JOURNAL OF MICROENCAPSULATION
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2018
·
IF 1.793
Zhen Jiao,Xiudong Wang,Yuting Yin,Jingxin Xia,Yanan Mei
Vitamin C (VC) and folic acid (FA) are the important nutrient and antioxidant in human body. In order to improve their stability, their co-loaded liposomes (VCFA-Lip) and chitosan-coated liposomes (CS-VCFA-Lip) are prepared and characterised. The mean particle size of VCFA-Lip and CS-VCFA-Lip is 138 nm and 249 nm, respectively. The encapsulation efficiencies of both drugs for CS-VCFA-Lip are much higher than those for VCFA-Lip. Furthermore, the experimental results show that the antioxidant activity of CS-VCFA-Lip is higher than that of VCFA-Lip. Moreover, the storage stability study reveals that the chitosan coating can efficiently improve the physical stability of VCFA-Lip. These results indicate that stability of VC and FA can be greatly improved after being wrapped by liposomes. In addition, the performance of CS-VCFA-Lip is better than VCFA-Lip, indicating CS-VCFA-Lip can be applied as a promising delivery system for the antioxidant defence system to the food industry and cosmetic industry.
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高影响因子
Scientific Reports
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2018
·Vol. 8
·期 1
·1-10
·
IF 4.122
Liu Weixiang,Qin Yukun,Liu Song,Xing Ronge,Yu Huahua,Chen Xiaolin,Li Kecheng,Li Pengcheng
Based on a condensation reaction, a chitosan-derivative-bearing amino pyridine group was prepared and subsequently followed by coordination with cupric ions, zinc ions and nickel ions to synthesize chitosan metal complexes. The calculations using the density functional theory (DFT) show that the copper ions and nickel ions underwent dsp 2 hybridization, the zinc ions underwent sp 3 hybridization, and they all formed a coordination bond with the carbon atom in the p-π conjugate group. The antifungal properties of O-CSPX-M against Phytophthora capsici (P. capsici) , Verticillium alboatrum (V. alboatrum) , Botrytis cinerea (B. cinerea) and Rhizoctonia solani (R. solani) were also assayed. Apparently, chitosan metal complexes showed enhanced antifungal activity against four fungi at the tested concentrations compared to that of chitosan. It was shown that Cu complexes can inhibit the growth of P. capsici 100%, and Ni complexes can inhibit the growth of B. cinerea 77.1% at a concentration of 0.4 mg/mL and 0.2 mg/mL, respectively. The pot experiment also verified the result. In addition, the phytotoxicity experiment showed that O-CSPX-M had no obvious toxicity on wheat leaves. This kind of complexes may represent as an attractive direction for chemical modifications of metal fungicides.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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2014
·
IF 3.432
Ke-Guang Cheng,Chun-Hua Su,Lin-Dong Yang,Jun Liu,Zhen-Feng Chen
Five dimeric oleanolic acids linked at C-28 by 1,6-hexanediamine, or built around the carbon chains of varying lengths between two carboxyl groups were synthesized, to investigate the effect of internal spacer length and species upon the stereochemical features and anti-tumor activity of the resultant bis-oleanolic acids. The IC 50 values of these dimeric compounds for cytotoxicity evaluation in vitro against Hep-G2, A549, BGC-823, MCF-7 and PC-3 tumor cell lines, were mainly under 10.0 μM. This result was much better than the inhibition of proliferation against tested tumor cell lines of the monomer oleanolic acid and the commercial anticancer drug 5-fluorouracil. The cytotoxicity selectivity detection revealed that dimer 11c exhibited low cytotoxicity towards normal human liver cell HL-7702. A combination of fluorescence staining observation and flow cytometric analysis indicated that 11c could induce Hep-G2 cell apoptosis . Molecular mechanism studies suggested that 11c induced apoptosis is mediated through the intrinsic apoptotic pathway with changes in mitochondrial membrane potential by finally activating effector caspase-3/9 to trigger cell apoptosis. Further studies revealed that 11c caused cell cycle arrest at G1 phase in Hep-G2 cells. Taken together, these results suggest that 11c may be a potential candidate for further cancer research.
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MICROCHIMICA ACTA
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2015
·Vol. 182
·期 15
·2411-2417
·
IF 3.741
Yang Zhen,Liu Yan,Lei Chong,Sun Xue-cheng,Zhou Yong
We report on a method for the determination of magnetic bead-labeled C-reactive protein (CRP), a biomarker of cardiovascular diseases and inflammations. It is using a flexible giant magnetoimpedance (GMI)-based platform. Micro-patterned GMI sensing elements were prepared from a cobalt-based commercial amorphous ribbon (Metglas® 2714A) using micro electro-mechanical system (MEMS) technology. A gold film was then deposited on the GMI sensing element to act as a support for the immuno platform. Sandwich assays are performed using antibody-antigen combinations and biotin-streptavidin interactions on the gold film substrate surface via self-assembled layers. The GMI ratios of the sensors with different concentrations of antigen against CRP were investigated. The results show that the presence of CRP antigens on the biosensor improves the GMI effect owing to the induced magnetic dipole of superparamagnetic beads, and that the GMI ratios show distinct changes at high frequency. This bioassay for CRP has a linear detection range between 1 to 10 ng·mL −1 . This new method in our perception provides a widely applicable basis for rapid diagnostic testing and will pave the way for future development of electrochemical point-of-care diagnostic devices for cardiac diseases.
(a) Graphical illustration of CRP test setup. (b) Magnetic field arrangement of the beads under an applied magnetic field. (c) GMI changes in relation to the concentration of the CRP
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JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
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2015
·
IF 3.564
Xiao-ning Ye,Qiang Lu,Wen-tao Li,Pan Gao,Bin Hu,Zhi-bo Zhang,Chang-qing Dong
A new technique was proposed to selectively produce nicotyrine, a valuable alkaloidal product, from catalytic fast pyrolysis of tobacco mixed with the Pd/C catalyst. Pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) experiments were performed to investigate the effects of pyrolysis temperature and catalyst-to-tobacco ratio on the selective nicotyrine production. The actual nicotyrine yields under different reaction conditions were quantitatively determined. Moreover, the catalytic activity of the Pd/C catalyst was compared with those of the activated carbon (AC), Ru/C and Pd/SBA-15 catalysts. The results indicated that during the catalytic fast pyrolysis process, the Pd/C catalyst possessed promising dehydrogenation capability to selectively convert the nicotine in tobacco into the nicotyrine, and it performed much better than the other three catalysts. The maximal nicotyrine yield reached as high as 2.80 wt%, obtained at the pyrolysis temperature of 400 °C and catalyst-to-tobacco ratio of 2.
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ANALYTICAL CHEMISTRY
·
2013
·
IF 5.695
Lu-Lu Qu,Da-Wei Li,Li-Xia Qin,Jin Mu,John S. Fossey,Yi-Tao Long
A novel surface-enhanced Raman scattering (SERS) nanosensor was developed by modifying oxidized cytochrome c (Cyt c) on gold nanoparticles (Au NPs) for the sensitive and selective determination of intracellular superoxide anion radical (O2•–). On the basis of the differences in the SERS spectra between the oxidized and reduced form of Cyt c, this nanosensor could be employed to investigate O2•– concentration by measuring the SERS spectra of the reduced Cyt c. Using this SERS nanosensor, a detection limit of 1.0 × 10–8 M for O2•– could be attained. Additionally, the selectivity of the SERS nanosensor for O2•– was examined, showing that other reactive oxygen species (ROS) and biologically relevant species did not influence the detection of O2•–. More importantly, the nanosensor could be delivered to the living HeLa and normal human liver cells and permitted the concentration of O2•– to be monitored in real time and in a noninvasive manner, which indicates that this nanosensor will be suitable for the qualitative and quantitative analysis of O2•– in biosystems, thus leading to a greater understanding of oxidative-stress-related diseases at a cellular level.
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RSC Advances
·
2015
·Vol. 5
·期 91
·74774-74782
·
IF 3.84
Wenjun Zhu,Hui Yang,Wenkui Zhang,Hui Huang,Xinyong Tao,Yang Xia,Yongping Gan,Xingzhong Guo
A Li4Ti5O12/TiO2/carbon (Li4Ti5O12/TiO2/C) nanocrystalline composite has been successfully synthesized by a facile sol–gel method and subsequent calcination treatment. Moreover, pure Li4Ti5O12, Li4Ti5O12/C and Li4Ti5O12/TiO2 composites have also been synthesized for comparison. All the samples present a nanocrystalline structure with a uniform size distribution, and abundant phase interfaces can be detected for the Li4Ti5O12/TiO2 and Li4Ti5O12/TiO2/C composites. Electrochemical measurements demonstrate that the resultant Li4Ti5O12/TiO2/C composite exhibits a superior rate capability and cycle stability in comparison with pure Li4Ti5O12, Li4Ti5O12/C and Li4Ti5O12/TiO2 composites, which can be attributed to a high grain boundary density, abundant phase interfaces and in situ formed carbon, for storing extra lithium ions, enhancing rapid lithium insertion/extraction kinetics and improving the electron transport rate.
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MATERIALS RESEARCH BULLETIN
·
2015
·
IF 2.288
Yu-zhi Su,Qi-zhi Xu,Qi-sui Zhong,Chan-juan Zhang,Shu-ting Shi,Chang-wei Xu
Glycerol has a very high value of onset potential on the Au/C electrode, so it is difficult to be electrochemically oxidized on the pure Au electrocatalyst. When Co 3 O 4 , NiO, Mn 3 O 4 and MgO are added to the Au/C, the values of onset potential of glycerol oxidation shift negatively 171, 191, 156 and 215 mV than that on the Au/C. Au–Co 3 O 4 (wt 4:1)/C, Au–NiO(wt 5:1)/C, Au–Mn 3 O 4 (wt 5:1)/C and Au–MgO(wt 2:1)/C show the highest activity for glycerol electrooxidation for respective oxide promoted Au/C. The addition of oxides to the Au/C obviously promotes the catalytic activity and stability for glycerol electrooxidation.
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SPECTROSCOPY LETTERS
·
2013
·
IF 0.667
Yun-Chang Fan,Xue-Yun Gong,Jing Li,Lei Zhang,Chun-Jia Sun
The interaction of an amino-functionalized ionic liquid, 1-(2-aminoethyl)-3-butylimidazolium bromide ([NH2C2C4im]Br), with cytochrome c (cyt c) at pH 7.4 was investigated using fluorescence and UV-Vis absorption spectroscopic techniques. From the experimental results, it is found that cyt c has a strong ability to quench the intrinsic fluorescence of [NH2C2C4im]Br and the quenching mechanism is considered as a static quenching process. The binding constants and the number of binding sites (n) were calculated at different temperatures. The thermodynamic parameters such as free energy change (ΔG), enthalpy change (ΔH), and entropy change (ΔS) were calculated by thermodynamic equations. According to the results, the values of ΔG, ΔH, and ΔS are all negative, suggesting that interaction between [NH2C2C4im]Br and cyt c is spontaneous and mainly driven by hydrogen bonding and van der Waals forces.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2015
·
IF 2.729
Xuan Wu,Zhi-qiang Shi,Cheng-yang Wang,Juan Jin
A series of nanostructured silica–carbon composites containing different contents of SiO 2 nanoparticles have been prepared from SiO 2 nanoparticles-incorporated polyacrylonitrile (PAN) fibers via electrospinning and subsequent thermal treatment. The SiO 2 /C composites as negative material for lithium ion batteries benefit from both the high capacity of nano-SiO 2 and the good performance of stable 3D nanostructured carbonaceous matrix. The nanostucture can effectively resist large volume changes and accelerate both the lithium ions diffusion and the electronic migration. The SiO 2 content significantly affects on both the morphology and the electrochemical performance of the SiO 2 /C composites. It is found that the composite obtained from the SiO 2 /PAN fibers with 15 wt% SiO 2 exhibits a large capacity of 658 mAh g −1 after 100 cycles at a current density of 50 mA g −1 and retains 356 mAh g −1 at 1000 mA g −1 , showing the best performance with high capacity, good rate capability and excellent cycling stability.
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BIORESOURCE TECHNOLOGY
·
2014
·
IF 5.039
Riyang Shu,Jinxing Long,Zhengqiu Yuan,Qi Zhang,Tiejun Wang,Chenguang Wang,Longlong Ma
An efficient lignin depolymerization process with highly controllable product distribution was presented using metal chloride (MCl x ) cooperated with Pd/C. The catalytic performances of MCl x were investigated. The effect of reaction conditions on the lignin depolymerization and products distribution were also studied. Results showed that more than 35.4% yield of phenolic monomer including 7.8% phenols and 1.1% guaiacols could be obtained under optimized condition. And the product distribution can be efficiently controlled by the modification of the metal cation through different pathway of Lewis acid catalysis and coordination catalysis. Furthermore, the Pd/C catalyst showed an excellent recyclability, where no significant loss of the catalytic activity was exhibited after 3 runs. Moreover, the product control mechanism was proposed.
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THIN SOLID FILMS
·
2017
·
IF 1.879
Xueyao Xie,Xin Yin,Lixin Song,Pingfan Du,Ni Li,Lin Qi,Jie Xiong
The flexible Al 2 O 3 /carbon composite nanofibers (ACNFs) film was synthesized by electrospinning. And the effects of carbonization temperature on the structures and properties of ACNFs were investigated. All the obtained ACNFs had rough surface and random orientations, and the alumina nanostructures were closely jointed to the carbon nanofibers . Besides, the crystallinity of alumina and carbon increased with carbonization temperature. As a result, the flexural property of ACNFs film decreased, and the electrical property greatly increased with the increase of carbonization temperature. When the carbonization temperature was 900 °C, the flexible ACNFs composite film was used as a counter electrode for flexible dye-sensitized solar cells. A power conversion efficiency of 2.84% was achieved. If the catalyst activity of the film was further improved, the conversion efficiency may be further improved.
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