COLLOIDS AND SURFACES B-BIOINTERFACES
·
2022
·
IF 5.999
Xiaoteng Liang,Yin Wang,Jie Song,Dan Xia,Qiang Li,Mingdong Dong
The disassembly and eliminating the amyloid-β (Aβ) aggregates has become an effective way to treat Alzheimer’s disease (AD). Herein, for the first time, the near-infrared (NIR) activated silicene nanosheets (SNSs) have been identified as an effective nontoxic photothermal conversion agent for irreversibly disassembly of the Aβ 33–42 aggregates. The SNSs synthesized by a combination of mild oxidation method and liquid exfoliation method possess good biocompatibility and biodegradability, and high near-infrared photothermal conversion capabilities. Under NIR light, the SNSs could disassemble the large and dense Aβ 33–42 mature fibrils into short fibrils and even form thin films, leading to the degradation rate of 96.47%. The circular dichroism spectrum, fluorescent spectra, and nanostructure were analyzed to monitor the photothermal degradation of mature Aβ 33–42 fibrils for elaborating the mechanism beneath. This study might provide a clue for developing potential therapeutic strategy for AD and related neurodegenerative diseases.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Fei Liu,Xuewu Wang,Xiaqing Li,Xiaodong Dai,Zhaoxiang Zhang,Daoxu Wang,Ye Wang,Shunyao Jiang
Well wall collapse due to massive fluid in water-based drilling fluids (WDFs) intrusion into the reservoir is an urgent issue during oil drilling. In this study, we synthesized the poly(ionic liquids) (PILs) based on β-cyclodextrin and investigated its novel application as fluid loss additive in WDFs. American Petroleum Institute standard filtration tests showed that the PILs exhibited excellent filtration control performance even after hot rolling at 180 °C for 16 h compared to commercial fluid loss additives (Driscal D, PAC-Lv, CMC). Specifically, the fluid loss volumes of Driscal D/WDFs, PAC-Lv/WDFs and CMC/WDFs were 10.4 mL, 12.4 mL and 14.8 mL respectively after hot roll at 180 °C for 16 h, however, the fluid loss of PILs/WDFs was only 2.8 mL. The extremely low filtration rate, thickness and permeability of the PILs/WDFs mud cake resulted in exceptionally low fluid loss volume. Additionally, the mechanism of PILs controlling fluid loss in WDFs was revealed by bentonite particle size measurement and Zeta potential measurement. This work demonstrates that PILs have the promising application as an efficient fluid loss additive in WDFs due to the outstanding filtration loss reduction behavior.
✓ 已验证
DOI
高影响因子
ANALYTICAL SCIENCES
·
2020
·Vol. 36
·期 6
·687-695
·
IF 2.049
Hui WANG,Yazhou SHUANG,Tianci ZHANG,Liang LI,Laisheng LI
A cholesterol mono-derivatized β-cyclodextrin was synthesized and bonded onto silica gel (SBA-15) to obtain a cholesterol mono-derivatized β-cyclodextrin-bonded stationary phase (CHCDP). The chemical structures of mono-derivatized β-cyclodextrin and CHCDP were characterized by infrared spectroscopy, mass spectrometry, elemental analysis and thermogravimetric analysis, correspondingly. Furthermore, the separation ability of CHCDP in terms of achiral compounds was systematically evaluated by separating benzene homologs, polycyclic aromatic hydrocarbons (PAHs) and some positional isomers. As a result, CHCDP completely separated five benzene homologs and nine PAHs within 30 min under the reversed-phase. In addition, the chiral chromatographic property of CHCDP was also evaluated by separating some racemic compounds including flavanones, triazoles, β-blockers, etc. The results showed that the CHCDP exhibited high enantioselectivities towards most of selected analytes. The enantioresolutions were in the range from 1.43 to 2.51 on CHCDP. Especially the resolutions of 2′-hydroxyflavanone, hexaconazole, Dns-serine and atenolol were as high as 1.94, 1.91, 2.15 and 1.57, respectively. Obviously, the CHCDP was a versatile stationary phase with chiral and achiral separation capabilities in multi-mode chromatography, which was related to the introduction of cholesterol to the port of cyclodextrin, enhancing the hydrophobic interaction of cyclodextrin with achiral compounds, while maintaining the inclusion complexation of it with chiral compounds as well.
✓ 已验证
DOI
PubMed
高影响因子
ACS Food Science & Technology
·
2022
·
IF 0
Feng Han,Qing-ping Chen,Guangxin Yang,Wenlei Zhai,Essy Kouadio Fodjo,Liang-liang Tian,Hui-juan Yu,Yong-fu Shi,Cong Kong
An effective and efficient method for the determination of 18 β-agonists in aquatic products using liquid chromatography tandem mass spectrometry (LC-MS/MS) was successfully established. The method optimization was conducted based on incurred samples to guarantee its practicability. In this method, the sample was hydrolyzed with β-glucuronidase-arylsulfatase in ammonium acetate solution and treated successively with protein precipitation in 5% trichloroacetic acid in water, lipid removal with n-hexane, and further concentration and cleanup by solid-phase extraction (hydrophilic–lipophilic balanced cartridge, primary–secondary amine cartridge). Isotope-labeled internal standards and matrix-matched calibration curves were used for quantification. The limit of quantification (LOQ) was verified at 0.5–1.0 μg/kg (S/N > 10). This method was evaluated with five different matrices, including eel, roasted eel, pufferfish, shrimp, and crab, at 1×, 2×, and 10× LOQs, with good recoveries (>77%) and high replicate repeatability (relative standard deviations (RSDs) <13%, intraday batch repeatability) and further validated by three other accredited laboratories. A total of 3 samples out of 37 tested aquatic products were found positive for unknown incur sources (ractopamine, 0.38–2.1 μg/kg; salbutamol 3.0 μg/kg; tulobuterol 2.9 μg/kg; clenbuterol 1.3 μg/kg; and clenpenterol, 0.3 μg/kg). The method has demonstrated to be reliable, sensitive, and stable for multiresidue screening of β-agonists for food safety monitoring.
✓ 已验证
DOI
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2022
·
IF 4.326
Xuewu Liu,Xingfei Li,Yuxiang Bai,Xing Zhou,Long Chen,Chao Qiu,Cheng Lu,Zhengyu Jin,Jie Long,Zhengjun Xie
This study presents a simple method to immobilize β-agarase onto amino-modified magnetic nanoparticles (MNPs) by biotin/streptavidin (BT/SA) recognition. The effect of BT functionalized with different lengths of poly(ethylene glycol) (PEG) on the activity and stability of heterogeneous biocatalysts was also investigated. The results showed that the enzymatic activity was retained above 93% under the immobilization conditions (pH 7.0, 25 °C, 6 h, and β-agarase concentration of 1 mg/mL). The optimal pH and temperature for both free and immobilized β-agarases were 7 and 30 °C, respectively. PEG length played an important role in the catalytic performance of the immobilized enzyme. As the PEG length increased, an increased trend in activity retention and yield of neoagarobiose was observed. Ultimately, the introduction of PEG24 improved the activity retention of immobilized β-agarase up to 135.67%, and retained 84.18 and 37.04% of residual activity after incubation for 6 h at 40 and 45 °C, respectively, while only 30.50 and 0% of residual activities were observed for free β-agarase at these temperatures, indicating the significantly enhanced stability of the β-agarase after immobilization. Additionally, β-agarase-BTPEG24-SA@MNPs showed the highest yield of neoagarobiose at 45 °C, which was 1.89-fold higher than that of the free enzyme. These results indicated that immobilization of β-agarase on BTPEG-SA@MNPs improved both the catalytic efficiency and stability of the enzyme, thereby promoting the continuous production of neoagarobiose.
✓ 已验证
DOI
高影响因子
Biomedical Materials
·
2017
·Vol. 13
·期 1
·015012
·
IF 2.469
Hang Yao,Junpei Kang,Weichang Li,Jian Liu,Renjian Xie,Yingjun Wang,Sa Liu,Dong-An Wang,Li Ren
Cartilage repairing grafts have been widely studied, and osteochondral replacement hydrogels have proven to be an excellent method in research and clinical fields. However, it has been difficult to simultaneously solve three main issues in osteochondral replacement preparation: surface lubrication, overall mechanical support and good simulations of cell regeneration. A novel integrated bilayered hydrogel osteochondral replacement was constructed by blending polyvinyl alcohol (PVA) and β-tricalcium phosphate (β-TCP) in this study. Separated nano-ball milling with ultrasound dispersion prepared β-TCP demonstrated suitable properties of tiny particle size, high purity and ideal distribution, improving the mechanical properties of the novel integrated hydrogel, and providing a cartilage-like lubrication effect and high biocompatibility, including cytocompatibility and osteogenesis. The reinforcement of β-TCP and integrated molding technology enabled the hydrogel to demonstrate excellent component compatibility and good bonding between the two layers, which promoted the strengthening of the compression modulus and tensile modulus up to three times by mechanical testing. The surface lubrication properties of the novel osteochondral hydrogel were similar to the natural cartilage by friction coefficient characterization. The two layers of the novel integrated graft provided a considerable bio-function by co-culturing with chondrocytes and synovium mesenchymal stem cells: chondrocytes promoted adherence achieved by the upper density layer and better osteogenesis performance of the porous lower layer. The design of the bilayered β-TCP/PVA osteochondral hydrogel is promising for use in articular cartilage repair.
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Jiahao Shi,Yuhe Zhang,Bin Ma,Haiyang Yong,Delu Che,Chaolan Pan,Wei He,Dezhong Zhou,Ming Li
Poly(β-amino ester)s (PAEs) have been widely developed for gene delivery, and hydrophobic modification can further enhance their gene transfection efficiency. However, systematic manipulation of amphiphilicity of PAEs through copolymerization with hydrophobic monomers is time-consuming and, to some extent, uncontrollable. Here, a modular strategy is developed to manipulate the amphiphilicity of the PAE/DNA polyplexes. A hydrophobic polymer (DD-C12–122) and a hydrophilic polymer (DD-90–122) are synthesized separately and used as a hydrophobic module and a hydrophilic module, respectively. The amphiphilicity of polyplexes could be manipulated by changing the ratio of the hydrophobic module and hydrophilic module. Using the modular strategy, the PAE/DNA polyplexes with the highest gene transfection efficiency and safety profile as well as possible mechanisms are identified. The modular strategy provides a novel way to engineer the hydrophobicity of PAEs to improve their gene transfection and can be easily generalized and potentially extended to other polymeric gene delivery systems.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF COORDINATION CHEMISTRY
·
2020
·
IF 1.41
Kun Lu,Zihan Zhu,Lin Peng,Hai Fu,Xinlong Wang,Enbo Wang
An unusual metal-organic framework, {H[Ag(I)L][Mo(VI)4O13]}n (1) (L=(4-((1H-1,2,4-triazol-1-yl)methyl)phenyl)methanol)), has been obtained under ionothermal conditions. According to the single-crystal X-ray diffraction analysis, 1 is a new 3-D framework based on β-[Mo8O26]4− type polymolybdate anions with two kinds of channels (A and B) along the b-axes and c-axes in the framework. The neighboring inorganic Mo8-Ag chains are linked by the organic ligands through the Ag centers resulting in 2-D layers. These adjacent 2-D layers extend into a 3-D framework through Ag1 nodes and β-[Mo8O26]4− anions, respectively, resulting in a topological symbol (64 · 82)2(64 · 82). In addition, the gas adsorption, proton conduction and luminescent properties of 1 are also discussed in detail. Moreover, the electrochemical impedance spectroscopy (EIS) measurements show a conductivity (1.9 × 10−4 S cm−1 at 65 °C and 95% relative humidity (RH)), with an activation energy of 0.41 eV for 1. The mechanism of proton conduction for 1 is proved to be the vehicular mechanism.
✓ 已验证
DOI
高影响因子
KEY ENGINEERING MATERIALS
·
2017
·
IF 0
Song Tao Cai,Jian Xin Luo,Hong Wei Liu
β-Cyclodextrin polymer were prepared by inverse-phase suspension polymerization using epichlorohydrin (EPI) as crosslinker. The architecture has been characterized by Fourier transform infrared spectra (FT-IR) and thermogravimetric analysis (TGA), which confirmed that cyclodextrin polymer have been synthesized successfully. β-Cyclodextrin polymer (EPI-CD) can interact with a variety of hydrophobic compounds to form inclusion complexes, such as phenol. Experimental results indicated that the adsorption reached to 58.51umol/g under the initial concentration of 120mg/L at 298K. The adsorption isotherm was fitted to the Langmuir and Freundlich models. From the experimental data, it may be inferred that EPI-CD polymer was an effective adsorbent for the removal of phenol in wastewater treatment.
✓ 已验证
DOI
JOURNAL OF ORGANIC CHEMISTRY
·
2021
·
IF 4.354
Yuxiu Li,Xiangqian Li,Xiaowei Li,Dayong Shi
The straightforward synthesis of α-fluoro-β-arylalkenyl sulfones under transition-metal- and base-free conditions has been described, which displays broad functional group compatibility and high stereoselectivity. In particular, the strategy is also applied to the late-stage modification of complex natural products and drugs.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
·
2019
·Vol. 93
·期 3
·289-299
·
IF 1.429
Li Zhendong,Liu Huijun,Qi Caixia,Yang Aohui,Deng Shanxia
Using ethylenediamine-β-cyclodextrin and α-naphthylacetic acid as raw material, a novel inclusion complex (en-β-CD@NAA) was synthesized. The inclusion complex structures and properties were analyzed by reliable spectroscopic and physicochemical techniques. The stoichiometry of the inclusion complex was 1:1 and the stability constant ( K S ) value was found to be 2511 M −1 at 293 K. Molecular thermodynamic parameters indicated that the spontaneous and exothermic nature of the process. The inclusion form was foreseen by Chem 3D program combined with 1 H-NMR experimental data. The solubilization curves ( K 1 = 2.05) and in-vitro dissolution data demonstrated that the en-β-CD@NAA inclusion complex has satisfactory water solubility.
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2021
·
IF 3.196
Ting-Hong Huang,Cheng Luo,Dan Zheng,Jing-Yang Tan,Yong Liu,Jing Tang
Based on α- and β-naphthylamine, two new diphosphines, N,N-bis((diphenylphos phino)methyl)naphthalen-1-amine ( 1 ) and N,N-bis((diphenylphosphino)methyl)naphthalene -2-amine ( 2 ), have been prepared and characterized by IR, 1 H NMR, 31 P NMR, TG, UV-Vis, XRD and X-ray crystal structure analysis. Structural analysis shows that the two Ph 2 PCH 2 - groups in 1 and 2 are disposed in an anti configuration, and the change of the position of the (Ph 2 PCH 2 ) 2 N-group on the naphthalene moiety results in different spatial configurations of the two Ph 2 P- groups and different weak interactions, such as C-H … π and π–π interactions. DFT studies show that the composition of the HOMOs for 1 and 2 are almost the same (the naphthyl group with admixed N and P atoms), but the ingredients of the LUMOs for 1 are different from that for 2, coinciding with the change of Mülliken atomic charges . Moreover, the emission spectra show that the emissions of complexes 1 and 2 in acetonitrile solution are not similar to those of solid-state samples.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）