APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2019
·Vol. 190
·期 2
·475-486
·
IF 2.14
Liu Yuting,Zong Shuai,Li Jinglei
ZnO and ZnO nanoparticles (ZnO NPs) are widely used in food packaging, food preservation, cosmetic preparation, and animal feed. ZnO is alleged showing multiple bioactivities including antimicrobial and anti-inflammation. It is hypothesized in this study that bulk ZnO and ZnO NPs could attenuate symptoms associated with high-fat-diet–induced obesity. Bulk ZnO and ZnO NPs with diameters of 30 and 90 nm were administered to high-fat-diet (HFD)–induced obese mice. Body weight, liver and fat tissue indices of ZnO-treated mice were decreased compared with those of obese mice (MOD). Blood glucose levels in oral glucose tolerant test and insulin tolerant test of ZnO-treated mice were lower than those of MOD. Serum lipid profile of ZnO-treated mice was ameliorated with lower total cholesterol, total triglyceride, and low-density lipoprotein cholesterol levels compared with that of MOD. In addition, the levels of serum IL-1β and LPS-binding protein were also decreased by ZnO treatment. Both bulk and nanosized ZnO could attenuate HFD-induced phenotypes related with obesity, but ZnO NP is more efficient to lower the fat index and bulk ZnO is better to restore the disturbed serum lipid profile.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2018
·Vol. 9
·期 1
·1-7
·
IF 12.353
Lei Zhouyue,Wu Peiyi
Biomimetic skin-like materials, capable of adapting shapes to variable environments and sensing external stimuli, are of great significance in a wide range of applications, including artificial intelligence, soft robotics, and smart wearable devices. However, such highly sophisticated intelligence has been mainly found in natural creatures while rarely realized in artificial materials. Herein, we fabricate a type of biomimetic iontronics to imitate natural skins using supramolecular polyelectrolyte hydrogels. The dynamic viscoelastic networks provide the biomimetic skin with a wide spectrum of mechanical properties, including flexible reconfiguration ability, robust elasticity, extremely large stretchability, autonomous self-healability, and recyclability. Meanwhile, polyelectrolytes’ ionic conductivity allows multiple sensory capabilities toward temperature, strain, and stress. This work provides not only insights into dynamic interactions and sensing mechanism of supramolecular iontronics, but may also promote the development of biomimetic skins with sophisticated intelligence similar to natural skins.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2019
·Vol. 10
·期 1
·1-11
·
IF 11.878
Yang Lu,Ma Zaijun,Wang Han,Niu Kongyan,Cao Ye,Sun Le,Geng Yang,Yang Bo,Gao Feng,Chen Zuolong,Wu Zhen,Li Qingqing,Shen Yong,Zhang Xumin,Jiang Hong,Chen Yelin,Liu Rui,Liu Nan,Zhang Yaoyang
The long-lived proteome constitutes a pool of exceptionally stable proteins with limited turnover. Previous studies on ubiquitin-mediated protein degradation primarily focused on relatively short-lived proteins; how ubiquitylation modifies the long-lived proteome and its regulatory effect on adult lifespan is unclear. Here we profile the age-dependent dynamics of long-lived proteomes in Drosophila by mass spectrometry using stable isotope switching coupled with antibody-enriched ubiquitylome analysis. Our data describe landscapes of long-lived proteins in somatic and reproductive tissues of Drosophila during adult lifespan, and reveal a preferential ubiquitylation of older long-lived proteins. We identify an age-modulated increase of ubiquitylation on long-lived histone 2A protein in Drosophila , which is evolutionarily conserved in mouse, monkey, and human. A reduction of ubiquitylated histone 2A in mutant flies is associated with longevity and healthy lifespan. Together, our data reveal an evolutionarily conserved biomarker of aging that links epigenetic modulation of the long-lived histone protein to lifespan.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Composites and Hybrid Materials
·
2019
·Vol. 2
·期 2
·279-288
·
IF 0
Li Shihua,Yang Chunying,Sarwar Shatila,Nautiyal Amit,Zhang Pengfei,Du Haishun,Liu Na,Yin Jialin,Deng Kuilin,Zhang Xinyu
As one of the most investigated conducting polymers, polyaniline (PANI) is considered to be of practical use in many applications. In this study, two new ionic liquids, 1-methylimidazolium hydrogen sulfate ([Hmim]HSO 4 ) and 1-methyl-3- n -butylimidazopersulfate ([C 4 mim] 2 S 2 O 8 ), which were synthesized from 1-methylimidazole ([Hmim]), were used as solvent and dopant, oxidizer, respectively, for in situ polymerization of aniline. Because of the application of the unique structure of ionic liquid, we obtained the ionic liquid–doped polyaniline (IL-PANI) with high solubility (25 mg mL −1 in dimethyl sulfoxide (DMSO)). And by adjusting the ratio of [C 4 mim] 2 S 2 O 8 to aniline monomer, the preferred PANI nanofibers could be controlled to form a three-dimensional porous structure. It was found that the ion/electron transport channels could be formed inside the 3D structure. Thus, the redox reactions could occur both at the surface and inside the PANI electrode. Electrochemical characterization showed that the fabricated PANI electrode exhibited a specific capacitance of 489 F g −1 at a current density of 0.5 A g −1 . Also, the capacity retention rate reached up to 81% after 4000 cycles investigated at 2 A g −1 . In addition, a high-energy density of 80.2 Wh kg −1 was measured when [Hmim]HSO 4 was used as an electrolyte. Thus, the present work suggested a new strategy for fabricating high-performance PANI electrode for supercapacitor applications.
Ionic-liquid templated assembly of conducting polymer nanostructures for energy applications.
✓ 已验证
产品关联
DOI
CELLULOSE
·
2019
·Vol. 26
·期 8
·4815-4825
·
IF 3.917
Yang Xixian,Li Shijie,Zhang Shiyi,Chen Xin,Peng Shuai
Abstract Commonly used nanocarbon composite materials are routinely synthesized from petroleum-based resources. To avoid their bad impact on the environment, using cellulose-based materials as the promising resources is a better choice due to its easy acquisition and rich reserves. In this study, microcrystalline cellulose was selected as the carbon precursor to synthesize novel cellulose-derived 3D-graphene/LiOH·H 2 O nanomaterials for chemical heat storage to improve the efficiency of thermal energy utilization. The characterization and performance test results show that LiOH·H 2 O particles (5–20 nm) were highly dispersed on the 3D graphene carbon skeleton. These materials had excellent heat storage densities and thermal conductivities due to a completely new, hydrophilic, nano-reactive interface on 3D graphene. Among the materials, 3D-GF-VC-LiOH·H 2 O (Ascorbic acid-modified 3D-graphene/LiOH·H 2 O) exhibited the best heat storage and thermal conductivity properties. It achieved a thermal conductivity of 2.6 W/m K, which was 1.5 times that obtained with pure LiOH·H 2 O, and its heat storage density (2157 kJ/kg) was 3.3 times that of pure LiOH·H 2 O (661 kJ/kg). The activation energy could decrease to 27.5 kJ/mol. Moreover, the heat storage temperature range of LiOH·H 2 O was clearly expanded by introduction of 3D graphene. Hence, the addition of cellulose-derived 3D graphene is a very efficient means by which the design of chemical heat storage materials can be improved. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2019
·Vol. 189
·期 2
·608-625
·
IF 2.14
Zhou Ruolin,Ren Zhiqing,Ye Jun,Fan Yawei,Liu Xiaoru,Yang Jianyuan,Deng Ze-Yuan,Li Jing
Soybean dregs fermented by Neurospora crassa is a typical traditional food in Gannan district of China. In this study, in vitro imitated gut fermentation was carried out to evaluate whether the oligosaccharides from this fermented soybean dregs had potential prebiotic properties. 11.91% of oligosaccharides were extracted from the fermented soybean dregs at the optimized condition which of 1:25 for ratio of soybean dregs (g) to 50% ethanol (ml), 90 min of extracted duration at 70 °C for twice. The soybean dreg oligosaccharides (SBOS) were progressively purified with Sevag method and on columns filled with AB-8 macroporous resin, and then identified as cellobiose by HPLC-ESI-MS and FT-IR. Oligosaccharides of soybean dregs with 800 mg/L significantly decreased pH value ( p < 0.05) and ammonia N concentration ( p < 0.05), and increased short chain fatty acid (SCFA) level ( p < 0.05) in imitated gut fermentation compared with control group. It was shown that this fermented soybean dregs could be a potential prebiotic food.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CELLULOSE
·
2019
·Vol. 26
·期 8
·5065-5074
·
IF 3.917
Hou Ting,Guo Kechun,Wang Zhongguo,Zhang Xiong-Fei,Feng Yi,He Ming,Yao Jianfeng
Self-standing and flexible regenerated cellulose membranes were fabricated by using a facile ZnCl 2 /CaCl 2 /cellulose dissolution system. The filtration experiments of the membranes were conducted by using methyl orange and Congo red as water contaminations. To improve the selectivity and stability, the crosslinkers of glutaraldehyde and polyvinyl alcohol were introduced to the membrane network. The best performance was observed over glutaraldehyde and polyvinyl alcohol crosslinked cellulose (P-G-RC) membrane with a Congo red rejection rate of 99.9% and a methyl orange rejection rate of 93.5%. The suitable pore radius (0.67 nm), low root-mean-square roughness (2.9 nm) and abundant hydroxyl groups were considered as the primary reasons contributed to the separation behavior. Furthermore, the P-G-RC membrane displayed excellent stability and reusability during the filtration tests.
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2018
·Vol. 9
·期 1
·1-11
·
IF 12.353
Zheng Guanhaojie,Zhu Cheng,Ma Jingyuan,Zhang Xiaonan,Tang Gang,Li Runguang,Chen Yihua,Li Liang,Hu Jinsong,Hong Jiawang,Chen Qi,Gao Xingyu,Zhou Huanping
Crystal orientations in multiple orders correlate to the properties of polycrystalline materials, and it is critical to manipulate these microstructural arrangements to enhance device performance. Herein, we report a controllable approach to manipulate the facet orientation within the ABX 3 hybrid perovskites polycrystalline films by cation cascade doping at A-site. Two-dimensional synchrotron radiation grazing incidence wide-angle X-ray scattering is employed to probe the crystal orientations in multiple orders in mixed perovskites thin films, revealing a general pattern to guide crystal planes stacking upon extrinsic doping during crystallization. Different from previous studies, this method enables to adjust the crystal stacking mode of certain crystallographic planes in polycrystalline perovskites. Moreover, the preferred facet orientation is found to facilitate photocarrier transport across the absorber and pertaining interface in the resultant PV device, which provides an exemplary paradigm for further explorations that relate to the microstructures of hybrid perovskite materials and relevant optoelectronics.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2019
·Vol. 30
·期 15
·14007-14021
·
IF 2.195
Ahmed Arsalan,Jia Yunming,Huang Yi,Khoso Nazakat Ali,Deb Hridam,Fan Qinguo,Shao Jianzhong
We developed a high-performance electrically conductive and transparent PVDF-TrFE based electrode for piezoelectric pressures sensor using the electrospinning technique. The electrode was produced by depositing the reduced graphene oxide (rGO), multiwall carbon nanotubes (rGO-MCNTs) via spray coating. Various concentration of rGO and MCNTs were used and optimized for improved electrical performance of the resultant electrode. The deposition of poly (3,4-ethylenedioxythiophene) (PEDOT) was successfully achieved by using vapor phase polymerization (VPP). The morphological characteristics of the as-prepared hybrid composite nanofiber mats were analyzed by using field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), Fourier transforms infrared spectroscopy (FT-IR), Raman spectroscopy, X-ray diffraction (X-RD), and UV–visible spectroscopy. The electrical performance of the fabricated composite nanofibers was measured by using a four-point probe device. The results showed significant enhancement in electrical conductivity of the hybrid nanocomposite which increased up to 3916 S cm −1 and sensitivity of the developed pressure sensor was achieved 67.4 kPa −1 . This work suggests that the hybrid nanocomposite can be used for the transparent electrodes in a piezoelectric pressure sensor.
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2019
·Vol. 411
·期 27
·7165-7175
·
IF 3.286
Zhang Meng Yuan,Huang Ren Feng,Ma Xiao Guo,Guo Li Hui,Wang Ying,Fan Yin Ming
A new fluorescence sensor (QDs-IIP), based on ion-imprinted polymers (IIP) as recognition element and Mn-doped ZnS quantum dots (QDs) as fluorophore, was synthesized for the selective and sensitive determination of hexavalent chromium (Cr(VI)) ions. The QD was first coated by SiO 2 layer, and then modified with Cr(VI)-imprinted polymer. Several parameters affecting fluorescence intensity such as tetraethylorthosilicate (TEOS) volume, ZnS:Mn@SiO 2 amount, and radiation time were investigated and optimized. The QDs-IIP was characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR), transmission electron microscope (TEM), and scanning electron microscope (SEM). Furthermore, the fluorescence quenching mechanism was investigated by using UV-VIS and fluorescence spectrophotometer, and it was found that internal filtration effect was the main fluorescence quenching mechanism. The relative fluorescence intensity (F 0 /F) increased linearly with the increase of Cr(VI) concentration in the range of 20 μg L −1 –1.0 mg L −1 . The QDs-IIP sensor showed high recognition selectivity for Cr(VI) in comparison with the QDs-NIP sensor with an imprinting factor (IF) of 2.53, and it could be reused 5 times. In addition, an analytical method of Cr(VI) based on the QDs-IIP sensor was established with a limit of detection of 5.48 μg L −1 , and was then applied to actual water samples with satisfactory results. Therefore, QDs-IIP can be deemed as a practicable fluorescent sensor for trace Cr(VI) detection.
Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Cellular and Molecular Bioengineering
·
2019
·Vol. 13
·期 1
·99-112
·
IF 2.477
Wang Yue,Li Xiaoli,Liu Lanlan,Liu Bingruo,Wang Feng,Chen Changsheng
Introduction Ultrasound-targeted microbubble destruction (UTMD) has been shown a promising approach for target-specific gene delivery and treatment of many diseases in the past decade. To improve the therapeutic potential of UTMD, the gene carrier of microbubbles should possess adequate DNA condensation capability and (or) specific cell or tissue selectivity. The tissue-targeted and ultrasound-targeted cationic microbubbles were developed to meet gene therapy. Methods A tissue-targeted stearic acid-inserted cationic microbubbles (SCMBs) were prepared for ultrasound-targeted gene delivery. Branched PEI was modified with stearic acid and further mixed with 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and biot-1,2-distearoyl-sn-glycero-3-phosphoethanolamine- N -[methoxy (polyethylene glycol)-2000] (ammonium salt) (Biot-DSPE-PEG2000), intercellular adhesion molecule-1 (ICAM-1) antibody and plasmid DNA to prepare cationic microbubbles through ultrasonic hydration. The ICAM-1 antibody and plasmid DNA were expected to assemble to the surface of SCMBs via biotin-avidin interaction and electrostatic interaction, respectively. Results It was found that the SCMBs had higher zeta potential compared with neutral microbubbles (NMBs) and cationic microbubbles (CMBs). In contrast, DNA incorporated SCMBs4 showed negative potential, exhibiting good DNA-binding capacity. Confocal images showed that the HeLa cells were attached around by the SCMBs4 from the view of green fluorescence of fluorescein isothiocyanate-loaded IgG which conjugated to ICAM-1 antibody on their surface. After ultrasound treatment, HeLa cells treated with SCMBs exhibited slightly stronger red fluorescence under confocal laser scanning microscope, indicating a synergistic promotion for transfection efficiency. Conclusions This tissue- and ultrasound-targeted cationic microbubble demonstrated here showed a promising strategy for improving gene therapy in the future.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2019
·Vol. 10
·期 1
·1-11
·
IF 11.878
Xiong Likun,Sun Zhongti,Zhang Xiang,Zhao Liang,Huang Peng,Chen Xiwen,Jin Huidong,Sun Hao,Lian Yuebin,Deng Zhao,Rümmerli Mark H.,Yin Wanjian,Zhang Duo,Wang Shuao,Peng Yang
Three-dimensional bimetallic nanoframes with high spatial diffusivity and surface heterogeneity possess remarkable catalytic activities owing to their highly exposed active surfaces and tunable electronic structure. Here we report a general one-pot strategy to prepare ultrathin octahedral Au 3 Ag nanoframes, with the formation mechanism explicitly elucidated through well-monitored temporal nanostructure evolution. Rich crystalline defects lead to lowered atomic coordination and varied electronic states of the metal atoms as evidenced by extensive structural characterizations. When used for electrocatalytic methanol oxidation, the Au 3 Ag nanoframes demonstrate superior performance with a high specific activity of 3.38 mA cm −2 , 3.9 times that of the commercial Pt/C. More intriguingly, the kinetics of methanol oxidation on the Au 3 Ag nanoframes is counter-intuitively promoted by carbon monoxide. The enhancement is ascribed to the altered reaction pathway and enhanced OH − co-adsorption on the defect-rich surfaces, which can be well understood from the d-band model and comprehensive density functional theory simulations.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）