Fe 3 O 4 /ZIF-8 complexes were prepared by a modified in-situ polymerization method, and then magnetic molecularly imprinted polymers (MMIPs) were prepared and synthetic route was optimized by applying density functional theory (DFT). The morphological characterization showed that the MMIPs were coarse porous spheres with an average particle size of 50 nm. The synthesized materials are highly selective for the organophosphorus pesticide dimethoate with an adsorption capacity of 461.50 mg·g −1 and are effective resistance to matrix effects. A novel method for the determination of DIT in cabbage was developed using the prepared MMIPs in combination with HPLC. The practical results showed that the method can meet the requirements for the determination of DIT in cabbage with recoveries of 85.6–121.1 % and detection limits of 0.033 μg·kg −1 .
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ChemistrySelect
·
2025
·Vol. 10
·期 35
·e03319
·
IF 2
Simombela Mikunga,Chanez Maouche,Peter Phiri,Shuang Wang,Chao Cheng,Juan Yang
The development of cost-effective, high-performance oxygen reduction reaction (ORR) electrocatalysts is pivotal for advancing energy conversion technologies such as metal–air batteries and fuel cells. Herein, we report a facile and efficient strategy to synthesize Mn nanoparticles loaded on N-doped hierarchically porous carbon framework (Mn/N-C) through utilizing ZIF-8 as a carbon/nitrogen precursor and MnCl 2 ·4H 2 O as the Mn source. The synthesis integrates mechanical grinding with an NaCl-assisted pyrolysis process, where molten NaCl acts as a dynamic template and intercalation agent to prevent structural collapse during carbonization, thereby creating a 3D porous architecture with coexisting micro-, meso-, and macropores. Physicochemical characterization reveals that the Mn/N-C-2 sample exhibits a high specific surface area (1770 m 2 /g), abundant defects, and uniform dispersion of Mn nanoparticles within the N-doped carbon matrix. Electrochemical evaluations demonstrate that Mn/N-C-2 catalyst possesses a higher half-wave potential ( E 1/2 ) of 0.836 V and a larger limiting current density ( J L ) of 5.54 mA/cm 2 , surpassing other control samples and most reported Mn-based catalysts and comparable to that of commercial Pt/C. When integrated into Zn–air batteries (ZABs), Mn/N-C-2-based ZABs deliver an open-circuit voltage of 1.49 V and a peak power density of 150.51 mW/cm 2 , outperforming benchmark Pt/C-based counterparts. This work offers a cost-effective electrocatalyst for ORR and can be used instead of noble metals in ZABs. Graphical Mn/N-C electrocatalysts are fabricated by a NaCl-assisted pyrolysis strategy. The optimized Mn/N-C-2 catalyst exhibits a large specific surface area, hierarchically porous architecture and high content of active N, presenting an E 1/2 of 0.836 V for ORR. When integrated into ZABs, it delivers an open-circuit voltage of 1.49 V and a peak power density of 150.5 mW/cm 2 .
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