JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2017
·
IF 1.9
Kwanghyok Jong,Benzhi Ju,Shufen Zhang
In this study, a novel type of pH-responsive polymer PyHES-NAC (2-hydroxy-3-(2-propynyloxy) propyl hydroxyethyl starch (PyHES)) – (N-acetyl-cysteine (NAC)) was synthesized. First, PyHES was prepared via hydrophobic modification of hydroxyl groups in hydroxyethyl starch (HES) with propynylglycidyl ether (PGE), and then pH-responsive carboxylic acid group was connected to propynyl group via thiol-yne click reaction with NAC. Aqueous PyHES-NAC solutions exhibited a good transference between hydrophobic (or self-assembly) and hydrophilic static along with the change of pH value and protective properties of drugs under acidic conditions. 10.0% DOX was released under artificial gastric fluid after 2 h, whereas an immediate release (above 80%) was observed under artificial intestinal fluid. Drug loading capacity of PyHES-NAC was increased by the increase of degree of substitution (DS) of hydrophobic propynyl groups in PyHES, and 41 wt% DOX Loading capacity was the highest value in our study area.
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高影响因子
Science Advances
·
2025
·Vol. 11
·期 32
·
IF 12.5
Runchuan Yan,Yan Zhang,Jingjing Zhang,Xiangyi Zhang,Yue Han,Mengfei Wang,Dan Wang,Shengnan Huang,Wei Liu,Qi Shi,Xiaoping Dong,Wen-Quan Zou,Zhen Li,Jiyan Ma
Rapid neurodegeneration distinguishes prion disease from other neurodegenerative disorders. Notably, normal prion protein (PrP C ) is essential for prion-induced rapid neurodegeneration, but the underlying mechanism remains unknown. Here, we show that the unstructured N-terminal region of PrP C induces rapid and lethal neurodegeneration in mice, accompanied by the hallmark of prion disease, spongiosis. The neurotoxic N-terminal PrP is soluble, associates peripherally with lipid membranes, and induces neurotoxicity only when a critical threshold is exceeded. Both the N-terminally localized KKRPKP sequence and octarepeats contribute to neurotoxicity, with KKRPKP being essential. Without it, the N-terminal PrP is innocuous but exacerbates either neurodegeneration caused by N-terminal PrP or neurodegeneration in prion disease induced by intracerebral prion inoculation in mice. Our findings establish that soluble N-terminal PrP causes rapid neurodegeneration in prion disease and is a target for intervention.
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PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2015
·
IF 6.723
Jing Kang,Jinsong Han,Yangyang Gao,Tianyi Gao,Shi Lan,Linghan Xiao,Yanling Zhang,Ge Gao,Harnoode Chokto,Alideertu Dong
Preventing bacterial infections is a main focus of medical care. Antibacterial agents with broad and excellent disinfection capability against pathogenic bacteria are in fact urgently required. Herein, a novel strategy for the development of N-halamine polymers from spheres to fibers using a combined copolymerization-electrospinning-chlorination technique was reported, allowing fight against bacterial pathogen. Optimizing the process conditions, e.g., comonomer molar ratio, concentration of electrospinning solution, chlorination order, and chlorination period, resulted in the formation of N-halamine fibers with controllable morphology. N-Halamine polymers were tested against two common bacterial pathogens, Escherichia coli and Staphylococcus aureus, and were found to be extremely potent against both bacteria, suggesting that they possess powerful sterilizing properties. Remarkably, compared with those with sphere morphology, N-halamine fibers show unexpected enhancement toward both pathogens possibly because of their shape (fiber morphology), surface state (rough surfaces), and surface charge (positive zeta potentials). It is believed that this approach has great potential to be utilized in various fields where antifouling and antibacterial properties are highly required.
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CHEMISTRY-A EUROPEAN JOURNAL
·
2020
·Vol. 26
·期 17
·3870-3876
·
IF 4.857
Xiaoshan Wang,Yao Liu,Jie Dai,Qian Chen,Xiao Huang,Wei Huang
Graphical By taking advantage of the crystal phase dependent electronic property of SnSe x based materials, SnSe( x %)/SnSe 2 (100− x %) p–n heterostructures were synthesized via a facile one-step colloidal method, and the SnSe(50 %)/SnSe 2 (50 %) based sensor exhibited much improved sensing performance due to the formation of p–n hetero-junctions. The formation of semiconductor heterostructures is an effective approach to achieve high performance in electrical gas sensing. However, such heterostructures are usually prepared via multi-step procedures. In this contribution, by taking advantage of the crystal phase-dependent electronic property of SnSe x based materials, we report a one-step colloid method for the preparation of SnSe( x %)/SnSe 2 (100− x %) p–n heterostructures, with x ≈30, 50, and 70. The obtained materials with solution processability were successfully fabricated into NO 2 sensors. Among them, the SnSe(50 %)/SnSe 2 (50 %) based sensor with an active layer thickness of 2 μm exhibited the highest sensitivity to NO 2 (30 % at 0.1 ppm) with a limit of detection (LOD) down to 69 ppb at room temperature (25 °C). This was mainly attributed to the formation of p–n junctions that allowed for gas-induced modification of the junction barriers. Under 405 nm laser illumination, the sensor performance was further enhanced, exhibiting a 3.5 times increased response toward 0.1 ppm NO 2 , along with a recovery time of 4.6 min.
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MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Rong Deng,Zhilan Wang,Jing Chen,Lianqin Zhu,Yaqin Shi,Wenli Xue
Ti 3 C 2 QDs with good water solubility and photoluminescence properties was prepared by nitrogen and phosphorus doping (N,P-Ti 3 C 2 QDs). The probe has a fluorescence emission peak at 420 nm and emits bright blue fluorescence, which can distinguish and detect two antibiotics with similar structures, chlortetracycline (CTC) and tetracycline (TC). The fluorescence enhancement effect can be realized by the interaction with CTC. The linear range is 2–22 μM, and the detection limit is as low as 0.53 μM. And the change of fluorescent color from bright blue to bright purple can be observed with the naked eye. At the same time, with the addition of TC, the fluorescence of N,P-Ti 3 C 2 QDs can be quenched by static quenching effect, and the fluorescence color changes from bright blue to yellowish green. The detection range is 4.1–20.5 μM, and the detection limit is as low as 0.16 μM.Therefore, on this basis, a strategy for simultaneous detection and recognition of CTC and TC is proposed. The method has been successfully applied to the determination of CTC and TC in milk samples. This paper provides a new detection method for the identification of tetracycline antibiotics and taps the application potential of Ti 3 C 2 QDs in food detection.
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高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Xiaoshun Wei,Xuechun Yang,Yun Guo,Guohao Li,Yinzhong Liu,Lingli Cheng,Zheng Jiao
Being one of toxic and flammable volatile organic compounds (VOC), n-butanol has brought about many potential health risks, there is an urgent demand for highly sensitive detection techniques to monitor its concentration in occupational environments and the air. In this paper, Ce-doped MOF:ZnO sensors under UV activation for room-temperature detection of n-butanol were synthesized by the co-precipitation method and systemically characterized by XRD, SEM, HRTEM, and XPS. The sensitive performances were evaluated by the use of a WS-30A gas sensor measurement system. The results showed that Ce doping has significantly enhanced the sensitivity of the MOF:ZnO sensors, and the response value of the 0.08 % Ce-doped ZnO sensor has achieved to 397.30, which was 9.32 times higher than that of the pristine MOF:ZnO. And the response and recovery times were 17 and 117 s respectively, demonstrating a speedy detection capability. In addition, the sensor gained excellent stability and reproducibility with special selectivity for n-butanol. The comprehensive achievements of this research would be promising to promote the development of volatile organic compound detection technology and beneficial to the well application in the fields of environmental monitoring, industrial safety, and public health.
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Nature Electronics
·
2024
·Vol. 7
·期 6
·444-453
·
IF 33.7
Bukke Ravindra Naik,Syzgantseva Olga A.,A. Syzgantseva Maria,Aidinis Konstantinos,Soultati Anastasia,Verykios Apostolis,Tountas Marinos,Psycharis Vassilis,Alshahrani Thamraa,Ullah Habib,P. Zorba Leandros,C. Vougioukalakis Georgios,Wang Jianxiao,Bao Xichang,Jang Jin,Nazeeruddin Mohammad Khaja,Vasilopoulou Maria,Mohd Yusoff Abd. Rashid bin
The engineering of tin halide perovskites has led to the development of p-type transistors with field-effect mobilities of over 70 cm 2 V −1 s −1 . However, due to their background hole doping, these perovskites are not suitable for n-type transistors. Ambipolar lead halide perovskites are potential candidates, but their defective nature limits electron mobilities to around 3–4 cm 2 V −1 s −1 , which makes the development of all-perovskite logic circuits challenging. Here we report formamidinium lead iodide perovskite n-type transistors with field-effect mobilities of up to 33 cm 2 V −1 s −1 measured in continuous bias mode. This is achieved through strain relaxation of the perovskite lattice using a methylammonium chloride additive, followed by suppression of undercoordinated lead through tetramethylammonium fluoride multidentate anchoring. Our approach stabilizes the alpha phase, balances strain and improves surface morphology, crystallinity and orientation. It also enables low-defect perovskite–dielectric interfaces. We use the transistors to fabricate unipolar inverters and eleven-stage ring oscillators.
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高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2024
·
IF 20.2
Lulu Li,Fenyang Tian,Fengyu Wu,Longyu Qiu,Shuo Geng,Menggang Li,Zhaoyu Chen,Weiwei Yang,Yequn Liu,Yongsheng Yu
Ni 4 Mo electrocatalyst stands out as the promising candidate for hydrogen evolution/oxidation reaction (HER/HOR), yet the intensive hydrogen adsorption leads to sluggish kinetics, decreasing hydrogen catalysis efficiency. Herein, the structure of Ni 4 Mo nanoparticles anchored on wafer-biscuit-like N-SrMoO 4 nanorods (Ni 4 Mo/N-SrMoO 4 ) is developed to accelerate reaction kinetics by modulating electronic structure. The designed N-SrMoO 4 support enables strong electronic metal-support interaction with Ni 4 Mo, resulting in a downward shift of d -band center and achieving thermally neutral hydrogen adsorption. Ni 4 Mo/N-SrMoO 4 exhibits HER performance with an ultralow overpotential of 15 mV at 10 mA cm −2 , superior to Pt/C ( η 10 =18 mV). The outstanding exchange current density of 10.2 mA cm −2 for HOR is three times higher than that of Pt/C (3.5 mA cm −2 ). Ni 4 Mo/N-SrMoO 4 is further assembled in anion exchange membrane water electrolyzer (AEMWE), resulting in a current density of 100 mA cm −2 at voltage of 1.71 V and the excellent stability of 300 hours. Theoretical calculations and in-situ spectroscopy indicate that the introduction of Sr in N-SrMoO 4 effectively enhances electronic metal-support interaction, facilitates the enrichment of adsorbed hydroxyl (OH ads ) on active sites and weakens hydrogen adsorption on Ni 4 Mo, thereby accelerating reaction kinetics of hydrogen electrocatalysis.
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高影响因子
APPLIED CATALYSIS A-GENERAL
·
2024
·
IF 4.7
Xinzheng Ma,Jingyi Chen,Ziang Zhao,Ronghe Lin,Xiaoling Mou,Yihui Li,Li Yan,Hejun Zhu,Yunjie Ding
Solvent-free oxidation of benzyl alcohol on bimetallic Pt-Bi catalysts supported on activated carbon (AC), carbon black, carbon nanotube, and N-doped carbon (NC) was studied. While the dispersions of both metals significantly increased on all the bimetallic catalysts, the composition and distribution of the metal species were strongly influenced by different supports. The formation of PtBi alloy was favored on most supports except AC, where aggregation of Bi was observed. Moreover, the oxidation activity was found to closely link to the surface Bi:Pt ratios. Extensive optimizations on PtBi/NC catalyst in batch and flow reactors yielded impressive benzaldehyde yields of 86 % and 70 %, respectively, under mild conditions, which are comparable or even superior to the performances of most state-of-the-art catalysts. Notably, a 96-hour continuous test in a trickle-bed reactor demonstrated stable operation without catalyst deactivation, demonstrating the promising industrial potential.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Lu Ji,Conghui Che,Fang Li,Wei Xue,Xiaoshu Ding,Dongsheng Zhang,Jing Li,Xinqiang Zhao,Yanji Wang
Methoxycarbonylation of aniline (AN) with dimethyl carbonate (DMC) to produce methyl N-phenylcarbamate (MPC), a key intermediate in non-phosgene diphenylmethane diisocyanate (MDI) synthesis, is facilitated using a newly developed CuO–CeO2 catalyst. This catalyst demonstrated a high AN conversion rate of 95.1% and an MPC selectivity of 92.7% at an nDMC/nAN ratio of 10. The catalyst's effectiveness is attributed to the synergistic interaction between CuO and CeO2, which enhances oxygen vacancy generation and increases the acid amount, as well as Lewis acid sites. Weak Lewis acid sites are conducive to MPC synthesis. There are three distinct copper species present in the CuO–CeO2 catalyst, among which the copper species doped into the CeO2 lattice is beneficial to MPC synthesis. The deactivation of the catalyst, due to the reduction of CuO by methanol, and catalyst regeneration through calcination are discussed. The catalytic mechanism is explored with in situ FT-IR, providing deeper insight into the methoxycarbonylation process.
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高影响因子
CHEMICAL PHYSICS LETTERS
·
2025
·
IF 3.1
Lei Cao,Lin Liu,Kaiyi Luo,Pingping Qian,Haowen Chen,Yixiao Deng,Lei Yang,Xiaoyong Wu,Jun Tang
Skutterudites (SKDs) are promising thermoelectric (TE) materials due to their cost-effectiveness and favorable electrical properties. However, their high thermal conductivity limits thermoelectric conversion efficiency. Herein, Y 2 O 3 nanoparticles (NPs)-decorated n-type Yb 0.3 Co 4 Sb 12 were prepared by spark plasma sintering (SPS). The heterointerfaces created by Y 2 O 3 nanoparticles enhance charge carrier localization through O-Sb hybridization and O-Co bonding, which increases the Seebeck coefficient. Additionally, heterointerfaces scatter phonons, reducing thermal conductivity. Consequently, a figure of merit ( ZT ) value of ∼1.48 at 773 K and an average ZT ave of ∼1.0 (293 ∼ 823 K) were achieved in this work.
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SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2025
·
IF 6.3
Ruishuo Guo,Huijia Wang,Qingwen Wen,Xin Xu,Yanlan Zhou,Xiaoqiang Shao,Ni Li
Phase change capsules effectively address the limitations of leakage and poor stability of phase change materials (PCMs). In this study, SiO 2 @n-Octadecane phase change nanocapsules (PCNCs) with controllable size and structure are prepared by controlling material ratios. When Water-to-EtOH ratio is 2:1 and C 18 -to-TEOS ratio is 3:3 in the reaction system, prepared PCNCs show excellent phase change enthalpy of 152.9 J/g and high encapsulation ratio of 73.77 %, with desirable thermal stability and reliability. After the irradiation of simulating sunlight for 1500 s, the PCNCs achieved a temperature buffer of 6 °C compared with blank cotton fabric, and the cotton fabric with the PU coating containing the PCNCs presents up to 13.2 °C temperature reduction compared with original cotton fabric. The prepared SiO 2 @n-Octadecane PCNCs present excellent heat storage and thermal management performance and effective strategy to develop long-term thermal comfort smart textiles.
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