Acta Biomaterialia
·
2018
·
IF 6.383
Xinyi Lin,Ming Wu,Ming Li,Zhixiong Cai,Haiyan Sun,Xionghong Tan,Jiong Li,Yongyi Zeng,Xiaolong Liu,Jingfeng Liu
The development of multifunctional carriers incorporating genetic and photodynamic therapy (PDT) for synergistic antitumor treatment has attracted intensive interests very recently. However, most of the currently reported systems employ passive gene release strategies depending on tumor microenvironment, which are negatively affected by the heterogeneity of cancer cells, thus resulting in limited controllability in therapeutic progress. Herein, a novel photo-responsive hollow silica nanoparticle (HNP)-based gene and photosensitizer (PS) co-delivery nanovehicle is designed for dual-wavelength light-triggered synergistic gene and PDT therapy. The resultant HNP conjugated with PDMAEMA polycation through a 405-nm light-cleavable Cou-linker, namely, HNP-Cou-PD, exhibits excellent gene condensation capacity, good biocompatibility, outstanding PS loading ability, and light-triggered gene release properties. HNP-Cou-PD with Chlorin e6 (Ce6) loaded inside the silica cavity and a plasmid encoding caspase-8 gene (CSP8) attached to the PDMAEMA outside layer (Ce6-HNP-Cou-PD/CSP8) has been proven to possess better antitumor effects under the irradiation of pre-405-nm and post-670-nm light both in vitro and in vivo because of the light-triggered intracellular gene release and reactive oxygen species (ROS) generation. Therefore, HNP-Cou-PD designed as a gene and PS co-delivery carrier might have promising applications in the future to precisely treat various types of cancers. Statement of Significance Multifunctional carriers incorporating genetic and photodynamic therapy (PDT) have drawn intense attention very recently, ascribing to their enhanced anticancer effects. However, in the present gene and PDT synergistic system, gene release strategies passively relying on tumor microenvironment often result in no or poor controllability compared with PDT (a spatial and temporal therapeutic modal), which may hinder their synergistic efficacy, especially in an on-demand manner. To resolve this problem, we designed a hollow silica nanoparticle-based dual-wavelength light-responsive gene and photosensitizer (PS) co-delivery platform to achieve photo-triggered gene and PDT synergistic therapy. We believe that our work may have extensive application prospects in precise treatment of various cancers and be of interest to the readership.
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DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2025
·
IF 4.7
Linkai Zhao,Jing Zhao,Zhao Mo,Ziyi Wang,Zhaoli Xue,Lei Feng,Long Zhao
Metalloporphyrin-coated semiconductor nanoparticals may be one potential option for photodegradation of organic pollutants in watertreatment. To examine the function of lone pair electron-containing substituents in photocatalytic interfacial charge transfer mechanism, we synthesized three meso‑ substituted zinc porphyrins (Znpors) containing 4-pyridyl, 3-pyridyl and phenyl, denominated as 4-Pyr-Znpor, 3-Pyr-Znpor and Ben-Znpor, respectively. Density functional theory (DFT) calculations revealed similar electronic structrues and bandgaps of the three porphyrins, with clearly negaitive charges on the isosurface of pyridine substituents. Photoelectrochemical and impedance measurements reveal that 4-Pyr-Znpor/TiO 2 and 3-Pyr-Znpor/TiO 2 exhibit greater photocurrent response and lower charge transfer resistance as compared to Ben-Znpor/TiO 2 . Photodegradation of the organic pollutant AB1 using the composites suggests efficient photocatalysis ability of the three porphyrin-sensitized TiO 2 nanoparticals, with 4-Pyr-Znpor/TiO 2 exhibiting the highest degradation rate at the first 30 min. Our findings suggest that the pyridine substituent may attract holes and facilitate the charge separation efficiency, therefore enhancing the photocatalytic efficiency.
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DOI
高影响因子
Advanced Optical Materials
·
2025
·Vol. 13
·期 27
·e01552
·
IF 7.2
Yongjie Wang,Yingju Yan,Dongshuo Li,Qingzhou Bu,Guotao Xiang,Li Li,Sha Jiang,Xianju Zhou,Qilong Gao,Yaroslav Zhydachevskyy,Mikhail G. Brik,Andrzej Suchocki
Broadband near-infrared (NIR) phosphors with superior thermal stability are critical enablers of high-power NIR pc-LEDs, emerging as essential light sources for NIR spectroscopy applications. In this work, an unprecedented high-temperature negative thermal quenching (NTQ) phenomenon persisting up to 500 K is reported in Cr 3+ -activated ScF 3 phosphors, which emit broadband NIR emission in the 700–1200 nm (λ em = 850 nm, FWHM = 132 nm). The theoretical calculations employing the Exchange-Charge Model (EMC) for crystal field parameters of Cr 3+ ions in [ScF 6 ] octahedral sites remain in perfect agreement with the experimental results. Critically, Yb 3+ -codoping enables efficient Cr 3+ → Yb 3+ energy transfer, achieving substantial spectral broadening (FWHM = 254 nm) and significantly enhanced thermal stability. The temperature-dependent X-ray diffraction (XRD) and theoretical calculations reveal that anisotropic F-atom vibrations drive negative thermal expansion (NTE) in cubic ScF 3 , distorting [ScF 6 ] octahedra. It is demonstrated that synergistic electron-phonon coupling and NTE-driven structural dynamics underpin the superior thermal stability of NIR emission. These findings establish a design paradigm for new broadband NIR phosphors with outstanding thermal stability for next-generation high-power NIR pc-LED applications.
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DOI
高影响因子
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2025
·Vol. 40
·期 3
·650-659
·
IF 1.1
Zheng Jingyan,Deng Yichao,Xu Mengying,Li Lian,Tremblay Pier-Luc,Zhang Tian
Ti 3 C 2 /BiOCl composite was successfully synthesized by combining BiOCl (BOC) with an exposed (110) crystal plane and Ti 3 C 2 using a simple hydrothermal process. The photocatalytic performance of produced composite was evaluated using the degradation of rhodamine B (RhB) and tetracycline hydrochloride (TCH) under visible light. The results demonstrated that Ti 3 C 2 /BOC composite had higher photocatalytic activity than pure BOC. The optimum incorporation amount of Ti 3 C 2 was 2 wt%. The photodegradation rate of 2 wt%-Ti 3 C 2 /BOC at 10 min to 20 mg/L RhB was 97.6%, which was much higher than that of BOC (75.3%). Similarly, the photodegradation rate of 2 wt%-Ti 3 C 2 /BOC to 10 mg/L TCH at 30 min was 80.4%, which was higher than BOC (68.1%). In addition, the prepared 2 wt%-Ti 3 C 2 /BOC composite also maintained good stability even after four cycles. Electrochemical impedance spectroscopy (EIS), transient photocurrent response (IT) and ultraviolet-visible diffuse reflectance spectroscopy (UV-vis) confirmed that the photoelectrochemical properties of 2 wt%-Ti 3 C 2 /BOC composite were significantly improved. On the basis of analyzing the action mechanism of photocatalyst, it was pointed out that ·O 2 - and h + were the main active substances in the photodegradation of RhB and TCH by 2 wt%-Ti 3 C 2 /BOC.
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DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 102
·100519-100525
·
IF 3.289
Fei Wang,Yang Qiu,Bing-Jie Wang,Hua-Lin Wang,Yi-Tao Long
A green method was developed to fabricate a novel porous polymer microsphere with SERS activity, which can be used for ultrasensitive detection because of its preconcentration function. Ultraviolet irradiation as “green” reduction was successfully achieved through several complex processes, namely, monomer solidification, hydrogen peroxide photolysis, and silver nanoparticle fabrication, in only one step. During the solidification process, H2O and O2, which are originally from H2O2 reduction, escaped from the emulsion templates, resulting in various interconnected micro-/nano-channels. The mean pore size of the prepared porous microspheres was 4 μm, and the specific surface area can reach 31 m2 g−1. The silver nanoparticles produced in the reduction process of silver nitrate were deposited on the porous surface of the microsphere and contributed to stable SERS activity with a SERS enhancement factor of up to 3.8 × 106 and a low detection limit of 10−13 M level for rhodamine 6G. This green method provides highly sensitive and uniform SERS substrates and ensures the stability and reliability of our “SERS substrate”.
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高影响因子
MATERIALS TECHNOLOGY
·
2018
·
IF 1.232
Guangyu Wu,Weinan Xing
Heterogeneous semiconductor photocatalysis has been considered as a cost-effective alternative for the eliminating hazardous pollutants and generating sustainable energy. Graphene, a 2D allotrope of carbon, has received significant attentions due to its outstanding properties. In this work, a highly efficient visible-light-driven ternary heterostructure semiconductor RGO/Ag2O/Ag2WO4 (RGAAW) Ag-based photocatalyst was prepared and its photocatalytic activity was evaluated by photodegradation of methylene orange (MO). The morphology, structure and optical absorption properties of the as-prepared RGAAW were characterized by SEM, XRD, XPS, FT-IR and UV−vis DRS, respectively. The obtained result was found that the as-prepared RGAAW exhibited the excellent photocatalytic activity, which was almost 11.5 and 7 times as high as those of individual Ag2O and Ag2WO4, respectively. The enhancement of photocatalytic performance could be attributed to the reduced graphene oxide sheets can function as an electron collector and transporter to lengthen the lifetime of the charge carriers. Moreover, the as-prepared RGAAW showed excellent stability toward the photodegradation of methyl orange (MO). The possible mechanism of photocatalytic activity enhancement was proposed.
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DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2018
·
IF 11.698
Jian Chen,Xiaoping Tao,Lin Tao,He Li,Chunzhi Li,Xiuli Wang,Can Li,Rengui Li,Qihua Yang
Artificial photosynthesis aiming to capture and convert renewable solar energy into solar fuels (e.g., hydrogen, chemicals) provides a blueprint for sustainable and carbon-neutral world. In artificial photosynthesis, developing novel semiconductors for visible-light-driven photocatalytic water splitting is one of the most demanding challenges. Herein, we designed and explored two kinds of novel bipyridine-based covalent organic polymers, Bp-COP (2,2′-bipyridine-5,5′-diamine: Bp-NH 2 ) and BpZn-COP (2,2′-bipyridine-5,5′-diamine Zn complex: Bp-Zn), both of which exhibit excellent light-harvesting properties with absorption edges expanding to larger than 600 nm and have appropriate band structures for water splitting. Polymers Bp-COP and BpZn-COP are found to enable efficient photocatalytic hydrogen production under visible light irradiation with Pt as the proton reduction cocatalyst. Further assembling conjugated organic polymers with TiO 2 as charge transferring mediate can remarkably boost their photocatalytic activities to more than 8 times (1333 vs. 162 μmol g −1 h −1 ), giving an apparent quantum efficiency (AQE) of over 2.5% at the input wavelength of 420 nm. This work not only presents a methodology for designing and synthesizing novel organic-based polymers, but also provides promising candidates for potential applications in solar energy conversion.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2019
·
IF 5.107
Yunxiang Tang,Xin Zhang,Yuxue Ma,Xiaotong Wang,Changhua Su,Dafeng Zhang,Xipeng Pu,Yanling Geng
Efficient separation of photogenerated charge carriers is vitally significant in the photocatalytic reaction process. In this work, a novel Zn 0.1 Cd 0.9 S/Snln 4 S 8 (ZCS/SIS) core-shell nanorods photocatalyst was prepared by a facile solvothermal method. The photocatalytic activity of the as-synthesized samples were evaluated by the degradation of Rhodamine B (RhB) and imidacloprid (IM) under visible light irradiation. Compared with the pristine ZCS and SIS, the core-shell composites displayed dramatically improved photocatalytic activity. The apparent rate constants of RhB and IM photodegradation over ZCS/SIS are 5.07 and 16.9 time higher than that of pure ZCS, respectively. In addition, the electrochemical measurements indicate that the charge carriers separation in ZCS/SIS core-shell composites is enhanced. The reason could be the formation of the core-shell ZCS/SIS heterojunction boosting the charge carriers separation and transfer. Besides, a possible photocatalytic mechanism was proposed.
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高影响因子
Materials Horizons
·
2019
·Vol. 6
·期 5
·1013-1019
·
IF 14.356
Di Chen,Yue Zhang,Chujun Ni,Chao Ma,Jie Yin,Hao Bai,Yingwu Luo,Feihe Huang,Tao Xie,Qian Zhao
Dynamic covalent polymer networks exhibit a unique stress relaxation behavior under mechanical deformation, which enables sophisticated shape manipulation in addition to their widely recognized capabilities of self-healing and thermoset recycling. Here we present an unusual ice-templated photo-patterning technique employing a disulfide-crosslinked hydrogel capable of photo-induced network rearrangement. First, freezing creates internal mechanical stress since the resulting ice crystals squeeze the polymer chains. Secondly, spatio-temporal UV light irradiation at this frozen state leads to localized stress relaxation via disulfide bond exchange. At the last step, subsequent ice melting leads to pore patterns, the porosity of which can be controlled by the light dosage. Taking advantage of the stimuli-responsiveness of the hydrogel, one single patterned sample is used as an adaptive stamp to produce multiple functional devices (e.g. antenna).
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2018
·Vol. 53
·期 20
·14337-14349
·
IF 2.993
He Shuai,Li Hui,Chen Hualin
The dispersion of graphene in water has generally been considered an insurmountable challenge owing to its hydrophobic nature. In this study, a new type of light-sensitive polymer/graphene composite (AzoPEO/β-CD–RGO) was synthesized by the reversible host–guest interaction between azobenzene-terminal poly(ethylene oxide) (AzoPEO) and a β-cyclodextrin (β-CD) host attached to the surface of graphene via hydrogen bonding. In water, the AzoPEO/β-CD–RGO composite not only is well dispersed, but also exhibits reversible dispersion/aggregation behavior triggered by UV and visible light. Moreover, the graphene composite can be used to fabricate a light-responsive graphene-based drug delivery system. This kind of light-responsive graphene composite, which efficiently allows the control of graphene dispersion/aggregation, may find wide applications in the preparation of intelligent drug delivery systems, smart sensors, and switching devices.
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高影响因子
ChemCatChem
·
2019
·Vol. 11
·期 11
·2596-2599
·
IF 4.495
Xin Fan,Yanling Yao,Yangsen Xu,Lei Yu,Chuntian Qiu
In this work, a highly efficient PCN-KCl (KCl-modified polymeric carbon nitride) nanosheet photocatalyst was synthesized with the assistance of KCl. The as-prepared PCN-KCl catalyst shows a more than 30-fold enhancement in the photocatalytic activity for H 2 evolution from water compared to the pristine PCN. More importantly, when PCN-KCl was composited with a second catalyst (Pd nanoparticles), the simultaneous production and utilization of active H species for alkenes hydrogenation was achieved by visible light irradiation under ambient conditions. Graphical Photo-ready : One-step photocatalytic generation of hydrogen from water and its subsequent utilization for reduction reactions was demonstrated with typical examples of olefin hydrogenation into the corresponding alkanes over a Pd/PCN-KCl bifunctional photocatalyst under mild conditions.
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高影响因子
Applied Sciences-Basel
·
2019
·Vol. 9
·期 12
·2567
·
IF 2.217
Dongpeng Zhao,Qiuchen Lu,Runzhou Su,Yuanzuo Li,Meiyu Zhao
The photovoltaic properties of two dyes (quercitin (Q) and rutin (R)) were experimentally investigated. The results showed that Q had excellent photoelectric properties withJscof 5.480 mA·cm−2,Vocof 0.582 V,ηof 2.151% larger than R withJscof 1.826 mA·cm−2,Vocof 0.547 V, and η of 0.713%. For a better understanding of the photoelectric properties of two molecules and illustrating why the performances of Q is better than R from the micro-level, the UV-VIs spectrum, Fourier transforms infrared (FT-IR) spectrum, and cyclic voltage current characteristics were experimentally investigated. What is more, density functional theory (DFT) and time dependent density functional theory (TD-DFT) have been implemented in theoretical calculation. Based on the calculated results, frontier molecular orbitals (FMOs), charge differential density (CDD), infrared vibration, first hyperpolarizability, projected density orbital analysis (PDOS), electrostatic potential (ESP), and natural bond orbital (NBO) were analyzed. Hole/electron reorganization energies (λh/λe), light harvesting efficiency (LHE), fluorescent lifetime (τ), absorption peak, and the vertical dipole moment (μnormal) were calculated, and the shift of conduction band edge of a semiconductor (ΔECB) has been analyzed, which has a close relationship withJscandVoc. The results demonstrated that, due to the higher LHE, τ,μnormal, and red-shifted absorption peak, Q has better photoelectric properties than R as a promising sensitizer.
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高影响因子
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