SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Wei Yue,Bingyong Lin,Yueyue Huang,Yueliang Wang,Yuanyuan Yao,Lifen Chen,Yanbo Zeng,Lei Li,Zhaosheng Qian,Longhua Guo
Microcystin-LR (MC-LR) is a strong liver toxin, which will enter the human body by eating MC-LR-contaminated aquatic products. Therefore, it is urgent to explore whether people are exposed to MC-LR-contaminated aquatic products. Herein, a sensing strategy based on aptamer-recognized SERS tag coupled with magnetic separation was developed for ultrasensitive and specific detection of MC-LR in fish organs. This sensor had a dynamic range of 0.1 ng/L to100 µg/L and a limit of detection down to 0.1 ng/L for MC-LR. This ultrasensitive and rapid separation strategy allow us to explore the bioaccumulated amount of MC-LR in different fish organs. The results show that the order of MC-LR content accumulated in different organs of local crucian carps were heart > liver > kidney > meat > spleen. The MC-LR content in fish meat was 1.1–8.5 times of the WHO proposed tolerable daily intake level (TDI), implying the aquatic products in local aquatic market had potential threats to human health.
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ACS Applied Nano Materials
·
2022
·
IF 6.14
Ya Lu,Zhuanfang Bi,Guangyi Shang
Detection of trace carbendazim in agricultural products or environment is challenging but important for human health and environmental protection. Developing a sensitive and recyclable surface-enhanced Raman scattering (SERS) substrate is one of the effective methods to detect such pesticide residues. In this work, we developed a facile method to fabricate a three-dimensional cactus-like Ag nanoparticles/CuO/Cu2O nanocomposite (CACN) based on a galvanic replacement reaction between Tollens’ reagent and Cu foam. This design combined the Raman enhancement effect and photocatalytic activity, providing a multifunctional and reusable substrate for highly sensitive SERS detection. It was found that the enhancement and photocatalysis of the CACN substrate were closely related to the concentration of Tollens’ reagent, and the 10-CACN substrate (prepared at 10 mM) demonstrated excellent sensitivity, reproducibility, and recyclability. The substrate was successfully applied for the detection of carbendazim solution with a detection limit of 1.5 × 10–10 M and could be reused up to 7 times. More importantly, the substrate can be employed for the detection of trace carbendazim in real apple peels with a detection limit of ∼8.5 × 10–4 ppm, which is far below that of 2.0 × 10–1 ppm suggested by China, United Kingdom, and European Union. These results suggest that the facile fabrication method and the excellent substrate would facilitate the SERS technology closer to practical application in the detection of pesticide residues.
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Analytical Methods
·
2023
·Vol. 15
·期 8
·1047-1053
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IF 3.1
Nan Zhang,Haiyang Lv,Jihong Wang,Zhanye Yang,Yanru Ding,Bing Zhao,Yuan Tian
Residues of sulfadimethoxine (SDM) in animal-derived foods have attracted widespread public concern. Herein, we propose an aptamer-based colorimetric/SERS dual-mode sensing strategy for the determination of SDM based on hexadecyl trimethyl ammonium bromide (CTAB) induced aggregation of nanoparticles. In the absence of SDM, the SDM aptamer formed a supramolecular composite with CTAB, and the 4-mercaptopyrimidine functionalized gold nanoparticles (AuNPs@4-MPY) remained dispersed due to the lack of CTAB. Upon the addition of SDM, the SDM aptamer preferentially combined with SDM, resulting in the release of CTAB and subsequent aggregation of AuNPs@4-MPY, and the solution color changed from red to blue and presented a dynamic UV-absorbance curve based on different aggregation states. On the other hand, when, gold–silver core–shell nanoparticles (Au@AgNPs) were added additionally, the released CTAB narrowed the nanogap between AuNPs@4-MPY and Au@AgNPs, thus exhibiting enhanced SERS intensity of 4-MPY. This strategy achieved colorimetric detection of SDM with a linear range of 4.00–200.00 ng mL−1 and a detection limit of 2.41 ng mL−1, while SERS had a detection range of 1.20–120.00 ng mL−1 with a detection limit of 0.89 ng mL−1. This strategy is simple and cost-effective for the rapid detection of SDM within 20 minutes. It was further applied for the detection of SDM in spiked milk and honey samples with satisfactory recoveries. Therefore, it exhibits great potential for fast and on-site SDM detection.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2023
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IF 6.2
Xiaoyu Han,Yan Wang,Tianyi Wang,Jihong Zhang,Jun Xie,Jianjun Han,Xiujian Zhao
Highly selective and sensitive detection of toxic mercury ions (Hg 2+ ) has become a critical issue in recent decades, due to increasing environmental and health requirements. Herein, carbon dots reduced and decorated Ag (CDs/Ag) nanoparticles based fiber probes were fabricated, providing a “turn-off” surface-enhanced Raman spectroscopy (SERS) for low-concentration Hg 2+ ions detection. The CDs/Ag nanoparticles fiber probe exhibits better SERS performance than that of Ag nanoparticles fiber, attributed to the stronger electromagnetic intensities induced by localized surface plasmon resonance (LSPR) and larger hot-spot areas resulting from the interaction between silver nanoparticles and carbon dots, under 532 nm beam excitation. As low as 10 −11 M Hg 2+ ions can be detected through the decrease in Raman scattering intensities of CV molecules, due to the SERS inactive Hg metal layer wrapping the surface of silver nanoparticles, through the reduction of Hg 2+ ions by carbon dots. The dropping of silver nanoparticles’ LSPR induced absorption peak, EDS elemental mapping, and XPS analysis all confirm that the wrapping decreases the LSPR effect and corresponding Raman intensity. Furthermore, the detection shows high selectivity and can only be applied for detecting Hg 2+ ions, owing to the reduction capability of carbon dots. The close analysis results obtained using SERS fiber probes and commercial inductively coupled plasma-mass spectrometry (ICP-MS) for detecting Hg 2+ ions in real water sample confirm the reliability of this detection method. This research indicates the CDs/Ag fiber probe has a great potential application for environmental Hg 2+ ions detection.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2023
·
IF 4.4
Meng Sun,Houjia Zhang,Hefu Li,Xuehui Hao,Changzheng Wang,Lijun Li,Zhenshan Yang,Cunwei Tian
Flexible and transparent surface-enhanced Raman scattering (SERS) substrates have attracted much attention as a fast, sensitive and in situ detection platform for practical applications. However, the large-area fabrication of flexible and transparent SERS substrates with high performance is still challenging. Here, a flexible and transparent SERS substrate based on large-area thin PDMS film decorated with Ag microlabyrinth/nanoparticles hierarchical structures (denoted as ALNHS@PDMS) is fabricated by using the floating-on-water method and magnetron sputtering technology. By optimizing the sputtering time, the ALNHS with multiple hot spots are uniformly distributed on the PDMS surface. Based on characterizing the rhodamine 6G (R6G) with a portable Raman spectrometer, the optimal ALNHS@PDMS film exhibits a high enhancement factor (5.2 × 10 6 ), excellent uniformity and reproducibility, as well as superior mechanical stability. In addition, thanks to the good sticky feature and bi-directional activation property of the thin ALNHS@PDMS film, the prepared flexible and transparent SERS substrate can achieve in situ detection of malachite green residues (10 -6 M) on apple and tomato skins. This large-area, thin, mechanically robust, flexible and transparent ALNHS@PDMS film, integrated with a portable Raman spectrometer, shows great potential for point-of-care testing (POCT) in practical applications.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Huanhuan Li,Xiaofeng Luo,Suleiman A. Haruna,Muhammad Zareef,Quansheng Chen,Zhen Ding,Yiyong Yan
Pesticide residue detection in food has become increasingly important. Herein, surface-enhanced Raman scattering (SERS) coupled with an intelligent algorithm was developed for the rapid and sensitive detection of pesticide residues in tea. By employing octahedral Cu 2 O templates, Au-Ag octahedral hollow cages (Au-Ag OHCs) were developed, which improved the surface plasma effect via rough edges and hollow inner structure, amplifying the Raman signals of pesticide molecules. Afterward, convolutional neural network (CNN), partial least squares (PLS), and extreme learning machine (ELM) algorithms were applied for the quantitative prediction of thiram and pymetrozine. CNN algorithms performed optimally for thiram and pymetrozine, with correlation values of 0.995 and 0.977 and detection limits (LOD) of 0.286 and 29 ppb, respectively. Accordingly, no significant difference ( P greater than 0.05) was observed between the developed approach and HPLC in detecting tea samples. Hence, the proposed Au-Ag OHCs-based SERS technique could be utilized for quantifying thiram and pymetrozine in tea.
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TALANTA
·
2023
·
IF 6.1
Xiaojun Wen,Huan Cheng,Weilong Zhang,Lijun You,Jumei Li
To enable the widespread application of surface-enhanced Raman scattering (SERS) technique in practical sensing of organic pollutants, it is essential to develop a reliable SERS substrate that offers both high sensitivity and reusability. In this study, we employed a simple and rapid in-situ deposition method to coat Ag nanoparticles onto flower-like Ni(OH) 2 spheres, resulting in the formation of Ni(OH) 2 /Ag composites with excellent photocatalytic performance and SERS activity. These composites were used as a promising SERS analysis tool for effective detection of organic pollutants, including ciprofloxacin hydrochloride (CIP) and methylene blue (MB). Notably, the composites exhibited outstanding detection limits of 10 −8 M for MB and 10 −7 M for CIP, respectively, and showed a strong linear relationship between SERS intensities and the logarithmic concentration (R 2 ≥ 0.97). Moreover, under simulated sunlight irradiation, the Ni(OH) 2 /Ag composites efficiently degraded MB and CIP molecules within a short period of 120 min for MB and 130 min for CIP. This demonstrated their practical reusability, as evidenced by their consistent performance over five cycles of SERS sensing. These findings underscore the significant potential of these composites for SERS-based detection of trace pollutants and ecological restoration through photocatalytic reactions in the future.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Xiaoming Su,Yangcenzi Xie,Xinyu Liu,Mingyang Chen,Chao Zheng,Hong Zhong,Ming Li
Exosomes (exos) widely existing in body fluids show great potential for noninvasive cancer diagnosis. Quantitative analysis of exos is traditionally performed by targeting specific exosomal surface proteins, but it is often imprecise due to the common expression of exosomal proteins and subtle expression differences between different cancer subtypes. Herein, we report quantitative surface-enhanced Raman spectroscopy (SERS) of serum exos through a combination of a paper-based lateral flow strip (LFS) biosensor with multivariate spectral unmixing analysis rather than simply quantifying exosomal proteins. Our SERS-LFS biosensor enables absolute quantification of two different serum exos with a limit of detection down to ∼106 particles/mL for both exos. We further exemplify the application of this strategy in quantitative dual-plex detection of serum exos from breast cancer patients. We find that human epidermal growth factor receptor 2+ (HER2+) and luminal A breast cancer patients undergoing no surgery are enriched in serum exos derived from SKBR-3 cells and MCF-7 cells (denoted as SKBR and MCF exos), respectively. The surgical treatment of these breast cancer patients accompanies an obvious decrease of either SKBR or MCF exos in the serum. These results suggest the great potential of the combination of the SERS-LFS biosensor and multivariate spectral unmixing for breast cancer subtyping and therapeutic surveillance with the powerful quantitative capability of exos in clinical samples.
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Journal of Materials Chemistry B
·
2022
·Vol. 11
·期 2
·441-451
·
IF 7.571
Imran Mahmood Khan,Sobia Niazi,Imran Pasha,Muhammad Kashif Iqbal Khan,Lin Yue,Hua Ye,Ali Mohsin,Muhammad Shoaib,Yin Zhang,Zhouping Wang
Fluorescent gold (Au) nanostructures have emerged as burgeoning materials to fabricate nanomaterial assemblies which play a vital role in improving the detection sensitivity and specificity for various biomolecules. In this work, a fluorescence labelled (Rhodamine-B-Isothiocyanate) silica shell with Au metal core (AuNPs@PVP@RITC@SiO2) and a graphene–Au nanostar nanocomposite (rGO–AuNS) are presented as a metal enhanced fluorescence (MEF) material and Raman signal enhancer, respectively. Their composite (AuNPs@PVP@RITC@SiO2NPs/rGO–AuNS) was employed as a dual-mode fluorescence (FL) and surface-enhanced Raman scattering (SERS) nanoprobe for selective and sensitive detection of T-2 toxin. To comprehend the dual-modality, a core–shell nanostructure, AuNPs@PVP@RITC@SiO2, was functionalized with an aptamer (donor) and adsorbed on the surface of rGO–AuNS through electrostatic forces and π–π stacking which act as a FL quencher and SERS signal enhancer. When exposed to T-2 toxin, the apt-AuNPs@PVP@RITC@SiO2NPs move away from the surface of rGO–AuNS, resulting in the restoration of FL and reduction of the SERS signal. There was distinct linearity between the T-2 toxin concentration and the dual FL and SERS signals with lower limits of detection (LOD) of 85 pM and 12 pM, as compared to the previous methods, respectively. The developed FL and SERS aptasensor presented excellent recovery ratio and RSD in wheat and maize, respectively, as compared with the standard ELISA method. The complementary performances of the developed stratagem revealed a high correlation between the FL and SERS sensing modes with exquisite detection properties.
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ANALYTICAL SCIENCES
·
2022
·Vol. 38
·期 11
·1385-1394
·
IF 1.967
Gao Yueying,Wan Yuqi,Liu Lin,Liu Jinghan,Li Jingkun,Li Yu,Ozaki Yukihiro,Pi Fuwei
Based on the Lewis acid’s coordination principle, a surface-enhanced Raman scattering (SERS) chip strategy had been developed for the ultrasensitive quantitation of SO 4 2− . Through the immobilization of silver nanoparticles (Ag NPs) and the construction of the boric acid-based sensing unit, the chip system displayed outstanding merits on the direct sensing of SO 4 2− , e.g., simple operation, ultra-high sensitivity, reproducibility, excellent selectivity and specificity. Moreover, an accurate evaluation was obtained by ratiometric calculations on characteristic peaks (1382 and 1070 cm −1 ) for quantitative detection of SO 4 2− . The detection limit was down to 10 nM. Tap water, beer, and mineral water samples were tested, and high recoveries were achieved (97.12–110.12%). Besides, such SERS chip also displayed strong applicability for the evaluation of SO 3 2− . Therefore, this SERS chip provided a promising idea for the quantification of trace amounts of SO 4 2− and SO 3 2− in the fields of food safety and environmental monitoring. Graphical abstract
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TALANTA
·
2022
·
IF 6.556
Muhammad Usman Amin,Lingwei Li,Ruiyuan Zhang,Jixiang Fang
In recent years, surface-enhanced Raman spectroscopy (SERS) has been widely used in various fields for the rapid detection of trace-level molecular targets. In this study, we have developed a simple and effective solution-based SERS protocol to improve the activity for the detection of cationic dye molecules in aquaculture. The polystyrene sulfonate functionalized gold nanobipyramids (PSS–Au BPs) were synthesized from the cetyltrimethylammonium bromide (CTAB) reaction system followed by the ligand exchange process. The halide ions-induced aggregation of PSS-Au BPs was carried out by using four type of different salts such as NaCl , NaBr, MgCl 2 and MgSO 4 to investigate their influence on the SERS activity. The results demonstrate that the ionic strength of the solution has an important impact on the colloidal stability and SERS activity. The PSS-Au BPs show an improved SERS sensitivity at lower concentrations of the aggregating agents in solution-based SERS by detecting the crystal violet (CV) molecules with a limit of detection (LOD) to 3.28 × 10 −11 M. Furthermore, to demonstrate the generality of our proposed strategy, trace amounts of three more dyes such as malachite green (MG), methylene blue (MB), and rhodamine 6G (R-6G), as well as other molecules such as thiram and bisphenol-S were also detected. This protocol not only provides a method for rapid on-site detection of trace-level molecules but can also be applied to other SERS-based analysis.
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PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2022
·Vol. 24
·期 23
·14479-14487
·
IF 3.945
Lingfeng Deng,Xiaoying Zhang,Jun Liu,Aixiang Wei,Yu ding He,Zhen Liu,Ningqi Luo
Rhenium diselenide (ReSe2) has attracted great interest due to its unique anisotropic structure and unusual in-plane anisotropic electrical and optical properties. However, efficient fabrication of large-area and high-quality 2D ReSe2 continuous films has become an increasingly important challenge. In this work, centimeter-scale 2D ReSe2 continuous films with the layer number varying from monolayer to 12 layers were successfully grown on a mica substrate using our space-confined CVD system via changing the position of the substrate. The fluorescence quenching effect and surface enhanced Raman scattering (SERS) effect on 2D ReSe2 films with different layer numbers were investigated using rhodamine 6G (R6G) dye molecules as a Raman probe. The large-area ReSe2 films show the layer-number-dependent nature of the SERS effect and a robust suppression effect of fluorescence. Our work explores the practical application of 2D ReSe2 films for molecular detection via the SERS technique.
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