Food Bioscience
·
2024
·
IF 4.8
Feng Du,Yiqun Huang,Zhijie Liu,Junjian Miao,Keqiang Lai
This study aimed to investigate the effects of pH (5.8, 7.0, and 10.0), linoleic acid , and reheating (heating: 180 °C, 30 min; reheating: 100 °C, 10 min) on the reactants, α-dicarbonyl compounds, and volatile compounds in the glucose-lysine model system, with a specific focus on exploring the influences of volatile compounds. The results showed that under three different pH glucose-lysine model system yielded the detection of 9, 15, and 29 volatile compounds, respectively. Notably, both the number and content of volatile compounds exhibited an upward trend as the pH increased. Reheating treatment led to changes in both the number and content of volatile compounds. The addition of linoleic acid affected the generation of heterocyclic compounds associated with the Maillard reaction . Volatile compounds such as aldehydes and alcohols were generated in systems containing linoleic acid, resulting in a higher number and content of volatile compounds compared to systems without linoleic acid.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Qiuyu Du,Yaoxing Wang,Xueqin Fan,Xueqi Li,Yingying Liu,Peng Jiao,Pengyu Xing,Ran Yin,Wentao Gan
The assembly of diverse active materials significantly enhances the efficiency of the electrocatalytic hydrogen evolution reaction (HER). Herein, we prepare a three-phase composite structure electrocatalyst on carbonized wood, in which molybdenum carbide and molybdenum phosphide are attached to molybdenum sulfide nanosheets (MoS2–MoP–Mo2C@CW) through the hydrothermal method in combination with high-temperature calcination for a pH-universal HER. MoS2 possesses abundant unsaturated coordination edge active sites, thus facilitating the adsorption and desorption of the hydrogen intermediate (H*). The synergistic effect between MoS2, MoP featuring favorable electronic conductivity, and Mo2C holding strong adsorption of H* enhances the catalytic activity for the pH-universal HER. Moreover, the carbonized wood with a hierarchical porous structure and aligned microchannels accelerates mass transport during the HER. As a result, the molybdenum-based self-supported composite electrode exhibits outstanding HER performance with the low overpotentials of 46, 84, and 65 mV to achieve the current density of 10 mA cm–2 and the corresponding Tafel slopes of 57, 111 mV, and 63 mV dec–1 in alkaline, neutral, and acidic environments, respectively. MoS2–MoP–Mo2C@CW also shows a long-term durability of 200 h over a broad pH range at 10 mA cm–2. This work provides an effective strategy for the development of multiphase carbonized wood-based electrocatalysts for the pH-universal HER.
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INDUSTRIAL CROPS AND PRODUCTS
·
2024
·
IF 5.6
Yanzhu Guo,Yunchuan Dai,Tao Zhang,Pengyu Hu,Tingting Chu,Haiqiang Shi,Haiming Li,Xing Wang,Zhiwei Wang,Qing-Shan Shi,Xiaobao Xie,Mingjie Chen
Lignin is the most abundant, but underutilization polyphenolic material on the earth. In this paper, an integrated platform for pH sensing and ions separation was prepared from lignin to make use of this abundant bioresource. Demethylation of enzymatic hydrolysis lignin was first achieved to mimic the catechol structure of dopamine. The demethylated lignin was then converted into carbon dots by a facile hydrothermal treatment. The as-prepared carbon dots emit green fluorescence with enhanced quantum yield, and exhibited pH-responsive color changes from yellow-green to blue. When incorporated into a chitosan aerogel , the pH-responsive property of the carbon dots was intact, whereas the adsorption capacity of the aerogel for Cu 2+ ions was noticeably improved, which was owed to the abundant oxygen containing functional groups and unique optical properties of the as-prepared carbon dots. This study provides a feasible approach to convert lignin into fluorescent nanomaterials for pH sensing and metal ions recovery from wastewater.
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JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2024
·
IF 11.2
Rui Ding,Zhang Yuan,Ke Wang,Pandi Peng,Jiaheng Liang,Kun Wang,Ke Lin,Hanxue Wu,Peng Li
Polyetheretherketone (PEEK) has been recognized for its immense potential in hard tissue repair applications due to its mechanical properties resembling those of natural bones. However, the inherent bioinertness of pristine PEEK results in insufficient osseointegration. Moreover, implant-associated infection (IAI) has become a serious threat in orthopedic surgery. These risks usually lead to implant loosening, delayed healing, and even the failure of implantation, hampering many clinical applications of PEEK. In this study, we present a facile strategy to endow PEEK implants with enhanced osseointegration and pH-responsive antibacterial activity. Briefly, pristine PEEK was first treated with mixed acids to obtain a porous structure (referred to as SNPEEK), and then the metal-phenolic networks (MPN) coating was prepared using layer-by-layer (LbL) assembly consisting of Sr 2+ and tannin acid (TA) (referred to as ST coating). The results demonstrated that the dual-functional PEEK displayed enhanced antibacterial activity in pH-responsive manner. At pH 7.4, the antibacterial ratios were 71.72% and 66.79% against Staphylococcus aureus (MSSA, ATCC 25923) and methicillin-resistant Staphylococcus aureus (MRSA, ATCC BAA-40), respectively. Remarkably, at pH 5.5, the antibacterial activities significantly increased, resulting in killing ratios of 99.98% and 100%, respectively. Furthermore, the dual-functional PEEK promoted osteogenic differentiation of pre-osteoblasts (MC3T3-E1) and migration of human umbilical vascular endothelial cells (HUVECs). In addition, the dual-functional PEEK demonstrated effective anti-infection ability and desirable new bone formation ability in vivo compared to both pristine PEEK and SNPEEK implants. Overall, this study provides a promising strategy to endow PEEK implants with effective osseointegration and anti-infective ability, representing a prospective solution to address current clinical challenges associated with PEEK implants.
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ACS Omega
·
2024
·
IF 3.7
Yurong Leng,Yanmei Wu,Wenjing Xiao,Xiaoquan Su,Zhe Liu
Nanomedicine provides promising new methodologies for the treatment of tumors but still faces several limitations, including poor colloidal stability, uncontrollable drug release, and insufficient drug targeting. Herein, hyaluronic acid (HA) was used to modify the surface of mesoporous silica nanoparticles (MSNs) via a dynamic-covalent linker, phenylborate ester (PBAE), termed MA. The HA modifier provided enhanced colloidal stability to the hybrid nanoparticles. As expected, MA exhibited an improved biocompatibility and high potential for biomedical applications. Moreover, MA with a negatively charged surface effectively adsorbed the drug Doxorubicin (DOX) inside the carriers, ensuring minimal drug leakage. In an acidic and reactive oxygen species (ROS)-containing condition mimicking the tumor microenvironment, MA@DOX (MAD) continuously released its payloads, likely due to the cleavage of the pH/ROS-sensitive PBAE. Compared with free DOX, MAD had 2.2 times higher accessibility to tumor cells than free DOX. The favorable stability and cancer-selective drug release make this nanoformulation a promising platform for potent cancer treatment.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
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IF 5.4
Yibiao Zhou,Xiaowei Yang,Chao Deng,Yongjie Xia,Shengping Tang,Hongwu Zeng,Bin Zhang,Xiaoyong Zhang,Guibing Fu,Chao You
Osteoporosis (OP) is a degenerative bone disease that commonly occurs in elderly people. It often manifests in bone pain and increased risk of fractures, significantly impacting the quality of life for middle-aged and elderly individuals. Several anti-osteoporosis drugs are currently available in clinical practice, their long-term use has shown limited efficacy and potential complications. The natural compound puerarin (Pue) has demonstrated to be promising for OP treatment via regulating osteoclast and osteoblast differentiation. However, its poor solubility, low bioavailability, and lack of bone-targeting severely impeded its clinical applications. To address the above issues, we reported herein the synthesis of Pue-based framework (HCCP-Pue-PEG-ALN, HPPA NPs) via conjugation of Pue, NH 2 -PEG, and alendronic acid (ALN) using hexachlorocyclotriphosphazene (HCCP) as the linkage. We demonstrated that the HPPA NPs display the features, including high water dispersibility, pH responsive drug release, low cytotoxicity, bone targeting feature, and positive effects on both osteoclasts and osteoblasts. Therefore, we believe this idea reported in this work will be of great interest in design natural compounds-based drug delivery systems and promotes clinic translation of natural compounds for OP treatment.
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JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2017
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IF 1.591
Wenjun Zhang,Xiao Sun,Xianlin Fan,Min Li,Gaohong He
pH-responsive Pickering emulsions were prepared, taking the hydrophobic modified calcium alginate nanoparticles (MCA) of pH sensitivity as emulsifiers. The MCAs were obtained via gelation between Ca2+ in emulsion and alginate sodium that reacted with diacetone acrylamide since alginate sodium was too hydrophilic to be used as a stabilizer. The effect of MCA characteristics, Ca2+ content, and pH on the preparation and property of emulsion was evaluated. Then, the released behaviors of MCA-stabilized emulsion loading oil-soluble drug of curcumin were investigated in vitro. The results demonstrated that Pickering emulsions released curcumin intestine-specifically (37% in 4 hours with a pH of 6.8), compared with the one in the gastric fluid (3% in 4 hours with a pH of 1.5), proving that MCA had similar pH sensitivity to alginates and probably as the promising candidate in oral drug controllable release.
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PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
·
2025
·
IF 2.5
Jie Wang,Xuemei Gu,Xia Gao,Jing Chen,Zhiyang Lv,Siyu Zhang,Siyu Ni,Fei Shi,Xialin Chen,Liang Cao,Zhenzhong Wang,Wei Xiao
In order to enhance the therapeutic value of curcumin in liver cancer treatment, glycyrrhetinic acid-modified pH-sensitive curcumin liposomes (GA-pH-Lip@Cur) was developed.GA-pH-Lip@Cur was prepared using a thin film dispersion ultrasonication method, and the optimal formulation process was selected through single-factor experiments and a Box-Behnken design-response surface methodology. The liposomes were evaluated for their morphological appearance, particle size, in vitro release at different pH levels, and biocompatibility. The anti-tumor effect of GA-pH-Lip@Cur was assessed using cell viability assays (CCK-8). The in vivo hepatic targeting and anti-liver tumor efficacy of GA-pH-Lip@Cur were evaluated through pharmacokinetic and pharmacological experiments.The results indicated that optimized GA-pH-Lip@Cur exhibited uniform particle size distribution, good stability, pH-sensitive in vitro release with sustained behavior. Compared to conventional liposomes, GA-pH-Lip@Cur showed prolonged average retention time in vivo and significantly increased curcumin distribution in liver tissues, indicating excellent liver targeting. Both in vitro and in vivo evaluations demonstrated the effectiveness of GA-pH-Lip@Cur in inhibiting liver cancer cell proliferation and suppressing liver tumor growth in tumor-bearing mice. In conclusion, GA-pH-Lip@Cur, by leveraging the acidic tumor microenvironment and overexpression of glycyrrhetinic acid receptors in liver cells, encapsulates curcumin to improve its bioavailability, and target its delivery to the liver tumor sites.
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高影响因子
RSC Advances
·
2024
·Vol. 14
·期 27
·19174-19184
·
IF 3.9
Peixin Hu,Hechao Lu,Qinting He,Fang Ren,Juan Wu,Wei Jiang
In this work, intelligent pH-sensitive sensors (Fe3O4/RhB@PAM) for Cr(VI) detection were successfully synthesized based on polyacrylamide (PAM) and Rhodamine B (RhB) co-modified Fe3O4 nanocomposites. The characterization results indicated that the sensors had many favorable properties, including suitable size, stable crystal structure and excellent magnetic response performance (47.59 emu g−1). In addition, the fluorescence changes during the detection process indicated that Fe3O4/RhB@PAM were “ON–OFF” intelligent sensors. When the Fe3O4/RhB@PAM sensors were placed in acidic Cr(VI) solution (pH 4), PAM acted as a pH-responsive “gatekeeper” releasing RhB, and the fluorescence intensity of released RhB was weakened by the complexation of Cr(VI). Furthermore, the fluorescence changes of the magnetic sensors were remarkably specific for Cr(VI) even in the presence of other competitive cations, and the limit of detection (LOD) for Cr(VI) was lower (0.347 μM) than the value recommended by the World Health Organization (0.96 μM). All the results presented in this study showed that the Fe3O4/RhB@PAM sensors had significant potential for Cr(VI) detection in acidic environmental samples.
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高影响因子
LANGMUIR
·
2024
·
IF 3.7
Jiahui Zhang,Dongxin Zhao,Kui Lu,Libo Yuan,Heng Du
Based on the typical similar repeat units (abcdefg)n of α-helical structure, the peptide H was designed to self-assemble into an organohydrogel in response to pH. Depending on the different pH, the proportions of secondary structure, microstructure, and mechanical properties of the gel were investigated. Circular dichroism (CD) and Fourier transform infrared (FT-IR) showed that the proportion of α-helical structure gradually increased to become dominant with the increase of pH. Combining transmission electron microscopy (TEM) and atomic force microscopy (AFM), it was found that the increase of the ordered α-helix structure promoted fiber formation. The further increase in pH changed the intermolecular forces, resulting in an increase in the α-helix content and the enhancement of helix–helix interaction, causing the gel fibers to converge into thicker and more dense ones. The temperature test showed the stable rheological properties of the organohydrogel between 20–60 °C. Drug release and cytotoxicity showed that the DOX-loaded organohydrogel could have a better release in an acidic environment, indicating its potential application as a drug local delivery carrier.
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JOURNAL OF POWER SOURCES
·
2025
·
IF 7.9
Xiaojing Dong,Jintao Wang,Yue Hao,Yiqiang Sun,Xu Zhang,Bo Xu,Cuncheng Li
Exploring oxygen evolution reaction (OER) electrocatalysts over a universal pH range to simultaneously achieve enhanced activity, improved stability and reduced cost is a rewarding yet challenging endeavor. Considering the hydrophilicity and electronegativity disparity between Pb and Ru, herein, a Pb doped RuO 2 catalyst and its application as electrocatalyst for OER under universal pH conditions are studied. Due to the modified hydrophilicity and electronic structure, the Pb 0.1 Ru 0.9 O 2 only requires an overpotential of 207 mV to obtain a current density of 10 mA cm −2 in acidic environment, and overpotentials of 232 mV and 363 mV are required in alkaline and neutral environments, respectively. Moreover, extensive stability assessments conducted over a 24-h period reveal remarkable stability of the catalyst in diverse environments, encompassing acidic, alkaline, and neutral conditions. Additionally, the utilization of density functional theory (DFT) computations offers persuasive evidence that the inclusion of Pb within RuO 2 can significantly alter its electronic configuration, thereby promoting efficient electron transfer processes. This modulation of the electronic structure is crucial for enhancing the catalytic performance of the material. This research paves the way for innovative designs of highly efficient oxygen evolution reaction (OER) catalysts, featuring minimized use of precious metals, heightened catalytic prowess, and unparalleled stability across a broad pH range.
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Journal of Materials Research and Technology-JMR&T
·
2024
·
IF 6.2
Bo Fang,Xinyue Zhang,Hongliang Liu,Fangchao Zhao,Yuzhu Li,Xiaotong Zeng,Zhenliang Feng,Wenzuo Li,Jie Liu
The pH-sensitive Tannic acid@ Benzotriazole@ Poly (hydroxypropyl acrylate-triethoxyvinylsilane -acrylic acid)/polyethyl enimide (TBP) gels loaded with corrosion inhibitors and the modified TBP composite coatings (TBP/EP coatings) were prepared innovatively. The TBP gels possessed excellent pH-sensitive properties and compatibility with epoxy coatings. Furthermore, the protective performance of the TBP/EP coatings was improved by the addition of TBP gels, which was attributed to the TBP gels filling the defects of the coatings after expansion of water absorption, and the released corrosion inhibitors formed the corrosion inhibitor films and the iron tannate films on the metal surface, respectively. Following the 181d immersion test, the TBP/EP coatings sustained an impedance value of 2.36 × 10 7 Ω cm 2 . In contrast, the impedance value of the epoxy coatings decreased to 6.86 × 10 4 Ω cm 2 . In comparison to epoxy coatings, the TBP/EP coatings demonstrated a notable enhancement in original adhesion and wet adhesion, with increases of 18.21% and 74.7%, respectively. In the end, the TBP/EP coatings corrosion inhibition functions were innovatively introduced.
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