JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2018
·
IF 3.412
Yang Lu,Shuhua Shan,Hanqing Li,Jiangying Shi,Xiaoli Zhang,Zhuoyu Li
Foxtail millet is the second-most widely planted species of millet and the most important cereal food in China. Our previous study showed that bound polyphenol of inner shell (BPIS) from foxtail millet bran displayed effective antitumor activities in vitro and in vivo. The present research further implied that BPIS has the ability to reverse the multidrug resistance of colorectal cancer in human HCT-8/Fu cells, the IC50 values of 5-fluorouracil (5-Fu), oxaliplatin (L–OHP), and vincristine (VCR) were decreased form 6593 ± 53.8, 799 ± 48.9, and 247 ± 10.3 μM to 5350 ± 22.3 (3261 ± 56.9), 416 ± 16.6 (252 ± 15.6), and 144 ± 8.30 (83.8 ± 5.60) μM when HCT-8/Fu cells were pretreated with 0.5 (1.0) mg/mL BPIS for 12 h. The 12 phenolic acid compounds of BPIS were identified by ultraperformance liquid chromatography-triple-time of flight/mass spectrometry (UPLC-Triple-TOF/MS) method. Especially, the fraction of molecular weight (MW) < 200 of BPIS reversed the multidrug resistance in HCT-8/Fu cells, and ferulic acid and p-coumaric acid were the main active components, the IC50 values were 1.23 ± 0.195 and 2.68 ± 0.163 mg/mL, respectively. The present data implied that BPIS significantly enhanced the sensitivity of chemotherapeutic drugs through inhibiting cell proliferation, promoting cell apoptosis, and increasing the accumulation of rhodamine-123 (Rh-123) in HCT-8/Fu cells. Real-time polymerase chain reaction (RT-PCR) and Western blot data indicated that BPIS also decreased the expression levels of multidrug resistance protein 1 (MRP1), P-glycoprotein (P-gp), and breast cancer resistance protein (BCRP). Collectively, these results show that BPIS has potential ability to be used as a new drug-resistance reversal agent in colorectal cancer.
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CARBON
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2018
·
IF 7.082
Zhiwei Li,Hongyu Mi,Lang Liu,Zhengyu Bai,Jinping Zhang,Qing Zhang,Jieshan Qiu
Core-shell hybrid precursors (ZIF-8/ PP -SiO 2 ) engineered by zeoliticimidazolate framework (ZIF-8) depositing on the polyelectrolyte-decorated silica ( PP -SiO 2 ) are successfully transformed into unusual N-rich hollow carbon shell frameworks (NHCSFs) with adjustable physicochemical properties by the layer-by-layer assembly, interface engineering and subsequent carbonization , which is the first example that systematically elucidates the formation and structure-property correlation of unique three-dimensional (3D) carbon frameworks. The optimal NHCSF-3 displays superior performance with high capacitance approaching 253.6 F g −1 at 1 A g −1 , excellent rate capability delivering 79% capacitance retention after a 50-fold increase of the rate, and long lifetime (92.1% retention for 20000 cycles). The studies on alkaline and neutral NHCSF-3//NHCSF-3 supercapacitors demonstrate that the latter with high voltage up to 1.6 V using a Na 2 SO 4 electrolyte can deliver high energy density of 13.3 Wh kg −1 . The distinctly enhanced performance illustrates that, except for the factors such as morphology, surface area, pore volume , and N-doping level, hierarchical porosity also significantly boosts electrochemical properties of the materials because of providing efficient charge/mass transport. Overall, this research provides an efficient platform for precisely modulating the structure of MOF-based carbons to develop multifunctional hollow architectures for satisfying enormous demands in upcoming energy devices.
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TALANTA
·
2018
·
IF 4.244
Yue Wang,Xue Li,Geoffrey I.N. Waterhouse,Yunlei Zhou,Huanshun Yin,Shiyun Ai
In this work, a novel and sensitive photoelectrochemical (PEC) strategy was designed for protein kinase A (PKA) detection, comprising carbon microsphere (CMS) modified ITO electrode, TiO 2 as the phosphate group recognition material and graphite-carbon nitride (g-C 3 N 4 ) as photoactive material. For the first time, gold nanoparticle decorated zeolitic imidazolate frameworks (Au-ZIF-8) was employed to fabricate biosensor for PKA activity assay with the function of substrate peptide immobilization and signal amplification. Firstly, substrate peptides were assembled on the Au-ZIF-8/CMS/ITO surface through the covalent bonding between the gold nanoparticles (AuNPs) and sulfydryl groups of the peptides. Then, in the presence of ATP , phosphorylation of the substrate peptide was achieved under PKA catalysis. Finally, TiO 2 -g-C 3 N 4 composites were further modified on the electrode surface based on bonding between TiO 2 and phosphate groups created via phosphorylation of the peptide (yielding TiO 2 -g-C 3 N 4 /P-peptide/Au-ZIF-8/CMS/ITO), which is different with our previous work by directly immobilizing g-C 3 N 4 composite on electrode surface. The developed method showed a wide linear range from 0.05–50 U mL −1 . The detection limit was 0.02 U mL −1 (S/N = 3). The constructed biosensor exhibited high detection specificity for PKA. In addition, the wide applicability of this biosensor was demonstrated by evaluating the inhibition ability of ellagic acid towards PKA.
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高影响因子
Small
·
2016
·Vol. 12
·期 40
·5564-5571
·
IF 8.315
Ming Zhong,Donghui Yang,Chenchao Xie,Zhang Zhang,Zhen Zhou,Xian-He Bu
Manganese oxides (MnO x ) are promising anode materials for lithium ion batteries, but they generally exhibit mediocre performances due to intrinsic low ionic conductivity, high polarization, and poor stability. Herein, yolk–shell nanorods comprising of nitrogen-doped carbon (N–C) coating on manganese monoxide (MnO) coupled with zinc manganate (ZnMn 2 O 4 ) nanoparticles are manufactured via one-step carbonization of α -MnO 2 /ZIF-8 precursors. When evaluated as anodes for lithium ion batteries, MnO@ZnMn 2 O 4 /N–C exhibits an reversible capacity of 803 mAh g −1 at 50 mA g −1 after 100 cycles, excellent cyclability with a capacity of 595 mAh g −1 at 1000 mAg −1 after 200 cycles, as well as better rate capability compared with those non-N–C shelled manganese oxides (MnO x ). The outstanding electrochemical performance is attributed to the unique yolk–shell nanorod structure, the coating effect of N–C and nanoscale size.
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高影响因子
LANGMUIR
·
2016
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IF 3.993
Ping Zhang,Ling Li,Yun Zhao,Zeyun Tian,Yumei Qin,Jun Lu
The fluorescent dye 8-anilino-1-naphthalenesulfonate (ANS) is a widely used fluorescent probe molecule for biochemistry analysis. This paper reported the fabrication of ANS/layered double hydroxide nanosheets (ANS/LDH)n ultrathin films (UTFs) via the layer-by-layer small anion assembly technique based on electrostatic interaction and two possible weak interactions: hydrogen-bond and induced electrostatic interactions between ANS and positive-charged LDH nanosheets. The obtained UTFs show a long-range-ordered periodic layered stacking structure and weak fluorescence in dry air or water, but it split into three narrow strong peaks in a weak polarity environment induced by the two-dimensional (2D) confinement effect of the LDH laminate; the fluorescence intensity increases with decreasing the solvent polarity, concomitant with the blue shift of the emission peaks, which show good sensoring reversibility. Meanwhile, the UTFs exhibit selective fluorescence enhancement to the bovine serum albumin (BSA)-like protein biomolecules, and the rate of fluorescence enhancement with the protein concentration is significantly different with the different protein aggregate states. The (ANS/LDH)n UTF has the potential to be a novel type of biological flourescence sensor material.
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JOURNAL OF HAZARDOUS MATERIALS
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2016
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IF 4.836
Siqi Li,Xiaodan Zhang,Yuming Huang
The nanoporous carbons (NPC) derived from a one-step carbonization of zeolitic imidazolate framework-8 (ZIF-8) were synthesized and used for ciprofloxacin (CIP) removal from water. The resultant products were characterized by SEM, TEM, FT-IR, Raman, N 2 adsorption-desorption analysis, XRD, TGA and Zeta potential. The optimized NPC-700 (carbonized at 700 °C for 2 h) exhibited an optimal performance in CIP adsorption removal. CIP adsorption on NPC-700 as a function of contact time, initial CIP concentration, adsorbent dosage, pH, ionic strength and humic acid concentration were investigated. Kinetics of CIP removal was found to follow pseudo-second-order rate equation. Both Langmuir and Freundlich models fitted the adsorption data well and gave similar correlation coefficients (>0.96). However, Freundlich isotherm gave a better fit ( r 2 = 0.9969), suggesting a multilayer adsorption of CIP onto surface of NPC-700 adsorbent. The maximum adsorption capacity for CIP based on Langmuir model was 416.7 mg/g, which was higher than those of other adsorbents. The NPC-700 material showed no apparent loss in CIP adsorption after seven cycles. These features reveal that the metal-organic framework (MOF) derived NPC may be a promising adsorbent for CIP removal from water.
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EUROPEAN POLYMER JOURNAL
·
2024
·
IF 5.8
Dan Zhang,Yue Zhao,Qi He,Kaixuan Feng,Zhi Hu,Guohong Ma,Zengxi Pan
Magnesium (Mg) alloys are susceptible to being attacked by corrosive ions in practical application environments, which limits their widespread application as the most promising engineering material. Herein, the superhydrophobic composite coating PVB/STA/ZIF-8@SiO 2 (PSZS) has been designed on the surface of Mg alloy by using a drop coating method to improve its corrosion resistance. In this study, we provide an approachable decoration strategy for hydrophobic and hierarchical modification of zeolite imidazolate frameworks (ZIF-8) with stearic acid (STA) and SiO 2 , and combined with polyvinyl butyral (PVB) to form a composite coating with excellent performance on the substrate surface. Notably, the PSZS composite coating exhibited superhydrophobic and the contact angle is greater than 150° after 300 cm of mechanical friction. The electrochemical testing of the PSZS composite coating indicated that it greatly protected the Mg alloys from corrosion. Moreover, the PSZS coating displayed highly effective corrosion resistance even after being immersed in 3.5 wt% NaCl aqueous solution for 7 days. Overall, the PSZS composite coating with the advantages of corrosion resistance, corrosion durability, superhydrophobic, abrasion resistance and simple preparation process broadens the horizons of Mg alloy corrosion resistance research.
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Food Chemistry-X
·
2024
·
IF 6.5
Doudou Lei,Lingling Li,Pengyue Song,QingBin Xu,Lihua Huang,Xiao Ma,Lidong Zhou,Weijun Kong
Glyphosate (Gly) is a widely-used herbicide in food production, while, the residue of which due to the long-term and excessive overspray poses serious threats to public health. The development of reliable methods for its sensitive detection is of great urgency. In this study, a novel ratiometric fluorescent nanosensor by encapsulating N-doped carbon dots (N-CDs) and gold nanoclusters (AuNCs) in zeolitic imidazole framework-8 (ZIF-8) as the dual-emissive fluorescence probes at 410 and 650 nm, respectively, was constructed for Gly detection. Due to the adsorption property of ZIF-8, the N-CDs/AuNCs@ZIF-8 nanoprobes accumulated Cu 2+ to quench the red fluorescence of AuNCs, and the blue fluorescence of N-CDs was stable. While thiocholine, a product of acetylthiocholine, hydrolyzed by acetylcholinesterase could coordinate with Cu 2+ , resulting in significant fluorescence recovery of AuNCs. This phenomenon was utilized for the quantitation of Gly, due to its inhibitory effect on acetylcholinesterase activity. By calculating the fluorescence intensity ratio ( I 650 /I 410 ), Gly in real sample could be accurately determined in a concentration range of 2–100 ng/mL with a limit of detection of 1.92 ng/mL because of the anti-interference and the self-correction ability of the two fluorescence signals. The N-CDs/AuNCs@ZIF-8 nanoprobes-assisted ratiometric fluorescent nanosensor exhibited unique merits of rapid construction, simple operation, high specificity, and good accuracy for Gly in edible and medicinal malt samples with recoveries of 93.7–108.2 %. This study presents a multiple tool for the versatile sensing of trace pesticides in more food matrices, which can be extended to a full range of environmental and food safety applications.
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ACS Biomaterials Science & Engineering
·
2024
·
IF 5.4
Yilin Mao,Liang Wang,Zhengyi Xu,Wenjia Xie,Yuting Wang,Wei Qiao,Zhou Zhu,Jian Wang
In recent years, nanomaterials have gained widespread use in the biomedical field, with ZIF-8 and ZnO emerging as promising candidates due to their remarkable performance in osteogenesis, angiogenesis, and antimicrobial therapy. However, before advancing these nanomaterials for clinical applications, it is imperative to evaluate their biocompatibility. In particular, comparing nanomaterials with similar biomedical functions is crucial for identifying the most suitable nanomaterials for further development and market entry. Our study aimed to compare the biocompatibility of nano-ZIF-8 and nano-ZnO under the same conditions. We found that nano-ZIF-8 exhibited lower toxicity both in vitro and in vivo compared to nano-ZnO. To gain insights into the underlying mechanisms responsible for this difference, we conducted further experiments to investigate lysosome damage, mitochondrial change, and the occurrence of ferroptosis. Additionally, we performed transcriptome sequencing to analyze the expression of relevant genes, thereby providing robust validation for our findings. In summary, our study highlighted the importance of evaluating nanomaterials with similar biomedical effects. Through this comparative study, we have not only shed light on the superior biocompatibility of nano-ZIF-8 over nano-ZnO, but also contributed valuable insights and methodological references for future material screening endeavors. Ultimately, our study served as a stepping stone toward the development of safer and more effective nanomaterials for various biomedical applications.
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TALANTA
·
2025
·
IF 6.1
Ninghan Tang,Chaoting Shi,Xiandeng Hou,Hui Xin,Lan Wu
Excessive use of tetracycline poses risks to human health and the ecological balance, which poses challenges to develop a method for facile and reliable detection of tetracycline. Herein, the MoS 2 QDs@ZIF-8 was prepared through a simple method, serving as an asynchronous response sensor for the naked-eye detection of tetracycline. The photoinduced electron transfer between the composite sensor and target tetracycline led to quench the blue fluorescence emitted by MoS 2 QDs. Hydrogen bond, chelation, π-π stacking and pore effect between the composite sensor and tetracycline made the aggregation of tetracycline, significantly enhancing the intrinsic yellow fluorescence of tetracycline. Moreover, it also exhibited good detection performance for the real samples such as river water, farm wastewater, honey and milk, demonstrating that it was suitable for naked-eye visualization detection in the field. This work provided a novel approach for constructing ratiometric fluorescence sensors with asynchronous response.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Yue Wang,Yaning Li,Meiwen Cao,Zeyu Yan,Fenggang Wei,Tianhao Ma,Ruochen Xie,Hongchao Ma
Tumor hypoxia, limited H 2 O 2 levels, and abundant glutathione (GSH) in the tumor microenvironment (TME) pose challenges for high-efficiency reactive oxygen species (ROS)-mediated therapies. To address these limitations, an intelligent ROS-mediated nanoplatform, Ce6@ZIF-8/PDA/CuO 2 /HA (CZPCH), with photodynamic activity, self-supplied H 2 O 2 , Fenton-like reaction, GSH-depletion and photothermal activity was designed for efficient tumor treatment. In the acidic TME, CuO 2 in CZPCH deposits into Cu 2+ and H 2 O 2 , consuming GSH and triggering Fenton-like reactions to generate hydroxyl radical (•OH), enabling efficient chemodynamic therapy (CDT). Moreover, the presence of Ce6 and PDA enables CZPCH to exhibit excellent singlet oxygen ( 1 O 2 ) and temperature increase performance 660 nm and 808 nm laser irradiation, respectively, resulting in efficient photodynamic therapy (PDT) and photothermal therapy (PTT) efficacy. Interestingly, the temperature increase from PTT significantly enhances •OH and 1 O 2 generation, achieving high-efficiency ROS-based therapeutic efficacy. This synergistic CDT/PDT/PTT treatment demonstrates excellent anti-tumor efficacy and illuminates novel ROS-based therapeutic strategy design.
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JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Yidan Ding,Mengjiao Xia,Jian Yu,Erqiao Chen,Congcong Zhou,Liguo Shen,Yang Jiao,Yanchao Xu,Hongjun Lin
Mixed matrix membranes (MMMs) incorporating ZIF-8 nanoparticles through non-solvent induced phase separation (NIPS) hold great potential in the organic solvent nanofiltration (OSN) field, but their advancement and application have been significantly hindered by ZIF-8’s instability of ZIF-8 in aqueous conditions and major interfacial incompatibilities with polymers. This study presents an approach to overcome these obstacles by initially forming crosslinked ZnO/polyimide (PI) MMMs via NIPS and crosslinking processes, followed by in-situ conversion of ZnO to ZIF-8 within the membrane structure. This method prevents direct contact of ZIF-8 with water, optimizes the interface between ZIF-8 and the polymer, and modulates the pore structure of the membranes. The resulting crosslinked ZIF-8/PI membranes exhibit an ultra-high ethanol permeance of 42.7 L m⁻ 2 h⁻ 1 bar⁻ 1 and a 99.5 % rejection of Rose Bengal dye, surpassing the performance of all state-of-the-art OSN MMMs to our knowledge. Additionally, these membranes also demonstrate excellent separation performance in harsh solvents such as DMF and NMP. The findings of this study not only significantly advance the development of OSN membranes but also offer insights into the optimization of membrane fabrication techniques, setting a new benchmark for the design of high-performance OSN membranes.
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危险品化学品经营许可证（带存储）